GB695504A - Method of isolating and purifying cholic and desoxycholic acids - Google Patents
Method of isolating and purifying cholic and desoxycholic acidsInfo
- Publication number
- GB695504A GB695504A GB12692/51A GB1269251A GB695504A GB 695504 A GB695504 A GB 695504A GB 12692/51 A GB12692/51 A GB 12692/51A GB 1269251 A GB1269251 A GB 1269251A GB 695504 A GB695504 A GB 695504A
- Authority
- GB
- United Kingdom
- Prior art keywords
- base
- acid
- desoxycholic
- cholic
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
Desoxycholic acid is isolated from a mixture of bile acids, by adding to the mixture a base in aqueous solution capable of causing preferential solution of the cholic acid. Any weak base have a dissociation constant 1 x 10-5 to 1 x 10-8 affords a good separation, e.g. ammonia, morpholine and triethanolamine. The base is added in an amount just sufficient to cause solution of the bile acids at an elevated temperature and on cooling the desoxycholic acid separates. When utilizing a volatile amine such as ammonia the base may be conveniently removed by evaporation depositing the desoxycholic acid. Any residual cholic acid in the deposited desoxycholic acid may be removed by treating with an aqueous isopropyl alcohol mixture made weakly basic by addition of 1 per cent of a weakly basic inorganic salt equal in chemical equivalent to sodium bicarbonate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US695504XA | 1950-10-18 | 1950-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB695504A true GB695504A (en) | 1953-08-12 |
Family
ID=22089726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB12692/51A Expired GB695504A (en) | 1950-10-18 | 1951-05-30 | Method of isolating and purifying cholic and desoxycholic acids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB695504A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012174229A2 (en) | 2011-06-16 | 2012-12-20 | Kythera Biopharmaceuticals, Inc. | Methods for the synthesis and purification of deoxycholic acid |
| US9683007B2 (en) | 2009-12-18 | 2017-06-20 | Kythera Biopharmaceuticals, Inc. | Methods for the purification of deoxycholic acid |
| CN115093454A (en) * | 2022-07-04 | 2022-09-23 | 青海夏都医药有限公司 | Co-production preparation method of cholic acid and deoxycholic acid compounds |
-
1951
- 1951-05-30 GB GB12692/51A patent/GB695504A/en not_active Expired
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9683007B2 (en) | 2009-12-18 | 2017-06-20 | Kythera Biopharmaceuticals, Inc. | Methods for the purification of deoxycholic acid |
| US10005813B2 (en) | 2009-12-18 | 2018-06-26 | Kythera Biopharmaceuticals, Inc. | Methods for the purification of deoxycholic acid |
| US10472384B2 (en) | 2009-12-18 | 2019-11-12 | Allergan Sales, Llc | Methods for the purification of deoxycholic acid |
| US10981946B2 (en) | 2009-12-18 | 2021-04-20 | Allergan Sales, Llc | Methods for the purification of deoxycholic acid |
| WO2012174229A2 (en) | 2011-06-16 | 2012-12-20 | Kythera Biopharmaceuticals, Inc. | Methods for the synthesis and purification of deoxycholic acid |
| EP2721047A2 (en) * | 2011-06-16 | 2014-04-23 | Kythera Biopharmaceuticals, Inc. | Methods for the synthesis and purification of deoxycholic acid |
| EP2721047A4 (en) * | 2011-06-16 | 2014-10-29 | Kythera Biopharmaceuticals Inc | Methods for the synthesis and purification of deoxycholic acid |
| EP3138850A1 (en) * | 2011-06-16 | 2017-03-08 | Kythera Biopharmaceuticals, Inc. | Compositions containing deoxycholic acid and c1-3-alcohols, directed to the purification of deoxycholic acid |
| CN115093454A (en) * | 2022-07-04 | 2022-09-23 | 青海夏都医药有限公司 | Co-production preparation method of cholic acid and deoxycholic acid compounds |
| CN115093454B (en) * | 2022-07-04 | 2023-09-01 | 青海夏都医药有限公司 | Co-production preparation method of cholic acid and deoxycholic acid compound |
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