CA2794864A1

CA2794864A1 - Compositions and methods useful for reducing the viscosity of protein-containing formulations

Compositions and methods useful for reducing the viscosity of protein-containing formulations Download PDF

Info

Publication number: CA2794864A1
Authority: CA; Canada
Prior art keywords: antibody; protein; viscosity; arginine; formulation
Prior art date: 2010-05-03
Legal status : Pending

Application number

CA 2794864

Other languages

English (en)

French (fr)

Inventor

Mayumi N. Bowen

Jun Liu

Ankit R. Patel

Current Assignee

Genentech Inc

Original Assignee

Genentech Inc

Priority date

2010-05-03

Filing date

2011-04-26

Publication date

2011-11-10

2011-04-26 Application filed by Genentech Inc filed Critical Genentech Inc

2011-11-10 Publication of CA2794864A1 publication Critical patent/CA2794864A1/en

Status Pending legal-status Critical Current

Links

108090000623 proteins and genes Proteins 0.000 title claims abstract description 182
102000004169 proteins and genes Human genes 0.000 title claims abstract description 175
239000000203 mixture Substances 0.000 title claims abstract description 167
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238000000034 method Methods 0.000 title claims abstract description 68
150000001875 compounds Chemical class 0.000 claims abstract description 52
235000018102 proteins Nutrition 0.000 claims description 170
239000004475 Arginine Substances 0.000 claims description 43
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 43
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 38
QYPPJABKJHAVHS-UHFFFAOYSA-N Agmatine Natural products NCCCCNC(N)=N QYPPJABKJHAVHS-UHFFFAOYSA-N 0.000 claims description 27
239000013011 aqueous formulation Substances 0.000 claims description 25
239000000243 solution Substances 0.000 claims description 24
238000004519 manufacturing process Methods 0.000 claims description 21
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 20
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims description 16
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