JP2015517981A5 - - Google Patents
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- Publication number
- JP2015517981A5 JP2015517981A5 JP2014560012A JP2014560012A JP2015517981A5 JP 2015517981 A5 JP2015517981 A5 JP 2015517981A5 JP 2014560012 A JP2014560012 A JP 2014560012A JP 2014560012 A JP2014560012 A JP 2014560012A JP 2015517981 A5 JP2015517981 A5 JP 2015517981A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- trifluoromethyl
- chloro
- optionally substituted
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261605059P | 2012-02-29 | 2012-02-29 | |
| US201261605071P | 2012-02-29 | 2012-02-29 | |
| US61/605,071 | 2012-02-29 | ||
| US61/605,059 | 2012-02-29 | ||
| PCT/US2013/028150 WO2013130703A2 (en) | 2012-02-29 | 2013-02-28 | Binhibitors of hepatitis b virus convalently closed circular dna formation and their method of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017083672A Division JP2017165751A (ja) | 2012-02-29 | 2017-04-20 | Ｂ型肝炎ウイルス共有結合閉環状ｄｎａ形成の阻害剤およびそれらの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517981A JP2015517981A (ja) | 2015-06-25 |
| JP2015517981A5 true JP2015517981A5 (enExample) | 2016-06-16 |
| JP6134338B2 JP6134338B2 (ja) | 2017-05-24 |
Family
ID=49083449
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560012A Expired - Fee Related JP6134338B2 (ja) | 2012-02-29 | 2013-02-28 | Ｂ型肝炎ウイルス共有結合閉環状ｄｎａ形成の阻害剤およびそれらの使用方法 |
| JP2017083672A Pending JP2017165751A (ja) | 2012-02-29 | 2017-04-20 | Ｂ型肝炎ウイルス共有結合閉環状ｄｎａ形成の阻害剤およびそれらの使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017083672A Pending JP2017165751A (ja) | 2012-02-29 | 2017-04-20 | Ｂ型肝炎ウイルス共有結合閉環状ｄｎａ形成の阻害剤およびそれらの使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9657013B2 (enExample) |
| EP (1) | EP2819671A4 (enExample) |
| JP (2) | JP6134338B2 (enExample) |
| CN (1) | CN104822267B (enExample) |
| AU (2) | AU2013226013B2 (enExample) |
| BR (1) | BR112014021498A2 (enExample) |
| CA (1) | CA2865962A1 (enExample) |
| NZ (1) | NZ631419A (enExample) |
| WO (1) | WO2013130703A2 (enExample) |
| ZA (1) | ZA201407798B (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013006394A1 (en) * | 2011-07-01 | 2013-01-10 | Institute For Hepatitis And Virus Research | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
| EP2794565B1 (en) | 2011-12-21 | 2017-07-26 | Novira Therapeutics Inc. | Hepatitis b antiviral agents |
| CA2881057C (en) | 2012-08-28 | 2020-10-27 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| JP6262743B2 (ja) | 2012-09-27 | 2018-01-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 置換スルホンアミド化合物 |
| HK1217649A1 (zh) | 2012-12-27 | 2017-01-20 | 德雷克塞尔大学 | 針對hbv感染的新型抗病毒劑 |
| JP6466348B2 (ja) | 2013-02-28 | 2019-02-06 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | スルファモイル−アリールアミドおよびｂ型肝炎を処置するための医薬品としてのその使用 |
| US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
| HUE033542T2 (en) | 2013-04-03 | 2017-12-28 | Janssen Sciences Ireland Uc | Their use as medicaments for the treatment of N-phenylcarboxamide derivatives and hepatitis B |
| TW202126620A (zh) | 2013-05-17 | 2021-07-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途 |
| WO2015011281A1 (en) | 2013-07-25 | 2015-01-29 | Janssen R&D Ireland | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| MX368158B (es) | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| US9181288B2 (en) | 2014-01-16 | 2015-11-10 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| JP6553059B2 (ja) | 2014-02-05 | 2019-07-31 | ノヴィラ・セラピューティクス・インコーポレイテッド | Ｈｂｖ感染の治療のための併用療法 |
| PL3102572T3 (pl) | 2014-02-06 | 2019-04-30 | Janssen Sciences Ireland Uc | Pochodne sulfamoilopirolamidu i ich zastosowanie jako leki do leczenia wirusowego zapalenia wątroby typu B |
| US9400280B2 (en) | 2014-03-27 | 2016-07-26 | Novira Therapeutics, Inc. | Piperidine derivatives and methods of treating hepatitis B infections |
