IL220225A0 - Methods for the purification of deoxycholic acid - Google Patents
Methods for the purification of deoxycholic acidInfo
- Publication number
- IL220225A0 IL220225A0 IL220225A IL22022512A IL220225A0 IL 220225 A0 IL220225 A0 IL 220225A0 IL 220225 A IL220225 A IL 220225A IL 22022512 A IL22022512 A IL 22022512A IL 220225 A0 IL220225 A0 IL 220225A0
- Authority
- IL
- Israel
- Prior art keywords
- purification
- methods
- deoxycholic acid
- deoxycholic
- acid
- Prior art date
Links
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 title 1
- 229960003964 deoxycholic acid Drugs 0.000 title 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28813209P | 2009-12-18 | 2009-12-18 | |
| US30200710P | 2010-02-05 | 2010-02-05 | |
| US30381610P | 2010-02-12 | 2010-02-12 | |
| GB1008726A GB2480632A (en) | 2010-05-25 | 2010-05-25 | Preparation of 12-keto and 12-alpha-hydroxy steroids |
| US34868610P | 2010-05-26 | 2010-05-26 | |
| PCT/US2010/061150 WO2011075701A2 (en) | 2009-12-18 | 2010-12-17 | Methods for the purification of deoxycholic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL220225A0 true IL220225A0 (en) | 2012-07-31 |
Family
ID=42341289
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL220225A IL220225A0 (en) | 2009-12-18 | 2012-06-07 | Methods for the purification of deoxycholic acid |
| IL261526A IL261526A (en) | 2009-12-18 | 2018-09-02 | Methods for the purification of deoxycholic acid |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL261526A IL261526A (en) | 2009-12-18 | 2018-09-02 | Methods for the purification of deoxycholic acid |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US20130137884A1 (enExample) |
| EP (2) | EP2513132B9 (enExample) |
| JP (2) | JP6393023B2 (enExample) |
| KR (3) | KR101862599B1 (enExample) |
| CN (3) | CN107011401A (enExample) |
| AU (1) | AU2010330760B2 (enExample) |
| CA (1) | CA2782478A1 (enExample) |
| EA (2) | EA031768B1 (enExample) |
| ES (1) | ES2575559T3 (enExample) |
| GB (1) | GB2480632A (enExample) |
| IL (2) | IL220225A0 (enExample) |
| MY (1) | MY167891A (enExample) |
| NZ (1) | NZ700195A (enExample) |
| PH (1) | PH12012501233A1 (enExample) |
| SG (3) | SG10201509046TA (enExample) |
| WO (1) | WO2011075701A2 (enExample) |
| ZA (1) | ZA201204388B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| GB2480632A (en) | 2010-05-25 | 2011-11-30 | Kythera Biopharmaceuticals Inc | Preparation of 12-keto and 12-alpha-hydroxy steroids |
| US20120237492A1 (en) | 2011-02-18 | 2012-09-20 | Kythera Biopharmaceuticals, Inc. | Treatment of submental fat |
| US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
| TWI665211B (zh) * | 2011-06-16 | 2019-07-11 | 美商凱瑟拉生物製藥有限公司 | 去氧膽酸之組成物及用途及其相關方法 |
| US20130102580A1 (en) * | 2011-09-22 | 2013-04-25 | Kythera Biopharmaceuticals, Inc. | Compositions and methods related to deoxycholic acid and its polymorphs |
| WO2013044119A1 (en) * | 2011-09-22 | 2013-03-28 | Kythera Biopharmaceuticals, Inc. | Compositions and methods related to deoxycholic acid and its polymorphs |
| CN104447929B (zh) * | 2014-10-28 | 2016-06-29 | 湖南科瑞生物制药股份有限公司 | 一种合成3-羰基-4-雄烯-17β羧酸的方法 |
| CN106146593B (zh) * | 2015-04-14 | 2021-06-01 | 南京迈诺威医药科技有限公司 | 一种制备去氧胆酸的方法 |
| CN106046093A (zh) * | 2016-05-30 | 2016-10-26 | 华东师范大学 | 一种石胆酸的合成方法 |
| EP3464315B1 (en) * | 2016-06-06 | 2021-09-29 | Crystal Pharma S.A.U. | Methods for the preparation of deoxycholic acid, and intermediates useful in the preparation of deoxycholic acid |
