JP2013517291A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013517291A5 JP2013517291A5 JP2012549122A JP2012549122A JP2013517291A5 JP 2013517291 A5 JP2013517291 A5 JP 2013517291A5 JP 2012549122 A JP2012549122 A JP 2012549122A JP 2012549122 A JP2012549122 A JP 2012549122A JP 2013517291 A5 JP2013517291 A5 JP 2013517291A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- substituted
- compound according
- alkyl
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 cycloalkyl ethylene Chemical group 0.000 claims description 45
- 150000001875 compounds Chemical class 0.000 claims description 42
- 125000000217 alkyl group Chemical group 0.000 claims description 41
- 125000000623 heterocyclic group Chemical group 0.000 claims description 32
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 30
- 125000003118 aryl group Chemical group 0.000 claims description 30
- 239000003112 inhibitor Substances 0.000 claims description 26
- 125000003342 alkenyl group Chemical group 0.000 claims description 23
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims description 18
- 125000000304 alkynyl group Chemical group 0.000 claims description 18
- 150000002148 esters Chemical class 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 15
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 13
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 13
- 125000004104 aryloxy group Chemical group 0.000 claims description 12
- 125000003545 alkoxy group Chemical group 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 8
- 108700008776 hepatitis C virus NS-5 Proteins 0.000 claims description 8
- 239000002777 nucleoside Substances 0.000 claims description 8
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 8
- 230000009385 viral infection Effects 0.000 claims description 8
- 208000036142 Viral infection Diseases 0.000 claims description 7
- 125000005133 alkynyloxy group Chemical group 0.000 claims description 7
- 125000004429 atom Chemical group 0.000 claims description 7
- 229910052736 halogen Inorganic materials 0.000 claims description 7
- 150000002367 halogens Chemical class 0.000 claims description 7
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 claims description 4
- 229940123073 Angiotensin antagonist Drugs 0.000 claims description 4
- 101001023866 Arabidopsis thaliana Mannosyl-oligosaccharide glucosidase GCS1 Proteins 0.000 claims description 4
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims description 4
- 241000710781 Flaviviridae Species 0.000 claims description 4
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 claims description 4
- 229940124771 HCV-NS3 protease inhibitor Drugs 0.000 claims description 4
- 102000014150 Interferons Human genes 0.000 claims description 4
- 108010050904 Interferons Proteins 0.000 claims description 4
- 101800001014 Non-structural protein 5A Proteins 0.000 claims description 4
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 4
- 241000700605 Viruses Species 0.000 claims description 4
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims description 4
- 239000005557 antagonist Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000000134 cyclophilin inhibitor Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 239000003623 enhancer Substances 0.000 claims description 4
- 229940079322 interferon Drugs 0.000 claims description 4
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- 229960000329 ribavirin Drugs 0.000 claims description 4
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims description 4
- 241000711549 Hepacivirus C Species 0.000 claims description 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 2
