CN101851278B - B细胞激活因子拮抗剂及其制备方法与用途 - Google Patents

B细胞激活因子拮抗剂及其制备方法与用途 Download PDF

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CN101851278B
CN101851278B CN2010101839059A CN201010183905A CN101851278B CN 101851278 B CN101851278 B CN 101851278B CN 2010101839059 A CN2010101839059 A CN 2010101839059A CN 201010183905 A CN201010183905 A CN 201010183905A CN 101851278 B CN101851278 B CN 101851278B
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activating factor
cell
factor antagonist
cell activating
baff
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CN101851278A (zh
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杨莉
魏于全
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Sichuan University
CSPC Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd
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Sichuan University
CSPC Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd
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Priority to CN2010101839059A priority Critical patent/CN101851278B/zh
Publication of CN101851278A publication Critical patent/CN101851278A/zh
Priority to KR1020127033484A priority patent/KR20130043642A/ko
Priority to PCT/CN2011/074687 priority patent/WO2011147320A1/zh
Priority to EP11786092.4A priority patent/EP2578603B1/en
Priority to US13/699,903 priority patent/US9290582B2/en
Priority to JP2013511528A priority patent/JP2013529900A/ja
Priority to KR1020167020322A priority patent/KR101810551B1/ko
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    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2010101839059A 2010-05-26 2010-05-26 B细胞激活因子拮抗剂及其制备方法与用途 Active CN101851278B (zh)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN2010101839059A CN101851278B (zh) 2010-05-26 2010-05-26 B细胞激活因子拮抗剂及其制备方法与用途
US13/699,903 US9290582B2 (en) 2010-05-26 2011-05-26 B cell activating factor antagonist and preparation method and use thereof
PCT/CN2011/074687 WO2011147320A1 (zh) 2010-05-26 2011-05-26 B细胞激活因子拮抗剂及其制备方法与用途
EP11786092.4A EP2578603B1 (en) 2010-05-26 2011-05-26 B cell activating factor antagonist and preparation method and use thereof
KR1020127033484A KR20130043642A (ko) 2010-05-26 2011-05-26 B세포활성인자길항제 및 그의 제조방법과 용도
JP2013511528A JP2013529900A (ja) 2010-05-26 2011-05-26 B細胞活性化因子の拮抗物質、その調製方法及び利用法
KR1020167020322A KR101810551B1 (ko) 2010-05-26 2011-05-26 B세포 활성인자길항제 및 그의 제조방법과 용도
JP2015151930A JP6320973B2 (ja) 2010-05-26 2015-07-31 B細胞活性化因子の拮抗物質、その調製方法及び利用法

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Application Number Priority Date Filing Date Title
CN2010101839059A CN101851278B (zh) 2010-05-26 2010-05-26 B细胞激活因子拮抗剂及其制备方法与用途

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CN101851278A CN101851278A (zh) 2010-10-06
CN101851278B true CN101851278B (zh) 2013-03-13

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US (1) US9290582B2 (enExample)
EP (1) EP2578603B1 (enExample)
JP (2) JP2013529900A (enExample)
KR (2) KR101810551B1 (enExample)
CN (1) CN101851278B (enExample)
WO (1) WO2011147320A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101851278B (zh) 2010-05-26 2013-03-13 石药集团中奇制药技术(石家庄)有限公司 B细胞激活因子拮抗剂及其制备方法与用途
CN106220740A (zh) * 2016-08-18 2016-12-14 中山大学 可溶性蛋白baff在b细胞体外培养及扩增的应用
EP3694870A1 (en) 2017-10-10 2020-08-19 Alpine Immune Sciences, Inc. Ctla-4 variant immunomodulatory proteins and uses thereof
ES2827148B2 (es) * 2019-11-19 2021-10-19 Instituto Nac De Investigacion Y Tecnologia Agraria Y Alimentaria Inia Plásmido codificante para el receptor del factor de activación de células B (BAFF-R) y usos del mismo en el tratamiento y prevención de enfermedades inflamatorias en peces
US12202882B2 (en) 2020-05-08 2025-01-21 Alpine Immune Sciences, Inc. APRIL and BAFF inhibitory immunomodulatory proteins and methods of use thereof
TW202440636A (zh) 2023-03-21 2024-10-16 美商傳記55有限公司 Cd19/cd38多特異性抗體

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1612750A (zh) * 2001-05-24 2005-05-04 津莫吉尼蒂克斯公司 Taci-免疫球蛋白融合蛋白质
CN1622995A (zh) * 2000-09-18 2005-06-01 比奥根公司 新的受体核酸及多肽
CN101678106A (zh) * 2007-03-27 2010-03-24 津莫吉尼蒂克斯公司 用于治疗自身免疫疾病的BLyS抑制和/或APRIL抑制与免疫抑制剂的组合

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
KR20040019105A (ko) 2001-08-03 2004-03-04 제넨테크, 인크. TACIs 및 BR3 폴리펩티드 및 이의 용도
ES2537738T3 (es) 2003-06-05 2015-06-11 Genentech, Inc. Terapia de combinación para trastornos de células B
CN1835972A (zh) * 2003-06-05 2006-09-20 健泰科生物技术公司 B细胞疾病的联合治疗
BRPI0518994A2 (pt) 2004-12-31 2008-12-02 Biogen Idec Inc anticorpos ou polipeptÍdeos que se ligam a br3, seus usos e formulaÇÕes lÍquidas
JP2010501622A (ja) 2006-08-28 2010-01-21 アレス トレーディング ソシエテ アノニム Fc−融合タンパク質の精製法
CA2739608A1 (en) * 2008-10-07 2010-04-15 The Regents Of The University Of California Recombinant nell protein production
CN101851278B (zh) * 2010-05-26 2013-03-13 石药集团中奇制药技术(石家庄)有限公司 B细胞激活因子拮抗剂及其制备方法与用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1622995A (zh) * 2000-09-18 2005-06-01 比奥根公司 新的受体核酸及多肽
CN1612750A (zh) * 2001-05-24 2005-05-04 津莫吉尼蒂克斯公司 Taci-免疫球蛋白融合蛋白质
CN101678106A (zh) * 2007-03-27 2010-03-24 津莫吉尼蒂克斯公司 用于治疗自身免疫疾病的BLyS抑制和/或APRIL抑制与免疫抑制剂的组合

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王燕等.人TACI-linker-BR3双受体融合基因真核表达载体构建及其在COS-7细胞中的表达.《第二军医大学学报》.2006,第27卷(第11期),1190-1195. *

Also Published As

Publication number Publication date
WO2011147320A1 (zh) 2011-12-01
KR20130043642A (ko) 2013-04-30
KR20160102066A (ko) 2016-08-26
US9290582B2 (en) 2016-03-22
CN101851278A (zh) 2010-10-06
KR101810551B1 (ko) 2017-12-19
JP2013529900A (ja) 2013-07-25
EP2578603A4 (en) 2014-03-26
EP2578603A1 (en) 2013-04-10
US20130089549A1 (en) 2013-04-11
EP2578603B1 (en) 2018-11-14
JP6320973B2 (ja) 2018-05-09
JP2016019527A (ja) 2016-02-04

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