| EP3511006B1 (en) * | 2016-08-11 | 2021-08-04 | Samsung Life Public Welfare Foundation | Composition for preventing, improving or treating hair loss comprising deoxycholic acid as active ingredient |
| JP6937893B2 (ja) | 2017-08-03 | 2021-09-22 | メディトックス インク． | 胆汁酸類を製造するための方法 |
| JP6899529B2 (ja) | 2017-08-10 | 2021-07-07 | パナソニックＩｐマネジメント株式会社 | 冷凍サイクル用作動媒体および冷凍サイクルシステム |
| CN114478676B (zh) * | 2022-02-18 | 2024-05-10 | 国药集团化学试剂有限公司 | 一种脱氧胆酸钠的制备方法 |
| CN116444597B (zh) * | 2023-03-30 | 2025-03-28 | 南京迈诺威医药科技有限公司 | 一种制备去氧胆酸中间体和去氧胆酸的方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US53446A (en) | 1866-03-27 | Improvement in cultivators | ||
| US2321598A (en) | 1940-10-07 | 1943-06-15 | George A Breon & Company Inc | Preparation of desoxycholic acid |
| US2509248A (en) * | 1947-09-05 | 1950-05-30 | Merck & Co Inc | Process for producing delta9, 11-3(alpha)-hydroxy-17-ketoetiocholene |
| GB695504A (en) | 1950-10-18 | 1953-08-12 | Drug Res Inc | Method of isolating and purifying cholic and desoxycholic acids |
| US2651643A (en) * | 1951-06-19 | 1953-09-08 | Armour & Co | Purification of desoxycholic acid |
| GB716670A (en) | 1951-06-19 | 1954-10-13 | Armour & Co | Improved process for purifying desoxycholic acid from contaminating cholic acid |
| US2891972A (en) | 1952-08-19 | 1959-06-23 | Drug Res Inc | Process of separating desoxycholic acid from mixed crude bile acids or salts thereof |
| US3533908A (en) | 1967-05-19 | 1970-10-13 | Brown Co | Porous paperboard sheet having plastic microspheres therein |
| IT1202370B (it) | 1976-07-12 | 1989-02-09 | Hoffmann La Roche | Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti |
| FR2446293A1 (fr) | 1978-12-11 | 1980-08-08 | Roussel Uclaf | Procede de purification de l'acide chenodesoxycholique |
| IT8167097A0 (it) | 1981-01-26 | 1981-01-26 | Unilever Nv | Composizione cosmetica per il trattamento della pelle o dei capelli |
| JP2812397B2 (ja) | 1988-04-08 | 1998-10-22 | ヘキスト マリオン ルーセル | ９α−ヒドロキシ−１７−メチレンステロイド，その製造方法及びコルチコステロイドの製造方法 |
| US5085864A (en) | 1989-10-30 | 1992-02-04 | Abbott Laboratories | Injectable formulation for lipophilic drugs |
| CA2033725C (en) | 1990-01-24 | 2001-05-29 | Folker Pittrof | Pharmaceutical and cosmetic compositions containing a salt of cholanic acid |
| WO1996003127A1 (en) | 1994-07-25 | 1996-02-08 | Nda International, Inc. | A method of treating chemical dependency in mammals and a composition therefor |
| US20020107291A1 (en) | 1997-05-26 | 2002-08-08 | Vincenzo De Tommaso | Clear, injectable formulation of an anesthetic compound |
| IL123998A (en) | 1998-04-08 | 2004-09-27 | Galmed Int Ltd | Conjugates of bile salts and pharmaceutical preparations containing them |
| US6417179B1 (en) | 1998-10-13 | 2002-07-09 | Craig G. Burkhart | Ear wax solution |
| JP2002536415A (ja) * | 1999-02-12 | 2002-10-29 | セルパス インコーポレイテッド | 抗腫瘍療法 |
| KR100848344B1 (ko) | 2000-02-04 | 2008-07-25 | 유서홍 | 담즙산 함유 청정 수용액 제형의 제조 |
| JP2004534042A (ja) | 2001-05-22 | 2004-11-11 | インフラジム ファーマシューティカルズ リミテッド | ステロイド−５−エン化合物のステロイド−５−エン−７−オン化合物へのアリル酸化、続くヒドロホウ素化および酸化による、６，７−ジヒドロキシステロイドの生成のための方法およびこの方法の中間体 |
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| SI2422789T1 (en) | 2004-05-19 | 2018-07-31 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Injectable coposition comprising sodium deoxycholate |
| US7754230B2 (en) | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
| US20060222695A1 (en) | 2005-04-01 | 2006-10-05 | Filiberto Zadini | Deoxycholic acid liposome-based dermatological topical preparation |
