IL220225A0 - Methods for the purification of deoxycholic acid - Google Patents
Methods for the purification of deoxycholic acidInfo
- Publication number
- IL220225A0 IL220225A0 IL220225A IL22022512A IL220225A0 IL 220225 A0 IL220225 A0 IL 220225A0 IL 220225 A IL220225 A IL 220225A IL 22022512 A IL22022512 A IL 22022512A IL 220225 A0 IL220225 A0 IL 220225A0
- Authority
- IL
- Israel
- Prior art keywords
- purification
- methods
- deoxycholic acid
- deoxycholic
- acid
- Prior art date
Links
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 title 1
- 229960003964 deoxycholic acid Drugs 0.000 title 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28813209P | 2009-12-18 | 2009-12-18 | |
| US30200710P | 2010-02-05 | 2010-02-05 | |
| US30381610P | 2010-02-12 | 2010-02-12 | |
| GB1008726A GB2480632A (en) | 2010-05-25 | 2010-05-25 | Preparation of 12-keto and 12-alpha-hydroxy steroids |
| US34868610P | 2010-05-26 | 2010-05-26 | |
| PCT/US2010/061150 WO2011075701A2 (en) | 2009-12-18 | 2010-12-17 | Methods for the purification of deoxycholic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL220225A0 true IL220225A0 (en) | 2012-07-31 |
Family
ID=42341289
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL220225A IL220225A0 (en) | 2009-12-18 | 2012-06-07 | Methods for the purification of deoxycholic acid |
| IL261526A IL261526A (en) | 2009-12-18 | 2018-09-02 | Methods for the purification of deoxycholic acid |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL261526A IL261526A (en) | 2009-12-18 | 2018-09-02 | Methods for the purification of deoxycholic acid |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US20130137884A1 (enExample) |
| EP (2) | EP2513132B9 (enExample) |
| JP (2) | JP6393023B2 (enExample) |
| KR (3) | KR101862599B1 (enExample) |
| CN (3) | CN102812035A (enExample) |
| AU (1) | AU2010330760B2 (enExample) |
| CA (1) | CA2782478A1 (enExample) |
| EA (2) | EA035380B1 (enExample) |
| ES (1) | ES2575559T3 (enExample) |
| GB (1) | GB2480632A (enExample) |
| IL (2) | IL220225A0 (enExample) |
| MY (1) | MY167891A (enExample) |
| NZ (1) | NZ700195A (enExample) |
| PH (1) | PH12012501233A1 (enExample) |
| SG (3) | SG10201803507YA (enExample) |
| WO (1) | WO2011075701A2 (enExample) |
| ZA (1) | ZA201204388B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| GB2480632A (en) | 2010-05-25 | 2011-11-30 | Kythera Biopharmaceuticals Inc | Preparation of 12-keto and 12-alpha-hydroxy steroids |
| US20120237492A1 (en) | 2011-02-18 | 2012-09-20 | Kythera Biopharmaceuticals, Inc. | Treatment of submental fat |
| US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
| EP2721047B1 (en) * | 2011-06-16 | 2016-11-16 | Kythera Biopharmaceuticals, Inc. | Methods for the synthesis and purification of deoxycholic acid |
| US20130102580A1 (en) * | 2011-09-22 | 2013-04-25 | Kythera Biopharmaceuticals, Inc. | Compositions and methods related to deoxycholic acid and its polymorphs |
| WO2013044119A1 (en) * | 2011-09-22 | 2013-03-28 | Kythera Biopharmaceuticals, Inc. | Compositions and methods related to deoxycholic acid and its polymorphs |
| CN104447929B (zh) * | 2014-10-28 | 2016-06-29 | 湖南科瑞生物制药股份有限公司 | 一种合成3-羰基-4-雄烯-17β羧酸的方法 |
| CN106146593B (zh) * | 2015-04-14 | 2021-06-01 | 南京迈诺威医药科技有限公司 | 一种制备去氧胆酸的方法 |
| CN106046093A (zh) * | 2016-05-30 | 2016-10-26 | 华东师范大学 | 一种石胆酸的合成方法 |
| US11117925B2 (en) | 2016-06-06 | 2021-09-14 | Bionice, S.L.U. | Methods for the preparation of deoxycholic acid, and intermediates useful in the preparation of deoxycholic acid |
