JP2013525484A - タンパク質含有製剤の粘度を低減させるために有用な組成物及び方法 - Google Patents
タンパク質含有製剤の粘度を低減させるために有用な組成物及び方法 Download PDFInfo
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- JP2013525484A JP2013525484A JP2013509113A JP2013509113A JP2013525484A JP 2013525484 A JP2013525484 A JP 2013525484A JP 2013509113 A JP2013509113 A JP 2013509113A JP 2013509113 A JP2013509113 A JP 2013509113A JP 2013525484 A JP2013525484 A JP 2013525484A
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- protein
- antibody
- arginine
- viscosity
- acid
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Classifications
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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| US33068910P | 2010-05-03 | 2010-05-03 | |
| US61/330,689 | 2010-05-03 | ||
| PCT/US2011/034001 WO2011139718A1 (en) | 2010-05-03 | 2011-04-26 | Compositions and methods useful for reducing the viscosity of protein-containing formulations |
Publications (2)
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| JP2013525484A true JP2013525484A (ja) | 2013-06-20 |
| JP2013525484A5 JP2013525484A5 (enExample) | 2014-06-19 |
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| US (1) | US20130058958A1 (enExample) |
| EP (1) | EP2566510A1 (enExample) |
| JP (1) | JP2013525484A (enExample) |
| KR (1) | KR20130060227A (enExample) |
| CN (1) | CN102958538A (enExample) |
| BR (1) | BR112012027828A2 (enExample) |
| CA (1) | CA2794864A1 (enExample) |
| MX (1) | MX2012012743A (enExample) |
| RU (1) | RU2012151500A (enExample) |
| WO (1) | WO2011139718A1 (enExample) |
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| JP2015017042A (ja) * | 2013-07-09 | 2015-01-29 | 国立大学法人 筑波大学 | 高濃度γグロブリン製剤の粘度低下方法 |
| JP2016534141A (ja) * | 2013-09-11 | 2016-11-04 | アーシア セラピューティクス， インコーポレイテッド | 粘度低下剤を含む液状タンパク質製剤 |
| US9574005B2 (en) | 2011-07-19 | 2017-02-21 | Chugai Seiyaku Kabushiki Kaisha | Stable Protein-containing preparation containing argininamide or analogous compound thereof |
| JP2017531682A (ja) * | 2014-10-23 | 2017-10-26 | アムジエン・インコーポレーテツド | 医薬製剤の粘度低下 |
| JP2018535242A (ja) * | 2015-11-30 | 2018-11-29 | メディミューン，エルエルシー | 高濃度のタンパク質ベースの治療剤を含有する医薬組成物中の非晶質安定化化合物としてのアミノ酸と糖との最適比 |
| JP2021521226A (ja) * | 2018-04-16 | 2021-08-26 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 高濃度タンパク質製剤の粘度低下 |
| US11471479B2 (en) | 2014-10-01 | 2022-10-18 | Eagle Biologics, Inc. | Polysaccharide and nucleic acid formulations containing viscosity-lowering agents |
| JP2022548150A (ja) * | 2019-09-17 | 2022-11-16 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 高濃縮タンパク質製剤中の粘度低減剤としてのカンファースルホン酸およびそのカチオン性賦形剤との組み合わせ |
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| FR2995214B1 (fr) | 2012-09-10 | 2014-11-21 | Adocia | Solution a viscosite reduite de proteine a concentration elevee |
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| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
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| US20170056352A1 (en) | 2015-08-25 | 2017-03-02 | Rgenix, Inc. | PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF |
| JP7377596B2 (ja) | 2017-02-22 | 2023-11-10 | アムジエン・インコーポレーテツド | 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法 |
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Also Published As
| Publication number | Publication date |
|---|---|
| US20130058958A1 (en) | 2013-03-07 |
| RU2012151500A (ru) | 2014-06-10 |
| WO2011139718A1 (en) | 2011-11-10 |
| CN102958538A (zh) | 2013-03-06 |
| CA2794864A1 (en) | 2011-11-10 |
| EP2566510A1 (en) | 2013-03-13 |
| MX2012012743A (es) | 2012-11-23 |
| KR20130060227A (ko) | 2013-06-07 |
| BR112012027828A2 (pt) | 2016-08-09 |
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