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 claims description 2
- 241000725619 Dengue virus Species 0.000 claims description 2
- 239000005977 Ethylene Substances 0.000 claims description 2
- 241000710842 Japanese encephalitis virus Species 0.000 claims description 2
- 241000710912 Kunjin virus Species 0.000 claims description 2
- 241000725177 Omsk hemorrhagic fever virus Species 0.000 claims description 2
- 241000710888 St. Louis encephalitis virus Species 0.000 claims description 2
- 241000710771 Tick-borne encephalitis virus Species 0.000 claims description 2
- 241000710886 West Nile virus Species 0.000 claims description 2
- 241000710772 Yellow fever virus Species 0.000 claims description 2
- 241000907316 Zika virus Species 0.000 claims description 2
- 125000002393 azetidinyl group Chemical group 0.000 claims description 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 206010014599 encephalitis Diseases 0.000 claims description 2
- 125000005842 heteroatom Chemical group 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000003386 piperidinyl group Chemical group 0.000 claims description 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 2
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 claims description 2
- 229940051021 yellow-fever virus Drugs 0.000 claims description 2
- 230000003510 anti-fibrotic effect Effects 0.000 claims 2
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 description 26
- 125000004446 heteroarylalkyl group Chemical group 0.000 description 14
- 229910052799 carbon Inorganic materials 0.000 description 7
- 125000005553 heteroaryloxy group Chemical group 0.000 description 6
- 125000003302 alkenyloxy group Chemical group 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 206010016654 Fibrosis Diseases 0.000 description 2
- 230000004761 fibrosis Effects 0.000 description 2
- 125000004641 (C1-C12) haloalkyl group Chemical group 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 125000001188 haloalkyl group Chemical group 0.000 description 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29557610P | 2010-01-15 | 2010-01-15 | |
| US61/295,576 | 2010-01-15 | ||
| US35348110P | 2010-06-10 | 2010-06-10 | |
| US61/353,481 | 2010-06-10 | ||
| PCT/US2011/021335 WO2011088345A1 (en) | 2010-01-15 | 2011-01-14 | Inhibitors of flaviviridae viruses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015215450A Division JP2016041732A (ja) | 2010-01-15 | 2015-11-02 | フラビウイルス科ウイルスのインヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517291A JP2013517291A (ja) | 2013-05-16 |
| JP2013517291A5 true JP2013517291A5 (OSRAM) | 2014-02-13 |
| JP5868872B2 JP5868872B2 (ja) | 2016-02-24 |
Family
ID=43538203
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012549122A Active JP5868872B2 (ja) | 2010-01-15 | 2011-01-14 | フラビウイルス科ウイルスのインヒビター |
| JP2015215450A Withdrawn JP2016041732A (ja) | 2010-01-15 | 2015-11-02 | フラビウイルス科ウイルスのインヒビター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015215450A Withdrawn JP2016041732A (ja) | 2010-01-15 | 2015-11-02 | フラビウイルス科ウイルスのインヒビター |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US8513298B2 (OSRAM) |
| EP (2) | EP2523950B1 (OSRAM) |
| JP (2) | JP5868872B2 (OSRAM) |
| KR (1) | KR101727776B1 (OSRAM) |
| CN (1) | CN102712633B (OSRAM) |
| AP (1) | AP3576A (OSRAM) |
| AR (1) | AR080001A1 (OSRAM) |
| AU (1) | AU2011205744B2 (OSRAM) |
| BR (1) | BR112012017382A2 (OSRAM) |
| CA (1) | CA2785567C (OSRAM) |
| CL (1) | CL2012001960A1 (OSRAM) |
| CR (1) | CR20120417A (OSRAM) |
| EA (1) | EA021196B1 (OSRAM) |
| EC (1) | ECSP12012104A (OSRAM) |
| ES (1) | ES2626150T3 (OSRAM) |
| IL (1) | IL220545B (OSRAM) |
