JP2013527217A5 - - Google Patents

Info

Publication number

JP2013527217A5

JP2013527217A5 JP2013512892A JP2013512892A JP2013527217A5 JP 2013527217 A5 JP2013527217 A5 JP 2013527217A5 JP 2013512892 A JP2013512892 A JP 2013512892A JP 2013512892 A JP2013512892 A JP 2013512892A JP 2013527217 A5 JP2013527217 A5 JP 2013527217A5

Authority

JP

Japan

Prior art keywords

process according

hemostatic composition

thrombin

hemostasis

biocompatible polymer

Prior art date

2011-06-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 238000000034 method Methods 0.000 claims description 58
• 239000000203 mixture Substances 0.000 claims description 28
• 230000002439 hemostatic effect Effects 0.000 claims description 23
• 108090000190 Thrombin Proteins 0.000 claims description 18
• 229960004072 thrombin Drugs 0.000 claims description 18
• 229920000249 biocompatible polymer Polymers 0.000 claims description 17
• 230000023597 hemostasis Effects 0.000 claims description 17
• 229920000642 polymer Polymers 0.000 claims description 17
• 238000002360 preparation method Methods 0.000 claims description 15
• 239000008187 granular material Substances 0.000 claims description 14
• 239000003085 diluting agent Substances 0.000 claims description 10
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
• 230000015271 coagulation Effects 0.000 claims description 8
• 238000005345 coagulation Methods 0.000 claims description 8
• 238000000576 coating method Methods 0.000 claims description 8
• 108010010803 Gelatin Proteins 0.000 claims description 6
• 239000003795 chemical substances by application Substances 0.000 claims description 6
• 229920000159 gelatin Polymers 0.000 claims description 6
• 239000008273 gelatin Substances 0.000 claims description 6
• 235000019322 gelatine Nutrition 0.000 claims description 6
• 235000011852 gelatine desserts Nutrition 0.000 claims description 6
• 230000001939 inductive effect Effects 0.000 claims description 6
• 102000009027 Albumins Human genes 0.000 claims description 4
• 108010088751 Albumins Proteins 0.000 claims description 4
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
• 235000010323 ascorbic acid Nutrition 0.000 claims description 4
• 239000011668 ascorbic acid Substances 0.000 claims description 4
• 229960005070 ascorbic acid Drugs 0.000 claims description 4
• 229920001282 polysaccharide Polymers 0.000 claims description 4
• 239000005017 polysaccharide Substances 0.000 claims description 4
• 150000004804 polysaccharides Chemical class 0.000 claims description 4
• 235000018102 proteins Nutrition 0.000 claims description 4
• 102000004169 proteins and genes Human genes 0.000 claims description 4
• 108090000623 proteins and genes Proteins 0.000 claims description 4
• 239000011248 coating agent Substances 0.000 claims description 3
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
• 229920000936 Agarose Polymers 0.000 claims description 2
• 108010076119 Caseins Proteins 0.000 claims description 2
• 102000011632 Caseins Human genes 0.000 claims description 2
• 229920001661 Chitosan Polymers 0.000 claims description 2
• 108010035532 Collagen Proteins 0.000 claims description 2
• 102000008186 Collagen Human genes 0.000 claims description 2
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
• 108010014258 Elastin Proteins 0.000 claims description 2
• 102000016942 Elastin Human genes 0.000 claims description 2
• IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 2
• 108010073385 Fibrin Proteins 0.000 claims description 2
• 102000009123 Fibrin Human genes 0.000 claims description 2
• BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 2
• 108010049003 Fibrinogen Proteins 0.000 claims description 2
• 102000008946 Fibrinogen Human genes 0.000 claims description 2
• 108010067306 Fibronectins Proteins 0.000 claims description 2
• 102000016359 Fibronectins Human genes 0.000 claims description 2
• 229920002683 Glycosaminoglycan Polymers 0.000 claims description 2
• 229920002488 Hemicellulose Polymers 0.000 claims description 2
• 102000001554 Hemoglobins Human genes 0.000 claims description 2
• 108010054147 Hemoglobins Proteins 0.000 claims description 2
• 108010076876 Keratins Proteins 0.000 claims description 2
• 102000011782 Keratins Human genes 0.000 claims description 2
• 108010085895 Laminin Proteins 0.000 claims description 2
• 102000007547 Laminin Human genes 0.000 claims description 2
• 229930195725 Mannitol Natural products 0.000 claims description 2
• 229920000881 Modified starch Polymers 0.000 claims description 2
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
• 229940072056 alginate Drugs 0.000 claims description 2
• 235000010443 alginic acid Nutrition 0.000 claims description 2
• 229920000615 alginic acid Polymers 0.000 claims description 2
• 239000003963 antioxidant agent Substances 0.000 claims description 2
• 235000006708 antioxidants Nutrition 0.000 claims description 2
• 239000005018 casein Substances 0.000 claims description 2
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
• 235000021240 caseins Nutrition 0.000 claims description 2
• 229920002678 cellulose Polymers 0.000 claims description 2
• 239000001913 cellulose Substances 0.000 claims description 2
• 239000000701 coagulant Substances 0.000 claims description 2
• 239000007931 coated granule Substances 0.000 claims description 2
• 229920001436 collagen Polymers 0.000 claims description 2
• 229920002549 elastin Polymers 0.000 claims description 2
• 229950003499 fibrin Drugs 0.000 claims description 2
• 229940012952 fibrinogen Drugs 0.000 claims description 2
• 239000007789 gas Substances 0.000 claims description 2
• 239000000017 hydrogel Substances 0.000 claims description 2
• 239000000411 inducer Substances 0.000 claims description 2
• 239000000594 mannitol Substances 0.000 claims description 2
• 235000010355 mannitol Nutrition 0.000 claims description 2
• 230000004048 modification Effects 0.000 claims description 2
• 238000012986 modification Methods 0.000 claims description 2
• 235000019426 modified starch Nutrition 0.000 claims description 2
• 229910052757 nitrogen Inorganic materials 0.000 claims description 2
• 239000011236 particulate material Substances 0.000 claims description 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
• 229920002401 polyacrylamide Polymers 0.000 claims description 2
• 229920000058 polyacrylate Polymers 0.000 claims description 2
• 229920001610 polycaprolactone Polymers 0.000 claims description 2
• 239000004632 polycaprolactone Substances 0.000 claims description 2
• 229920000193 polymethacrylate Polymers 0.000 claims description 2
• -1 polyoxyethylene Polymers 0.000 claims description 2
• 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
• 230000005855 radiation Effects 0.000 claims description 2
• 108010015680 recombinant human thrombin Proteins 0.000 claims description 2
• 150000003839 salts Chemical class 0.000 claims description 2
• 235000010378 sodium ascorbate Nutrition 0.000 claims description 2
• PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 2
• 229960005055 sodium ascorbate Drugs 0.000 claims description 2
• 239000011780 sodium chloride Substances 0.000 claims description 2
• PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 2
• 239000003381 stabilizer Substances 0.000 claims description 2
• 230000001954 sterilising effect Effects 0.000 claims description 2
• 238000004659 sterilization and disinfection Methods 0.000 claims description 2
• 229960003766 thrombin (human) Drugs 0.000 claims description 2
• 229920001221 xylan Polymers 0.000 claims description 2
• 150000004823 xylans Chemical class 0.000 claims description 2