JP2017061471A5 - - Google Patents
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- Publication number
- JP2017061471A5 JP2017061471A5 JP2016204089A JP2016204089A JP2017061471A5 JP 2017061471 A5 JP2017061471 A5 JP 2017061471A5 JP 2016204089 A JP2016204089 A JP 2016204089A JP 2016204089 A JP2016204089 A JP 2016204089A JP 2017061471 A5 JP2017061471 A5 JP 2017061471A5
- Authority
- JP
- Japan
- Prior art keywords
- multimer
- component
- protein
- cell
- components
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000623 proteins and genes Proteins 0.000 claims 23
- 235000018102 proteins Nutrition 0.000 claims 20
- 102000004169 proteins and genes Human genes 0.000 claims 20
- 238000000034 method Methods 0.000 claims 11
- 230000015572 biosynthetic process Effects 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- 101000979629 Homo sapiens Nucleoside diphosphate kinase A Proteins 0.000 claims 9
- 102100023252 Nucleoside diphosphate kinase A Human genes 0.000 claims 9
- 210000000130 stem cell Anatomy 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 239000003102 growth factor Substances 0.000 claims 4
- 230000006798 recombination Effects 0.000 claims 4
- 238000005215 recombination Methods 0.000 claims 4
- 239000000539 dimer Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 2
- 102100034256 Mucin-1 Human genes 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 102220484604 Nucleoside diphosphate kinase A_P96S_mutation Human genes 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 238000006471 dimerization reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 210000004681 ovum Anatomy 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161484052P | 2011-05-09 | 2011-05-09 | |
| US61/484,052 | 2011-05-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510413A Division JP2014517690A (ja) | 2011-05-09 | 2012-05-08 | 遺伝子操作した成長因子変異体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019211946A Division JP2020039359A (ja) | 2011-05-09 | 2019-11-25 | 遺伝子操作した成長因子変異体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017061471A JP2017061471A (ja) | 2017-03-30 |
| JP2017061471A5 true JP2017061471A5 (enExample) | 2017-10-12 |
| JP6717725B2 JP6717725B2 (ja) | 2020-07-01 |
Family
ID=47139949
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510413A Pending JP2014517690A (ja) | 2011-05-09 | 2012-05-08 | 遺伝子操作した成長因子変異体 |
| JP2016204089A Active JP6717725B2 (ja) | 2011-05-09 | 2016-10-18 | 遺伝子操作した成長因子変異体 |
| JP2019211946A Pending JP2020039359A (ja) | 2011-05-09 | 2019-11-25 | 遺伝子操作した成長因子変異体 |
| JP2021193554A Pending JP2022031824A (ja) | 2011-05-09 | 2021-11-29 | 遺伝子操作した成長因子変異体 |
| JP2024006988A Pending JP2024056702A (ja) | 2011-05-09 | 2024-01-19 | 遺伝子操作した成長因子変異体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510413A Pending JP2014517690A (ja) | 2011-05-09 | 2012-05-08 | 遺伝子操作した成長因子変異体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019211946A Pending JP2020039359A (ja) | 2011-05-09 | 2019-11-25 | 遺伝子操作した成長因子変異体 |
| JP2021193554A Pending JP2022031824A (ja) | 2011-05-09 | 2021-11-29 | 遺伝子操作した成長因子変異体 |
| JP2024006988A Pending JP2024056702A (ja) | 2011-05-09 | 2024-01-19 | 遺伝子操作した成長因子変異体 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20140065113A1 (enExample) |
| EP (1) | EP2707021B1 (enExample) |
| JP (5) | JP2014517690A (enExample) |
| CN (2) | CN103930439A (enExample) |
| AU (1) | AU2012253652B2 (enExample) |
| CA (1) | CA2835453A1 (enExample) |
| IL (1) | IL229316B (enExample) |
| WO (1) | WO2012154759A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2830503A1 (en) | 2011-03-17 | 2012-09-20 | Minerva Biotechnologies Corporation | Method for making pluripotent stem cells |
| WO2012154759A2 (en) * | 2011-05-09 | 2012-11-15 | Minerva Biotechnologies Corporation | Genetically engineered growth factor variants |
| WO2014130741A2 (en) * | 2013-02-20 | 2014-08-28 | Minerva Biotechnologies Corporation | Nme inhibitors and methods of using nme inhibitors |
| AU2015332389A1 (en) * | 2014-10-16 | 2017-04-20 | Myriad Women's Health, Inc. | Variant caller |
| US20230242678A1 (en) | 2020-06-26 | 2023-08-03 | Minerva Biotechnologies Corporation | Anti-nme antibody and method of treating cancer or cancer metastasis |
| KR20230148837A (ko) | 2021-02-25 | 2023-10-25 | 라이엘 이뮤노파마, 인크. | Ror1 표적화 키메라 항원 수용체 |
