JP2015517981A5 - - Google Patents
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- Publication number
- JP2015517981A5 JP2015517981A5 JP2014560012A JP2014560012A JP2015517981A5 JP 2015517981 A5 JP2015517981 A5 JP 2015517981A5 JP 2014560012 A JP2014560012 A JP 2014560012A JP 2014560012 A JP2014560012 A JP 2014560012A JP 2015517981 A5 JP2015517981 A5 JP 2015517981A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- trifluoromethyl
- chloro
- optionally substituted
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261605071P | 2012-02-29 | 2012-02-29 | |
| US201261605059P | 2012-02-29 | 2012-02-29 | |
| US61/605,059 | 2012-02-29 | ||
| US61/605,071 | 2012-02-29 | ||
| PCT/US2013/028150 WO2013130703A2 (en) | 2012-02-29 | 2013-02-28 | Binhibitors of hepatitis b virus convalently closed circular dna formation and their method of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017083672A Division JP2017165751A (ja) | 2012-02-29 | 2017-04-20 | B型肝炎ウイルス共有結合閉環状dna形成の阻害剤およびそれらの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517981A JP2015517981A (ja) | 2015-06-25 |
| JP2015517981A5 true JP2015517981A5 (enExample) | 2016-06-16 |
| JP6134338B2 JP6134338B2 (ja) | 2017-05-24 |
Family
ID=49083449
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560012A Expired - Fee Related JP6134338B2 (ja) | 2012-02-29 | 2013-02-28 | B型肝炎ウイルス共有結合閉環状dna形成の阻害剤およびそれらの使用方法 |
| JP2017083672A Pending JP2017165751A (ja) | 2012-02-29 | 2017-04-20 | B型肝炎ウイルス共有結合閉環状dna形成の阻害剤およびそれらの使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017083672A Pending JP2017165751A (ja) | 2012-02-29 | 2017-04-20 | B型肝炎ウイルス共有結合閉環状dna形成の阻害剤およびそれらの使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9657013B2 (enExample) |
| EP (1) | EP2819671A4 (enExample) |
| JP (2) | JP6134338B2 (enExample) |
| CN (1) | CN104822267B (enExample) |
| AU (2) | AU2013226013B2 (enExample) |
| BR (1) | BR112014021498A2 (enExample) |
| CA (1) | CA2865962A1 (enExample) |
| NZ (1) | NZ631419A (enExample) |
| WO (1) | WO2013130703A2 (enExample) |
| ZA (1) | ZA201407798B (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5977347B2 (ja) * | 2011-07-01 | 2016-08-24 | バルーク エス.ブルームバーグ インスティテュート | Hbv感染に対する抗ウイルス剤としてのスルファモイルベンズアミド誘導体 |
| EA037918B1 (ru) | 2011-12-21 | 2021-06-07 | Новира Терапьютикс, Инк. | Противовирусные агенты против гепатита в |
| HK1208465A1 (en) | 2012-08-28 | 2016-03-04 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| BR112015006737A2 (pt) * | 2012-09-27 | 2017-07-04 | Hoffmann La Roche | compostos de sulfonamida substituídos |
| US9938236B2 (en) | 2012-12-27 | 2018-04-10 | Drexel University | Antiviral agents against HBV infection |
| DK2961732T3 (en) | 2013-02-28 | 2017-07-10 | Janssen Sciences Ireland Uc | SULFAMOYLARYLAMIDS AND USE THEREOF AS MEDICINES TO TREAT HEPATITIS B |
| US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
| WO2014161888A1 (en) | 2013-04-03 | 2014-10-09 | Janssen R&D Ireland | N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| ES2774749T3 (es) | 2013-07-25 | 2020-07-22 | Janssen Sciences Ireland Unlimited Co | Derivados de pirrolamida sustituidos con glioxamida y su uso como medicamentos para el tratamiento de la hepatitis B |
| KR102290189B1 (ko) | 2013-10-23 | 2021-08-17 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 카르복스아미드 유도체 및 b형 간염 치료용 의약으로서의 이의 용도 |
| US9181288B2 (en) | 2014-01-16 | 2015-11-10 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| KR20160128305A (ko) | 2014-02-05 | 2016-11-07 | 노비라 테라퓨틱스, 인코포레이티드 | Hbv 감염의 치료를 위한 병용 요법 |
| DK3102572T3 (en) | 2014-02-06 | 2019-02-04 | Janssen Sciences Ireland Uc | SULFAMOYLPYRROLAMIDE DERIVATIVES AND THEIR USE AS MEDICINES TO TREAT HEPATITIS B |
| US9400280B2 (en) | 2014-03-27 | 2016-07-26 | Novira Therapeutics, Inc. | Piperidine derivatives and methods of treating hepatitis B infections |