| MX (1) | MX2012008211A (OSRAM) |
| NZ (1) | NZ600817A (OSRAM) |
| PE (1) | PE20130281A1 (OSRAM) |
| PL (1) | PL2523950T3 (OSRAM) |
| PT (1) | PT2523950T (OSRAM) |
| SG (2) | SG182475A1 (OSRAM) |
| SI (1) | SI2523950T1 (OSRAM) |
| TW (1) | TWI491609B (OSRAM) |
| UY (1) | UY33183A (OSRAM) |
| WO (1) | WO2011088345A1 (OSRAM) |
| ZA (1) | ZA201205248B (OSRAM) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA020816B1 (ru) * | 2009-07-21 | 2015-01-30 | Джилид Сайэнс, Инк. | Ингибиторы вирусов flaviviridae |
| JP5774008B2 (ja) | 2009-09-09 | 2015-09-02 | ギリアード サイエンシーズ， インコーポレイテッド | Ｆｌａｖｉｖｉｒｉｄａｅウイルスの阻害剤 |
| KR20120123678A (ko) | 2010-01-15 | 2012-11-09 | 길리애드 사이언시즈, 인코포레이티드 | 플라비비리다에 바이러스의 억제제 |
| AU2011205744B2 (en) * | 2010-01-15 | 2015-06-25 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| TW201701876A (zh) | 2010-12-20 | 2017-01-16 | 吉李德科學股份有限公司 | 治療ｃ型肝炎病毒（ｈｃｖ）之方法 |
| DE102011003295A1 (de) * | 2011-01-28 | 2012-08-02 | Kiekert Ag | Kraftfahrzeugschloss |
| AU2012280959B2 (en) * | 2011-07-13 | 2015-08-06 | Gilead Sciences, Inc. | Thiophen-2-carboxylic acid derivatives useful as inhibitors of Flaviviridae viruses |
| EP2709613B2 (en) * | 2011-09-16 | 2020-08-12 | Gilead Pharmasset LLC | Methods for treating hcv |
| CN103087052A (zh) * | 2011-10-31 | 2013-05-08 | 上海壹志医药科技有限公司 | 噻吩衍生物及其药物用途 |
| MX2014014766A (es) * | 2012-06-08 | 2015-05-11 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae. |
| AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| JP6209600B2 (ja) | 2012-06-08 | 2017-10-04 | ギリアード サイエンシーズ， インコーポレイテッド | フラビウイルス科ウイルスの大環状阻害剤 |
| US8927741B2 (en) * | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8759544B2 (en) * | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
| PL2950786T3 (pl) | 2013-01-31 | 2020-05-18 | Gilead Pharmasset Llc | Formulacja skojarzona dwóch związków przeciwwirusowych |
| CN107074904B (zh) | 2014-10-23 | 2022-12-23 | 深圳华大智造科技股份有限公司 | 信号约束测序(scs)和用于信号约束测序的核苷酸类似物 |
| CN118286245A (zh) | 2014-12-26 | 2024-07-05 | 埃莫里大学 | N4-羟基胞苷和衍生物及与其相关的抗病毒用途 |
| BR112018072298A2 (pt) * | 2016-05-02 | 2019-02-12 | Florida State University Research Foundation, Inc. | tratamento de infecções pelo vírus da zika usando inibidores da alfa-glicosidase |
| WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| EP3454856B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| WO2017197051A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Amine-linked c3-glutarimide degronimers for target protein degradation |
| PL3464336T3 (pl) | 2016-06-01 | 2022-05-16 | Athira Pharma, Inc. | Związki |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| US11331331B2 (en) | 2017-12-07 | 2022-05-17 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| CN108096562B (zh) * | 2017-12-25 | 2021-05-11 | 武汉百药联科科技有限公司 | 20s蛋白酶体抑制剂在制备治疗日本乙型脑炎病毒感染的药物中的用途 |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US743729A (en) * | 1903-03-02 | 1903-11-10 | William Clark Kirk | Work-support for lathes. |
| US3533088A (en) * | 1967-10-31 | 1970-10-06 | Rca Corp | Control circuit for memory |
| US4714839A (en) * | 1986-03-27 | 1987-12-22 | Advanced Micro Devices, Inc. | Control circuit for disabling or enabling the provision of redundancy |
| US4721868A (en) * | 1986-09-23 | 1988-01-26 | Advanced Micro Devices, Inc. | IC input circuitry programmable for realizing multiple functions from a single input |
| JPH02146195A (ja) * | 1988-11-28 | 1990-06-05 | Nec Corp | 半導体記憶装置 |
| JPH03214500A (ja) * | 1990-01-18 | 1991-09-19 | Sony Corp | メモリ装置 |
| JP2575919B2 (ja) * | 1990-03-22 | 1997-01-29 | 株式会社東芝 | 半導体記憶装置の冗長回路 |