| IL316221A (en) | 2022-04-12 | 2024-12-01 | Minerva Biotechnologies Corp | Anti-MUC1* variant antibodies and their uses |
| CN117736272B (zh) * | 2024-02-19 | 2024-04-30 | 四川省医学科学院·四川省人民医院 | 一种具有促成骨功能的生物活性多肽 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0495910B1 (en) * | 1989-10-18 | 2001-09-26 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Production and use of human nm23-h2 protein and antibodies therefor |
| US5958671A (en) * | 1996-04-23 | 1999-09-28 | Presidents And Fellows Of Harvard College | Methods and compositions for regulating T cell subsets by modulating transcription factor activity |
| US20050112607A1 (en) * | 1999-01-23 | 2005-05-26 | Bamdad Cynthia C. | Rapid and sensitive detection of protein aggregation |
| US7550143B2 (en) * | 2005-04-06 | 2009-06-23 | Ibc Pharmaceuticals, Inc. | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
| WO2001003737A1 (en) * | 1999-07-13 | 2001-01-18 | Bolder Biotechnology Inc. | Immunoglobulin fusion proteins |
| BR0013231A (pt) * | 1999-08-09 | 2002-07-23 | Lexigen Pharm Corp | Complexos citocina-anticorpo múltiplos |
| US20020169290A1 (en) * | 2000-11-02 | 2002-11-14 | Claus Bornaes | New multimeric interferon beta polypeptides |
| AU2002212108A1 (en) * | 2000-11-02 | 2002-05-15 | Maxygen Aps | Single-chain multimeric polypeptides |
| US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| AU2002306921A1 (en) * | 2001-03-27 | 2002-10-08 | Massachusetts Institute Of Technology | Methods and products related to fgf dimerization |
| EP1353182A3 (en) * | 2002-04-12 | 2004-02-04 | Smithkline Beecham Corporation | Method of predicting cell-based assay results using binding profiles |
| CA2499580A1 (en) * | 2002-09-24 | 2004-04-08 | The Burnham Institute | Novel agents that modulate eph receptor activity |
| JP5091476B2 (ja) * | 2003-06-27 | 2012-12-05 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 均質な抗体溶液の生成のための疎水性相互作用クロマトグラフィーまたはヒンジ領域改変の使用 |
| US20050054752A1 (en) * | 2003-09-08 | 2005-03-10 | O'brien John P. | Peptide-based diblock and triblock dispersants and diblock polymers |
| JP2008504012A (ja) * | 2004-01-28 | 2008-02-14 | シントニックス・ファーマシューティカルズ・インコーポレーテッド | 不妊治療のためのへテロ二量体卵胞刺激ホルモン−Ｆｃ（ＦＳＨ−Ｆｃ）融合タンパク質 |
| NZ596865A (en) * | 2006-06-12 | 2013-07-26 | Emergent Product Dev Seattle | Single-chain multivalent binding proteins with effector function |
| CN101652469B (zh) * | 2006-12-06 | 2014-04-16 | 米纳瓦生物技术公司 | 用于鉴定和操作细胞的方法 |
| KR20110044992A (ko) * | 2008-07-02 | 2011-05-03 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | ＴＧＦ-β 길항제 다중-표적 결합 단백질 |
| JP2012505636A (ja) * | 2008-10-09 | 2012-03-08 | ミネルバ バイオテクノロジーズ コーポレーション | 細胞において多能性を誘導する方法 |
| MX2011013385A (es) * | 2009-06-11 | 2012-05-29 | Minerva Biotechnologies Corp | Metodos para cultivar celulas madre y celulas progenitoras. |
| US20130040845A1 (en) * | 2010-02-16 | 2013-02-14 | Immune Disease Institute, Inc. | Method for screening receptors/ligands interactions |
| CA2830503A1 (en) * | 2011-03-17 | 2012-09-20 | Minerva Biotechnologies Corporation | Method for making pluripotent stem cells |
| WO2012154759A2 (en) * | 2011-05-09 | 2012-11-15 | Minerva Biotechnologies Corporation | Genetically engineered growth factor variants |
-
2012
- 2012-05-08 WO PCT/US2012/036975 patent/WO2012154759A2/en not_active Ceased
- 2012-05-08 EP EP12782984.4A patent/EP2707021B1/en active Active
- 2012-05-08 CN CN201280034119.XA patent/CN103930439A/zh active Pending
- 2012-05-08 JP JP2014510413A patent/JP2014517690A/ja active Pending
- 2012-05-08 CN CN202010915430.1A patent/CN112028985A/zh active Pending
- 2012-05-08 CA CA2835453A patent/CA2835453A1/en active Pending
- 2012-05-08 AU AU2012253652A patent/AU2012253652B2/en active Active
-
2013
- 2013-11-07 IL IL229316A patent/IL229316B/en active IP Right Grant
- 2013-11-11 US US14/077,061 patent/US20140065113A1/en not_active Abandoned
-
2016
- 2016-10-18 JP JP2016204089A patent/JP6717725B2/ja active Active
-
2019
- 2019-06-20 US US16/447,812 patent/US20200062812A1/en not_active Abandoned
- 2019-11-25 JP JP2019211946A patent/JP2020039359A/ja active Pending
-
2021
- 2021-11-29 JP JP2021193554A patent/JP2022031824A/ja active Pending
-
2024
- 2024-01-19 JP JP2024006988A patent/JP2024056702A/ja active Pending
- 2024-04-19 US US18/640,690 patent/US20240294590A1/en not_active Abandoned
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