AU2010330760B2 - Methods for the purification of deoxycholic acid - Google Patents

Methods for the purification of deoxycholic acid Download PDF

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Publication number
AU2010330760B2
AU2010330760B2 AU2010330760A AU2010330760A AU2010330760B2 AU 2010330760 B2 AU2010330760 B2 AU 2010330760B2 AU 2010330760 A AU2010330760 A AU 2010330760A AU 2010330760 A AU2010330760 A AU 2010330760A AU 2010330760 B2 AU2010330760 B2 AU 2010330760B2
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AU
Australia
Prior art keywords
compound
dca
reaction
pct
solvent
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010330760A
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English (en)
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AU2010330760A1 (en
Inventor
Robert M. Moriarty
John Gregory Reid
Roy A. Swaringen Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kythera Biopharmaceuticals LLC
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Kythera Biopharmaceuticals LLC
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Publication of AU2010330760A1 publication Critical patent/AU2010330760A1/en
Application granted granted Critical
Publication of AU2010330760B2 publication Critical patent/AU2010330760B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2010330760A 2009-12-18 2010-12-17 Methods for the purification of deoxycholic acid Ceased AU2010330760B2 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US28813209P 2009-12-18 2009-12-18
US61/288,132 2009-12-18
US30200710P 2010-02-05 2010-02-05
US61/302,007 2010-02-05
US30381610P 2010-02-12 2010-02-12
US61/303,816 2010-02-12
GB1008726A GB2480632A (en) 2010-05-25 2010-05-25 Preparation of 12-keto and 12-alpha-hydroxy steroids
GB1008726.0 2010-05-25
US34868610P 2010-05-26 2010-05-26
US61/348,686 2010-05-26
PCT/US2010/061150 WO2011075701A2 (en) 2009-12-18 2010-12-17 Methods for the purification of deoxycholic acid

Publications (2)

Publication Number Publication Date
AU2010330760A1 AU2010330760A1 (en) 2012-06-21
AU2010330760B2 true AU2010330760B2 (en) 2015-01-22

Family

ID=42341289

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010330760A Ceased AU2010330760B2 (en) 2009-12-18 2010-12-17 Methods for the purification of deoxycholic acid

Country Status (17)

Country Link
US (5) US20130137884A1 (enExample)
EP (2) EP2513132B9 (enExample)
JP (2) JP6393023B2 (enExample)
KR (3) KR101862599B1 (enExample)
CN (3) CN102812035A (enExample)
AU (1) AU2010330760B2 (enExample)
CA (1) CA2782478A1 (enExample)
EA (2) EA035380B1 (enExample)
ES (1) ES2575559T3 (enExample)
GB (1) GB2480632A (enExample)
IL (2) IL220225A0 (enExample)
MY (1) MY167891A (enExample)
NZ (1) NZ700195A (enExample)
PH (1) PH12012501233A1 (enExample)
SG (3) SG10201803507YA (enExample)
WO (1) WO2011075701A2 (enExample)
ZA (1) ZA201204388B (enExample)

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US20060127468A1 (en) 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
GB2480632A (en) 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
US20120237492A1 (en) 2011-02-18 2012-09-20 Kythera Biopharmaceuticals, Inc. Treatment of submental fat
US8653058B2 (en) 2011-04-05 2014-02-18 Kythera Biopharmaceuticals, Inc. Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
EP2721047B1 (en) * 2011-06-16 2016-11-16 Kythera Biopharmaceuticals, Inc. Methods for the synthesis and purification of deoxycholic acid
US20130102580A1 (en) * 2011-09-22 2013-04-25 Kythera Biopharmaceuticals, Inc. Compositions and methods related to deoxycholic acid and its polymorphs
WO2013044119A1 (en) * 2011-09-22 2013-03-28 Kythera Biopharmaceuticals, Inc. Compositions and methods related to deoxycholic acid and its polymorphs
CN104447929B (zh) * 2014-10-28 2016-06-29 湖南科瑞生物制药股份有限公司 一种合成3-羰基-4-雄烯-17β羧酸的方法
CN106146593B (zh) * 2015-04-14 2021-06-01 南京迈诺威医药科技有限公司 一种制备去氧胆酸的方法
CN106046093A (zh) * 2016-05-30 2016-10-26 华东师范大学 一种石胆酸的合成方法
US11117925B2 (en) 2016-06-06 2021-09-14 Bionice, S.L.U. Methods for the preparation of deoxycholic acid, and intermediates useful in the preparation of deoxycholic acid
US20190125648A1 (en) * 2016-08-11 2019-05-02 Samsung Life Public Welfare Foundation Composition for preventing, improving or treating hair loss comprising deoxycholic acid as active ingredient
WO2019024920A1 (en) 2017-08-03 2019-02-07 Medytox Inc. PROCESSES FOR PREPARING BILARY ACIDS
JP6899529B2 (ja) 2017-08-10 2021-07-07 パナソニックＩｐマネジメント株式会社 冷凍サイクル用作動媒体および冷凍サイクルシステム
CN114478676B (zh) * 2022-02-18 2024-05-10 国药集团化学试剂有限公司 一种脱氧胆酸钠的制备方法
CN116444597B (zh) * 2023-03-30 2025-03-28 南京迈诺威医药科技有限公司 一种制备去氧胆酸中间体和去氧胆酸的方法

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Also Published As

Publication number Publication date
US10005813B2 (en) 2018-06-26
US10981946B2 (en) 2021-04-20
SG10201803507YA (en) 2018-05-30
EP3040342A1 (en) 2016-07-06
GB201008726D0 (en) 2010-07-07
EA201290334A1 (ru) 2013-06-28
NZ700195A (en) 2016-03-31
KR20120107982A (ko) 2012-10-04
PH12012501233A1 (en) 2012-11-05
CN106955287A (zh) 2017-07-18
US10472384B2 (en) 2019-11-12
JP6568025B2 (ja) 2019-08-28
KR102058420B1 (ko) 2019-12-24
EA031768B1 (ru) 2019-02-28
US20190135855A1 (en) 2019-05-09
EA035380B1 (ru) 2020-06-04
CN102812035A (zh) 2012-12-05
AU2010330760A1 (en) 2012-06-21
EP2513132B9 (en) 2017-12-27
MY167891A (en) 2018-09-26
US20170320905A1 (en) 2017-11-09
EP2513132A2 (en) 2012-10-24
US9683007B2 (en) 2017-06-20
CN107011401A (zh) 2017-08-04
JP2013515006A (ja) 2013-05-02
KR101862599B1 (ko) 2018-05-31
KR101787719B1 (ko) 2017-10-18
IL261526A (en) 2018-10-31
CA2782478A1 (en) 2011-06-23
WO2011075701A4 (en) 2012-09-13
WO2011075701A2 (en) 2011-06-23
KR20180059568A (ko) 2018-06-04
JP6393023B2 (ja) 2018-09-19
KR20170049635A (ko) 2017-05-10
ES2575559T3 (es) 2016-06-29
SG181768A1 (en) 2012-07-30
EP2513132B1 (en) 2016-03-09
GB2480632A (en) 2011-11-30
ZA201204388B (en) 2013-07-31
US20200095274A1 (en) 2020-03-26
US20130137884A1 (en) 2013-05-30
JP2016193948A (ja) 2016-11-17
US20150141679A1 (en) 2015-05-21
IL220225A0 (en) 2012-07-31
WO2011075701A3 (en) 2012-07-26
SG10201509046TA (en) 2015-12-30
EA201791511A1 (ru) 2018-03-30

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired