CA2835453A1 - Genetically engineered growth factor variants - Google Patents
Genetically engineered growth factor variants Download PDFInfo
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- CA2835453A1 CA2835453A1 CA2835453A CA2835453A CA2835453A1 CA 2835453 A1 CA2835453 A1 CA 2835453A1 CA 2835453 A CA2835453 A CA 2835453A CA 2835453 A CA2835453 A CA 2835453A CA 2835453 A1 CA2835453 A1 CA 2835453A1
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Classifications
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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Landscapes
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| Application Number | Priority Date | Filing Date | Title |
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| US201161484052P | 2011-05-09 | 2011-05-09 | |
| US61/484,052 | 2011-05-09 | ||
| PCT/US2012/036975 WO2012154759A2 (en) | 2011-05-09 | 2012-05-08 | Genetically engineered growth factor variants |
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| JP (5) | JP2014517690A (enExample) |
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| CA (1) | CA2835453A1 (enExample) |
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| EP2686418A4 (en) | 2011-03-17 | 2015-04-22 | Minerva Biotechnologies Corp | METHOD FOR THE PRODUCTION OF PLURIPOTENTAL STEM CELLS |
| JP2014517690A (ja) * | 2011-05-09 | 2014-07-24 | ミネルバ バイオテクノロジーズ コーポレーション | 遺伝子操作した成長因子変異体 |
| IL240695B2 (en) * | 2013-02-20 | 2024-03-01 | Minerva Biotechnologies Corp | Nme inhibitors and methods of using nme inhibitors |
| CN107076729A (zh) * | 2014-10-16 | 2017-08-18 | 康希尔公司 | 变异体调用器 |
| WO2021263227A2 (en) | 2020-06-26 | 2021-12-30 | Minerva Biotechnologies Corporation | Anti-nme antibody and method of treating cancer or cancer metastasis |
| US12144827B2 (en) | 2021-02-25 | 2024-11-19 | Lyell Immunopharma, Inc. | ROR1 targeting chimeric antigen receptor |
| KR20250009592A (ko) | 2022-04-12 | 2025-01-17 | 미네르바 바이오테크놀로지 코포레이션 | 항-가변 muc1* 항체 및 그의 용도 |
| CN117736272B (zh) * | 2024-02-19 | 2024-04-30 | 四川省医学科学院·四川省人民医院 | 一种具有促成骨功能的生物活性多肽 |
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| ATE206129T1 (de) * | 1989-10-18 | 2001-10-15 | Us Health | Herstellung und verwendung des menschlichen nm23- h2-proteins und dagegen gerichtete antikörper |
| US5958671A (en) * | 1996-04-23 | 1999-09-28 | Presidents And Fellows Of Harvard College | Methods and compositions for regulating T cell subsets by modulating transcription factor activity |
| US20050112607A1 (en) * | 1999-01-23 | 2005-05-26 | Bamdad Cynthia C. | Rapid and sensitive detection of protein aggregation |
| US7550143B2 (en) * | 2005-04-06 | 2009-06-23 | Ibc Pharmaceuticals, Inc. | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
| JP4944324B2 (ja) * | 1999-07-13 | 2012-05-30 | ボルダー バイオテクノロジー， インコーポレイテッド | 免疫グロブリン融合タンパク質 |
| PL202058B1 (pl) * | 1999-08-09 | 2009-05-29 | Merck Patent Gmbh | Wielofunkcyjne białko fuzyjne cytokin i przeciwciała |
| US20020169290A1 (en) * | 2000-11-02 | 2002-11-14 | Claus Bornaes | New multimeric interferon beta polypeptides |
| AU2002212108A1 (en) * | 2000-11-02 | 2002-05-15 | Maxygen Aps | Single-chain multimeric polypeptides |
| US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
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| EP1353182A3 (en) * | 2002-04-12 | 2004-02-04 | Smithkline Beecham Corporation | Method of predicting cell-based assay results using binding profiles |
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| US20050054752A1 (en) * | 2003-09-08 | 2005-03-10 | O'brien John P. | Peptide-based diblock and triblock dispersants and diblock polymers |
| AU2005207960A1 (en) * | 2004-01-28 | 2005-08-11 | Syntonix Pharmaceuticals, Inc. | Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility |
| US8409577B2 (en) * | 2006-06-12 | 2013-04-02 | Emergent Product Development Seattle, Llc | Single chain multivalent binding proteins with effector function |
| US20090075926A1 (en) * | 2006-12-06 | 2009-03-19 | Bamdad Cynthia C | Method for identifying and manipulating cells |
| KR20110044992A (ko) * | 2008-07-02 | 2011-05-03 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | ＴＧＦ-β 길항제 다중-표적 결합 단백질 |
| KR20140101876A (ko) * | 2008-10-09 | 2014-08-20 | 미네르바 바이오테크놀로지 코포레이션 | 세포내에서 다능성을 유도하기 위한 방법 |
| KR20120025601A (ko) * | 2009-06-11 | 2012-03-15 | 미네르바 바이오테크놀로지 코포레이션 | 줄기 세포 및 전구 세포를 배양하는 방법 |
| US20130040845A1 (en) * | 2010-02-16 | 2013-02-14 | Immune Disease Institute, Inc. | Method for screening receptors/ligands interactions |
| EP2686418A4 (en) * | 2011-03-17 | 2015-04-22 | Minerva Biotechnologies Corp | METHOD FOR THE PRODUCTION OF PLURIPOTENTAL STEM CELLS |
| JP2014517690A (ja) * | 2011-05-09 | 2014-07-24 | ミネルバ バイオテクノロジーズ コーポレーション | 遺伝子操作した成長因子変異体 |
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2012
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- 2012-05-08 WO PCT/US2012/036975 patent/WO2012154759A2/en not_active Ceased
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2016
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2019
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Also Published As
| Publication number | Publication date |
|---|---|
| US20240294590A1 (en) | 2024-09-05 |
| JP2020039359A (ja) | 2020-03-19 |
| US20200062812A1 (en) | 2020-02-27 |
| EP2707021A4 (en) | 2015-08-05 |
| JP2024056702A (ja) | 2024-04-23 |
| IL229316B (en) | 2020-02-27 |
| AU2012253652A1 (en) | 2013-11-28 |
| EP2707021C0 (en) | 2024-02-21 |
| CN103930439A (zh) | 2014-07-16 |
| AU2012253652B2 (en) | 2017-07-06 |
| JP6717725B2 (ja) | 2020-07-01 |
| IL229316A0 (en) | 2014-01-30 |
| EP2707021B1 (en) | 2024-02-21 |
| US20140065113A1 (en) | 2014-03-06 |
| CN112028985A (zh) | 2020-12-04 |
| JP2014517690A (ja) | 2014-07-24 |
| EP2707021A2 (en) | 2014-03-19 |
| JP2017061471A (ja) | 2017-03-30 |
| WO2012154759A3 (en) | 2014-05-01 |
| JP2022031824A (ja) | 2022-02-22 |
| WO2012154759A2 (en) | 2012-11-15 |
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