|
NL297170A
(enExample)
|
1963-04-04 |
1900-01-01 |
|
|
|
NL128365C
(enExample)
|
1963-11-05 |
|
|
|
|
US3449427A
(en)
*
|
1965-06-03 |
1969-06-10 |
Smithkline Corp |
Aminocyclopropane derivatives of 5h-dibenzo(a,d)cycloheptenes
|
|
US3697506A
(en)
*
|
1970-08-07 |
1972-10-10 |
Pfizer |
Crystalline alkali metal salts of {60 -carboxybenzylpenicillin and process therefor
|
|
US3686335A
(en)
*
|
1970-12-21 |
1972-08-22 |
Smith Kline French Lab |
5-vinyl-5h-di benzo(a,d)cycloheptenes
|
|
US4432987A
(en)
*
|
1982-04-23 |
1984-02-21 |
Pfizer Inc. |
Crystalline benzenesulfonate salts of sultamicillin
|
|
US4547505A
(en)
|
1983-03-25 |
1985-10-15 |
Degussa Aktiengesellschaft |
N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
|
|
CS244821B2
(en)
|
1983-06-16 |
1986-08-14 |
Boehringer Ingelheim Ltd |
Production method of new substituted phenylalkyl(piperazinyl or homopiperazinyle)-prpylureas or thioureas
|
|
DE3418167A1
(de)
|
1984-05-16 |
1985-11-21 |
Bayer Ag, 5090 Leverkusen |
Verwendung von amiden zur verbesserung der kulturpflanzen-vertraeglichkeit von herbizid wirksamen heteroaryloxyacetamiden
|
|
DE3600288A1
(de)
|
1986-01-08 |
1987-07-16 |
Bayer Ag |
Verwendung von amiden zur verbesserung der kulturpflanzen-vertraeglichkeit von herbizid wirksamen sulfonylharnstoff-derivaten
|
|
DE3618004A1
(de)
|
1986-05-28 |
1987-12-03 |
Bayer Ag |
Verwendung von amiden zur verbesserung der kulturpflanzen-vertraeglichkeit von herbizid wirksamen sulfonyliso(thio)-harnstoff-derivaten
|
|
AU658134B2
(en)
|
1989-12-28 |
1995-04-06 |
Virginia Commonwealth University |
Sigma receptor ligands and the use thereof
|
|
EP0435320B1
(en)
*
|
1989-12-29 |
1994-10-05 |
Banyu Pharmaceutical Co., Ltd. |
2(2-Cyclopropylpyrrolidin-4-ylthio)-carbapenem derivatives
|
|
JPH06505502A
(ja)
|
1991-08-22 |
1994-06-23 |
モンサント・カンパニー |
毒性緩和除草剤ピラゾリルスルホニル尿素
|
|
DE4131139A1
(de)
*
|
1991-09-19 |
1993-03-25 |
Bayer Ag |
Verfahren zur herstellung von 1-fluor-cyclopropan-1-carbonsaeure
|
|
DE69427469T2
(de)
*
|
1993-03-12 |
2001-10-31 |
Pharmacia & Upjohn Co., Kalamazoo |
Kristallines ceftiofur (freie säure)
|
|
AU4368996A
(en)
|
1994-11-23 |
1996-06-17 |
Neurogen Corporation |
Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands
|
|
US5604253A
(en)
|
1995-05-22 |
1997-02-18 |
Merck Frosst Canada, Inc. |
N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
|
|
US5859246A
(en)
|
1997-01-30 |
1999-01-12 |
Neurogen Corporation |
1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
|
|
EP0968200A1
(en)
|
1997-02-24 |
2000-01-05 |
ZymoGenetics, Inc. |
Calcitonin mimetics
|
|
US6160134A