| WO2016149581A1 (en) | 2015-03-19 | 2016-09-22 | Novira Therapeutics, Inc. | Azocane and azonane derivatives and methods of treating hepatitis b infections |
| US10442788B2 (en) | 2015-04-01 | 2019-10-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| HK1259410A1 (zh) | 2015-09-29 | 2019-11-29 | 诺维拉治疗公司 | 乙型肝炎抗病毒剂的晶体形式 |
| US10280175B2 (en) | 2016-02-02 | 2019-05-07 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| BR112018067964B1 (pt) | 2016-03-07 | 2024-01-16 | Enanta Pharmaceuticals, Inc | Composto, composição farmacêutica que o compreende e uso do referido composto |
| EP3442524A2 (en) | 2016-04-15 | 2019-02-20 | Novira Therapeutics Inc. | Combinations and methods comprising a capsid assembly inhibitor |
| MX2018015315A (es) | 2016-06-10 | 2019-04-25 | Enanta Pharm Inc | Agentes antivirales contra la hepatitis b. |
| MA45999A (fr) | 2016-08-22 | 2019-06-26 | Arbutus Biopharma Corp | Anticorps anti-pd-1, ou leurs fragments, pour le traitement de l'hépatite b |
| US10821103B2 (en) | 2016-11-07 | 2020-11-03 | Arbutus Biopharma Corporation | Substituted pyridinone-containing trycyclic compounds, and methods using same |
| WO2018086530A1 (zh) * | 2016-11-08 | 2018-05-17 | 正大天晴药业集团股份有限公司 | 作为cccDNA抑制剂的磺酰胺类化合物 |
| WO2018086531A1 (zh) * | 2016-11-08 | 2018-05-17 | 正大天晴药业集团股份有限公司 | 作为cccDNA抑制剂的磺酰胺类化合物 |
| MA49014A (fr) | 2017-03-21 | 2020-02-05 | Arbutus Biopharma Corp | Dihydroindène-4-carboxamides substitués, leurs analogues et procédés d'utilisation correspondant |
| IL272941B2 (en) | 2017-08-28 | 2023-03-01 | Enanta Pharm Inc | Antiviral agents for viral hepatitis b |
| TW201927789A (zh) | 2017-12-06 | 2019-07-16 | 美商因那塔製藥公司 | B型肝炎抗病毒試劑 |
| TW201936192A (zh) | 2017-12-06 | 2019-09-16 | 美商因那塔製藥公司 | B 型肝炎抗病毒試劑 |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| EA202092171A1 (ru) | 2018-03-14 | 2020-12-01 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Схема дозирования модулятора сборки капсида |
| WO2019191166A1 (en) | 2018-03-29 | 2019-10-03 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| TWI869058B (zh) | 2018-07-27 | 2025-01-01 | 加拿大商愛彼特生物製藥公司 | 經取代四氫環戊[c]吡咯、經取代二氫吡咯,其類似物及使用其之方法 |
| WO2020061435A1 (en) | 2018-09-21 | 2020-03-26 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| KR102819704B1 (ko) | 2018-11-21 | 2025-06-11 | 이난타 파마슈티칼스, 인코포레이티드 | 항바이러스제로서의 작용화된 헤테로사이클 |
| TW202415643A (zh) | 2018-12-12 | 2024-04-16 | 加拿大商愛彼特生物製藥公司 | 經取代之芳基甲基脲類及雜芳基甲基脲類、其類似物及其使用方法 |
| MA55020A (fr) | 2019-02-22 | 2021-12-29 | Janssen Sciences Ireland Unlimited Co | Dérivés d'amide utiles dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b |
| BR112021021454A2 (pt) | 2019-05-06 | 2021-12-21 | Janssen Sciences Ireland Unlimited Co | Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv |
| US11236111B2 (en) | 2019-06-03 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11760755B2 (en) | 2019-06-04 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11472808B2 (en) | 2019-06-04 | 2022-10-18 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents |
| US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| JP2024508817A (ja) * | 2021-02-24 | 2024-02-28 | エフ. ホフマン-ラ ロシュ アーゲー | B型肝炎ウイルス感染症の処置および予防のためのベンゾチアゾリルビシクロ[1.1.1]ペンタン誘導体 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU567140B2 (en) | 1984-01-06 | 1987-11-12 | Shionogi & Co., Ltd. | Sulphonamido-benzamide derivatives |
| FR2743073B1 (fr) * | 1995-12-29 | 1998-02-20 | Fournier Ind & Sante | Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique |
| JP4467648B2 (ja) * | 1997-03-14 | 2010-05-26 | スミスクライン・ビーチャム・コーポレイション | 新規インドールカルボキサミド、医薬組成物およびカルパインの阻害方法 |
| JPH11292840A (ja) * | 1998-04-06 | 1999-10-26 | Soyaku Gijutsu Kenkyusho:Kk | ノルスタチン誘導体又はその塩 |
| DE19907532A1 (de) | 1999-02-22 | 2000-08-31 | Basf Ag | Verfahren zur Herstellung von Acetylenalkoholen und deren Folgeprodukten |
