JP2015517981A5 - - Google Patents

Download PDF

Info

Publication number
JP2015517981A5
JP2015517981A5 JP2014560012A JP2014560012A JP2015517981A5 JP 2015517981 A5 JP2015517981 A5 JP 2015517981A5 JP 2014560012 A JP2014560012 A JP 2014560012A JP 2014560012 A JP2014560012 A JP 2014560012A JP 2015517981 A5 JP2015517981 A5 JP 2015517981A5
Authority
JP
Japan
Prior art keywords
phenyl
trifluoromethyl
chloro
optionally substituted
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014560012A
Other languages
English (en)
Japanese (ja)
Other versions
JP6134338B2 (ja
JP2015517981A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/028150 external-priority patent/WO2013130703A2/en
Publication of JP2015517981A publication Critical patent/JP2015517981A/ja
Publication of JP2015517981A5 publication Critical patent/JP2015517981A5/ja
Application granted granted Critical
Publication of JP6134338B2 publication Critical patent/JP6134338B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014560012A 2012-02-29 2013-02-28 Ｂ型肝炎ウイルス共有結合閉環状ｄｎａ形成の阻害剤およびそれらの使用方法 Expired - Fee Related JP6134338B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261605059P 2012-02-29 2012-02-29
US201261605071P 2012-02-29 2012-02-29
US61/605,071 2012-02-29
US61/605,059 2012-02-29
PCT/US2013/028150 WO2013130703A2 (en) 2012-02-29 2013-02-28 Binhibitors of hepatitis b virus convalently closed circular dna formation and their method of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017083672A Division JP2017165751A (ja) 2012-02-29 2017-04-20 Ｂ型肝炎ウイルス共有結合閉環状ｄｎａ形成の阻害剤およびそれらの使用方法

Publications (3)

Publication Number Publication Date
JP2015517981A JP2015517981A (ja) 2015-06-25
JP2015517981A5 true JP2015517981A5 (enExample) 2016-06-16
JP6134338B2 JP6134338B2 (ja) 2017-05-24

Family

ID=49083449

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014560012A Expired - Fee Related JP6134338B2 (ja) 2012-02-29 2013-02-28 Ｂ型肝炎ウイルス共有結合閉環状ｄｎａ形成の阻害剤およびそれらの使用方法
JP2017083672A Pending JP2017165751A (ja) 2012-02-29 2017-04-20 Ｂ型肝炎ウイルス共有結合閉環状ｄｎａ形成の阻害剤およびそれらの使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017083672A Pending JP2017165751A (ja) 2012-02-29 2017-04-20 Ｂ型肝炎ウイルス共有結合閉環状ｄｎａ形成の阻害剤およびそれらの使用方法

Country Status (10)