(en)
|
1997-12-24 |
2000-12-12 |
Bristol-Myers Squibb Co. |
Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines
|
|
EA200000768A1
(ru)
|
1998-01-27 |
2001-06-25 |
Эвентис Фармасьютикалз Продактс Инк. |
ЗАМЕЩЕННЫЕ ОКСОАЗАГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ ФАКТОРА Ха
|
|
US6268367B1
(en)
|
1998-02-23 |
2001-07-31 |
Zymogenetics, Inc. |
Piperazine derivatives for treating bone deficit conditions
|
|
EP1090919A4
(en)
*
|
1998-06-26 |
2002-05-22 |
Chugai Pharmaceutical Co Ltd |
L-ALPHA-AMINOADIPIC ACID DERIVATIVE IN FINE POWDER, ORAL SOLID PREPARATIONS CONTAINING SAID DERIVATIVE AND BULK POWDER PROCESSING PROCESS
|
|
US6284761B1
(en)
*
|
1999-01-08 |
2001-09-04 |
Neurogen Corporation |
1-phenyl-4-(1-[2-aryl]cyclopropyl)methylpiperazines: dopamine receptor ligands
|
|
CN1167694C
(zh)
|
1999-01-08 |
2004-09-22 |
纽罗根公司 |
1-苯基-4-(1-[2-芳基]环丙基)甲基哌嗪:多巴胺受体配体
|
|
GB9913083D0
(en)
*
|
1999-06-04 |
1999-08-04 |
Novartis Ag |
Organic compounds
|
|
AU5426500A
(en)
|
1999-06-16 |
2001-01-02 |
Takeda Chemical Industries Ltd. |
Benzazepine derivatives, process for the preparation of the same and uses thereof
|
|
WO2001022963A1
(en)
|
1999-09-27 |
2001-04-05 |
Merck & Co., Inc. |
Method of preventing osteoporosis
|
|
AU2930501A
(en)
*
|
2000-01-07 |
2001-07-24 |
Transform Pharmaceuticals, Inc. |
High-throughput formation, identification, and analysis of diverse solid-forms
|
|
CN1242989C
(zh)
|
2000-06-29 |
2006-02-22 |
艾伯特公司 |
芳基苯基环丙基硫醚衍生物及其作为抑制细胞粘附的抗炎和免疫抑制剂的用途
|
|
US6521619B2
(en)
|
2000-06-29 |
2003-02-18 |
Icos Corporation |
Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
|
|
KR20030024799A
(ko)
|
2000-07-20 |
2003-03-26 |
뉴로젠 코포레이션 |
캡사이신 수용체 리간드
|
|
KR20030062447A
(ko)
|
2000-12-25 |
2003-07-25 |
아지노모토 가부시키가이샤 |
광학 활성 할로하이드린 화합물의 제조방법
|
|
PT1379520E
(pt)
*
|
2001-02-23 |
2006-08-31 |
Merck & Co Inc |
Antagonistas (nao-aril)-heterociclicos n-substituidos de nmda/nr2b
|
|
ATE449090T1
(de)
|
2001-07-02 |
2009-12-15 |
High Point Pharmaceuticals Llc |
Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
|
|
CA2456754A1
(en)
|
2001-08-08 |
2003-02-20 |
Yuji Iizawa |
Benzazepine derivative, process for producing the same, and use
|
|
EP1442038A4
(en)
|
2001-09-26 |
2005-01-05 |
Merck & Co Inc |
CRYSTALLINE FORMS OF CARBAPENEM ANTIBIOTICS AND MANUFACTURING METHOD
|
|
WO2003037271A2
(en)
|
2001-10-30 |
2003-05-08 |
Millennium Pharmaceuticals,Inc. |
Compounds, pharmaceutical compositions and methods of use therefor
|
|
US6861432B2
(en)
*
|
2001-11-23 |
2005-03-01 |
Schering Aktiengesellschaft |
Piperazine derivatives that destabilize androgen receptors