| EP3271019A1 (en) | 2015-03-19 | 2018-01-24 | Novira Therapeutics Inc. | Azocane and azonane derivatives and methods of treating hepatitis b infections |
| WO2016161268A1 (en) * | 2015-04-01 | 2016-10-06 | Enanta Pharmaceuticals, Inc. | Hepatitis b antviral agents |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| AR106192A1 (es) | 2015-09-29 | 2017-12-20 | Novira Therapeutics Inc | Formas cristalinas de un agente antiviral contra la hepatitis b |
| WO2017136403A1 (en) | 2016-02-02 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| KR102398439B1 (ko) | 2016-03-07 | 2022-05-16 | 이난타 파마슈티칼스, 인코포레이티드 | B형 간염 항바이러스제 |
| WO2017181141A2 (en) | 2016-04-15 | 2017-10-19 | Novira Therapeutics, Inc. | Combinations and methods comprising a capsid assembly inhibitor |
| EP3468561A4 (en) | 2016-06-10 | 2019-12-04 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2018039131A1 (en) | 2016-08-22 | 2018-03-01 | Protiva Biotherapeutics, Inc. | Anti-pd-1 antibodies, or fragments thereof, for treating hepatitis b |
| JP7113009B2 (ja) | 2016-11-07 | 2022-08-04 | アービュタス バイオファーマ コーポレイション | 置換ピリジノン含有三環式化合物およびそれを使用する方法 |
| CN109843855B (zh) * | 2016-11-08 | 2021-06-25 | 正大天晴药业集团股份有限公司 | 作为cccDNA抑制剂的磺酰胺类化合物 |
| WO2018086531A1 (zh) * | 2016-11-08 | 2018-05-17 | 正大天晴药业集团股份有限公司 | 作为cccDNA抑制剂的磺酰胺类化合物 |
| AU2017379901B2 (en) | 2016-12-21 | 2024-02-15 | Arbutus Biopharma Corporation | Methods for ameliorating infusion reactions |
| MA49014A (fr) | 2017-03-21 | 2020-02-05 | Arbutus Biopharma Corp | Dihydroindène-4-carboxamides substitués, leurs analogues et procédés d'utilisation correspondant |
| SG11202001685TA (en) | 2017-08-28 | 2020-03-30 | Enanta Pharm Inc | Hepatitis b antiviral agents |
| US10723733B2 (en) | 2017-12-06 | 2020-07-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2019113173A1 (en) | 2017-12-06 | 2019-06-13 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| SG11202007097QA (en) | 2018-03-14 | 2020-08-28 | Janssen Sciences Ireland Unlimited Co | Capsid assembly modulator dosing regimen |
| US10729688B2 (en) | 2018-03-29 | 2020-08-04 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| TWI869058B (zh) | 2018-07-27 | 2025-01-01 | 加拿大商愛彼特生物製藥公司 | 經取代四氫環戊[c]吡咯、經取代二氫吡咯，其類似物及使用其之方法 |
| TW202024093A (zh) | 2018-09-21 | 2020-07-01 | 美商安塔製藥公司 | 作為抗病毒劑之官能化雜環 |
| EP3883570A4 (en) | 2018-11-21 | 2022-07-13 | Enanta Pharmaceuticals, Inc. | FUNCTIONALIZED HETEROCYCLES AS ANTIVIRAL AGENTS |
| TWI827760B (zh) | 2018-12-12 | 2024-01-01 | 加拿大商愛彼特生物製藥公司 | 經取代之芳基甲基脲類及雜芳基甲基脲類、其類似物及其使用方法 |
| AU2020223865A1 (en) | 2019-02-22 | 2021-07-15 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases |
| BR112021021454A2 (pt) | 2019-05-06 | 2021-12-21 | Janssen Sciences Ireland Unlimited Co | Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| WO2020247561A1 (en) * | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| US11472808B2 (en) | 2019-06-04 | 2022-10-18 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents |
| WO2021007488A1 (en) | 2019-07-11 | 2021-01-14 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| US11802125B2 (en) | 2020-03-16 | 2023-10-31 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| WO2022180003A1 (en) * | 2021-02-24 | 2022-09-01 | F. Hoffmann-La Roche Ag | Benzothiazolyl bicyclo[1.1.1]pentane derivatives for the treatment and prophylaxis of hepatitis b virus infection |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU567140B2 (en) * | 1984-01-06 | 1987-11-12 | Shionogi & Co., Ltd. | Sulphonamido-benzamide derivatives |
| FR2743073B1 (fr) * | 1995-12-29 | 1998-02-20 | Fournier Ind & Sante | Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique |
| CA2284041C (en) * | 1997-03-14 | 2010-05-18 | Smithkline Beecham Corporation | Indolecarboxamides, pharmaceutical compositions and methods of inhibiting calpain |