| CN101148468A (zh) | 2006-09-19 | 2008-03-26 | 天津科技大学 | 以动物胆汁为原料高效提取胆红素和胆汁酸技术 |
| BRPI0808684B1 (pt) * | 2007-01-19 | 2021-08-10 | Intercept Pharmaceuticals, Inc | Compostos moduladores de tgr5, composição e seus usos |
| SI2407475T1 (sl) * | 2007-06-19 | 2016-03-31 | Kythera Biopharmaceuticals, Inc. | Priprava sintetične žolčne kisline |
| JOP20180077A1 (ar) * | 2007-06-19 | 2019-01-30 | Kythera Biopharmaceuticals Inc | تركيبات وطرق لحمض صفراوي تخليقي |
| US20080318870A1 (en) | 2007-06-19 | 2008-12-25 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| US8309746B2 (en) * | 2008-06-06 | 2012-11-13 | Harbor Therapeutics, Inc | Methods for preparing 17-alkynyl-7-hydroxy steroids and related compounds |
| GB2480632A (en) | 2010-05-25 | 2011-11-30 | Kythera Biopharmaceuticals Inc | Preparation of 12-keto and 12-alpha-hydroxy steroids |
| TWI665211B (zh) | 2011-06-16 | 2019-07-11 | 美商凱瑟拉生物製藥有限公司 | 去氧膽酸之組成物及用途及其相關方法 |
| US20130102580A1 (en) | 2011-09-22 | 2013-04-25 | Kythera Biopharmaceuticals, Inc. | Compositions and methods related to deoxycholic acid and its polymorphs |
-
2010
- 2010-05-25 GB GB1008726A patent/GB2480632A/en not_active Withdrawn
- 2010-12-17 KR KR1020177011484A patent/KR101862599B1/ko not_active Expired - Fee Related
- 2010-12-17 KR KR1020127017236A patent/KR101787719B1/ko not_active Expired - Fee Related
- 2010-12-17 SG SG10201509046TA patent/SG10201509046TA/en unknown
- 2010-12-17 CA CA2782478A patent/CA2782478A1/en not_active Abandoned
- 2010-12-17 EA EA201290334A patent/EA031768B1/ru not_active IP Right Cessation
- 2010-12-17 CN CN201710119383.8A patent/CN107011401A/zh active Pending
- 2010-12-17 CN CN201710119352.2A patent/CN106955287A/zh active Pending
- 2010-12-17 MY MYPI2012002415A patent/MY167891A/en unknown
- 2010-12-17 WO PCT/US2010/061150 patent/WO2011075701A2/en not_active Ceased
- 2010-12-17 CN CN2010800567638A patent/CN102812035A/zh active Pending
- 2010-12-17 US US13/140,421 patent/US20130137884A1/en not_active Abandoned
- 2010-12-17 SG SG2012044665A patent/SG181768A1/en unknown
- 2010-12-17 ES ES10798913.9T patent/ES2575559T3/es active Active
- 2010-12-17 EP EP10798913.9A patent/EP2513132B9/en not_active Not-in-force
- 2010-12-17 JP JP2012544924A patent/JP6393023B2/ja not_active Expired - Fee Related
- 2010-12-17 AU AU2010330760A patent/AU2010330760B2/en not_active Ceased
- 2010-12-17 PH PH1/2012/501233A patent/PH12012501233A1/en unknown
- 2010-12-17 EP EP15202046.7A patent/EP3040342A1/en not_active Withdrawn
- 2010-12-17 KR KR1020187014486A patent/KR102058420B1/ko not_active Expired - Fee Related
- 2010-12-17 EA EA201791511A patent/EA035380B1/ru not_active IP Right Cessation
- 2010-12-17 SG SG10201803507YA patent/SG10201803507YA/en unknown
-
2012
- 2012-06-07 IL IL220225A patent/IL220225A0/en unknown
- 2012-06-14 ZA ZA2012/04388A patent/ZA201204388B/en unknown
-
2014
- 2014-09-19 NZ NZ700195A patent/NZ700195A/en not_active IP Right Cessation
- 2014-11-04 US US14/532,940 patent/US9683007B2/en active Active
-
2016
- 2016-08-22 JP JP2016161932A patent/JP6568025B2/ja not_active Expired - Fee Related
-
2017
- 2017-05-23 US US15/603,290 patent/US10005813B2/en active Active
-
2018
- 2018-05-25 US US15/990,135 patent/US10472384B2/en active Active
- 2018-09-02 IL IL261526A patent/IL261526A/en unknown
-
2019
- 2019-10-02 US US16/591,539 patent/US10981946B2/en active Active
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