|
|
CN1642947A
(zh)
*
|
2002-03-22 |
2005-07-20 |
株式会社Lg生命科学 |
( 2 S )-N-5-[氨基(亚氨基)甲基]-2-噻吩基甲基-1-( 2 R ) -2-[(羧甲基) 氨基]-3 ,3-二苯基丙酰-2-吡咯烷甲酰胺·nH2O的新晶形
|
|
AU2003236686A1
(en)
|
2002-06-07 |
2003-12-22 |
Altana Pharma Ag |
4,5-dihydro-imidazo(4,5,1-j) quinolin-6-ones as parp inhibitors
|
|
US20040209858A1
(en)
*
|
2002-10-22 |
2004-10-21 |
Bennani Youssef L. |
Cycloalkylamides and their therapeutic applications
|
|
US20040077618A1
(en)
|
2002-10-22 |
2004-04-22 |
Bennani Youssef L. |
Cycloalkylamides and their therapeutic applications
|
|
JPWO2004046110A1
(ja)
|
2002-11-15 |
2006-03-16 |
アステラス製薬株式会社 |
メラニン凝集ホルモン受容体拮抗剤
|
|
DE60318891T2
(de)
|
2002-12-13 |
2009-01-22 |
Smithkline Beecham Corp. |
Cyclopropylverbindungen als ccr5 antagonisten
|
|
SI1615909T1
(sl)
*
|
2003-04-23 |
2008-12-31 |
Glaxo Group Ltd |
Derivati piperazina in njihova uporaba za zdravljenje nevroloĺ kih in psihiatriäśnih bolezni
|
|
WO2004099156A1
(en)
|
2003-05-01 |
2004-11-18 |
Bristol-Myers Squibb Company |
Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
|
|
TWI339206B
(en)
|
2003-09-04 |
2011-03-21 |
Vertex Pharma |
Compositions useful as inhibitors of protein kinases
|
|
CN1901971A
(zh)
|
2003-12-15 |
2007-01-24 |
日本烟草产业株式会社 |
环丙烷化合物及其药物应用
|
|
AU2004321997A1
(en)
|
2004-07-06 |
2006-02-09 |
Xenon Pharmaceuticals Inc. |
Nicotinamide derivatives and their use as therapeutic agents
|
|
AR050865A1
(es)
|
2004-09-09 |
2006-11-29 |
Sanofi Aventis |
Derivados de 2- morfolino-4-pirimidona
|
|
ATE499356T1
(de)
|
2004-09-29 |
2011-03-15 |
Mitsubishi Tanabe Pharma Corp |
6-(pyridinyl)-4-pyrimidonderivate als inhibitoren der tau-proteinkinase-1
|
|
HRP20080227T3
(hr)
|
2004-10-15 |
2008-06-30 |
Glaxo Group Limited |
Pirolidinski derivati kao ligandi histaminskih receptora
|
|
CN101128435A
(zh)
|
2004-12-27 |
2008-02-20 |
阿斯利康(瑞典)有限公司 |
作为代谢型谷氨酸受体激动剂用于治疗神经病学及精神病学病症的吡唑酮化合物
|
|
WO2006079916A1
(en)
|
2005-01-26 |
2006-08-03 |
Pharmacia & Upjohn Company Llc |
Thieno [2,3-d] pyrimidine compounds as inhibitors of adp-mediated platelets aggregation
|
|
WO2006087169A1
(en)
|
2005-02-15 |
2006-08-24 |
Glaxo Group Limited |
Compounds which potentiate glutamate receptor and uses thereof in medicine
|
|
EP1849773B1
(en)
|
2005-02-17 |
2013-10-16 |
Astellas Pharma Inc. |
Piperazine derivatives for the treatment of urinary incontinence and pain
|
|
US20080176857A1
(en)
|
2005-03-25 |
2008-07-24 |
Michael Dalton Ennis |
4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors
|
|
WO2006103544A2
(en)
|
2005-03-28 |
2006-10-05 |
Pharmacia & Upjohn Company Llc |