| US5959445A (en) * | 1995-09-29 | 1999-09-28 | Intel Corporation | Static, high-sensitivity, fuse-based storage cell |
| US5861421A (en) | 1995-12-21 | 1999-01-19 | Smithkline Beecham Corporation | 4,4-(disubstituted) cyclohexan-1-one monomers and related compounds |
| US6037799A (en) * | 1995-12-29 | 2000-03-14 | Stmicroelectronics, Inc. | Circuit and method for selecting a signal |
| US20020002199A1 (en) | 1998-03-12 | 2002-01-03 | Lone Jeppesen | Modulators of protein tyrosine phosphatases (ptpases) |
| US20050119332A1 (en) | 1998-03-12 | 2005-06-02 | Lone Jeppesen | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) |
| US6175261B1 (en) * | 1999-01-07 | 2001-01-16 | Texas Instruments Incorporated | Fuse cell for on-chip trimming |
| US6275063B1 (en) * | 1999-08-24 | 2001-08-14 | Micron Technology, Inc. | Method and apparatus for limited reprogrammability of fuse options using one-time programmable elements |
| US6353336B1 (en) * | 2000-03-24 | 2002-03-05 | Cypress Semiconductor Corp. | Electrical ID method for output driver |
| EA007484B1 (ru) | 2001-06-11 | 2006-10-27 | Вирокем Фарма Инк. | Соединения и способы лечения или предупреждения инфекций flavivirus |
| CA2449999C (en) | 2001-06-11 | 2012-07-31 | Shire Biochem Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| KR100481179B1 (ko) * | 2002-09-10 | 2005-04-07 | 삼성전자주식회사 | 퓨즈를 구비한 회로 및 이를 이용한 반도체 장치 |
| JP3884374B2 (ja) * | 2002-12-06 | 2007-02-21 | 株式会社東芝 | 半導体装置 |
| WO2004052885A1 (en) | 2002-12-10 | 2004-06-24 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| PT1569929E (pt) * | 2002-12-10 | 2010-06-18 | Virochem Pharma Inc | Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus |
| KR100569585B1 (ko) * | 2003-12-05 | 2006-04-10 | 주식회사 하이닉스반도체 | 내부 전원 드라이버 제어 회로 |
| DE10359791A1 (de) | 2003-12-19 | 2005-07-21 | Bayer Healthcare Ag | Substituierte Thiophene |
| WO2005081954A2 (en) | 2004-02-25 | 2005-09-09 | Wyeth | Inhibitors of protein tyrosine phosphatase 1b |
| WO2005095386A1 (en) * | 2004-03-30 | 2005-10-13 | Chiron Corporation | Substituted thiophene derivatives as anti-cancer agents |
| DE102005028077A1 (de) | 2004-12-22 | 2006-07-13 | Aicuris Gmbh & Co. Kg | Alkinyl-substituierte Thiophene |
| DE102004061746A1 (de) | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
| NZ563909A (en) | 2005-05-13 | 2011-10-28 | Virochem Pharma Inc | Thiophene derivatives and their use for the treatment or prevention of flavivirus infections |
| WO2007006091A1 (en) | 2005-07-07 | 2007-01-18 | Athlomics Pty Ltd | Polynucleotide marker genes and their expression, for diagnosis of endotoxemia |
| GB0602046D0 (en) | 2006-02-01 | 2006-03-15 | Smithkline Beecham Corp | Compounds |
| JP2009526794A (ja) | 2006-02-15 | 2009-07-23 | サノフィ−アベンティス | 新規なアミノアルコール置換アリールチエノピリミジノン、それらの製造方法及び薬剤としてそれらの使用 |
| NZ576780A (en) * | 2006-11-15 | 2011-12-22 | Virochem Pharma Inc | Thiophene analogues for the treatment or prevention of flavivirus infections |
| US20090274655A1 (en) | 2006-11-17 | 2009-11-05 | Richard Martin Grimes | 2-carboxy thiophene derivatives as anti viral agents |
| SG171890A1 (en) | 2008-12-03 | 2011-07-28 | Presidio Pharmaceuticals Inc | Inhibitors of hcv ns5a |
| EA020816B1 (ru) * | 2009-07-21 | 2015-01-30 | Джилид Сайэнс, Инк. | Ингибиторы вирусов flaviviridae |
| JP5774008B2 (ja) | 2009-09-09 | 2015-09-02 | ギリアード サイエンシーズ， インコーポレイテッド | Ｆｌａｖｉｖｉｒｉｄａｅウイルスの阻害剤 |
| AU2010326225A1 (en) | 2009-11-25 | 2012-06-07 | Vertex Pharmaceuticals Incorporated | 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections |
| KR20120123678A (ko) * | 2010-01-15 | 2012-11-09 | 길리애드 사이언시즈, 인코포레이티드 | 플라비비리다에 바이러스의 억제제 |
