JP2013521252A5 - - Google Patents
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- Publication number
- JP2013521252A5 JP2013521252A5 JP2012555403A JP2012555403A JP2013521252A5 JP 2013521252 A5 JP2013521252 A5 JP 2013521252A5 JP 2012555403 A JP2012555403 A JP 2012555403A JP 2012555403 A JP2012555403 A JP 2012555403A JP 2013521252 A5 JP2013521252 A5 JP 2013521252A5
- Authority
- JP
- Japan
- Prior art keywords
- binding protein
- seq
- antigen binding
- val
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000025171 antigen binding proteins Human genes 0.000 claims 44
- 108091000831 antigen binding proteins Proteins 0.000 claims 44
- 108010045517 Serum Amyloid P-Component Proteins 0.000 claims 22
- 102100036202 Serum amyloid P-component Human genes 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 14
- 238000000034 method Methods 0.000 claims 11
- 230000000779 depleting effect Effects 0.000 claims 10
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical group COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 230000003941 amyloidogenesis Effects 0.000 claims 3
- 125000000180 D-prolyl group Chemical class N1[C@@H](C(=O)*)CCC1 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 101001092910 Homo sapiens Serum amyloid P-component Proteins 0.000 claims 2
- NSTPXGARCQOSAU-VIFPVBQESA-N N-formyl-L-phenylalanine Chemical class O=CN[C@H](C(=O)O)CC1=CC=CC=C1 NSTPXGARCQOSAU-VIFPVBQESA-N 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 206010002022 amyloidosis Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 108010094108 Amyloid Proteins 0.000 claims 1
- 102000001049 Amyloid Human genes 0.000 claims 1
- 208000037259 Amyloid Plaque Diseases 0.000 claims 1
- 206010059245 Angiopathy Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000016463 Wild type ABeta2M amyloidosis Diseases 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000004154 complement system Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- -1 glycerol cyclic pyruvate derivative Chemical class 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000022256 primary systemic amyloidosis Diseases 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30995710P | 2010-03-03 | 2010-03-03 | |
| US61/309,957 | 2010-03-03 | ||
| PCT/EP2011/053038 WO2011107480A1 (en) | 2010-03-03 | 2011-03-01 | Antigen binding proteins specific for serum amyloid p component |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016020718A Division JP6236478B2 (ja) | 2010-03-03 | 2016-02-05 | 血清アミロイドｐ成分に特異的な抗原結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013521252A JP2013521252A (ja) | 2013-06-10 |
| JP2013521252A5 true JP2013521252A5 (enExample) | 2014-03-20 |
| JP5922592B2 JP5922592B2 (ja) | 2016-05-24 |
Family
ID=43881068
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012555403A Expired - Fee Related JP5922592B2 (ja) | 2010-03-03 | 2011-03-01 | 血清アミロイドｐ成分に特異的な抗原結合タンパク質 |
| JP2016020718A Expired - Fee Related JP6236478B2 (ja) | 2010-03-03 | 2016-02-05 | 血清アミロイドｐ成分に特異的な抗原結合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016020718A Expired - Fee Related JP6236478B2 (ja) | 2010-03-03 | 2016-02-05 | 血清アミロイドｐ成分に特異的な抗原結合タンパク質 |
Country Status (39)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2506876B1 (en) * | 2009-12-02 | 2016-10-12 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
| EA031025B1 (ru) * | 2012-12-21 | 2018-11-30 | Сиэтл Дженетикс, Инк. | Антитела против ntb-a и связанные с ними композиции и способы |
