JP2013512962A5 - - Google Patents

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Publication number
JP2013512962A5
JP2013512962A5 JP2012543213A JP2012543213A JP2013512962A5 JP 2013512962 A5 JP2013512962 A5 JP 2013512962A5 JP 2012543213 A JP2012543213 A JP 2012543213A JP 2012543213 A JP2012543213 A JP 2012543213A JP 2013512962 A5 JP2013512962 A5 JP 2013512962A5
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JP
Japan
Prior art keywords
sulfonamide
alkyl
aryl
benzene
methanesulfonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012543213A
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English (en)
Japanese (ja)
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JP2013512962A (ja
JP5826762B2 (ja
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Application filed filed Critical
Priority claimed from PCT/US2010/059335 external-priority patent/WO2011071951A2/en
Publication of JP2013512962A publication Critical patent/JP2013512962A/ja
Publication of JP2013512962A5 publication Critical patent/JP2013512962A5/ja
Application granted granted Critical
Publication of JP5826762B2 publication Critical patent/JP5826762B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2012543213A 2009-12-07 2010-12-07 N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体 Expired - Fee Related JP5826762B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26740109P 2009-12-07 2009-12-07
US61/267,401 2009-12-07
US29122409P 2009-12-30 2009-12-30
US61/291,224 2009-12-30
PCT/US2010/059335 WO2011071951A2 (en) 2009-12-07 2010-12-07 N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015203216A Division JP2016094394A (ja) 2009-12-07 2015-10-14 N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体

Publications (3)

Publication Number Publication Date
JP2013512962A JP2013512962A (ja) 2013-04-18
JP2013512962A5 true JP2013512962A5 (enExample) 2014-01-23
JP5826762B2 JP5826762B2 (ja) 2015-12-02

Family

ID=43877339

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012543213A Expired - Fee Related JP5826762B2 (ja) 2009-12-07 2010-12-07 N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体
JP2015203216A Pending JP2016094394A (ja) 2009-12-07 2015-10-14 N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015203216A Pending JP2016094394A (ja) 2009-12-07 2015-10-14 N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体

Country Status (10)

Country Link
US (4) US20110144067A1 (enExample)
EP (1) EP2509941B1 (enExample)
JP (2) JP5826762B2 (enExample)
CN (2) CN102753520B (enExample)
AU (2) AU2010328234B2 (enExample)
CA (1) CA2782110A1 (enExample)
ES (1) ES2719101T3 (enExample)
IN (1) IN2012DN05025A (enExample)
MX (1) MX2012006349A (enExample)
WO (1) WO2011071951A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104119310B (zh) 2007-09-26 2017-04-12 约翰斯霍普金斯大学 作为新的在生理学上可用于硝酰基供体的n‑羟基磺酰胺衍生物及包含其的医药组合物
US20110160200A1 (en) * 2009-11-23 2011-06-30 Cardioxyl Pharmaceuticals, Inc. Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension
US9018411B2 (en) * 2009-12-07 2015-04-28 Cardioxyl Pharmaceuticals, Inc. Bis-acylated hydroxylamine derivatives
CN104053647B (zh) 2011-10-17 2018-06-01 约翰斯霍普金斯大学 作为hno供体的经羟胺取代的米氏酸、巴比妥酸和吡唑啉酮衍生物
WO2014070919A1 (en) 2012-11-01 2014-05-08 The Johns Hopkins University Controlled hno release through intramolecular cyclization-elimination
RS56968B1 (sr) 2013-01-18 2018-05-31 Cardioxyl Pharmaceuticals Inc Donori nitroksila sa poboljšanim terapijskim indeksom
WO2015109210A1 (en) 2014-01-17 2015-07-23 Cardioxyl Pharmaceuticals, Inc. N-hydroxymethanesulfonamide nitroxyl donors
US9464061B2 (en) 2014-05-27 2016-10-11 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives
EP3148983A1 (en) 2014-05-27 2017-04-05 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives as nitroxyl donors
ES2749682T3 (es) 2014-05-27 2020-03-23 Cardioxyl Pharmaceuticals Inc Derivados de pirazolona como donadores de nitroxilo
US10583141B2 (en) 2015-06-26 2020-03-10 The Johns Hopkins University N-substituted hydroxamic acids with carbon-based leaving groups as efficient HNO donors and uses thereof
JP2018526448A (ja) * 2015-09-07 2018-09-13 浙江華海薬業股▲フン▼有限公司 一酸化窒素を放出可能なプロドラッグ分子
WO2017070084A1 (en) * 2015-10-19 2017-04-27 Cardioxyl Pharmaceuticals, Inc. N-hydroxylsulfonamide derivatives as nitroxyl donors
WO2017070081A1 (en) 2015-10-19 2017-04-27 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors
CN110139854A (zh) 2016-07-28 2019-08-16 约翰斯霍普金斯大学 O-取代异羟肟酸
KR20190103281A (ko) 2017-01-03 2019-09-04 카르디옥실 파마슈티칼스 인코포레이티드 니트록실 공여 화합물의 투여 방법
CN108318615A (zh) * 2018-03-16 2018-07-24 湖北亿诺瑞生物制药有限公司 顶空气相色谱法检测肝素钠中残留溶剂的方法
CN113621098B (zh) * 2020-05-09 2022-11-04 中国石油天然气股份有限公司 丙烯聚合催化剂、丙烯聚合催化剂体系及其制备与应用
CN114195731A (zh) * 2021-11-24 2022-03-18 海南大学 一种氢化亚硝酰供体化合物及其制备方法
WO2025043108A1 (en) 2023-08-23 2025-02-27 Bristol -Myers S Quibb Company Co-crystals of nitroxyl donating compounds

