JP6867998B2 - ガンを処置するのに使用するための置換疎水性ベンゼンスルホンアミドチアゾール化合物 - Google Patents

ガンを処置するのに使用するための置換疎水性ベンゼンスルホンアミドチアゾール化合物 Download PDF

Info

Publication number
JP6867998B2
JP6867998B2 JP2018503213A JP2018503213A JP6867998B2 JP 6867998 B2 JP6867998 B2 JP 6867998B2 JP 2018503213 A JP2018503213 A JP 2018503213A JP 2018503213 A JP2018503213 A JP 2018503213A JP 6867998 B2 JP6867998 B2 JP 6867998B2
Authority
JP
Japan
Prior art keywords
alkyl
phenyl
thiazole
aryl
acetamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018503213A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018527324A (ja
JP2018527324A5 (enExample
Inventor
ロッシ，ステファン
ベニダ，ラシッド
バロッティ，ロベール
プレザン，マガリ
ロンコ，シリル
ミレー，アントワーヌ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite de Nice Sophia Antipolis UNSA
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite de Nice Sophia Antipolis UNSA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite de Nice Sophia Antipolis UNSA filed Critical Centre National de la Recherche Scientifique CNRS
Publication of JP2018527324A publication Critical patent/JP2018527324A/ja
Publication of JP2018527324A5 publication Critical patent/JP2018527324A5/ja
Application granted granted Critical
Publication of JP6867998B2 publication Critical patent/JP6867998B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2018503213A 2015-07-24 2016-07-22 ガンを処置するのに使用するための置換疎水性ベンゼンスルホンアミドチアゾール化合物 Active JP6867998B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15306213.8 2015-07-24
EP15306213 2015-07-24
PCT/EP2016/067506 WO2017017004A1 (en) 2015-07-24 2016-07-22 Substituted hydrophobic benzene sulfonamide thiazole compounds for use in treating cancer

Publications (3)

Publication Number Publication Date
JP2018527324A JP2018527324A (ja) 2018-09-20
JP2018527324A5 JP2018527324A5 (enExample) 2020-12-17
JP6867998B2 true JP6867998B2 (ja) 2021-05-12

Family

ID=53758161

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018503213A Active JP6867998B2 (ja) 2015-07-24 2016-07-22 ガンを処置するのに使用するための置換疎水性ベンゼンスルホンアミドチアゾール化合物

Country Status (4)

Country Link
US (2) US10815207B2 (enExample)
EP (1) EP3325452B1 (enExample)
JP (1) JP6867998B2 (enExample)
WO (1) WO2017017004A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3117916A1 (en) 2018-11-23 2020-05-28 Martin Quibell Compounds
CN115477626B (zh) * 2021-06-16 2024-08-02 上海璃道医药科技有限公司 N-取代苯基磺酰胺类化合物及其用途
EP4201928A1 (en) 2021-12-21 2023-06-28 Institut National de la Santé et de la Recherche Médicale (INSERM) Benzene sulfonamide thiazole compounds and their use for the treatment of cancers
WO2024084013A1 (en) * 2022-10-20 2024-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Combination therapy for the treatment of cancer
WO2025219595A1 (en) * 2024-04-19 2025-10-23 Biper Therapeutics Method for combination treatments using alkynylbenzenesulphonamides for cancer therapy
EP4635480A1 (en) 2024-04-19 2025-10-22 Biper Therapeutics SAS Compositions comprising a benzene sulfonamide thiazole compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2817219B2 (ja) 1988-09-08 1998-10-30 武田薬品工業株式会社 カルバジン酸誘導体、その製造法及び製剤
US7163952B2 (en) 2001-12-03 2007-01-16 Japan Tobacco Inc. Azole compound and medicinal use thereof
EP1971597A2 (en) 2005-12-12 2008-09-24 Genelabs Technologies, Inc. N-(5-membered heteroaromatic ring)-amido anti-viral compounds
EP2062181A2 (en) * 2006-08-28 2009-05-27 Dan Theodorescu Prediction of an agent's or agents' activity across different cells and tissue types
BRPI0814432A2 (pt) 2007-07-17 2017-05-09 Rigel Pharmaceuticals Inc pirimidinadiaminas substituídas por amina cíclica como inibidores de pkc
WO2009146013A1 (en) * 2008-03-31 2009-12-03 Georgetown University Myosin light chain phosphatase inhibitors
JP6539839B2 (ja) * 2012-11-09 2019-07-10 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル）Ｉｎｓｅｒｍ（Ｉｎｓｔｉｔｕｔ Ｎａｔｉｏｎａｌ Ｄｅｌａ Ｓａｎｔｅ Ｅｔ Ｄｅ Ｌａ Ｒｅｃｈｅｒｃｈｅ Ｍｅｄｉｃａｌｅ） 新規のベンゼンスルホンアミドチアゾール化合物

