CN102812035A - 脱氧胆酸的纯化方法 - Google Patents
脱氧胆酸的纯化方法 Download PDFInfo
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- CN102812035A CN102812035A CN2010800567638A CN201080056763A CN102812035A CN 102812035 A CN102812035 A CN 102812035A CN 2010800567638 A CN2010800567638 A CN 2010800567638A CN 201080056763 A CN201080056763 A CN 201080056763A CN 102812035 A CN102812035 A CN 102812035A
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- ZVCVUYCHMIUYDF-ZYTIWRKMSA-N C[C@H](CCC(OC)=O)C(CCC1C(CC[C@H]2[C@]3(C)CCCC2)[C@@]32O[C@@H]22)[C@@]1(C)C2O Chemical compound C[C@H](CCC(OC)=O)C(CCC1C(CC[C@H]2[C@]3(C)CCCC2)[C@@]32O[C@@H]22)[C@@]1(C)C2O ZVCVUYCHMIUYDF-ZYTIWRKMSA-N 0.000 description 1
- FKEDTKXWEOKYFM-MVKNEBPWSA-N C[C@H](CCC(OC)=O)C(CCC1C2C(C3)C(C)(CCCC4)C4CC2)[C@@]1(C)[C@@H]3O Chemical compound C[C@H](CCC(OC)=O)C(CCC1C2C(C3)C(C)(CCCC4)C4CC2)[C@@]1(C)[C@@H]3O FKEDTKXWEOKYFM-MVKNEBPWSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710119383.8A CN107011401A (zh) | 2009-12-18 | 2010-12-17 | 脱氧胆酸化合物及其纯化方法 |
| CN201710119352.2A CN106955287A (zh) | 2009-12-18 | 2010-12-17 | 脱氧胆酸的组合物、用途及其纯化方法 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28813209P | 2009-12-18 | 2009-12-18 | |
| US61/288,132 | 2009-12-18 | ||
| US30200710P | 2010-02-05 | 2010-02-05 | |
| US61/302,007 | 2010-02-05 | ||
| US30381610P | 2010-02-12 | 2010-02-12 | |
| US61/303,816 | 2010-02-12 | ||
| GB10087260 | 2010-05-25 | ||
| GB1008726A GB2480632A (en) | 2010-05-25 | 2010-05-25 | Preparation of 12-keto and 12-alpha-hydroxy steroids |
| US34868610P | 2010-05-26 | 2010-05-26 | |
| US61/348,686 | 2010-05-26 | ||
| PCT/US2010/061150 WO2011075701A2 (en) | 2009-12-18 | 2010-12-17 | Methods for the purification of deoxycholic acid |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710119383.8A Division CN107011401A (zh) | 2009-12-18 | 2010-12-17 | 脱氧胆酸化合物及其纯化方法 |
| CN201710119352.2A Division CN106955287A (zh) | 2009-12-18 | 2010-12-17 | 脱氧胆酸的组合物、用途及其纯化方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102812035A true CN102812035A (zh) | 2012-12-05 |
Family
ID=42341289
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710119383.8A Pending CN107011401A (zh) | 2009-12-18 | 2010-12-17 | 脱氧胆酸化合物及其纯化方法 |
| CN2010800567638A Pending CN102812035A (zh) | 2009-12-18 | 2010-12-17 | 脱氧胆酸的纯化方法 |
| CN201710119352.2A Pending CN106955287A (zh) | 2009-12-18 | 2010-12-17 | 脱氧胆酸的组合物、用途及其纯化方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710119383.8A Pending CN107011401A (zh) | 2009-12-18 | 2010-12-17 | 脱氧胆酸化合物及其纯化方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710119352.2A Pending CN106955287A (zh) | 2009-12-18 | 2010-12-17 | 脱氧胆酸的组合物、用途及其纯化方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US20130137884A1 (enExample) |
| EP (2) | EP3040342A1 (enExample) |
| JP (2) | JP6393023B2 (enExample) |
| KR (3) | KR102058420B1 (enExample) |
| CN (3) | CN107011401A (enExample) |
| AU (1) | AU2010330760B2 (enExample) |
| CA (1) | CA2782478A1 (enExample) |
| EA (2) | EA031768B1 (enExample) |
| ES (1) | ES2575559T3 (enExample) |
| GB (1) | GB2480632A (enExample) |
| IL (2) | IL220225A0 (enExample) |
| MY (1) | MY167891A (enExample) |
| NZ (1) | NZ700195A (enExample) |
| PH (1) | PH12012501233A1 (enExample) |
| SG (3) | SG181768A1 (enExample) |
| WO (1) | WO2011075701A2 (enExample) |
| ZA (1) | ZA201204388B (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106046093A (zh) * | 2016-05-30 | 2016-10-26 | 华东师范大学 | 一种石胆酸的合成方法 |
