JP2018537419A5 - - Google Patents

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Publication number
JP2018537419A5
JP2018537419A5 JP2018519918A JP2018519918A JP2018537419A5 JP 2018537419 A5 JP2018537419 A5 JP 2018537419A5 JP 2018519918 A JP2018519918 A JP 2018519918A JP 2018519918 A JP2018519918 A JP 2018519918A JP 2018537419 A5 JP2018537419 A5 JP 2018537419A5
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JP
Japan
Prior art keywords
sulfonamide
alkyl
methoxy
membered
benzene
Prior art date
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Granted
Application number
JP2018519918A
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English (en)
Japanese (ja)
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JP6957459B2 (ja
JP2018537419A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/057478 external-priority patent/WO2017070084A1/en
Publication of JP2018537419A publication Critical patent/JP2018537419A/ja
Publication of JP2018537419A5 publication Critical patent/JP2018537419A5/ja
Application granted granted Critical
Publication of JP6957459B2 publication Critical patent/JP6957459B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2018519918A 2015-10-19 2016-10-18 ニトロキシルドナーとしてのｎ−ヒドロキシルスルホンアミド誘導体 Expired - Fee Related JP6957459B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562243267P 2015-10-19 2015-10-19
US62/243,267 2015-10-19
PCT/US2016/057478 WO2017070084A1 (en) 2015-10-19 2016-10-18 N-hydroxylsulfonamide derivatives as nitroxyl donors

Publications (3)

Publication Number Publication Date
JP2018537419A JP2018537419A (ja) 2018-12-20
JP2018537419A5 true JP2018537419A5 (enExample) 2019-11-28
JP6957459B2 JP6957459B2 (ja) 2021-11-02

Family

ID=57223781

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018519918A Expired - Fee Related JP6957459B2 (ja) 2015-10-19 2016-10-18 ニトロキシルドナーとしてのｎ−ヒドロキシルスルホンアミド誘導体

Country Status (6)

Country Link
US (1) US10730828B2 (enExample)
EP (1) EP3365325A1 (enExample)
JP (1) JP6957459B2 (enExample)
KR (1) KR20180070672A (enExample)
CN (1) CN108368038A (enExample)
WO (1) WO2017070084A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10723704B2 (en) 2015-10-19 2020-07-28 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors
KR20190070912A (ko) 2016-07-28 2019-06-21 더 존스 홉킨스 유니버시티 O-치환된 히드록삼산
CN110520116A (zh) 2017-01-03 2019-11-29 卡尔迪奥克斯尔制药公司 供硝酰化合物的给予方法
MA52616A (fr) * 2018-05-15 2021-03-24 Bayer Ag Benzamides à substitution 1,3-thiazol-2-yl pour le traitement de maladies associées à la sensibilisation de fibres nerveuses
WO2025043108A1 (en) * 2023-08-23 2025-02-27 Bristol -Myers S Quibb Company Co-crystals of nitroxyl donating compounds
WO2025121401A1 (ja) * 2023-12-06 2025-06-12 日産化学株式会社 ピラゾール化合物及び有害生物防除剤

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE666766A (enExample) * 1964-07-11
EP0503838A3 (en) * 1991-03-08 1992-10-07 Merck & Co. Inc. Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists
JPH04321671A (ja) * 1991-04-17 1992-11-11 Mitsubishi Petrochem Co Ltd カルバモイルトリアゾール誘導体およびそれを有効成分とする除草剤
US5734081A (en) * 1994-08-05 1998-03-31 Warner-Lambert Company Arylthio compounds
JP2001026506A (ja) * 1999-04-28 2001-01-30 Takeda Chem Ind Ltd スルホンアミド誘導体
US6586617B1 (en) * 1999-04-28 2003-07-01 Sumitomo Chemical Takeda Agro Company, Limited Sulfonamide derivatives
US20040038947A1 (en) 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
US6936639B2 (en) 2002-08-21 2005-08-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxyl progenitors in the treatment of heart failure
JP2007522135A (ja) 2004-01-30 2007-08-09 ザ ジョンズ ホプキンス ユニバーシティ ニトロキシル前駆化合物および使用方法
CA2613477C (en) 2005-06-23 2013-12-03 Johns Hopkins University Thiol-sensitive positive inotropes
AU2007227457B2 (en) 2006-03-17 2013-03-28 Cardioxyl Pharmaceuticals, Inc. N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
US7696373B2 (en) 2006-04-13 2010-04-13 Wake Forest University Health Sciences C-nitroso-derived nitroxyl donors
US8227639B2 (en) 2007-09-26 2012-07-24 Cardioxyl Pharmaceuticals N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
DK2278975T3 (en) 2008-05-07 2016-12-19 Cardioxyl Pharmaceuticals Inc NOVEL nitroso compounds WHICH NITROXYLDONORER AND METHODS OF USE THEREOF
US20110160200A1 (en) 2009-11-23 2011-06-30 Cardioxyl Pharmaceuticals, Inc. Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension
IN2012DN05028A (enExample) 2009-12-07 2015-10-23 Univ Johns Hopkins
CA2782110A1 (en) 2009-12-07 2011-06-16 Johns Hopkins University N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives
CN108409662B (zh) 2011-10-17 2021-10-26 约翰斯霍普金斯大学 作为hno供体的经羟胺取代的米氏酸、巴比妥酸和吡唑啉酮衍生物
WO2014070919A1 (en) 2012-11-01 2014-05-08 The Johns Hopkins University Controlled hno release through intramolecular cyclization-elimination
MX363843B (es) 2013-01-18 2019-04-05 Cardioxyl Pharmaceuticals Inc Composiciones farmaceuticas que comprenden donadores de nitroxilo.
EP3126329B1 (en) 2014-01-17 2019-05-29 Cardioxyl Pharmaceuticals Inc. N-hydroxymethanesulfonamide nitroxyl donors
EP3148972B1 (en) 2014-05-27 2019-08-21 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors
WO2015183838A1 (en) 2014-05-27 2015-12-03 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives as nitroxyl donors
EP3313831B1 (en) 2015-06-26 2021-03-10 The Johns Hopkins University N-substituted hydroxamic acids with carbon-based leaving groups as efficient hno donors and uses thereof
US10723704B2 (en) 2015-10-19 2020-07-28 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors

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