KR20130060227A - 단백질-함유 제제의 점도 감소에 유용한 조성물 및 방법 - Google Patents

단백질-함유 제제의 점도 감소에 유용한 조성물 및 방법 Download PDF

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Publication number
KR20130060227A
KR20130060227A KR20127031426A KR20127031426A KR20130060227A KR 20130060227 A KR20130060227 A KR 20130060227A KR 20127031426 A KR20127031426 A KR 20127031426A KR 20127031426 A KR20127031426 A KR 20127031426A KR 20130060227 A KR20130060227 A KR 20130060227A
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KR
South Korea
Prior art keywords
protein
viscosity
arginine
antibody
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR20127031426A
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English (en)
Korean (ko)
Inventor
마유미 엔. 보웬
준 리우
안키트 알. 파텔
Original Assignee
제넨테크, 인크.
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Application filed by 제넨테크, 인크. filed Critical 제넨테크, 인크.
Publication of KR20130060227A publication Critical patent/KR20130060227A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR20127031426A 2010-05-03 2011-04-26 단백질-함유 제제의 점도 감소에 유용한 조성물 및 방법 Withdrawn KR20130060227A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33068910P 2010-05-03 2010-05-03
US61/330,689 2010-05-03
PCT/US2011/034001 WO2011139718A1 (en) 2010-05-03 2011-04-26 Compositions and methods useful for reducing the viscosity of protein-containing formulations

Publications (1)

Publication Number Publication Date
KR20130060227A true KR20130060227A (ko) 2013-06-07

Family

ID=44263176

Family Applications (1)

Application Number Title Priority Date Filing Date
KR20127031426A Withdrawn KR20130060227A (ko) 2010-05-03 2011-04-26 단백질-함유 제제의 점도 감소에 유용한 조성물 및 방법

Country Status (10)

Country Link
US (1) US20130058958A1 (enExample)
EP (1) EP2566510A1 (enExample)
JP (1) JP2013525484A (enExample)
KR (1) KR20130060227A (enExample)
CN (1) CN102958538A (enExample)
BR (1) BR112012027828A2 (enExample)
CA (1) CA2794864A1 (enExample)
MX (1) MX2012012743A (enExample)
RU (1) RU2012151500A (enExample)
WO (1) WO2011139718A1 (enExample)

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KR20160055243A (ko) * 2013-09-11 2016-05-17 알시아 테라퓨틱스 인코퍼레이티드 점도저하제를 함유하는 액체 단백질 제형
KR20210110396A (ko) * 2013-09-11 2021-09-07 이글 바이오로직스 인코퍼레이티드 점도저하제를 함유하는 액체 단백질 제형
KR20220123552A (ko) * 2013-09-11 2022-09-07 이글 바이오로직스 인코퍼레이티드 점도저하제를 함유하는 액체 단백질 제형
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US20130058958A1 (en) 2013-03-07
RU2012151500A (ru) 2014-06-10
WO2011139718A1 (en) 2011-11-10
CN102958538A (zh) 2013-03-06
CA2794864A1 (en) 2011-11-10
EP2566510A1 (en) 2013-03-13
MX2012012743A (es) 2012-11-23
BR112012027828A2 (pt) 2016-08-09

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