| CN103239713A (zh) * | 2013-05-28 | 2013-08-14 | 东南大学 | 一种糖尿病肾病微炎症小鼠模型的建立方法 |
| US9737505B2 (en) * | 2014-04-29 | 2017-08-22 | Glaxosmithkline Intellectual Property Development Limited | Prodrug of 1,1′-(1,6-dioxo-1,6-hexanediyl)bis-D-proline |
| GB201407506D0 (en) | 2014-04-29 | 2014-06-11 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| CN108136012B (zh) | 2015-08-07 | 2022-10-04 | 伊麦吉纳博公司 | 靶向分子的抗原结合构建体 |
| US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
| WO2019185502A1 (en) | 2018-03-26 | 2019-10-03 | Glaxosmithkline Intellectual Property Development Limited | Antibodies comprising methionine sulfoxide at the ch2-ch3 interface |
| CN116925216B (zh) * | 2022-04-11 | 2024-09-24 | 东莞市朋志生物科技有限公司 | 抗血清淀粉样蛋白a抗体、检测血清淀粉样蛋白a的试剂和试剂盒 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57106673A (en) | 1980-12-24 | 1982-07-02 | Chugai Pharmaceut Co Ltd | Dibenzo(b,f)(1,4)oxazepin derivative |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| EP0605522B1 (en) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methods for the production of humanized antibodies |
| GB9122820D0 (en) | 1991-10-28 | 1991-12-11 | Wellcome Found | Stabilised antibodies |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
| CA2140280A1 (en) | 1992-08-17 | 1994-03-03 | Avi J. Ashkenazi | Bispecific immunoadhesins |
| WO1994029347A1 (en) | 1993-06-03 | 1994-12-22 | Therapeutic Antibodies Inc. | Antibody fragments in therapy |
| GB9317120D0 (en) * | 1993-08-17 | 1993-09-29 | Royal Postgrad Med School | Human serum amyloid p component |
| US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
| US5795737A (en) | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| CN1252075A (zh) | 1997-02-07 | 2000-05-03 | 麦克公司 | 合成的hiv gag基因 |
| DE69808017T2 (de) | 1997-10-31 | 2003-04-30 | F. Hoffmann-La Roche Ag, Basel | D-Prolinderivate |
| GB9806530D0 (en) | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7504256B1 (en) | 1999-10-19 | 2009-03-17 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing polypeptide |
| JP2005538706A (ja) | 2001-07-12 | 2005-12-22 | ジェファーソン フーテ， | スーパーヒト化抗体 |
| CA2838062C (en) | 2001-08-03 | 2015-12-22 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| US6903129B2 (en) | 2001-12-14 | 2005-06-07 | Hoffman-La Roche Inc. | D-proline prodrugs |
| GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
| EP3321282A1 (en) | 2002-09-27 | 2018-05-16 | Xencor, Inc. | Optimized fc variants and methods for their generation |
| WO2004059318A2 (en) | 2002-12-23 | 2004-07-15 | William Marsh Rice University | Methods of detecting the inhibition of fibrocyte formation and methods and compositions for enhancing fibrocyte formation |
| JP2006524039A (ja) | 2003-01-09 | 2006-10-26 | マクロジェニクス，インコーポレーテッド | 変異型Ｆｃ領域を含む抗体の同定および作製ならびにその利用法 |
| CA2525302A1 (en) | 2003-05-12 | 2004-11-18 | David Bundle | Multivalent inhibitors of serum amyloid p component |
| JP2008512353A (ja) | 2004-07-21 | 2008-04-24 | グライコフィ， インコーポレイテッド | 主にＧｌｃＮＡｃ２Ｍａｎ３ＧｌｃＮＡｃ２グリコフォームを含むイムノグロブリン |
| GB0712503D0 (en) * | 2007-06-27 | 2007-08-08 | Therapeutics Pentraxin Ltd | Use |
| AU2008358292B2 (en) * | 2008-06-27 | 2015-05-07 | Pentraxin Therapeutics Limited | Use |
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2011
- 2011-01-03 UA UAA201210015A patent/UA108227C2/uk unknown
- 2011-03-01 MY MYPI2012003903A patent/MY159255A/en unknown
- 2011-03-01 PH PH1/2012/501743A patent/PH12012501743A1/en unknown
- 2011-03-01 RS RS20160741A patent/RS55133B1/sr unknown
- 2011-03-01 EP EP11705617.6A patent/EP2542261B1/en active Active