4-piperazinylthieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors
|
|
CA2602538A1
(en)
|
2005-03-28 |
2006-10-05 |
Pharmacia & Upjohn Company Llc |
4-piperazinothieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors
|
|
JP2008534571A
(ja)
|
2005-03-28 |
2008-08-28 |
ファルマシア・アンド・アップジョン・カンパニー・エルエルシー |
血小板凝集阻害物質としての4−ピペラジニルチエノ[2,3−d]ピリミジン化合物
|
|
JP2009501235A
(ja)
|
2005-07-15 |
2009-01-15 |
シェーリング コーポレイション |
癌処置において有用なキナゾリン誘導体
|
|
TW200740779A
(en)
*
|
2005-07-22 |
2007-11-01 |
Mitsubishi Pharma Corp |
Intermediate compound for synthesizing pharmaceutical agent and production method thereof
|
|
WO2007016496A2
(en)
|
2005-08-02 |
2007-02-08 |
Neurogen Corporation |
Dipiperazinyl ketones and related analogues
|
|
PT1948607E
(pt)
|
2005-09-16 |
2010-06-02 |
Janssen Pharmaceutica Nv |
Ciclopropilaminas como moduladores do receptor h3 de histamina
|
|
US8158673B2
(en)
|
2005-10-27 |
2012-04-17 |
Pfizer Inc. |
Histamine-3 receptor antagonists
|
|
NZ592864A
(en)
|
2005-10-31 |
2012-09-28 |
Janssen Pharmaceutica Nv |
Processes for the preparation of cyclopropyl-amide derivatives
|
|
EP2308872A1
(en)
|
2005-12-21 |
2011-04-13 |
Vertex Pharmaceuticals Incorporated |
Heterocyclic derivatives as modulators of ion channels
|
|
WO2007076140A2
(en)
|
2005-12-23 |
2007-07-05 |
University Of Cincinnati |
Treatment methods employing histamine h3 receptor antagonists, including betahistine
|
|
RU2008132966A
(ru)
*
|
2006-01-13 |
2010-02-20 |
Ф.Хоффманн-Ля Рош Аг (Ch) |
Производные циклогексилпиперазинилметанона и их применение в качестве модуляторов гистамин н3 рецептора
|
|
CN101384581B
(zh)
*
|
2006-02-17 |
2013-09-18 |
弗·哈夫曼-拉罗切有限公司 |
作为5ht2/d3调节剂的苯甲酰基-哌啶衍生物
|
|
EP2004568A4
(en)
|
2006-03-01 |
2010-12-01 |
Cementech Pty Ltd |
MATRIX FOR MASONRY ELEMENTS AND METHOD FOR MANUFACTURING THE SAME
|
|
JP2009132621A
(ja)
|
2006-03-13 |
2009-06-18 |
Ajinomoto Co Inc |
シクロプロピルアミド化合物の製造方法
|
|
US7524848B2
(en)
|
2006-03-23 |
2009-04-28 |
Amgen Inc. |
Diaza heterocyclic amide compounds and their uses
|
|
WO2007138928A1
(ja)
|
2006-05-26 |
2007-12-06 |
Kaneka Corporation |
光学活性3-アミノ-2-ヒドロキシプロピオン酸シクロプロピルアミド誘導体およびその塩の製造方法
|
|
US9108948B2
(en)
*
|
2006-06-23 |
2015-08-18 |
Abbvie Inc. |
Cyclopropyl amine derivatives
|
|
BRPI0712823A2
(pt)
*
|
2006-06-23 |
2012-07-24 |
Abbott Lab |
derivados de ciclopropil amina como moduladores de receptor de histamina h3
|
|
CA2657702A1
(en)
|
2006-07-03 |
2008-01-10 |
Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek E N Patieentenzorg |
Quinazolines and related heterocyclic comp0unds, and their therapeutic use
|
|
GB0615620D0
(en)
*
