MX2012012743A

MX2012012743A - Composiciones y metodos utiles para reducir la viscosidad de formulaciones que contienen proteina.

Composiciones y metodos utiles para reducir la viscosidad de formulaciones que contienen proteina.

Info

Publication number: MX2012012743A
Authority: MX; Mexico
Prior art keywords: protein; arginine; viscosity; antibody; formulation
Prior art date: 2010-05-03

Application number

MX2012012743A

Other languages

English (en)

Spanish (es)

Inventor

Jun Liu

Mayumi N Bowen

Ankit R Patel

Original Assignee

Genentech Inc

Priority date

2010-05-03

Filing date

2011-04-26

Publication date

2012-11-23

2011-04-26 Application filed by Genentech Inc filed Critical Genentech Inc

2012-11-23 Publication of MX2012012743A publication Critical patent/MX2012012743A/es

Links

108090000623 proteins and genes Proteins 0.000 title claims abstract description 185
102000004169 proteins and genes Human genes 0.000 title claims abstract description 178
239000000203 mixture Substances 0.000 title claims abstract description 167
238000009472 formulation Methods 0.000 title claims abstract description 122
238000000034 method Methods 0.000 title claims abstract description 68
230000001603 reducing effect Effects 0.000 title claims abstract description 55
150000001875 compounds Chemical class 0.000 claims abstract description 53
-1 for example Chemical class 0.000 claims abstract description 31
235000018102 proteins Nutrition 0.000 claims description 174
239000004475 Arginine Substances 0.000 claims description 36
229960003121 arginine Drugs 0.000 claims description 36
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 36
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 33
239000013011 aqueous formulation Substances 0.000 claims description 26
239000000243 solution Substances 0.000 claims description 25
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HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 16
239000002253 acid Substances 0.000 claims description 16
VHRGRCVQAFMJIZ-UHFFFAOYSA-N cadaverine Chemical compound NCCCCCN VHRGRCVQAFMJIZ-UHFFFAOYSA-N 0.000 claims description 16
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 16
KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 claims description 16
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims description 14
ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 claims description 14
PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 claims description 14
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 13
BHKSYEZGBQDNRW-SCGRZTRASA-N C(CCC(=O)O)(=O)O.N[C@@H](CCCNC(N)=N)C(=O)O.N[C@@H](CCCNC(N)=N)C(=O)O Chemical compound C(CCC(=O)O)(=O)O.N[C@@H](CCCNC(N)=N)C(=O)O.N[C@@H](CCCNC(N)=N)C(=O)O BHKSYEZGBQDNRW-SCGRZTRASA-N 0.000 claims description 12
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QYPPJABKJHAVHS-UHFFFAOYSA-N Agmatine Natural products NCCCCNC(N)=N QYPPJABKJHAVHS-UHFFFAOYSA-N 0.000 claims description 10
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