JP2013515006A5 - - Google Patents
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- Publication number
- JP2013515006A5 JP2013515006A5 JP2012544924A JP2012544924A JP2013515006A5 JP 2013515006 A5 JP2013515006 A5 JP 2013515006A5 JP 2012544924 A JP2012544924 A JP 2012544924A JP 2012544924 A JP2012544924 A JP 2012544924A JP 2013515006 A5 JP2013515006 A5 JP 2013515006A5
- Authority
- JP
- Japan
- Prior art keywords
- dca
- synthetic
- pharmaceutical composition
- weight
- total amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000003786 synthesis reaction Methods 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 5
- XXVDSHGQWYNBEP-SQVHVIJFSA-N C[C@H](CCC(O)=O)[C@@H](CC[C@H]1[C@H](CC2)[C@H](C3)[C@@](C)(CC4)[C@@]2(C)C[C@@H]4O)[C@@]1(C)[C@H]3O Chemical compound C[C@H](CCC(O)=O)[C@@H](CC[C@H]1[C@H](CC2)[C@H](C3)[C@@](C)(CC4)[C@@]2(C)C[C@@H]4O)[C@@]1(C)[C@H]3O XXVDSHGQWYNBEP-SQVHVIJFSA-N 0.000 description 3
- 0 C[C@](CC*)[C@@](CC[C@]1[C@](CC2)[C@@](C3)[C@@](C)(CC4)[C@@]2C[C@@]4O)[C@@]1(C)[C@@]3O Chemical compound C[C@](CC*)[C@@](CC[C@]1[C@](CC2)[C@@](C3)[C@@](C)(CC4)[C@@]2C[C@@]4O)[C@@]1(C)[C@@]3O 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000019439 ethyl acetate Nutrition 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28813209P | 2009-12-18 | 2009-12-18 | |
| US61/288,132 | 2009-12-18 | ||
| US30200710P | 2010-02-05 | 2010-02-05 | |
| US61/302,007 | 2010-02-05 | ||
| US30381610P | 2010-02-12 | 2010-02-12 | |
| US61/303,816 | 2010-02-12 | ||
| GB1008726A GB2480632A (en) | 2010-05-25 | 2010-05-25 | Preparation of 12-keto and 12-alpha-hydroxy steroids |
| GB1008726.0 | 2010-05-25 | ||
| US34868610P | 2010-05-26 | 2010-05-26 | |
| US61/348,686 | 2010-05-26 | ||
| PCT/US2010/061150 WO2011075701A2 (en) | 2009-12-18 | 2010-12-17 | Methods for the purification of deoxycholic acid |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016161932A Division JP6568025B2 (ja) | 2009-12-18 | 2016-08-22 | デオキシコール酸の合成および精製のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515006A JP2013515006A (ja) | 2013-05-02 |
| JP2013515006A5 true JP2013515006A5 (enExample) | 2018-03-22 |
| JP6393023B2 JP6393023B2 (ja) | 2018-09-19 |
Family
ID=42341289
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012544924A Expired - Fee Related JP6393023B2 (ja) | 2009-12-18 | 2010-12-17 | デオキシコール酸の調製のための方法 |
| JP2016161932A Expired - Fee Related JP6568025B2 (ja) | 2009-12-18 | 2016-08-22 | デオキシコール酸の合成および精製のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016161932A Expired - Fee Related JP6568025B2 (ja) | 2009-12-18 | 2016-08-22 | デオキシコール酸の合成および精製のための方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US20130137884A1 (enExample) |
| EP (2) | EP2513132B9 (enExample) |
| JP (2) | JP6393023B2 (enExample) |
| KR (3) | KR102058420B1 (enExample) |
| CN (3) | CN102812035A (enExample) |
| AU (1) | AU2010330760B2 (enExample) |
| CA (1) | CA2782478A1 (enExample) |
| EA (2) | EA035380B1 (enExample) |
| ES (1) | ES2575559T3 (enExample) |
| GB (1) | GB2480632A (enExample) |
| IL (2) | IL220225A0 (enExample) |
| MY (1) | MY167891A (enExample) |
| NZ (1) | NZ700195A (enExample) |
| PH (1) | PH12012501233A1 (enExample) |
| SG (3) | SG181768A1 (enExample) |
| WO (1) | WO2011075701A2 (enExample) |
| ZA (1) | ZA201204388B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| GB2480632A (en) | 2010-05-25 | 2011-11-30 | Kythera Biopharmaceuticals Inc | Preparation of 12-keto and 12-alpha-hydroxy steroids |
| US20120237492A1 (en) | 2011-02-18 | 2012-09-20 | Kythera Biopharmaceuticals, Inc. | Treatment of submental fat |
| US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
| EP3138850B8 (en) * | 2011-06-16 | 2019-09-11 | Allergan Sales, LLC | Compositions containing deoxycholic acid and 10% deionized water in ethanol, directed to the purification of deoxycholic acid |