| AU2011205744B2 (en) | 2010-01-15 | 2015-06-25 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| MX2012014918A (es) | 2010-06-28 | 2013-04-08 | Vertex Pharma | Compuestos y metodos para tratamiento o prevencion de infecciones por flavivirus. |
| AU2012280959B2 (en) | 2011-07-13 | 2015-08-06 | Gilead Sciences, Inc. | Thiophen-2-carboxylic acid derivatives useful as inhibitors of Flaviviridae viruses |
-
2011
- 2011-01-14 AU AU2011205744A patent/AU2011205744B2/en active Active
- 2011-01-14 UY UY0001033183A patent/UY33183A/es not_active Application Discontinuation
- 2011-01-14 MX MX2012008211A patent/MX2012008211A/es active IP Right Grant
- 2011-01-14 BR BR112012017382A patent/BR112012017382A2/pt not_active Application Discontinuation
- 2011-01-14 NZ NZ600817A patent/NZ600817A/en not_active IP Right Cessation
- 2011-01-14 JP JP2012549122A patent/JP5868872B2/ja active Active
- 2011-01-14 PE PE2012000999A patent/PE20130281A1/es not_active Application Discontinuation
- 2011-01-14 SG SG2012051181A patent/SG182475A1/en unknown
- 2011-01-14 TW TW100101437A patent/TWI491609B/zh active
- 2011-01-14 PL PL11700988T patent/PL2523950T3/pl unknown
- 2011-01-14 SI SI201131169A patent/SI2523950T1/sl unknown
- 2011-01-14 CA CA2785567A patent/CA2785567C/en active Active
- 2011-01-14 SG SG10201500298PA patent/SG10201500298PA/en unknown
- 2011-01-14 PT PT117009886T patent/PT2523950T/pt unknown
- 2011-01-14 US US13/007,150 patent/US8513298B2/en active Active
- 2011-01-14 KR KR1020127021314A patent/KR101727776B1/ko active Active
- 2011-01-14 CN CN201180005975.8A patent/CN102712633B/zh active Active
- 2011-01-14 AP AP2012006414A patent/AP3576A/xx active
- 2011-01-14 ES ES11700988.6T patent/ES2626150T3/es active Active
- 2011-01-14 EA EA201290576A patent/EA021196B1/ru not_active IP Right Cessation
- 2011-01-14 EP EP11700988.6A patent/EP2523950B1/en active Active
- 2011-01-14 AR ARP110100126A patent/AR080001A1/es unknown
- 2011-01-14 WO PCT/US2011/021335 patent/WO2011088345A1/en not_active Ceased
- 2011-01-14 EP EP17160365.7A patent/EP3219713A1/en not_active Withdrawn
-
2012
- 2012-06-21 IL IL220545A patent/IL220545B/en not_active IP Right Cessation
- 2012-07-13 ZA ZA2012/05248A patent/ZA201205248B/en unknown
- 2012-07-13 CL CL2012001960A patent/CL2012001960A1/es unknown
- 2012-08-10 CR CR20120417A patent/CR20120417A/es unknown
- 2012-08-13 EC ECSP12012104 patent/ECSP12012104A/es unknown
-
2013
- 2013-07-11 US US13/939,695 patent/US9321753B2/en active Active
-
2015
- 2015-11-02 JP JP2015215450A patent/JP2016041732A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013517291A5 (OSRAM) | ||
| JP2013517286A5 (OSRAM) | ||
| JP7195360B2 (ja) | Ｔｌｒ７作動薬およびｈｂｖカプシド集合阻害剤を用いた併用処置 | |
| JP2011518835A5 (OSRAM) | ||
| ES2626150T3 (es) | Inhibidores de virus flaviviridae | |
| JP5854841B2 (ja) | デングウイルス感染を治療及び予防するためのチエノピリジン誘導体類 | |
| JP2012533630A5 (OSRAM) | ||
| JP2013514359A5 (OSRAM) | ||
| JP2011521903A5 (OSRAM) | ||
| JP2014514308A5 (OSRAM) | ||
| JP2010539241A5 (OSRAM) | ||
| JP2016503800A5 (OSRAM) | ||
| JP2012504632A5 (OSRAM) | ||
| JP2013538230A5 (OSRAM) | ||
| JP2014504643A5 (OSRAM) | ||
| KR20110054056A (ko) | 마크로사이클릭 ｈｃｖ 저해제 및 뉴클레오시드의 상승적 배합물 | |
| JP2012504126A5 (OSRAM) | ||
| EP3970750A1 (en) | Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor | |
| JP2012504129A5 (OSRAM) | ||
| JP2013504576A5 (OSRAM) | ||
| RU2015151200A (ru) | Композиции и способы модулирования экспрессии аполипопротеина (а) | |
| RU2017126995A (ru) | Производные и способы лечения инфекций гапатита в | |
| JP2015512860A5 (OSRAM) | ||
| JP2012504132A5 (OSRAM) | ||
| RU2015123641A (ru) | 2-алкинилзамещенные производные нуклеозидов, предназначенные для лечения вирусных заболеваний |