- 2011-03-01 CA CA2789557A patent/CA2789557A1/en not_active Abandoned
- 2011-03-01 AR ARP110100618A patent/AR080432A1/es not_active Application Discontinuation
- 2011-03-01 WO PCT/EP2011/053038 patent/WO2011107480A1/en not_active Ceased
- 2011-03-01 BR BR112012021926-0A patent/BR112012021926A2/pt not_active IP Right Cessation
- 2011-03-01 EP EP15178026.9A patent/EP3025729B1/en active Active
- 2011-03-01 MA MA35252A patent/MA34135B1/fr unknown
- 2011-03-01 PT PT117056176T patent/PT2542261T/pt unknown
- 2011-03-01 ES ES11705617.6T patent/ES2593454T3/es active Active
- 2011-03-01 LT LTEP15178026.9T patent/LT3025729T/lt unknown
- 2011-03-01 PL PL11705617.6T patent/PL2542261T3/pl unknown
- 2011-03-01 RS RS20181162A patent/RS57708B1/sr unknown
- 2011-03-01 PL PL15178026T patent/PL3025729T3/pl unknown
- 2011-03-01 LT LTEP11705617.6T patent/LT2542261T/lt unknown
- 2011-03-01 JP JP2012555403A patent/JP5922592B2/ja not_active Expired - Fee Related
- 2011-03-01 HU HUE11705617A patent/HUE028960T2/en unknown
- 2011-03-01 EA EA201290671A patent/EA026375B1/ru not_active IP Right Cessation
- 2011-03-01 ES ES15178026T patent/ES2699078T3/es active Active
- 2011-03-01 SG SG2012060216A patent/SG183316A1/en unknown
- 2011-03-01 MX MX2012010129A patent/MX340350B/es active IP Right Grant
- 2011-03-01 HR HRP20161096TT patent/HRP20161096T1/hr unknown
- 2011-03-01 NZ NZ601763A patent/NZ601763A/en not_active IP Right Cessation
- 2011-03-01 DK DK11705617.6T patent/DK2542261T3/en active
- 2011-03-01 DK DK15178026.9T patent/DK3025729T3/en active
- 2011-03-01 SI SI201130964A patent/SI2542261T1/sl unknown
- 2011-03-01 SM SM20180633T patent/SMT201800633T1/it unknown
- 2011-03-01 PE PE2012001385A patent/PE20130040A1/es not_active Application Discontinuation
- 2011-03-01 SG SG10201500382SA patent/SG10201500382SA/en unknown
- 2011-03-01 SI SI201131594T patent/SI3025729T1/sl unknown
- 2011-03-01 CN CN201180017717.1A patent/CN102858371B/zh not_active Expired - Fee Related
- 2011-03-01 AU AU2011223048A patent/AU2011223048C1/en not_active Ceased
- 2011-03-01 TW TW100106740A patent/TWI558409B/zh not_active IP Right Cessation
- 2011-03-01 JO JOP/2011/0075A patent/JO3188B1/ar active
- 2011-03-01 PT PT15178026T patent/PT3025729T/pt unknown
- 2011-03-01 KR KR1020127025884A patent/KR101817265B1/ko not_active Expired - Fee Related
- 2011-03-01 ME MEP-2016-161A patent/ME02491B/me unknown
- 2011-03-03 UY UY0001033258A patent/UY33258A/es not_active Application Discontinuation
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2012
- 2012-08-12 IL IL221418A patent/IL221418A/en not_active IP Right Cessation
- 2012-08-22 DO DO2012000232A patent/DOP2012000232A/es unknown
- 2012-08-30 ZA ZA2012/06529A patent/ZA201206529B/en unknown
- 2012-08-31 CL CL2012002418A patent/CL2012002418A1/es unknown
- 2012-08-31 CO CO12149377A patent/CO6602134A2/es unknown
- 2012-09-27 CR CR20120491A patent/CR20120491A/es unknown
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2016
- 2016-02-05 JP JP2016020718A patent/JP6236478B2/ja not_active Expired - Fee Related
- 2016-09-23 CY CY20161100950T patent/CY1118046T1/el unknown
- 2016-09-26 SM SM201600337T patent/SMT201600337B/it unknown
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2017
- 2017-03-08 IL IL251031A patent/IL251031A/en not_active IP Right Cessation
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2018
- 2018-10-12 HR HRP20181666TT patent/HRP20181666T1/hr unknown
- 2018-10-31 CY CY181101126T patent/CY1120803T1/el unknown