JP2013529900A - B細胞活性化因子の拮抗物質、その調製方法及び利用法 - Google Patents

B細胞活性化因子の拮抗物質、その調製方法及び利用法 Download PDF

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JP2013529900A
JP2013529900A JP2013511528A JP2013511528A JP2013529900A JP 2013529900 A JP2013529900 A JP 2013529900A JP 2013511528 A JP2013511528 A JP 2013511528A JP 2013511528 A JP2013511528 A JP 2013511528A JP 2013529900 A JP2013529900 A JP 2013529900A
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protein
amino acid
antagonist
seq
cell activator
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JP2013529900A5 (enExample
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▲楊▼莉
魏于全
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CSPC Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd
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CSPC Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd
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    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Biophysics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013511528A 2010-05-26 2011-05-26 B細胞活性化因子の拮抗物質、その調製方法及び利用法 Pending JP2013529900A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201010183905.9 2010-05-26
CN2010101839059A CN101851278B (zh) 2010-05-26 2010-05-26 B细胞激活因子拮抗剂及其制备方法与用途
PCT/CN2011/074687 WO2011147320A1 (zh) 2010-05-26 2011-05-26 B细胞激活因子拮抗剂及其制备方法与用途

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JP2013529900A true JP2013529900A (ja) 2013-07-25
JP2013529900A5 JP2013529900A5 (enExample) 2014-12-04

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JP2015151930A Active JP6320973B2 (ja) 2010-05-26 2015-07-31 B細胞活性化因子の拮抗物質、その調製方法及び利用法

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US (1) US9290582B2 (enExample)
EP (1) EP2578603B1 (enExample)
JP (2) JP2013529900A (enExample)
KR (2) KR101810551B1 (enExample)
CN (1) CN101851278B (enExample)
WO (1) WO2011147320A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101851278B (zh) * 2010-05-26 2013-03-13 石药集团中奇制药技术(石家庄)有限公司 B细胞激活因子拮抗剂及其制备方法与用途
CN106220740A (zh) * 2016-08-18 2016-12-14 中山大学 可溶性蛋白baff在b细胞体外培养及扩增的应用
CN115812077A (zh) 2020-05-08 2023-03-17 高山免疫科学股份有限公司 April和baff抑制性免疫调节蛋白及其使用方法
WO2024197157A1 (en) 2023-03-21 2024-09-26 Biograph 55, Inc. Cd19/cd38 multispecific antibodies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010042654A2 (en) * 2008-10-07 2010-04-15 The Regents Of The University Of California Recombinant nell protein production
CN101851278A (zh) * 2010-05-26 2010-10-06 四川大学 B细胞激活因子拮抗剂及其制备方法与用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA83458C2 (uk) * 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
DK1436003T3 (da) * 2001-05-24 2010-03-15 Zymogenetics Inc TACI-immunoglobulin-fusionsproteiner
KR20040019105A (ko) 2001-08-03 2004-03-04 제넨테크, 인크. TACIs 및 BR3 폴리펩티드 및 이의 용도
EP2272868B1 (en) 2003-06-05 2015-03-04 Genentech, Inc. Combination therapy for B cell disorders
SI1631313T1 (sl) 2003-06-05 2015-06-30 Genentech, Inc. Kombinirana terapija za B-celične motnje
KR20070107687A (ko) 2004-12-31 2007-11-07 제넨테크, 인크. Br3과 결합하는 폴리펩티드, 및 그의 용도
JP2010501622A (ja) 2006-08-28 2010-01-21 アレス トレーディング ソシエテ アノニム Fc−融合タンパク質の精製法
ES2422479T3 (es) * 2007-03-27 2013-09-11 Zymogenetics Inc Combinación de inhibición de BLyS y micofenolato de mofetilo para tratamiento de enfermedades autoinmunitarias

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010042654A2 (en) * 2008-10-07 2010-04-15 The Regents Of The University Of California Recombinant nell protein production
CN101851278A (zh) * 2010-05-26 2010-10-06 四川大学 B细胞激活因子拮抗剂及其制备方法与用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6014029202; Acad J Sec Mil Med Univ., 2006年, 第27巻, 1190-1195ページ *
JPN6014029204; Biochemistry, 2003年, 第42巻, 5977-5983ページ *
JPN6014029211; J Biol Chem., 2005年, 第280巻, 7218-7227ページ *

Also Published As

Publication number Publication date
EP2578603A1 (en) 2013-04-10
EP2578603A4 (en) 2014-03-26
KR20130043642A (ko) 2013-04-30
KR101810551B1 (ko) 2017-12-19
KR20160102066A (ko) 2016-08-26
CN101851278A (zh) 2010-10-06
JP2016019527A (ja) 2016-02-04
WO2011147320A1 (zh) 2011-12-01
US20130089549A1 (en) 2013-04-11
JP6320973B2 (ja) 2018-05-09
EP2578603B1 (en) 2018-11-14
US9290582B2 (en) 2016-03-22
CN101851278B (zh) 2013-03-13

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