|
2006-08-05 |
2006-09-13 |
Astrazeneca Ab |
A process for the preparation of optically active intermediates
|
|
WO2008024284A2
(en)
|
2006-08-21 |
2008-02-28 |
Merck & Co., Inc. |
Sulfonylated piperazines as cannabinoid-1 receptor modulators
|
|
TW200828371A
(en)
|
2006-09-21 |
2008-07-01 |
Matsushita Electric Industrial Co Ltd |
Chip-type filter
|
|
DE102006056526A1
(de)
*
|
2006-11-30 |
2008-06-05 |
Archimica Gmbh |
Verfahren zur stereoselektiven Synthese von chiralen Epoxiden durch ADH-Reduktion von alpha-Abgangsgruppen-substituierten Ketonen und Cyclisierung
|
|
US7737149B2
(en)
|
2006-12-21 |
2010-06-15 |
Astrazeneca Ab |
N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
|
|
WO2008147864A2
(en)
|
2007-05-22 |
2008-12-04 |
Xenon Pharmaceuticals Inc. |
Methods of using piperazine compounds in treating sodium channel-mediated diseases or conditions
|
|
JP2010528007A
(ja)
|
2007-05-23 |
2010-08-19 |
メルク・シャープ・エンド・ドーム・コーポレイション |
シクロプロピルピロリジンオレキシン受容体アンタゴニスト
|
|
ES2350511T3
(es)
|
2007-06-11 |
2011-01-24 |
F. Hoffmann-La Roche Ag |
Derivados ciclohexilo.
|
|
TW201446748A
(zh)
*
|
2007-08-22 |
2014-12-16 |
Astrazeneca Ab |
環丙基醯胺衍生物
|
|
MX2010003155A
(es)
*
|
2007-10-04 |
2010-04-01 |
Hoffmann La Roche |
Derivados de ciclopropil aril amida y uso de los mismos.
|
|
AR070107A1
(es)
*
|
2008-01-15 |
2010-03-17 |
Lilly Co Eli |
R-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida en forma cristalina, composicion farmaceutica que la comprende y su uso para la manufactura de un medicamento util para la prevencion o tratamiento de hiperglicemia
|
|
DE102008049371A1
(de)
|
2008-03-06 |
2009-09-10 |
Mühlbauer Ag |
Einrichtung mit einem RFID-Transponder in einem elektrisch leitfähigen Gegenstand und Herstellungsverfahren hierfür
|
|
JP2011525478A
(ja)
*
|
2008-03-20 |
2011-09-22 |
フォレスト・ラボラトリーズ・ホールディングス・リミテッド |
ステアロイル−CoAデサチュラーゼの阻害剤としての新規ピペラジン誘導体
|
|
US8691804B2
(en)
*
|
2008-05-08 |
2014-04-08 |
Evotec Ag |
Azetidines and cyclobutanes as histamine H3 receptor antagonists
|
|
EP2313360B1
(en)
|
2008-07-28 |
2012-09-05 |
Syddansk Universitet |
Compounds for the treatment of metabolic diseases
|
|
CN101462980B
(zh)
|
2009-01-05 |
2013-01-09 |
扬州天辰精细化工有限公司 |
2,6—二氟苯甲酰胺的工业化生产方法
|
|
TW201039825A
(en)
*
|
2009-02-20 |
2010-11-16 |
Astrazeneca Ab |
Cyclopropyl amide derivatives 983
|
|
SG183231A1
(en)
|
2010-02-18 |
2012-09-27 |
Astrazeneca Ab |
Solid forms comprising a cyclopropyl amide derivative
|
|
NZ602110A
(en)
|
2010-02-18 |
2014-09-26 |
Astrazeneca Ab |
Processes for making cyclopropyl amide derivatives and intermediates associated therewith
|