Country Link
US (1) US9657013B2 (enExample)
EP (1) EP2819671A4 (enExample)
JP (2) JP6134338B2 (enExample)
CN (1) CN104822267B (enExample)
AU (2) AU2013226013B2 (enExample)
BR (1) BR112014021498A2 (enExample)
CA (1) CA2865962A1 (enExample)
NZ (1) NZ631419A (enExample)
WO (1) WO2013130703A2 (enExample)
ZA (1) ZA201407798B (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5977347B2 (ja) * 2011-07-01 2016-08-24 バルーク エス．ブルームバーグ インスティテュート Ｈｂｖ感染に対する抗ウイルス剤としてのスルファモイルベンズアミド誘導体
SG11201402660YA (en) 2011-12-21 2014-10-30 Novira Therapeutics Inc Hepatitis b antiviral agents
SG10201605291WA (en) 2012-08-28 2016-08-30 Janssen Sciences Ireland Uc Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
CA2885908A1 (en) 2012-09-27 2014-04-03 F. Hoffmann-La Roche Ag Substituted sulfonamide compounds
KR101942151B1 (ko) 2012-12-27 2019-01-24 드렉셀유니버시티 Hbv 감염에 대한 항바이러스 물질
PT2961732T (pt) 2013-02-28 2017-06-26 Janssen Sciences Ireland Uc Sulfamoil-arilamidas e utilização das mesmas como medicamentos para o tratamento de hepatite b
WO2014165128A2 (en) 2013-03-12 2014-10-09 Novira Therapeutics, Inc. Hepatitis b antiviral agents
MX353412B (es) 2013-04-03 2018-01-10 Janssen Sciences Ireland Uc Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
LT3024819T (lt) 2013-07-25 2018-06-11 Janssen Sciences Ireland Uc Pirolamido dariniai, turintys glioksamido pakaitų, ir jų panaudojimas kaip vaistų hepatito b gydymui
NZ717629A (en) 2013-10-23 2021-12-24 Janssen Sciences Ireland Uc Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
US9181288B2 (en) 2014-01-16 2015-11-10 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US20150216938A1 (en) 2014-02-05 2015-08-06 Novira Therapeutics Inc. Combination therapy for treatment of hbv infections
DK3102572T3 (en) 2014-02-06 2019-02-04 Janssen Sciences Ireland Uc SULFAMOYLPYRROLAMIDE DERIVATIVES AND THEIR USE AS MEDICINES TO TREAT HEPATITIS B
US9400280B2 (en) 2014-03-27 2016-07-26 Novira Therapeutics, Inc. Piperidine derivatives and methods of treating hepatitis B infections
HK1247147A1 (zh) 2015-03-19 2018-09-21 诺维拉治疗公司 氮杂环辛烷和氮杂环壬烷衍生物以及治疗乙型肝炎感染的方法
WO2016161268A1 (en) * 2015-04-01 2016-10-06 Enanta Pharmaceuticals, Inc. Hepatitis b antviral agents
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
WO2017011552A1 (en) 2015-07-13 2017-01-19 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
AR106192A1 (es) 2015-09-29 2017-12-20 Novira Therapeutics Inc Formas cristalinas de un agente antiviral contra la hepatitis b
WO2017136403A1 (en) 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
BR112018067964B1 (pt) 2016-03-07 2024-01-16 Enanta Pharmaceuticals, Inc Composto, composição farmacêutica que o compreende e uso do referido composto
WO2017181141A2 (en) 2016-04-15 2017-10-19 Novira Therapeutics, Inc. Combinations and methods comprising a capsid assembly inhibitor
EP3468561A4 (en) 2016-06-10 2019-12-04 Enanta Pharmaceuticals, Inc. ANTIVIRAL AGENTS AGAINST HEPATITIS B
US20210284733A1 (en) 2016-08-22 2021-09-16 Arbutus Biopharma Corporation Anti-pd-1 antibodies, or fragments thereof, for treating hepatitis b
JP7113009B2 (ja) 2016-11-07 2022-08-04 アービュタス バイオファーマ コーポレイション 置換ピリジノン含有三環式化合物およびそれを使用する方法
CN109843855B (zh) * 2016-11-08 2021-06-25 正大天晴药业集团股份有限公司 作为cccDNA抑制剂的磺酰胺类化合物
CN109803951B (zh) * 2016-11-08 2020-12-04 正大天晴药业集团股份有限公司 作为cccDNA抑制剂的磺酰胺类化合物
US11098010B2 (en) 2017-03-21 2021-08-24 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
TWI811236B (zh) 2017-08-28 2023-08-11 美商因那塔製藥公司 B型肝炎抗病毒試劑
WO2019113173A1 (en) 2017-12-06 2019-06-13 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
TW201936192A (zh) 2017-12-06 2019-09-16 美商因那塔製藥公司 B 型肝炎抗病毒試劑
US11058678B2 (en) 2018-01-22 2021-07-13 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2019175657A1 (en) 2018-03-14 2019-09-19 Janssen Sciences Ireland Unlimited Company Capsid assembly modulator dosing regimen
US10729688B2 (en) 2018-03-29 2020-08-04 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
TWI826492B (zh) 2018-07-27 2023-12-21 加拿大商愛彼特生物製藥公司 經取代四氫環戊[c]吡咯、經取代二氫吡咯，其類似物及使用其之方法
CA3113235A1 (en) 2018-09-21 2020-03-26 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11198693B2 (en) 2018-11-21 2021-12-14 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
TWI827760B (zh) 2018-12-12 2024-01-01 加拿大商愛彼特生物製藥公司 經取代之芳基甲基脲類及雜芳基甲基脲類、其類似物及其使用方法
MX2021010145A (es) 2019-02-22 2021-09-14 Janssen Sciences Ireland Unlimited Co Derivados de amida utiles en el tratamiento de una infeccion por vhb o de enfermedades inducidas por vhb.
JP2022532526A (ja) 2019-05-06 2022-07-15 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Ｈｂｖ感染又はｈｂｖ誘導性疾患の処置において有用なアミド誘導体
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2020247561A1 (en) * 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2020247575A1 (en) * 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2021007488A1 (en) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021055425A2 (en) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
WO2022180003A1 (en) * 2021-02-24 2022-09-01 F. Hoffmann-La Roche Ag Benzothiazolyl bicyclo[1.1.1]pentane derivatives for the treatment and prophylaxis of hepatitis b virus infection

