JP2013525484A5 - - Google Patents
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- Publication number
- JP2013525484A5 JP2013525484A5 JP2013509113A JP2013509113A JP2013525484A5 JP 2013525484 A5 JP2013525484 A5 JP 2013525484A5 JP 2013509113 A JP2013509113 A JP 2013509113A JP 2013509113 A JP2013509113 A JP 2013509113A JP 2013525484 A5 JP2013525484 A5 JP 2013525484A5
- Authority
- JP
- Japan
- Prior art keywords
- arginine
- methyl ester
- protein
- viscosity
- reducing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33068910P | 2010-05-03 | 2010-05-03 | |
| US61/330,689 | 2010-05-03 | ||
| PCT/US2011/034001 WO2011139718A1 (en) | 2010-05-03 | 2011-04-26 | Compositions and methods useful for reducing the viscosity of protein-containing formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013525484A JP2013525484A (ja) | 2013-06-20 |
| JP2013525484A5 true JP2013525484A5 (enExample) | 2014-06-19 |
Family
ID=44263176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013509113A Pending JP2013525484A (ja) | 2010-05-03 | 2011-04-26 | タンパク質含有製剤の粘度を低減させるために有用な組成物及び方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20130058958A1 (enExample) |
| EP (1) | EP2566510A1 (enExample) |
| JP (1) | JP2013525484A (enExample) |
| KR (1) | KR20130060227A (enExample) |
| CN (1) | CN102958538A (enExample) |
| BR (1) | BR112012027828A2 (enExample) |
| CA (1) | CA2794864A1 (enExample) |
| MX (1) | MX2012012743A (enExample) |
| RU (1) | RU2012151500A (enExample) |
| WO (1) | WO2011139718A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013025845A2 (pt) * | 2011-04-07 | 2018-09-04 | Glaxosmithkline Llc | formulações com viscosidade reduzida |
| JP6176849B2 (ja) * | 2011-07-19 | 2017-08-09 | 中外製薬株式会社 | アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤 |
| AU2012332767C1 (en) | 2011-10-31 | 2017-02-02 | Genentech, Inc. | Antibody formulations |
| US9169304B2 (en) | 2012-05-01 | 2015-10-27 | Pfenex Inc. | Process for purifying recombinant Plasmodium falciparum circumsporozoite protein |
| CN104520326A (zh) * | 2012-06-21 | 2015-04-15 | Ucb医药有限公司 | 药物制剂 |
| SI3495387T1 (sl) | 2012-07-13 | 2021-12-31 | Roche Glycart Ag | Bispecifična protitelesa proti VEGF/proti ANG-2 in njihova uporaba pri zdravljenju bolezni očesnih žil |
| FR2994390B1 (fr) | 2012-08-10 | 2014-08-15 | Adocia | Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee |
| FR2995214B1 (fr) | 2012-09-10 | 2014-11-21 | Adocia | Solution a viscosite reduite de proteine a concentration elevee |
| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| JP6179939B2 (ja) * | 2013-07-09 | 2017-08-16 | 国立大学法人 筑波大学 | 高濃度γグロブリン製剤の粘度低下方法 |
| IL312865B2 (en) * | 2013-09-11 | 2025-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-lowering agents |
| CN104740630A (zh) * | 2013-12-25 | 2015-07-01 | 浙江海正药业股份有限公司 | 一种含有抗cd52单抗的药物组合物 |
| US10478498B2 (en) | 2014-06-20 | 2019-11-19 | Reform Biologics, Llc | Excipient compounds for biopolymer formulations |
| US11357857B2 (en) | 2014-06-20 | 2022-06-14 | Comera Life Sciences, Inc. | Excipient compounds for protein processing |
| WO2015196091A1 (en) * | 2014-06-20 | 2015-12-23 | Reform Biologics, Llc | Viscosity-reducing excipient compounds for protein formulations |
| SG11201702614SA (en) | 2014-10-01 | 2017-04-27 | Eagle Biolog Inc | Polysaccharide and nucleic acid formulations containing viscosity-lowering agents |
| ES2964713T3 (es) * | 2014-10-23 | 2024-04-09 | Amgen Inc | Reducción de la viscosidad de formulaciones farmacéuticas |
| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
| MA41629A (fr) | 2015-03-04 | 2018-01-09 | Center For Human Reproduction | Compositions et méthodes d'utilisation de l'hormone anti-müllérienne pour le traitement de l'infertilité |
| US20170056352A1 (en) | 2015-08-25 | 2017-03-02 | Rgenix, Inc. | PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF |
| EP3383435A4 (en) * | 2015-11-30 | 2019-07-10 | Medimmune, LLC | OPTIMIZED RATES OF AMINO ACIDS AND SUGARS AS AMORPHOUS STABILIZING COMPOUNDS IN PHARMACEUTICAL COMPOSITIONS HAVING HIGH CONCENTRATIONS IN PROTEIN-BASED THERAPEUTICS |