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1283890A (fr) * 1959-12-28 1962-02-09 Ajinomoto Kk Procédé de préparation d'inosinate de sodium
US3219428A (en) * 1961-04-17 1965-11-23 Hooker Chemical Corp O,n-diacylated-3,4-dihalophenylhydroxylamines as herbicides
US3382243A (en) * 1965-05-17 1968-05-07 American Home Prod Acetamides and their preparation
US3458570A (en) * 1966-07-28 1969-07-29 Stauffer Chemical Co N-substituted phenylsulfonyl-hydroxylamines
US3948967A (en) * 1968-01-03 1976-04-06 Velsicol Chemical Corporation Aryl urea carbonates
US3661944A (en) * 1970-07-01 1972-05-09 Smith Kline French Lab 4-(n-lower alkanoyl)hydroxylamino-4'-aminodiphenylsulfone compounds
US3746727A (en) * 1971-06-07 1973-07-17 Shell Oil Co Benzenesulfhydroxamic acids and their derivatives
GB1570362A (en) * 1976-03-09 1980-07-02 Agfa Gevaert Ag Method of introducing photographic additives into silver salt emulsions
JPS567710A (en) 1979-06-28 1981-01-27 Sansho Seiyaku Kk Whitening cosmetic
US4405357A (en) * 1980-06-02 1983-09-20 Fmc Corporation Herbicidal 3-isoxazolidinones and hydroxamic acids
US4539321A (en) * 1981-10-26 1985-09-03 William H. Rorer, Inc. 5-Diaza-aryl-3-substituted pyridone compounds
EP0188040B1 (en) * 1985-01-11 1991-08-14 Abbott Laboratories Limited Slow release solid preparation
US4663351A (en) * 1985-08-23 1987-05-05 Berlex Laboratories, Inc. Dobutamine tri-isobutyric acid ester and the use thereof as a cardiotonic agent
US4798824A (en) * 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US4954526A (en) * 1989-02-28 1990-09-04 The United States Of America As Represented By The Department Of Health And Human Services Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US5039705A (en) * 1989-09-15 1991-08-13 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5212204A (en) * 1989-10-18 1993-05-18 The United States Of America As Represented By The Department Of Health And Human Services Antihypertensive compositions and use thereof
JPH04235171A (ja) * 1990-07-26 1992-08-24 Sumitomo Chem Co Ltd スルホヒドロキサム酸誘導体、その製造法およびそれを有効成分とする除草剤
JP2773959B2 (ja) * 1990-07-10 1998-07-09 信越化学工業株式会社 大腸内放出性固形製剤
US5418212A (en) * 1990-11-30 1995-05-23 Kumiai Chemical Industry Co., Ltd. Alkanoic acid amide derivative or its salt, and herbicidal composition
JPH05341461A (ja) * 1992-06-05 1993-12-24 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
US5278192A (en) * 1992-07-02 1994-01-11 The Research Foundation Of State University Of New York Method of vasodilator therapy for treating a patient with a condition
AU704173B2 (en) * 1993-11-02 1999-04-15 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College, The Use of nitric oxide releasing compounds as protective agents in ischemia reperfusion injury
US5532256A (en) * 1994-05-18 1996-07-02 American Home Products Corporation New azolidinediones and thiadiazolidinediones as antihyperglycemic agents
DE19533023B4 (de) * 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
US6043232A (en) * 1997-07-23 2000-03-28 Nitromed, Inc. Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US5674894A (en) * 1995-05-15 1997-10-07 G.D. Searle & Co. Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
US5714511A (en) * 1995-07-31 1998-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