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU567140B2 (en) 1984-01-06 1987-11-12 Shionogi & Co., Ltd. Sulphonamido-benzamide derivatives
FR2743073B1 (fr) * 1995-12-29 1998-02-20 Fournier Ind & Sante Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique
ES2230676T3 (es) * 1997-03-14 2005-05-01 Smithkline Beecham Corporation Nuevos indolcarboxamidas, composiciones farmaceuticas y procedimientos de inhibicion de la calpaina.
JPH11292840A (ja) * 1998-04-06 1999-10-26 Soyaku Gijutsu Kenkyusho:Kk ノルスタチン誘導体又はその塩
DE19907532A1 (de) 1999-02-22 2000-08-31 Basf Ag Verfahren zur Herstellung von Acetylenalkoholen und deren Folgeprodukten
FR2790260B1 (fr) * 1999-02-26 2001-05-04 Fournier Ind & Sante Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique
WO2000050391A1 (en) * 1999-02-26 2000-08-31 Merck & Co., Inc. Novel sulfonamide compounds and uses thereof
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
US6759428B2 (en) * 2001-12-04 2004-07-06 Roche Palo Alto Llc Indole nitriles
EP1680431A1 (en) * 2003-10-17 2006-07-19 Rigel Pharmaceuticals, Inc. Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors
WO2006004622A2 (en) 2004-06-25 2006-01-12 The Burnham Institute Inhibition of bid-induced cell-death using small organic molecules
US20070225322A1 (en) 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
US8143288B2 (en) * 2005-06-06 2012-03-27 Bristol-Myers Squibb Company Inhibitors of HCV replication
JP2009526065A (ja) * 2006-02-08 2009-07-16 ワイス Ｃ型肝炎ウイルスによる感染を治療するためのスルホンアミド誘導体
TW200817319A (en) * 2006-08-10 2008-04-16 Astellas Pharma Inc Sulfonamide compound or salt thereof
CN101134769A (zh) * 2006-08-28 2008-03-05 曾昭斌 熊去氧胆酸恩替卡韦酰胺及其制法和用途
PT2144604E (pt) * 2007-02-28 2011-10-19 Conatus Pharmaceuticals Inc Métodos para o tratamento da hepatite c viral crónica utilizando ro-113-0830
TW200902526A (en) * 2007-04-24 2009-01-16 Shionogi & Amp Co Ltd Aminodihydrothiazin derivative substituted with a cyclic group
PE20090995A1 (es) 2007-08-29 2009-08-03 Schering Corp Derivados indolicos 2,3-sustituidos como inhibidores del virus de la hepatitis c (vhc)
US8642660B2 (en) 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
EP2280001B1 (en) * 2008-04-24 2014-10-15 Msd K.K. Long-chain fatty acid elongation enzyme inhibitor comprising arylsulfonyl derivative as active ingredient
WO2009133863A1 (ja) * 2008-04-28 2009-11-05 国立大学法人浜松医科大学 Ｅｐ１アゴニストを含有してなる免疫増強剤
DE102008061214A1 (de) * 2008-12-09 2010-06-10 Merck Patent Gmbh Chinazolinamidderivate
WO2010141805A1 (en) * 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Heterocyclic amides as modulators of trpa1
WO2011041713A2 (en) * 2009-10-02 2011-04-07 Glaxosmithkline Llc Piperazinyl antiviral agents
WO2011050284A1 (en) * 2009-10-23 2011-04-28 Glaxosmithkline Llc Pyrazolylpyridine antiviral agents
EA201200823A1 (ru) * 2009-12-08 2013-02-28 Новартис Аг Гетероциклические производные сульфонамидов
EP2566853B1 (en) * 2010-05-05 2017-01-25 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
WO2012037108A1 (en) 2010-09-13 2012-03-22 Glaxosmithkline Llc Aminoquinoline derivatives as antiviral agents

Similar Documents

Publication Publication Date Title
JP2015517981A5 (enExample)
JP2018522823A5 (enExample)
RU2264389C2 (ru) Азотсодержащие ароматические производные, их применение, лекарственное средство на их основе и способ лечения
RU2201927C2 (ru) Амидиновые соединения и фармацевтическая композиция, обладающая фактор ха ингибирующим действием
JP2007519754A5 (enExample)
RU2010101633A (ru) Новое сульфонамидное производное малоновой кислоты и его фармацевтическое применение
JP2004504301A5 (enExample)
HRP20181076T1 (hr) Pirazolski derivati kao modulatori kalcijevih kanala aktiviranih oslobađanjem kalcija
JP2013505903A5 (enExample)
RU2009148673A (ru) Производные пиразинона и их применение для лечения легочных заболеваний
JP2010505881A5 (enExample)
RU2017145650A (ru) Ингибиторы тирозинкиназы брутона
JP2017530185A5 (enExample)
JP2017533968A5 (enExample)
JP2016503786A5 (enExample)
JP2012510989A5 (enExample)
JP2006519258A5 (enExample)
JP2011529037A5 (enExample)
JP2017511794A5 (enExample)
JP2005526723A5 (enExample)
IL276946B (en) Antiproliferative compounds and methods of use thereof
JP2016534134A5 (enExample)
HRP20170638T1 (hr) MODULATORI RETINOIDNIMA SRODNOG SIROČETA RECEPTORA γ (ROR-γ), NAMIJENJENI UPOTREBI U LIJEČENJU AUTOIMUNIH I PROTUUPALNIH BOLESTI
JP2009503107A5 (enExample)
JP2020523388A5 (enExample)