| JPH11292840A (ja) * | 1998-04-06 | 1999-10-26 | Soyaku Gijutsu Kenkyusho:Kk | ノルスタチン誘導体又はその塩 |
| DE19907532A1 (de) | 1999-02-22 | 2000-08-31 | Basf Ag | Verfahren zur Herstellung von Acetylenalkoholen und deren Folgeprodukten |
| FR2790260B1 (fr) * | 1999-02-26 | 2001-05-04 | Fournier Ind & Sante | Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique |
| CN1348442A (zh) * | 1999-02-26 | 2002-05-08 | 默克公司 | 新的磺胺化合物及其应用 |
| EP1314733A1 (en) * | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
| US6759428B2 (en) * | 2001-12-04 | 2004-07-06 | Roche Palo Alto Llc | Indole nitriles |
| US20050130974A1 (en) * | 2003-10-17 | 2005-06-16 | Rigel Pharmaceuticals, Inc. | Benzothiazole compositions and their use as ubiquitin ligase inhibitors |
| WO2006004622A2 (en) | 2004-06-25 | 2006-01-12 | The Burnham Institute | Inhibition of bid-induced cell-death using small organic molecules |
| US20070225322A1 (en) | 2005-05-25 | 2007-09-27 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the night insomnia |
| US8143288B2 (en) * | 2005-06-06 | 2012-03-27 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| US20070225344A1 (en) | 2006-02-08 | 2007-09-27 | Ariamala Gopalsamy | Sulfonamide derivatives to treat infection with hepatitis C virus |
| TW200817319A (en) * | 2006-08-10 | 2008-04-16 | Astellas Pharma Inc | Sulfonamide compound or salt thereof |
| CN101134769A (zh) * | 2006-08-28 | 2008-03-05 | 曾昭斌 | 熊去氧胆酸恩替卡韦酰胺及其制法和用途 |
| WO2008106166A2 (en) * | 2007-02-28 | 2008-09-04 | Conatus Pharmaceuticals, Inc. | Methods for the treatment of liver diseases using specified matrix metalloproteinase (mmp) inhibitors |
| AU2008245082B8 (en) * | 2007-04-24 | 2012-09-13 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
| RU2010111550A (ru) * | 2007-08-29 | 2011-10-10 | Шеринг Корпорейшн (US) | 2,3-замещенные индольные производные для лечения вирусных инфекций |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| CN104352492B (zh) * | 2008-04-24 | 2017-12-05 | Msd K.K.公司 | 以芳基磺酰基衍生物作为有效成分的长链脂肪酸延长酶抑制剂 |
| JPWO2009133863A1 (ja) | 2008-04-28 | 2011-09-01 | 国立大学法人浜松医科大学 | Ｅｐ１アゴニストを含有してなる免疫増強剤 |
| DE102008061214A1 (de) * | 2008-12-09 | 2010-06-10 | Merck Patent Gmbh | Chinazolinamidderivate |
| WO2010141805A1 (en) * | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of trpa1 |
| WO2011041713A2 (en) * | 2009-10-02 | 2011-04-07 | Glaxosmithkline Llc | Piperazinyl antiviral agents |
| WO2011050284A1 (en) | 2009-10-23 | 2011-04-28 | Glaxosmithkline Llc | Pyrazolylpyridine antiviral agents |
| PE20121384A1 (es) * | 2009-12-08 | 2012-10-13 | Novartis Ag | Derivados de sulfonamida heterociclicos |
| CA2798330A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| WO2012037108A1 (en) | 2010-09-13 | 2012-03-22 | Glaxosmithkline Llc | Aminoquinoline derivatives as antiviral agents |
-
2013
- 2013-02-28 NZ NZ631419A patent/NZ631419A/en not_active IP Right Cessation
- 2013-02-28 CN CN201380011882.5A patent/CN104822267B/zh not_active Expired - Fee Related
- 2013-02-28 BR BR112014021498A patent/BR112014021498A2/pt not_active IP Right Cessation
- 2013-02-28 CA CA2865962A patent/CA2865962A1/en not_active Abandoned
- 2013-02-28 WO PCT/US2013/028150 patent/WO2013130703A2/en not_active Ceased
- 2013-02-28 EP EP13755289.9A patent/EP2819671A4/en not_active Withdrawn
- 2013-02-28 AU AU2013226013A patent/AU2013226013B2/en not_active Ceased
- 2013-02-28 JP JP2014560012A patent/JP6134338B2/ja not_active Expired - Fee Related
- 2013-02-28 US US14/382,074 patent/US9657013B2/en not_active Expired - Fee Related
-
2014
- 2014-10-24 ZA ZA2014/07798A patent/ZA201407798B/en unknown
-
2016
- 2016-11-02 AU AU2016253583A patent/AU2016253583A1/en not_active Abandoned
-
2017
- 2017-04-20 JP JP2017083672A patent/JP2017165751A/ja active Pending
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