| FR2790260B1 (fr) * | 1999-02-26 | 2001-05-04 | Fournier Ind & Sante | Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique |
| EP1159263A1 (en) * | 1999-02-26 | 2001-12-05 | Merck & Co., Inc. | Novel sulfonamide compounds and uses thereof |
| EP1314733A1 (en) * | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
| US6759428B2 (en) * | 2001-12-04 | 2004-07-06 | Roche Palo Alto Llc | Indole nitriles |
| US20050130974A1 (en) * | 2003-10-17 | 2005-06-16 | Rigel Pharmaceuticals, Inc. | Benzothiazole compositions and their use as ubiquitin ligase inhibitors |
| WO2006004622A2 (en) | 2004-06-25 | 2006-01-12 | The Burnham Institute | Inhibition of bid-induced cell-death using small organic molecules |
| US20070225322A1 (en) | 2005-05-25 | 2007-09-27 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the night insomnia |
| US8143288B2 (en) * | 2005-06-06 | 2012-03-27 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| WO2007092558A2 (en) * | 2006-02-08 | 2007-08-16 | Wyeth | Sulfonamide derivatives to treat infection with hepatitis c virus |
| TW200817319A (en) * | 2006-08-10 | 2008-04-16 | Astellas Pharma Inc | Sulfonamide compound or salt thereof |
| CN101134769A (zh) * | 2006-08-28 | 2008-03-05 | 曾昭斌 | 熊去氧胆酸恩替卡韦酰胺及其制法和用途 |
| HRP20110713T1 (hr) * | 2007-02-28 | 2011-11-30 | Conatus Pharmaceuticals | Postupci liječenja kroničnog virusnog hepatitisa c uz upotrebu ro 113-0830 |
| EP2689780A1 (en) * | 2007-04-24 | 2014-01-29 | Shionogi & Co., Ltd. | Intermediates for aminodihydrothiazine derivatives substituted with a cyclic group |
| RU2010111550A (ru) * | 2007-08-29 | 2011-10-10 | Шеринг Корпорейшн (US) | 2,3-замещенные индольные производные для лечения вирусных инфекций |
| US8642660B2 (en) | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| JP5501226B2 (ja) | 2008-04-24 | 2014-05-21 | Msd株式会社 | アリールスルホニル誘導体を有効成分とする長鎖脂肪酸伸長酵素阻害剤 |
| US20110038884A1 (en) | 2008-04-28 | 2011-02-17 | National University Co., Hamamatsu Univer. School Of Medicine | Immunopotentiating agent comprising ep1 agonist |
| DE102008061214A1 (de) * | 2008-12-09 | 2010-06-10 | Merck Patent Gmbh | Chinazolinamidderivate |
| US8614201B2 (en) * | 2009-06-05 | 2013-12-24 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of TRPA1 |
| WO2011041713A2 (en) * | 2009-10-02 | 2011-04-07 | Glaxosmithkline Llc | Piperazinyl antiviral agents |
| WO2011050284A1 (en) | 2009-10-23 | 2011-04-28 | Glaxosmithkline Llc | Pyrazolylpyridine antiviral agents |
| ES2484171T3 (es) * | 2009-12-08 | 2014-08-11 | Novartis Ag | Derivados de sulfonamidas heterocíclicas |
| EP3159331A1 (en) * | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| WO2012037108A1 (en) * | 2010-09-13 | 2012-03-22 | Glaxosmithkline Llc | Aminoquinoline derivatives as antiviral agents |
-
2013
- 2013-02-28 EP EP13755289.9A patent/EP2819671A4/en not_active Withdrawn
- 2013-02-28 JP JP2014560012A patent/JP6134338B2/ja not_active Expired - Fee Related
- 2013-02-28 BR BR112014021498A patent/BR112014021498A2/pt not_active IP Right Cessation
- 2013-02-28 CN CN201380011882.5A patent/CN104822267B/zh not_active Expired - Fee Related
- 2013-02-28 NZ NZ631419A patent/NZ631419A/en not_active IP Right Cessation
- 2013-02-28 WO PCT/US2013/028150 patent/WO2013130703A2/en not_active Ceased
- 2013-02-28 AU AU2013226013A patent/AU2013226013B2/en not_active Ceased
- 2013-02-28 US US14/382,074 patent/US9657013B2/en not_active Expired - Fee Related
- 2013-02-28 CA CA2865962A patent/CA2865962A1/en not_active Abandoned
-
2014
- 2014-10-24 ZA ZA2014/07798A patent/ZA201407798B/en unknown
-
2016
- 2016-11-02 AU AU2016253583A patent/AU2016253583A1/en not_active Abandoned
-
2017
- 2017-04-20 JP JP2017083672A patent/JP2017165751A/ja active Pending
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