CO6620018A2 - Proceso para fabricar composiciones hemostáticas secas y estables - Google Patents
Proceso para fabricar composiciones hemostáticas secas y establesInfo
- Publication number
- CO6620018A2 CO6620018A2 CO12235702A CO12235702A CO6620018A2 CO 6620018 A2 CO6620018 A2 CO 6620018A2 CO 12235702 A CO12235702 A CO 12235702A CO 12235702 A CO12235702 A CO 12235702A CO 6620018 A2 CO6620018 A2 CO 6620018A2
- Authority
- CO
- Colombia
- Prior art keywords
- component
- final container
- dry
- providing
- stable hemostatic
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
- B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
- B65B5/12—Introducing successive articles, e.g. confectionery products, of different shape or size in predetermined positions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mechanical Engineering (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Se describe un proceso para fabricar una composición hemostásica seca y estable, comprendiendo el citado proceso a) proporcionar un primer componente que contiene una preparación seca de un agente que induce coagulación, b) proporcionar un segundo componente que contiene una preparación seca de un polímero biocompatible, apropiado para uso en hemostasia, c) proporcionar el citado primer componente y el citado segundo componente en una forma combinada en un recipiente final, c1) cargando el citado primer componente y el citado segundo componente en el citado recipiente final, con el fin de obtener una mezcla seca en el citado recipiente final, c2) o proporcionando el citado primer componente o el citado segundo componente en el citado recipiente final y agregando el citado segundo componente o el citado primer componente, con el fin de obtener una combinación del citado primer componente con el citado segundo componente en el citado recipiente final, d) terminar el recipiente final en un dispositivo farmacéutico almacenable, que contiene el citado primer componente y el citado segundo componente en una forma combinada como una composición hemostásica seca y estable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35026610P | 2010-06-01 | 2010-06-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6620018A2 true CO6620018A2 (es) | 2013-02-15 |
Family
ID=44626900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO12235702A CO6620018A2 (es) | 2010-06-01 | 2012-12-28 | Proceso para fabricar composiciones hemostáticas secas y estables |
Country Status (12)
Country | Link |
---|---|
US (4) | US9084728B2 (es) |
EP (1) | EP2575775B1 (es) |
JP (2) | JP5973997B2 (es) |
KR (2) | KR101967085B1 (es) |
CN (1) | CN103037847B (es) |
AU (1) | AU2011260258B2 (es) |
BR (1) | BR112012030455B1 (es) |
CA (1) | CA2801116C (es) |
CO (1) | CO6620018A2 (es) |
ES (1) | ES2676208T3 (es) |
MX (1) | MX344402B (es) |
WO (1) | WO2011151384A1 (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2716872C (en) | 2008-02-29 | 2015-02-10 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
EP2575775B1 (en) | 2010-06-01 | 2018-04-04 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
KR102102002B1 (ko) * | 2011-10-11 | 2020-04-20 | 백스터 인터내셔널 인코포레이티드 | 지혈 조성물 |
RU2657955C2 (ru) | 2012-03-06 | 2018-06-18 | Ферросан Медикал Дивайсиз А/С | Контейнер под давлением, содержащий гемостатическую пасту |
US10780228B2 (en) | 2012-05-07 | 2020-09-22 | Medline Industries, Inc. | Prefilled container systems |
PT2851085T (pt) * | 2012-05-14 | 2019-10-11 | Teijin Pharma Ltd | Composição proteica esterilizada por radiação |
BR112014030962A2 (pt) | 2012-06-12 | 2017-06-27 | Ferrosan Medical Devices As | métodos para preparação e para reconstituição de uma composição seca adequada para uso em hemostase e cicatrização de feridas, e, kit hemostático |
WO2014086996A1 (en) | 2012-12-07 | 2014-06-12 | Baxter International Inc. | Hemostatic foam |
CN105188740A (zh) * | 2013-03-07 | 2015-12-23 | 普罗菲布里克有限公司 | 包含凝血酶和纤维蛋白原的粉末制剂 |