DE19545878A1 (de) * 1995-12-08 1997-06-12 Basf Ag Pyridylcarbamate, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
WO1998007702A1 (en) * 1996-08-23 1998-02-26 Kowa Co., Ltd. Diamide compounds and drugs containing the same
US5962521A (en) * 1997-04-04 1999-10-05 Guilford Pharmaceuticals Inc. Hydroxamic acid derivatives
TW453999B (en) * 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
GB9726989D0 (en) * 1997-12-22 1998-02-18 Ciba Geigy Ag Organic compounds
UA73092C2 (uk) * 1998-07-17 2005-06-15 Брістол-Майерс Сквібб Компані Таблетка з ентеросолюбільним покриттям і спосіб її приготування
US6638534B1 (en) 1998-07-28 2003-10-28 Tanabe Seiyaku Co., Ltd. Preparation capable of releasing drug at target site in intestine
CA2348741C (en) * 1998-10-30 2010-04-20 Nitromed Inc. Nitrosasted and nitrosylated nonsteroidal antiinflammatory compounds, comositions and methods of use
CA2382549C (en) * 1999-08-30 2005-03-15 Aventis Pharma Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
WO2001093872A1 (de) * 2000-06-08 2001-12-13 Jomaa Pharmaka Gmbh Verwendung von phosphororganischen hydroxamsäurederivaten zur herstellung von arzneimitteln
US20010053795A1 (en) * 2000-06-20 2001-12-20 Bond Richard A. Paradoxical pharmacology
WO2001098286A1 (en) * 2000-06-22 2001-12-27 Nitromed, Inc. Nitrosated and nitrosylated taxanes, compositions and methods of use
AU2002249812B2 (en) * 2000-12-21 2005-11-10 Nicox S.A. Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
US20030068386A1 (en) 2001-09-05 2003-04-10 Stoyanovsky Detcho A. Method of treating cancerous disease
US20040038947A1 (en) 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
US20040077691A1 (en) * 2002-06-21 2004-04-22 Medinox, Inc. Hydroxamate derivatives of non-steroidal anti-inflammatory drugs
US6936639B2 (en) * 2002-08-21 2005-08-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxyl progenitors in the treatment of heart failure
US20090281067A1 (en) * 2004-01-30 2009-11-12 The John Hopkins University Nitroxyl progenitor compounds and methods of use
US20090298795A1 (en) * 2005-06-23 2009-12-03 The Johns Hopins University Thiol-Sensitive Positive Inotropes
TWI282084B (en) 2005-07-08 2007-06-01 Jeng-Tzung Chen Guitar
WO2007045962A2 (en) * 2005-10-18 2007-04-26 Orchid Research Laboratories Limited Novel hdac inhibitors
JP2009518397A (ja) * 2005-12-08 2009-05-07 ジョンズ ホプキンズ ユニヴァーシティー 高い抗癌活性及び持続性抗マラリア活性を有するトリオキサンダイマー
CN103435524B (zh) * 2006-03-17 2016-02-10 约翰斯霍普金斯大学 作为有生理学价值的硝酰氧基供体的n-羟基磺酰胺衍生物
JP4783657B2 (ja) * 2006-03-27 2011-09-28 富士フイルム株式会社 ポジ型レジスト組成物及び該組成物を用いたパターン形成方法
AU2007238600B2 (en) 2006-04-13 2012-01-19 Wake Forest University Health Sciences C-nitroso-derived nitroxyl donors
CN104119310B (zh) * 2007-09-26 2017-04-12 约翰斯霍普金斯大学 作为新的在生理学上可用于硝酰基供体的n‑羟基磺酰胺衍生物及包含其的医药组合物
MX2010011924A (es) 2008-05-07 2010-11-30 Cardioxyl Pharmaceuticals Inc Nuevos compuestos nitrosos como donadores de nitroxilo y metodos de uso de los mismos.
US20110160200A1 (en) * 2009-11-23 2011-06-30 Cardioxyl Pharmaceuticals, Inc. Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension
US9018411B2 (en) * 2009-12-07 2015-04-28 Cardioxyl Pharmaceuticals, Inc. Bis-acylated hydroxylamine derivatives

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