Also Published As

Publication number Publication date
US10815207B2 (en) 2020-10-27
US20180215723A1 (en) 2018-08-02
JP2018527324A (ja) 2018-09-20
EP3325452B1 (en) 2022-03-30
US20210040054A1 (en) 2021-02-11
EP3325452A1 (en) 2018-05-30
WO2017017004A1 (en) 2017-02-02

Similar Documents

Publication Publication Date Title
JP6867998B2 (ja) ガンを処置するのに使用するための置換疎水性ベンゼンスルホンアミドチアゾール化合物
EP2917190B1 (en) New benzene sulfonamide thiazole compounds
JP4405602B2 (ja) ヒストン脱アセチル化酵素阻害剤
KR101486026B1 (ko) 플루오렌, 안트라센, 잔텐, 디벤조수베론 및 아크리딘의 유도체 및 이의 용도
CN105646389B (zh) 一种作为吲哚胺-2,3-双加氧酶抑制剂的氨基磺酸脂及其制备方法和用途
WO2017152857A1 (zh) 一种含氮烷基化和芳基化亚砜亚胺的吲哚胺-2,3-双加氧酶抑制剂
WO2018161831A1 (zh) Gpr84受体拮抗剂及其应用
WO2001021206A1 (en) PREVENTIVES OR REMEDIES FOR MYOCARDITIS, DILATED CARDIOMYOPATHY AND CARDIAC INSUFFICIENCY CONTAINING NF-λB INHIBITORS AS THE ACTIVE INGREDIENT
CN110156674A (zh) 一种作为吲哚胺-2,3-双加氧酶抑制剂的螺环化合物
JPH11269140A (ja) 分化誘導剤
MX2010011289A (es) Compuestos que tienen actividad antagonista del receptor y5 de neuropeptido y.
JP2010527344A (ja) ビシクロスルホニル酸（ｂｃｓａ）化合物及び治療薬としてのその使用
JP2016505584A (ja) ダウン症候群及びアルツハイマー病に関連する認知欠損の治療のための、ｄｙｒｋ１ａタンパク質阻害剤としての３，５−ジアリールアザインドール類
WO2016037592A1 (zh) 一种氨基磺酰基类化合物、其制备方法及用途
KR102253721B1 (ko) 벤조티오펜 화합물
WO2025043079A1 (en) Compounds, compositions, and methods
CN107663202B (zh) 3-(脲基-甲基)-4-芳基-吡啶衍生物及其制备方法和作为抗肝癌药物的应用
JP2024537311A (ja) Ｓｈｐ２阻害剤、それを含む医薬組成物およびその使用
HK1257006A1 (en) Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof
CN115677703A (zh) 吡啶酮类化合物及其用途
HK1257006B (en) Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof
WO2019141095A1 (zh) 脒类和胍类衍生物、其制备方法及其在医药上的应用
BR112020000564A2 (pt) novos derivados de heteroarilamida como inibidores seletivos das histonas desacetilases 1 e/ou 2 (hdac1-2)
JP2004035484A (ja) シクロヘキサンジアミン誘導体
JP2004035486A (ja) パラフェニレンジアミン誘導体

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190719

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200707

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200804

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20201102

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210316

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210409

R150 Certificate of patent or registration of utility model

Ref document number: 6867998

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250