CO6660512A2 - Proceso para fabricar composiciones hemostáticas secas y estables - Google Patents

Proceso para fabricar composiciones hemostáticas secas y estables

Info

Publication number
CO6660512A2
CO6660512A2 CO12235698A CO12235698A CO6660512A2 CO 6660512 A2 CO6660512 A2 CO 6660512A2 CO 12235698 A CO12235698 A CO 12235698A CO 12235698 A CO12235698 A CO 12235698A CO 6660512 A2 CO6660512 A2 CO 6660512A2
Authority
CO
Colombia
Prior art keywords
agent
dry
stable hemostatic
hemostatic compositions
induces coagulation
Prior art date
Application number
CO12235698A
Other languages
English (en)
Inventor
Andreas Goessl
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44626890&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6660512(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Int filed Critical Baxter Int
Publication of CO6660512A2 publication Critical patent/CO6660512A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4833Thrombin (3.4.21.5)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1658Proteins, e.g. albumin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028Polypeptides; Proteins; Degradation products thereof
    • A61L26/0038Gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/04Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Se describe un proceso para fabricar una composición hemostásica seca y estable, comprendiendo el citado proceso a) proporcionar una preparación granular seca de un polímero biocompatible, apropiado para uso en hemostasia, b) recubrir los gránulos en la citada preparación granular seca con una preparación de un agente que induce coagulación, obteniendo en esa forma gránulos de polímero recubiertos con un agente que induce coagulación, c) cargar los citados gránulos de polímero recubiertos con un agente, que induce coagulación, en un recipiente final, d) terminar el recipiente final en un dispositivo farmacéutico almacenable que contiene los citados gránulos de polímero recubiertos con un agente, que induce coagulación, como una composición hemostásica seca y estable.
CO12235698A 2010-06-01 2012-12-28 Proceso para fabricar composiciones hemostáticas secas y estables CO6660512A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35023710P 2010-06-01 2010-06-01

Publications (1)

Publication Number Publication Date
CO6660512A2 true CO6660512A2 (es) 2013-04-30

Family

ID=44626890

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12235698A CO6660512A2 (es) 2010-06-01 2012-12-28 Proceso para fabricar composiciones hemostáticas secas y estables

Country Status (12)

Country Link
US (1) US8940335B2 (es)
EP (1) EP2575770B1 (es)
JP (2) JP5968308B2 (es)
KR (3) KR20130083393A (es)
CN (1) CN103037845B (es)
AU (1) AU2011260260B2 (es)
BR (1) BR112012030463B1 (es)
CA (1) CA2801118C (es)
CO (1) CO6660512A2 (es)
ES (1) ES2629349T3 (es)
MX (1) MX345479B (es)
WO (1) WO2011151386A1 (es)

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BR112012030455B1 (pt) 2010-06-01 2021-08-17 Baxter Healthcare S.A. Processo para fabricar uma composição hemostática seca e estável, recipiente acabado final, e, kit para administrar uma composição hemostática
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US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
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KR101989054B1 (ko) * 2017-11-28 2019-06-13 (주)다림티센 지혈용 조성물 및 이를 포함하는 용기
CN111787958A (zh) 2017-12-29 2020-10-16 巴克斯特国际公司 喷雾干燥凝血酶以及使用和制造喷雾干燥凝血酶的方法
KR20210008479A (ko) 2018-05-09 2021-01-22 훼로산 메디칼 디바이스 에이/에스 지혈 조성물을 제조하는 방법
KR102093839B1 (ko) * 2019-05-28 2020-05-04 (주)다림티센 지혈용 조성물 및 이를 포함하는 용기
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US20210308064A1 (en) * 2020-04-02 2021-10-07 The Board Of Trustees Of The University Of Illinois Catalytic Microgelators for Decoupled Control of Gelation Rate and Rigidity of Biological Gels
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JP2024535530A (ja) 2021-10-08 2024-09-30 コウシュウ・バイオシール・バイオテック・カンパニー・リミテッド 流動性治療用組成物を手術部位に送達するための動水力を使用するシステム、デバイス、及び方法
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