US11071805B2 (en) | 2013-04-22 | 2021-07-27 | Sealantium Medical Ltd. | Fibrinogen-based tissue adhesive patches |
RU2700162C2 (ru) | 2013-06-21 | 2019-09-13 | Ферросан Медикал Дивайсиз А/С | Расширенная под вакуумом сухая композиция и шприц для ее сохранения |
US10765774B2 (en) * | 2013-07-09 | 2020-09-08 | Ethicon, Inc. | Hemostatic pad assembly kit and method |
EP3470094B1 (en) | 2013-12-11 | 2020-07-22 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
WO2016022807A1 (en) | 2014-08-08 | 2016-02-11 | The Brigham And Women's Hospital, Inc. | Elastic biopolymer and use as a tissue adhesive |
CA2960309A1 (en) | 2014-10-13 | 2016-04-21 | Ferrosan Medical Devices A/S | Dry composition for use in haemostasis and wound healing |
EP3009354A1 (en) * | 2014-10-15 | 2016-04-20 | F. Hoffmann-La Roche AG | Method for providing in a primary packaging container a dried solid product containing an active pharmaceutical ingredient |
CN107206165B (zh) | 2014-12-24 | 2020-10-23 | 弗罗桑医疗设备公司 | 用于保持并混合第一和第二物质的注射器 |
EP3270985B1 (en) | 2015-03-19 | 2021-02-24 | The Brigham and Women's Hospital, Inc. | Polypeptide compositions and methods of using the same |
AU2016290433B2 (en) | 2015-07-03 | 2018-05-24 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
US10660945B2 (en) | 2015-08-07 | 2020-05-26 | Victor Matthew Phillips | Flowable hemostatic gel composition and its methods of use |
US10751444B2 (en) | 2015-08-07 | 2020-08-25 | Victor Matthew Phillips | Flowable hemostatic gel composition and its methods of use |
CN108697829B (zh) | 2015-10-19 | 2021-06-11 | 西兰丁姆医疗公司 | 改进的基于纤维蛋白原的组织粘合贴片 |
US11471556B2 (en) | 2015-10-19 | 2022-10-18 | Sealantium Medical Ltd. | Fibrinogen-based tissue adhesive patch |
US10159720B2 (en) | 2015-12-08 | 2018-12-25 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, preparation and uses thereof |
IL242984A0 (en) * | 2015-12-08 | 2016-02-29 | Omrix Biopharmaceuticals Ltd | Thrombin microcapsules, their preparation and how to use them |
JP6887435B2 (ja) | 2016-02-08 | 2021-06-16 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | 角膜修復のための生体接着剤 |
US20170349313A1 (en) * | 2016-06-01 | 2017-12-07 | Centurion Medical Products Corporation | Methods for manufacturing non-glass prefilled syringes |
CN106178089A (zh) * | 2016-07-21 | 2016-12-07 | 青岛中腾生物技术有限公司 | 一种医用韧性封闭止血材料及组合物 |
CN106139236A (zh) * | 2016-08-17 | 2016-11-23 | 林春梅 | 一种可吸收医用止血材料及其制备工艺 |
JP6989757B2 (ja) * | 2017-06-19 | 2022-02-03 | 澁谷工業株式会社 | ゼラチン架橋体の製造方法および製造装置 |
US11679177B2 (en) | 2017-08-08 | 2023-06-20 | Baxter International Inc. | Polymeric compositions, delivery devices, and methods |
JP7173447B2 (ja) | 2017-11-03 | 2022-11-16 | バクスター・インターナショナル・インコーポレイテッド | ポリマー組成物、送達デバイス、及び方法 |
KR101989054B1 (ko) * | 2017-11-28 | 2019-06-13 | (주)다림티센 | 지혈용 조성물 및 이를 포함하는 용기 |
WO2019107887A2 (ko) * | 2017-11-28 | 2019-06-06 | (주)다림티센 | 지혈용 조성물 및 이를 포함하는 용기 |
SG11202005231RA (en) | 2017-12-29 | 2020-07-29 | Baxter Int | Spray-dried thrombin and methods of using and making spray-dried thrombin |
WO2019215274A1 (en) | 2018-05-09 | 2019-11-14 | Ferrosan Medical Devices A/S | Method for preparing a haemostatic composition |
CN109821059A (zh) * | 2019-04-16 | 2019-05-31 | 大连医科大学附属第一医院 | 一种可吸收流体明胶止血材料的制备方法 |
KR102093839B1 (ko) * | 2019-05-28 | 2020-05-04 | (주)다림티센 | 지혈용 조성물 및 이를 포함하는 용기 |
WO2022208218A1 (en) | 2021-03-31 | 2022-10-06 | Ethicon, Inc. | Systems, devices and methods for dispensing flowable hemostats that incorporate safety mechanisms for preventing air embolisms |
CN113134113B (zh) * | 2021-04-07 | 2022-07-01 | 赛克赛斯生物科技股份有限公司 | 可吸收止血流体明胶的制备方法及可吸收止血流体明胶 |
WO2023056588A1 (en) | 2021-10-08 | 2023-04-13 | Guangzhou Bioseal Biotech Co., Ltd. | Systems, devices and methods of using hydraulic forces for delivering flowable, therapeutic compositions to surgical sites |
AU2022381171A1 (en) * | 2021-11-03 | 2024-05-23 | Baxter Healthcare Sa | Synthetic surgical hemostat |