| US20190125648A1 (en) * | 2016-08-11 | 2019-05-02 | Samsung Life Public Welfare Foundation | Composition for preventing, improving or treating hair loss comprising deoxycholic acid as active ingredient |
| WO2019024920A1 (en) | 2017-08-03 | 2019-02-07 | Medytox Inc. | PROCESSES FOR PREPARING BILARY ACIDS |
| JP6899529B2 (ja) | 2017-08-10 | 2021-07-07 | パナソニックＩｐマネジメント株式会社 | 冷凍サイクル用作動媒体および冷凍サイクルシステム |
| CN114478676B (zh) * | 2022-02-18 | 2024-05-10 | 国药集团化学试剂有限公司 | 一种脱氧胆酸钠的制备方法 |
| CN116444597B (zh) * | 2023-03-30 | 2025-03-28 | 南京迈诺威医药科技有限公司 | 一种制备去氧胆酸中间体和去氧胆酸的方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US53446A (en) | 1866-03-27 | Improvement in cultivators | ||
| US2321598A (en) | 1940-10-07 | 1943-06-15 | George A Breon & Company Inc | Preparation of desoxycholic acid |
| US2509248A (en) * | 1947-09-05 | 1950-05-30 | Merck & Co Inc | Process for producing delta9, 11-3(alpha)-hydroxy-17-ketoetiocholene |
| GB695504A (en) | 1950-10-18 | 1953-08-12 | Drug Res Inc | Method of isolating and purifying cholic and desoxycholic acids |
| US2651643A (en) * | 1951-06-19 | 1953-09-08 | Armour & Co | Purification of desoxycholic acid |
| GB716670A (en) | 1951-06-19 | 1954-10-13 | Armour & Co | Improved process for purifying desoxycholic acid from contaminating cholic acid |
| US2891972A (en) | 1952-08-19 | 1959-06-23 | Drug Res Inc | Process of separating desoxycholic acid from mixed crude bile acids or salts thereof |
| US3533908A (en) | 1967-05-19 | 1970-10-13 | Brown Co | Porous paperboard sheet having plastic microspheres therein |
| IT1202370B (it) | 1976-07-12 | 1989-02-09 | Hoffmann La Roche | Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti |
| FR2446293A1 (fr) | 1978-12-11 | 1980-08-08 | Roussel Uclaf | Procede de purification de l'acide chenodesoxycholique |
| IT8167097A0 (it) | 1981-01-26 | 1981-01-26 | Unilever Nv | Composizione cosmetica per il trattamento della pelle o dei capelli |
| HU208437B (en) | 1988-04-08 | 1993-10-28 | Roussel Uclaf | Process for producing 9-alpha-hydroxy- -17-methylene-steroides for synthetizing corticosteroides |
| US5085864A (en) | 1989-10-30 | 1992-02-04 | Abbott Laboratories | Injectable formulation for lipophilic drugs |
| CA2033725C (en) | 1990-01-24 | 2001-05-29 | Folker Pittrof | Pharmaceutical and cosmetic compositions containing a salt of cholanic acid |
| WO1996003127A1 (en) | 1994-07-25 | 1996-02-08 | Nda International, Inc. | A method of treating chemical dependency in mammals and a composition therefor |
| US20020107291A1 (en) | 1997-05-26 | 2002-08-08 | Vincenzo De Tommaso | Clear, injectable formulation of an anesthetic compound |
| IL123998A (en) | 1998-04-08 | 2004-09-27 | Galmed Int Ltd | Conjugates of bile salts and pharmaceutical preparations containing them |
| US6417179B1 (en) | 1998-10-13 | 2002-07-09 | Craig G. Burkhart | Ear wax solution |
| WO2000047215A2 (en) * | 1999-02-12 | 2000-08-17 | Cellpath, Inc. | Methods for anti-tumor therapy |
| CN100558407C (zh) | 2000-02-04 | 2009-11-11 | 柳署弘 | 制备含有胆汁酸的澄清水溶液剂型 |
| US6696580B2 (en) | 2001-05-22 | 2004-02-24 | Inflazyme Pharmaceuticals Ltd. | Process for the production of 6,7-diols of steroidal compounds |
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| US7754230B2 (en) | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
| ES2372499T3 (es) | 2004-05-19 | 2012-01-20 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Uso de un detergente para la eliminación no quirúrgica de grasa. |