| US20130102580A1 (en) * | 2011-09-22 | 2013-04-25 | Kythera Biopharmaceuticals, Inc. | Compositions and methods related to deoxycholic acid and its polymorphs |
| WO2013044119A1 (en) * | 2011-09-22 | 2013-03-28 | Kythera Biopharmaceuticals, Inc. | Compositions and methods related to deoxycholic acid and its polymorphs |
| CN104447929B (zh) * | 2014-10-28 | 2016-06-29 | 湖南科瑞生物制药股份有限公司 | 一种合成3-羰基-4-雄烯-17β羧酸的方法 |
| CN106146593B (zh) * | 2015-04-14 | 2021-06-01 | 南京迈诺威医药科技有限公司 | 一种制备去氧胆酸的方法 |
| CN106046093A (zh) * | 2016-05-30 | 2016-10-26 | 华东师范大学 | 一种石胆酸的合成方法 |
| JP7050008B2 (ja) * | 2016-06-06 | 2022-04-07 | クリスタル ファーマ，エセ．ア．ウ． | デオキシコール酸の調製方法、およびデオキシコール酸の調製に有用な中間体 |
| US20190125648A1 (en) * | 2016-08-11 | 2019-05-02 | Samsung Life Public Welfare Foundation | Composition for preventing, improving or treating hair loss comprising deoxycholic acid as active ingredient |
| KR20200026273A (ko) | 2017-08-03 | 2020-03-10 | (주)메디톡스 | 담즙산류를 제조하기 위한 방법 |
| JP6899529B2 (ja) | 2017-08-10 | 2021-07-07 | パナソニックＩｐマネジメント株式会社 | 冷凍サイクル用作動媒体および冷凍サイクルシステム |
| CN114478676B (zh) * | 2022-02-18 | 2024-05-10 | 国药集团化学试剂有限公司 | 一种脱氧胆酸钠的制备方法 |
| CN116444597B (zh) * | 2023-03-30 | 2025-03-28 | 南京迈诺威医药科技有限公司 | 一种制备去氧胆酸中间体和去氧胆酸的方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US53446A (en) | 1866-03-27 | Improvement in cultivators | ||
| US2321598A (en) | 1940-10-07 | 1943-06-15 | George A Breon & Company Inc | Preparation of desoxycholic acid |
| US2509248A (en) * | 1947-09-05 | 1950-05-30 | Merck & Co Inc | Process for producing delta9, 11-3(alpha)-hydroxy-17-ketoetiocholene |
| GB695504A (en) | 1950-10-18 | 1953-08-12 | Drug Res Inc | Method of isolating and purifying cholic and desoxycholic acids |
| GB716670A (en) | 1951-06-19 | 1954-10-13 | Armour & Co | Improved process for purifying desoxycholic acid from contaminating cholic acid |
| US2651643A (en) * | 1951-06-19 | 1953-09-08 | Armour & Co | Purification of desoxycholic acid |
| US2891972A (en) | 1952-08-19 | 1959-06-23 | Drug Res Inc | Process of separating desoxycholic acid from mixed crude bile acids or salts thereof |
| US3533908A (en) | 1967-05-19 | 1970-10-13 | Brown Co | Porous paperboard sheet having plastic microspheres therein |
| IT1202370B (it) | 1976-07-12 | 1989-02-09 | Hoffmann La Roche | Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti |
| FR2446293A1 (fr) | 1978-12-11 | 1980-08-08 | Roussel Uclaf | Procede de purification de l'acide chenodesoxycholique |
| IT8167097A0 (it) | 1981-01-26 | 1981-01-26 | Unilever Nv | Composizione cosmetica per il trattamento della pelle o dei capelli |
| EP0336521B1 (en) | 1988-04-08 | 1992-04-01 | Roussel-Uclaf | 9-alpha-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids |
| US5085864A (en) | 1989-10-30 | 1992-02-04 | Abbott Laboratories | Injectable formulation for lipophilic drugs |
| CA2033725C (en) | 1990-01-24 | 2001-05-29 | Folker Pittrof | Pharmaceutical and cosmetic compositions containing a salt of cholanic acid |
| AU4613296A (en) | 1994-07-25 | 1996-04-19 | Nda International, Inc. | A method of treating chemical dependency in mammals and a composition therefor |
| US20020107291A1 (en) | 1997-05-26 | 2002-08-08 | Vincenzo De Tommaso | Clear, injectable formulation of an anesthetic compound |
| IL123998A (en) | 1998-04-08 | 2004-09-27 | Galmed Int Ltd | Conjugates of bile salts and pharmaceutical preparations containing them |
| US6417179B1 (en) | 1998-10-13 | 2002-07-09 | Craig G. Burkhart | Ear wax solution |
| AU2879300A (en) * | 1999-02-12 | 2000-08-29 | Cellpath, Inc. | Methods for anti-tumor therapy |
| CN100558407C (zh) | 2000-02-04 | 2009-11-11 | 柳署弘 | 制备含有胆汁酸的澄清水溶液剂型 |
| JP2004534042A (ja) * | 2001-05-22 | 2004-11-11 | インフラジム ファーマシューティカルズ リミテッド | ステロイド−５−エン化合物のステロイド−５−エン−７−オン化合物へのアリル酸化、続くヒドロホウ素化および酸化による、６，７−ジヒドロキシステロイドの生成のための方法およびこの方法の中間体 |
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| US7754230B2 (en) | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