WO2023097148A1 (en) * | 2021-11-29 | 2023-06-01 | Baxter International Inc. | Improved hemostat reconstitution methods and devices |
WO2023119265A1 (en) | 2021-12-21 | 2023-06-29 | Omrix Biopharmaceuticals Ltd. | Fibrinogen comprising formulation and uses thereof |
CN114470302A (zh) * | 2022-01-19 | 2022-05-13 | 株洲茂物医疗科技有限公司 | 一种止血凝胶及其制备方法 |
WO2023170680A1 (en) | 2022-03-08 | 2023-09-14 | Equashield Medical Ltd | Fluid transfer station in a robotic pharmaceutical preparation system |
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US9629798B2 (en) * | 2008-04-03 | 2017-04-25 | Mallinckrodt Pharma Ip Trading D.A.C. | Hemostatic microspheres |
US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
JP5719355B2 (ja) | 2009-06-16 | 2015-05-20 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 止血スポンジ |
KR20120125465A (ko) * | 2010-01-08 | 2012-11-15 | 프로피브릭스 비.브이. | 건조 분말 피브린 실란트 |
AU2011260260B2 (en) | 2010-06-01 | 2015-09-03 | Baxter Healthcare S.A. | Process for making dry and stable hemostatic compositions |
EP2575775B1 (en) | 2010-06-01 | 2018-04-04 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
CA2801120C (en) | 2010-06-01 | 2019-08-20 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
WO2019215274A1 (en) | 2018-05-09 | 2019-11-14 | Ferrosan Medical Devices A/S | Method for preparing a haemostatic composition |
WO2023097148A1 (en) * | 2021-11-29 | 2023-06-01 | Baxter International Inc. | Improved hemostat reconstitution methods and devices |
-
2011
- 2011-06-01 EP EP11724602.5A patent/EP2575775B1/en not_active Revoked
- 2011-06-01 WO PCT/EP2011/059062 patent/WO2011151384A1/en active Application Filing
- 2011-06-01 BR BR112012030455-0A patent/BR112012030455B1/pt not_active IP Right Cessation
- 2011-06-01 US US13/151,048 patent/US9084728B2/en active Active
- 2011-06-01 KR KR1020177027830A patent/KR101967085B1/ko active IP Right Review Request
- 2011-06-01 KR KR1020127034213A patent/KR101814841B1/ko active IP Right Grant
- 2011-06-01 ES ES11724602.5T patent/ES2676208T3/es active Active
- 2011-06-01 MX MX2012014002A patent/MX344402B/es active IP Right Grant
- 2011-06-01 CA CA2801116A patent/CA2801116C/en active Active
- 2011-06-01 CN CN201180037586.3A patent/CN103037847B/zh active Active
- 2011-06-01 JP JP2013512891A patent/JP5973997B2/ja active Active
- 2011-06-01 AU AU2011260258A patent/AU2011260258B2/en active Active
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2012
- 2012-12-28 CO CO12235702A patent/CO6620018A2/es unknown
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2015
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- 2015-07-23 JP JP2015145502A patent/JP2015193651A/ja not_active Withdrawn
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2019
- 2019-02-11 US US16/272,302 patent/US10994045B2/en active Active
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2021
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US10245348B2 (en) | 2019-04-02 |
US20120121532A1 (en) | 2012-05-17 |
EP2575775A1 (en) | 2013-04-10 |
US20210220512A1 (en) | 2021-07-22 |
KR101967085B9 (ko) | 2022-07-20 |
WO2011151384A1 (en) | 2011-12-08 |
CN103037847B (zh) | 2016-01-20 |
CN103037847A (zh) | 2013-04-10 |
MX344402B (es) | 2016-12-14 |
EP2575775B1 (en) | 2018-04-04 |
BR112012030455A2 (pt) | 2016-08-09 |
JP2013532139A (ja) | 2013-08-15 |
US9084728B2 (en) | 2015-07-21 |
KR20130121701A (ko) | 2013-11-06 |
US20190231922A1 (en) | 2019-08-01 |
US20150367022A1 (en) | 2015-12-24 |
JP2015193651A (ja) | 2015-11-05 |
JP5973997B2 (ja) | 2016-08-23 |
AU2011260258B2 (en) | 2015-07-09 |
BR112012030455B1 (pt) | 2021-08-17 |
MX2012014002A (es) | 2013-02-12 |
CA2801116A1 (en) | 2011-12-08 |
KR101814841B1 (ko) | 2018-01-03 |
US10994045B2 (en) | 2021-05-04 |
AU2011260258A1 (en) | 2012-12-06 |
ES2676208T3 (es) | 2018-07-17 |
KR101967085B1 (ko) | 2019-04-08 |
CA2801116C (en) | 2019-02-12 |
KR20170118948A (ko) | 2017-10-25 |
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