| CN106146593A (zh) * | 2015-04-14 | 2016-11-23 | 南京诺瑞特医药科技有限公司 | 一种制备去氧胆酸的方法 |
| CN109195605A (zh) * | 2016-08-11 | 2019-01-11 | 社会福祉法人三星生命公益财团 | 包含脱氧胆酸作为有效成分的用于预防、改善或治疗脱发的组合物 |
| CN114478676A (zh) * | 2022-02-18 | 2022-05-13 | 国药集团化学试剂有限公司 | 一种高纯脱氧胆酸钠的制备方法 |
| CN116444597A (zh) * | 2023-03-30 | 2023-07-18 | 南京迈诺威医药科技有限公司 | 一种制备去氧胆酸中间体和去氧胆酸的方法 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| GB2480632A (en) | 2010-05-25 | 2011-11-30 | Kythera Biopharmaceuticals Inc | Preparation of 12-keto and 12-alpha-hydroxy steroids |
| WO2012112940A1 (en) | 2011-02-18 | 2012-08-23 | Kythera Biopharmaceuticals, Inc. | Treatment of submental fat |
| US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
| EP3138850B8 (en) * | 2011-06-16 | 2019-09-11 | Allergan Sales, LLC | Compositions containing deoxycholic acid and 10% deionized water in ethanol, directed to the purification of deoxycholic acid |
| US20130102580A1 (en) * | 2011-09-22 | 2013-04-25 | Kythera Biopharmaceuticals, Inc. | Compositions and methods related to deoxycholic acid and its polymorphs |
| WO2013044119A1 (en) * | 2011-09-22 | 2013-03-28 | Kythera Biopharmaceuticals, Inc. | Compositions and methods related to deoxycholic acid and its polymorphs |
| CN104447929B (zh) * | 2014-10-28 | 2016-06-29 | 湖南科瑞生物制药股份有限公司 | 一种合成3-羰基-4-雄烯-17β羧酸的方法 |
| ES2905546T3 (es) * | 2016-06-06 | 2022-04-11 | Crystal Pharma Sau | Métodos para la preparación de ácido desoxicólico e intermedios útiles en la preparación de ácido desoxicólico |
| KR20200026273A (ko) | 2017-08-03 | 2020-03-10 | (주)메디톡스 | 담즙산류를 제조하기 위한 방법 |
| JP6899529B2 (ja) | 2017-08-10 | 2021-07-07 | パナソニックＩｐマネジメント株式会社 | 冷凍サイクル用作動媒体および冷凍サイクルシステム |
Citations (1)
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| WO2008157635A2 (en) * | 2007-06-19 | 2008-12-24 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid composition, method, and preparation |
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| GB695504A (en) | 1950-10-18 | 1953-08-12 | Drug Res Inc | Method of isolating and purifying cholic and desoxycholic acids |
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| GB716670A (en) | 1951-06-19 | 1954-10-13 | Armour & Co | Improved process for purifying desoxycholic acid from contaminating cholic acid |
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| FR2446293A1 (fr) | 1978-12-11 | 1980-08-08 | Roussel Uclaf | Procede de purification de l'acide chenodesoxycholique |
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| JP2002536415A (ja) * | 1999-02-12 | 2002-10-29 | セルパス インコーポレイテッド | 抗腫瘍療法 |
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| US7754230B2 (en) | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| ES2660172T3 (es) | 2004-05-19 | 2018-03-21 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Composición inyectable que comprende desoxicolato de sodio |
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| CN101148468A (zh) | 2006-09-19 | 2008-03-26 | 天津科技大学 | 以动物胆汁为原料高效提取胆红素和胆汁酸技术 |
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| CN106146593B (zh) * | 2015-04-14 | 2021-06-01 | 南京迈诺威医药科技有限公司 | 一种制备去氧胆酸的方法 |
| CN106046093A (zh) * | 2016-05-30 | 2016-10-26 | 华东师范大学 | 一种石胆酸的合成方法 |
| CN109195605A (zh) * | 2016-08-11 | 2019-01-11 | 社会福祉法人三星生命公益财团 | 包含脱氧胆酸作为有效成分的用于预防、改善或治疗脱发的组合物 |
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