| JP7377596B2 (ja) | 2017-02-22 | 2023-11-10 | アムジエン・インコーポレーテツド | 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法 |
| WO2018160178A1 (en) | 2017-03-01 | 2018-09-07 | Rgenix, Inc. | Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof |
| US12103979B2 (en) * | 2017-04-28 | 2024-10-01 | Amgen Inc. | N-acetylated and non-acetylated dipeptides containing arginine to reduce the viscosity of viscous compositions of therapeutic polypeptides |
| MA48461A (fr) | 2017-04-28 | 2020-03-04 | Amgen Inc | Excipients pour réduire la viscosité de formulations d'anticorps et compositions de formulation |
| CN110913906A (zh) | 2017-05-02 | 2020-03-24 | 默沙东公司 | 抗lag3抗体的制剂和抗lag3抗体与抗pd-1抗体的共制剂 |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| US10646569B2 (en) | 2017-05-16 | 2020-05-12 | Bhami's Research Laboratory, Pvt. Ltd. | High concentration protein formulations with reduced viscosity |
| EP3624828B1 (en) * | 2017-05-18 | 2024-08-07 | Merck Sharp & Dohme LLC | Pharmaceutical formulation comprising incretin-insulin conjugates |
| EP3678700B1 (en) | 2017-09-05 | 2024-06-19 | Merck Sharp & Dohme LLC | Compounds for reducing the viscosity of biological formulations |
| CN111699004A (zh) | 2018-02-06 | 2020-09-22 | 豪夫迈·罗氏有限公司 | 眼科疾病的治疗 |
| AU2019254483B2 (en) * | 2018-04-16 | 2025-02-27 | Merck Patent Gmbh | Viscosity reduction of highly concentrated protein formulations |
| RS67656B1 (sr) | 2018-05-10 | 2026-02-27 | Regeneron Pharma | Formulacije koje sadrže visoke koncentracije fuzionog proteina vegf receptora |
| MX2021004356A (es) | 2018-10-18 | 2021-05-31 | Merck Sharp & Dohme Llc | Formulaciones de anticuerpos anti-rsv y metodos de uso de las mismas. |
| MA54089A (fr) | 2018-10-31 | 2022-02-09 | Merck Sharp & Dohme | Anticorps anti-pd-1 humain et procédés d'utilisation associés |
| JP7503056B6 (ja) | 2018-11-07 | 2024-07-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体および抗ｐｄ－１抗体の共－製剤 |
| GB201900728D0 (en) * | 2019-01-18 | 2019-03-06 | Univ Birmingham | Drug delivery system |
| AU2020347827A1 (en) * | 2019-09-17 | 2022-05-05 | Merck Patent Gmbh | Camphorsulfonic acid and combinations thereof with cationic excipients as viscosity reducing agents in high concentrated protein formulations |
| JP2023505687A (ja) | 2019-12-11 | 2023-02-10 | インスピルナ，インコーポレーテッド | 癌の処置方法 |
| WO2021195418A1 (en) | 2020-03-26 | 2021-09-30 | Vanderbilt University | Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2) |
| CA3187322A1 (en) * | 2020-07-13 | 2022-01-20 | Merck Patent Gmbh | Viscosity reducing excipients and combinations thereof for highly concentrated protein formulations |
| CA3214867A1 (en) * | 2021-04-09 | 2022-10-13 | Courtney O'DELL | Performance-enhancing excipients and methods of reducing viscosity and increasing stability of biologic formulations |
| WO2023075702A1 (en) * | 2021-10-29 | 2023-05-04 | Aslan Pharmaceuticals Pte Ltd | Anti-il-13r antibody formulation |
| WO2023075700A1 (en) * | 2021-10-29 | 2023-05-04 | Aslan Pharmaceuticals Pte Ltd | Anti-il-13r antibody formulation |
| TW202342095A (zh) * | 2021-11-05 | 2023-11-01 | 英商阿斯特捷利康英國股份有限公司 | 用於治療和預防ｃｏｖｉｄ—１９之組成物 |
| TW202342510A (zh) | 2022-02-18 | 2023-11-01 | 英商Ｒｑ生物科技有限公司 | 抗體 |
| TW202527982A (zh) * | 2023-09-11 | 2025-07-16 | 美商默門塔醫藥公司 | Fcrn抗體之醫藥組成物 |
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-
2011
- 2011-04-26 BR BR112012027828A patent/BR112012027828A2/pt not_active IP Right Cessation
- 2011-04-26 EP EP20110720633 patent/EP2566510A1/en not_active Withdrawn
- 2011-04-26 RU RU2012151500/15A patent/RU2012151500A/ru not_active Application Discontinuation
- 2011-04-26 WO PCT/US2011/034001 patent/WO2011139718A1/en not_active Ceased
- 2011-04-26 JP JP2013509113A patent/JP2013525484A/ja active Pending
- 2011-04-26 CA CA 2794864 patent/CA2794864A1/en active Pending
- 2011-04-26 CN CN2011800320023A patent/CN102958538A/zh active Pending
- 2011-04-26 KR KR20127031426A patent/KR20130060227A/ko not_active Withdrawn
- 2011-04-26 MX MX2012012743A patent/MX2012012743A/es not_active Application Discontinuation
-
2012
- 2012-11-02 US US13/666,990 patent/US20130058958A1/en not_active Abandoned
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