JP2013529900A5 - - Google Patents
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- Publication number
- JP2013529900A5 JP2013529900A5 JP2013511528A JP2013511528A JP2013529900A5 JP 2013529900 A5 JP2013529900 A5 JP 2013529900A5 JP 2013511528 A JP2013511528 A JP 2013511528A JP 2013511528 A JP2013511528 A JP 2013511528A JP 2013529900 A5 JP2013529900 A5 JP 2013529900A5
- Authority
- JP
- Japan
- Prior art keywords
- antagonist
- cell activator
- cell
- nucleotide sequence
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005557 antagonist Substances 0.000 claims 18
- 239000012190 activator Substances 0.000 claims 12
- 210000003719 b-lymphocyte Anatomy 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 9
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102100036922 Tumor necrosis factor ligand superfamily member 13B Human genes 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000000746 purification Methods 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 2
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 2
- 230000003042 antagnostic effect Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 108010028006 B-Cell Activating Factor Proteins 0.000 claims 1
- 230000003844 B-cell-activation Effects 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 108700002109 Transmembrane Activator and CAML Interactor Proteins 0.000 claims 1
- 102000050862 Transmembrane Activator and CAML Interactor Human genes 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000004440 column chromatography Methods 0.000 claims 1
- 201000006754 cone-rod dystrophy Diseases 0.000 claims 1
- 201000000464 cone-rod dystrophy 2 Diseases 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 239000012516 mab select resin Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101839059A CN101851278B (zh) | 2010-05-26 | 2010-05-26 | B细胞激活因子拮抗剂及其制备方法与用途 |
| PCT/CN2011/074687 WO2011147320A1 (zh) | 2010-05-26 | 2011-05-26 | B细胞激活因子拮抗剂及其制备方法与用途 |
| CN201010183905.9 | 2011-05-26 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015151930A Division JP6320973B2 (ja) | 2010-05-26 | 2015-07-31 | Ｂ細胞活性化因子の拮抗物質、その調製方法及び利用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013529900A JP2013529900A (ja) | 2013-07-25 |
| JP2013529900A5 true JP2013529900A5 (enExample) | 2014-12-04 |
Family
ID=42802979
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013511528A Pending JP2013529900A (ja) | 2010-05-26 | 2011-05-26 | Ｂ細胞活性化因子の拮抗物質、その調製方法及び利用法 |
| JP2015151930A Active JP6320973B2 (ja) | 2010-05-26 | 2015-07-31 | Ｂ細胞活性化因子の拮抗物質、その調製方法及び利用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015151930A Active JP6320973B2 (ja) | 2010-05-26 | 2015-07-31 | Ｂ細胞活性化因子の拮抗物質、その調製方法及び利用法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9290582B2 (enExample) |
| EP (1) | EP2578603B1 (enExample) |
| JP (2) | JP2013529900A (enExample) |
| KR (2) | KR101810551B1 (enExample) |
| CN (1) | CN101851278B (enExample) |
| WO (1) | WO2011147320A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101851278B (zh) * | 2010-05-26 | 2013-03-13 | 石药集团中奇制药技术（石家庄）有限公司 | B细胞激活因子拮抗剂及其制备方法与用途 |
| CN106220740A (zh) * | 2016-08-18 | 2016-12-14 | 中山大学 | 可溶性蛋白baff在b细胞体外培养及扩增的应用 |
| WO2019074983A1 (en) | 2017-10-10 | 2019-04-18 | Alpine Immune Sciences, Inc. | CTLA-4 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF |
| ES2827148B2 (es) * | 2019-11-19 | 2021-10-19 | Instituto Nac De Investigacion Y Tecnologia Agraria Y Alimentaria Inia | Plásmido codificante para el receptor del factor de activación de células B (BAFF-R) y usos del mismo en el tratamiento y prevención de enfermedades inflamatorias en peces |
| WO2021226551A1 (en) | 2020-05-08 | 2021-11-11 | Alpine Immune Sciences, Inc. | April and baff inhibitory immunomodulatory proteins and methods of use thereof |
| CN121263449A (zh) | 2023-03-21 | 2026-01-02 | 拜格拉夫55公司 | Cd19/cd38多特异性抗体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA83458C2 (uk) * | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
| EA010594B1 (ru) * | 2001-05-24 | 2008-10-30 | Займодженетикс, Инк. | Слитые белки taci-иммуноглобулина |
| CA2453995A1 (en) | 2001-08-03 | 2003-02-20 | Genentech, Inc. | Tacis and br3 polypeptides and uses thereof |
| PT2272868E (pt) | 2003-06-05 | 2015-07-07 | Genentech Inc | Terapêutica de combinação para distúrbios de células b |
| SI2272868T1 (sl) | 2003-06-05 | 2015-07-31 | Genentech, Inc., | Kombinirana terapija za B-celične motnje |
| WO2010042654A2 (en) * | 2008-10-07 | 2010-04-15 | The Regents Of The University Of California | Recombinant nell protein production |
| EA200701211A1 (ru) | 2004-12-31 | 2007-12-28 | Дженентек, Инк. | Полипептиды, которые связываются с br3, и их применение |
| JP2010501622A (ja) | 2006-08-28 | 2010-01-21 | アレス トレーディング ソシエテ アノニム | Ｆｃ−融合タンパク質の精製法 |
| CA2681728C (en) * | 2007-03-27 | 2015-12-22 | Zymogenetics, Inc. | Combination of blys and/or april inhibition and immunnosuppressants for treatment of autoimmune disease |
| CN101851278B (zh) | 2010-05-26 | 2013-03-13 | 石药集团中奇制药技术（石家庄）有限公司 | B细胞激活因子拮抗剂及其制备方法与用途 |
-
2010
- 2010-05-26 CN CN2010101839059A patent/CN101851278B/zh active Active
-
2011
- 2011-05-26 EP EP11786092.4A patent/EP2578603B1/en active Active
- 2011-05-26 JP JP2013511528A patent/JP2013529900A/ja active Pending
- 2011-05-26 US US13/699,903 patent/US9290582B2/en active Active
- 2011-05-26 KR KR1020167020322A patent/KR101810551B1/ko active Active
- 2011-05-26 KR KR1020127033484A patent/KR20130043642A/ko not_active Ceased
- 2011-05-26 WO PCT/CN2011/074687 patent/WO2011147320A1/zh not_active Ceased
-
2015
- 2015-07-31 JP JP2015151930A patent/JP6320973B2/ja active Active