| US20060222695A1 (en) | 2005-04-01 | 2006-10-05 | Filiberto Zadini | Deoxycholic acid liposome-based dermatological topical preparation |
| CN101148468A (zh) | 2006-09-19 | 2008-03-26 | 天津科技大学 | 以动物胆汁为原料高效提取胆红素和胆汁酸技术 |
| CA2928178C (en) * | 2007-01-19 | 2019-09-10 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
| US20080318870A1 (en) | 2007-06-19 | 2008-12-25 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| JOP20180077A1 (ar) * | 2007-06-19 | 2019-01-30 | Kythera Biopharmaceuticals Inc | تركيبات وطرق لحمض صفراوي تخليقي |
| DK2407475T3 (en) * | 2007-06-19 | 2015-10-26 | Kythera Biopharmaceuticals Inc | Preparation of synthetic bile acid |
| DK2300489T3 (en) * | 2008-06-06 | 2016-02-15 | Neurmedix Inc | PROCESSES FOR PREPARING 17-alkynyl-7-HYDROXY STEROIDS AND RELATED COMPOUNDS |
| GB2480632A (en) | 2010-05-25 | 2011-11-30 | Kythera Biopharmaceuticals Inc | Preparation of 12-keto and 12-alpha-hydroxy steroids |
| EP2721047B1 (en) | 2011-06-16 | 2016-11-16 | Kythera Biopharmaceuticals, Inc. | Methods for the synthesis and purification of deoxycholic acid |
| US20130102580A1 (en) | 2011-09-22 | 2013-04-25 | Kythera Biopharmaceuticals, Inc. | Compositions and methods related to deoxycholic acid and its polymorphs |
-
2010
- 2010-05-25 GB GB1008726A patent/GB2480632A/en not_active Withdrawn
- 2010-12-17 WO PCT/US2010/061150 patent/WO2011075701A2/en not_active Ceased
- 2010-12-17 JP JP2012544924A patent/JP6393023B2/ja not_active Expired - Fee Related
- 2010-12-17 SG SG10201803507YA patent/SG10201803507YA/en unknown
- 2010-12-17 MY MYPI2012002415A patent/MY167891A/en unknown
- 2010-12-17 KR KR1020177011484A patent/KR101862599B1/ko not_active Expired - Fee Related
- 2010-12-17 ES ES10798913.9T patent/ES2575559T3/es active Active
- 2010-12-17 EA EA201791511A patent/EA035380B1/ru not_active IP Right Cessation
- 2010-12-17 CA CA2782478A patent/CA2782478A1/en not_active Abandoned
- 2010-12-17 PH PH1/2012/501233A patent/PH12012501233A1/en unknown
- 2010-12-17 SG SG2012044665A patent/SG181768A1/en unknown
- 2010-12-17 SG SG10201509046TA patent/SG10201509046TA/en unknown
- 2010-12-17 CN CN2010800567638A patent/CN102812035A/zh active Pending
- 2010-12-17 AU AU2010330760A patent/AU2010330760B2/en not_active Ceased
- 2010-12-17 EP EP10798913.9A patent/EP2513132B9/en not_active Not-in-force
- 2010-12-17 KR KR1020127017236A patent/KR101787719B1/ko not_active Expired - Fee Related
- 2010-12-17 CN CN201710119383.8A patent/CN107011401A/zh active Pending
- 2010-12-17 EA EA201290334A patent/EA031768B1/ru not_active IP Right Cessation
- 2010-12-17 EP EP15202046.7A patent/EP3040342A1/en not_active Withdrawn
- 2010-12-17 CN CN201710119352.2A patent/CN106955287A/zh active Pending
- 2010-12-17 KR KR1020187014486A patent/KR102058420B1/ko not_active Expired - Fee Related
- 2010-12-17 US US13/140,421 patent/US20130137884A1/en not_active Abandoned
-
2012
- 2012-06-07 IL IL220225A patent/IL220225A0/en unknown
- 2012-06-14 ZA ZA2012/04388A patent/ZA201204388B/en unknown
-
2014
- 2014-09-19 NZ NZ700195A patent/NZ700195A/en not_active IP Right Cessation
- 2014-11-04 US US14/532,940 patent/US9683007B2/en active Active
-
2016
- 2016-08-22 JP JP2016161932A patent/JP6568025B2/ja not_active Expired - Fee Related
-
2017
- 2017-05-23 US US15/603,290 patent/US10005813B2/en active Active
-
2018
- 2018-05-25 US US15/990,135 patent/US10472384B2/en active Active
- 2018-09-02 IL IL261526A patent/IL261526A/en unknown
-
2019
- 2019-10-02 US US16/591,539 patent/US10981946B2/en active Active
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