JP2016520053A5 - - Google Patents
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- Publication number
- JP2016520053A5 JP2016520053A5 JP2016512207A JP2016512207A JP2016520053A5 JP 2016520053 A5 JP2016520053 A5 JP 2016520053A5 JP 2016512207 A JP2016512207 A JP 2016512207A JP 2016512207 A JP2016512207 A JP 2016512207A JP 2016520053 A5 JP2016520053 A5 JP 2016520053A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- tumstatin
- amino acid
- cd137l
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310163407.1 | 2013-05-06 | ||
| CN201310162738.3A CN103214584B (zh) | 2013-05-06 | 2013-05-06 | 具有抑制肿瘤微环境血管再生和激活适应性免疫应答双功能的融合蛋白及其基因和应用 |
| CN201310162738.3 | 2013-05-06 | ||
| CN201310163407.1A CN103232543B (zh) | 2013-05-06 | 2013-05-06 | 具有Tumstatin活性的重组蛋白Tumstatin-CD137L4及其制备和应用 |
| PCT/CN2014/076768 WO2014180288A1 (zh) | 2013-05-06 | 2014-05-05 | 具有抑制肿瘤微环境血管再生和激活适应性免疫应答双功能的融合蛋白及其基因和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016520053A JP2016520053A (ja) | 2016-07-11 |
| JP2016520053A5 true JP2016520053A5 (enExample) | 2018-05-31 |
Family
ID=51866722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512207A Pending JP2016520053A (ja) | 2013-05-06 | 2014-05-05 | 腫瘍微小環境における血管再生の抑制及び適応免疫応答の活性化を有する二機能の融合タンパク質及びその遺伝子並びに使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10875903B2 (enExample) |
| EP (1) | EP2995626B1 (enExample) |
| JP (1) | JP2016520053A (enExample) |
| DK (1) | DK2995626T3 (enExample) |
| ES (1) | ES2686968T3 (enExample) |
| WO (1) | WO2014180288A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| KR102692708B1 (ko) | 2016-12-20 | 2024-08-07 | 에프. 호프만-라 로슈 아게 | 항-cd20/항-cd3 이중특이성 항체 및 4-1bb(cd137) 작용물질의 병용 요법 |
| HRP20230937T1 (hr) | 2017-01-05 | 2023-11-24 | Kahr Medical Ltd. | Pd1-41bbl fuzijski protein i metode korištenja istog |
| WO2018127916A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A pd1-cd70 fusion protein and methods of use thereof |
| WO2018127918A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A sirp alpha-cd70 fusion protein and methods of use thereof |
| PT3565828T (pt) | 2017-01-05 | 2022-02-08 | Kahr Medical Ltd | Proteína de fusão sirp1 alfa-41bbl e seus métodos de utilização |
| SG11202013170RA (en) | 2018-07-11 | 2021-01-28 | Kahr Medical Ltd | Pd1-4-1bbl variant fusion protein and methods of use thereof |
| KR20210044220A (ko) | 2018-07-11 | 2021-04-22 | 카 메디컬 리미티드 | SIRPalpha-4-1BBL 변이체 융합 단백질 및 이의 사용 방법 |
| CN116462769A (zh) * | 2022-04-02 | 2023-07-21 | 广东东阳光药业有限公司 | 一种嵌合受体及其应用 |
| WO2025217063A1 (en) * | 2024-04-08 | 2025-10-16 | Baylor College Of Medicine | Dual stimulatory receptors for immunotherapy |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1019515A1 (en) * | 1997-10-01 | 2000-07-19 | G.D. SEARLE & CO. | Fusion proteins comprising an angiostatin moiety and their use in anti-tumour treatment |
| WO1999065940A1 (en) * | 1998-06-17 | 1999-12-23 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and methods of use thereof |
| JP2006508635A (ja) * | 2002-05-06 | 2006-03-16 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 治療用または診断用試薬を送達するためのターゲティングタンパク質 |
| WO2006010891A2 (en) * | 2004-07-26 | 2006-02-02 | Asterion Limited | Linkers |
| WO2009086132A2 (en) * | 2007-12-20 | 2009-07-09 | University Of Southern California | Design of spacers to increase the expression of recombinant fusion proteins |
| CN101265482A (zh) * | 2008-04-25 | 2008-09-17 | 罗以勤 | 重组肿瘤抑素-肿瘤坏死因子分泌型真核表达载体及其制备方法和用途 |
| PL219845B1 (pl) | 2011-01-05 | 2015-07-31 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Przeciwnowotworowe białko fuzyjne |
| US9822179B2 (en) | 2011-04-01 | 2017-11-21 | Universitat Stuttgart | Recombinant TNF ligand family member polypeptides with antibody binding domain and uses therefor |
| ES2659161T3 (es) * | 2011-08-17 | 2018-03-14 | The Regents Of The University Of Colorado, A Body Corporate | Proteína de fusión de transferrina-tumstatina y métodos para producir y usar la misma |
| CN103232543B (zh) * | 2013-05-06 | 2014-12-03 | 中国药科大学 | 具有Tumstatin活性的重组蛋白Tumstatin-CD137L4及其制备和应用 |
| CN103214584B (zh) * | 2013-05-06 | 2014-07-09 | 中国药科大学 | 具有抑制肿瘤微环境血管再生和激活适应性免疫应答双功能的融合蛋白及其基因和应用 |
-
2014
- 2014-05-05 ES ES14795356.6T patent/ES2686968T3/es active Active
- 2014-05-05 US US14/895,959 patent/US10875903B2/en not_active Expired - Fee Related
- 2014-05-05 EP EP14795356.6A patent/EP2995626B1/en not_active Not-in-force
- 2014-05-05 JP JP2016512207A patent/JP2016520053A/ja active Pending
- 2014-05-05 DK DK14795356.6T patent/DK2995626T3/en active
- 2014-05-05 WO PCT/CN2014/076768 patent/WO2014180288A1/zh not_active Ceased
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