| PL2422789T3 (pl) | 2004-05-19 | 2018-09-28 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Wstrzykiwalna kompozycja zawierająca deoksycholan sodu |
| US20060222695A1 (en) | 2005-04-01 | 2006-10-05 | Filiberto Zadini | Deoxycholic acid liposome-based dermatological topical preparation |
| CN101148468A (zh) | 2006-09-19 | 2008-03-26 | 天津科技大学 | 以动物胆汁为原料高效提取胆红素和胆汁酸技术 |
| CA2928178C (en) * | 2007-01-19 | 2019-09-10 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
| US20080318870A1 (en) | 2007-06-19 | 2008-12-25 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| NZ581081A (en) * | 2007-06-19 | 2012-12-21 | Kythera Biopharmaceuticals Inc | Synthetic deoxycholic acid (dca) or an ester, hydroxamale, or hydroxyamide thereof |
| JOP20180077A1 (ar) | 2007-06-19 | 2019-01-30 | Kythera Biopharmaceuticals Inc | تركيبات وطرق لحمض صفراوي تخليقي |
| AU2009256009B2 (en) * | 2008-06-06 | 2014-02-06 | Neurmedix, Inc. | Methods for preparing 17-alkynyl-7-hydroxy steroids and related compounds |
| GB2480632A (en) | 2010-05-25 | 2011-11-30 | Kythera Biopharmaceuticals Inc | Preparation of 12-keto and 12-alpha-hydroxy steroids |
| EP3138850B8 (en) | 2011-06-16 | 2019-09-11 | Allergan Sales, LLC | Compositions containing deoxycholic acid and 10% deionized water in ethanol, directed to the purification of deoxycholic acid |
| US20130102580A1 (en) | 2011-09-22 | 2013-04-25 | Kythera Biopharmaceuticals, Inc. | Compositions and methods related to deoxycholic acid and its polymorphs |
-
2010
- 2010-05-25 GB GB1008726A patent/GB2480632A/en not_active Withdrawn
- 2010-12-17 SG SG2012044665A patent/SG181768A1/en unknown
- 2010-12-17 EP EP10798913.9A patent/EP2513132B9/en not_active Not-in-force
- 2010-12-17 EP EP15202046.7A patent/EP3040342A1/en not_active Withdrawn
- 2010-12-17 CA CA2782478A patent/CA2782478A1/en not_active Abandoned
- 2010-12-17 CN CN2010800567638A patent/CN102812035A/zh active Pending
- 2010-12-17 MY MYPI2012002415A patent/MY167891A/en unknown
- 2010-12-17 CN CN201710119352.2A patent/CN106955287A/zh active Pending
- 2010-12-17 JP JP2012544924A patent/JP6393023B2/ja not_active Expired - Fee Related
- 2010-12-17 EA EA201791511A patent/EA035380B1/ru not_active IP Right Cessation
- 2010-12-17 SG SG10201803507YA patent/SG10201803507YA/en unknown
- 2010-12-17 SG SG10201509046TA patent/SG10201509046TA/en unknown
- 2010-12-17 EA EA201290334A patent/EA031768B1/ru not_active IP Right Cessation
- 2010-12-17 PH PH1/2012/501233A patent/PH12012501233A1/en unknown
- 2010-12-17 KR KR1020187014486A patent/KR102058420B1/ko not_active Expired - Fee Related
- 2010-12-17 ES ES10798913.9T patent/ES2575559T3/es active Active
- 2010-12-17 WO PCT/US2010/061150 patent/WO2011075701A2/en not_active Ceased
- 2010-12-17 KR KR1020177011484A patent/KR101862599B1/ko not_active Expired - Fee Related
- 2010-12-17 KR KR1020127017236A patent/KR101787719B1/ko not_active Expired - Fee Related
- 2010-12-17 AU AU2010330760A patent/AU2010330760B2/en not_active Ceased
- 2010-12-17 CN CN201710119383.8A patent/CN107011401A/zh active Pending
- 2010-12-17 US US13/140,421 patent/US20130137884A1/en not_active Abandoned
-
2012
- 2012-06-07 IL IL220225A patent/IL220225A0/en unknown
- 2012-06-14 ZA ZA2012/04388A patent/ZA201204388B/en unknown
-
2014
- 2014-09-19 NZ NZ700195A patent/NZ700195A/en not_active IP Right Cessation
- 2014-11-04 US US14/532,940 patent/US9683007B2/en active Active
-
2016
- 2016-08-22 JP JP2016161932A patent/JP6568025B2/ja not_active Expired - Fee Related
-
2017
- 2017-05-23 US US15/603,290 patent/US10005813B2/en active Active
-
2018
- 2018-05-25 US US15/990,135 patent/US10472384B2/en active Active
- 2018-09-02 IL IL261526A patent/IL261526A/en unknown
-
2019
- 2019-10-02 US US16/591,539 patent/US10981946B2/en active Active
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