JP2016534984A5 - - Google Patents
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- Publication number
- JP2016534984A5 JP2016534984A5 JP2016519325A JP2016519325A JP2016534984A5 JP 2016534984 A5 JP2016534984 A5 JP 2016534984A5 JP 2016519325 A JP2016519325 A JP 2016519325A JP 2016519325 A JP2016519325 A JP 2016519325A JP 2016534984 A5 JP2016534984 A5 JP 2016534984A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- heteroaryl
- aryl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052757 nitrogen Inorganic materials 0.000 claims 48
- 229910052760 oxygen Inorganic materials 0.000 claims 46
- 125000001072 heteroaryl group Chemical group 0.000 claims 43
- 125000003118 aryl group Chemical group 0.000 claims 41
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 33
- 125000000753 cycloalkyl group Chemical group 0.000 claims 33
- 229910052717 sulfur Inorganic materials 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 19
- 150000001409 amidines Chemical class 0.000 claims 12
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 claims 12
- -1 or N Inorganic materials 0.000 claims 10
- 125000001544 thienyl group Chemical group 0.000 claims 4
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims 3
- 125000004404 heteroalkyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000002785 azepinyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 125000003585 oxepinyl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 2
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000003944 tolyl group Chemical group 0.000 claims 2
- 125000005023 xylyl group Chemical group 0.000 claims 2
- FRVQGCBWBSJTQC-UHFFFAOYSA-N CCc1nc(sc1C(=O)NCCOCCOCCN)N1CCC(CC1)C1CCN(CC1)C(=O)c1ccc(cc1)-c1nc2ccccc2[nH]1 Chemical compound CCc1nc(sc1C(=O)NCCOCCOCCN)N1CCC(CC1)C1CCN(CC1)C(=O)c1ccc(cc1)-c1nc2ccccc2[nH]1 FRVQGCBWBSJTQC-UHFFFAOYSA-N 0.000 claims 1
- ZFOFFCQSWVUJAX-UHFFFAOYSA-N NCCOCCOCCNC(=O)c1ccc2nc([nH]c2c1)-c1ccccc1 Chemical compound NCCOCCOCCNC(=O)c1ccc2nc([nH]c2c1)-c1ccccc1 ZFOFFCQSWVUJAX-UHFFFAOYSA-N 0.000 claims 1
- 241000534944 Thia Species 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- GGNIKGLUPSHSBV-UHFFFAOYSA-N thiazole-5-carboxamide Chemical compound NC(=O)C1=CN=CS1 GGNIKGLUPSHSBV-UHFFFAOYSA-N 0.000 claims 1
- 0 *NC(c1cccc(NC(OC(CC2)CCN2C(c2ccc(*=*(*3)c4ccccc4)c3c2)=O)=O)c1)=O Chemical compound *NC(c1cccc(NC(OC(CC2)CCN2C(c2ccc(*=*(*3)c4ccccc4)c3c2)=O)=O)c1)=O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361885146P | 2013-10-01 | 2013-10-01 | |
| US61/885,146 | 2013-10-01 | ||
| US201462025994P | 2014-07-17 | 2014-07-17 | |
| US62/025,994 | 2014-07-17 | ||
| PCT/IB2014/064998 WO2015049651A1 (en) | 2013-10-01 | 2014-10-01 | Compounds for affinity chromatography and for extending the half-life of a therapeutic agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016534984A JP2016534984A (ja) | 2016-11-10 |
| JP2016534984A5 true JP2016534984A5 (enExample) | 2017-11-16 |
Family
ID=51743521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519325A Pending JP2016534984A (ja) | 2013-10-01 | 2014-10-01 | アフィニティークロマトグラフィーのためおよび治療薬の半減期の延長のための化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9809558B2 (enExample) |
| EP (1) | EP3052483B1 (enExample) |
| JP (1) | JP2016534984A (enExample) |
| KR (1) | KR20160060660A (enExample) |
| CN (1) | CN105593222B (enExample) |
| AU (1) | AU2014330781B2 (enExample) |
| BR (1) | BR112016007371A2 (enExample) |
| CA (1) | CA2925862A1 (enExample) |
| ES (1) | ES2721098T3 (enExample) |
| RU (1) | RU2016117052A (enExample) |
| SG (1) | SG11201601870VA (enExample) |
| WO (1) | WO2015049651A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10697983B2 (en) | 2015-09-08 | 2020-06-30 | Merck Patent Gmbh | Methods of evaluating quality of media suitable for removing anti-A or anti-B antibodies |
| US10697982B2 (en) | 2015-09-08 | 2020-06-30 | Merck Patent Gmbh | Methods of evaluating quality of a chromatography media which binds anti-A or anti-B antibodies |
| US20170066839A1 (en) | 2015-09-08 | 2017-03-09 | Merck Patent Gmbh | Novel affinity chromatography media for removal of anti-a and/or anti-b antibodies |
| US20200047084A1 (en) * | 2017-03-30 | 2020-02-13 | Hitachi Chemical Company, Ltd. | Separation material |
| US20220009959A1 (en) * | 2018-11-26 | 2022-01-13 | North Carolina State University | Peptide ligands for capture of host cell proteins |
| BR112021011595A2 (pt) | 2018-12-21 | 2021-11-30 | Jiangsu Hengrui Medicine Co | Proteína biespecífica |
| DK4069691T3 (da) | 2019-12-06 | 2024-10-28 | Vertex Pharma | Substituerede tetrahydrofuraner som modulatorer af natriumkanaler |
| MA64853B1 (fr) | 2021-06-04 | 2025-11-28 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hétéro)aryl) tétrahydrofuran carboxamides utilisés en tant que modulateurs de canaux sodiques |
| IL309175A (en) | 2021-06-18 | 2024-02-01 | Aligos Therapeutics Inc | Methods and preparations for targeting PD-L1 |
| CN119212987A (zh) | 2021-12-16 | 2024-12-27 | 安力高医药股份有限公司 | 用于靶向pd-l1的方法和组合物 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH187973A4 (de) * | 1973-02-09 | 1977-03-31 | Hoechst Ag | Verfahren zum optischen Aufhellen von Textilmaterialien |
| US4722896A (en) | 1981-01-26 | 1988-02-02 | The Beth Israel Hospital Association | Method for affinity purification of hybridoma antibodies |
| US5849874A (en) | 1991-07-12 | 1998-12-15 | Gist-Brocades, N.V. | Process for the purification of serum albumin |
| JP2825755B2 (ja) * | 1993-04-07 | 1998-11-18 | 大塚製薬株式会社 | ピペリジン誘導体を有効成分とする末梢血管拡張剤および新規ピペリジン誘導体 |
| JPH09511492A (ja) * | 1994-02-03 | 1997-11-18 | ザ ピコワー インスティテュート フォア メディカル リサーチ | アミロイドーシスの前進性グリコシル化終末産物仲介モジュレーション用組成物及び方法 |
| WO2003084469A2 (en) | 2002-04-01 | 2003-10-16 | Utah Ventures Ii, L.P. | Tissue-specific endothelial membrane proteins |
| GB9914825D0 (en) * | 1999-06-24 | 1999-08-25 | Smithkline Beecham Spa | Novel compounds |
| CA2363274A1 (en) | 1999-12-27 | 2001-07-05 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs for hepatitis c |
| DE10139416A1 (de) * | 2001-08-17 | 2003-03-06 | Aventis Pharma Gmbh | Aminoalkyl substituierte aromatische Bicyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| ATE425753T1 (de) | 2002-08-02 | 2009-04-15 | Genesoft Pharmaceuticals Inc | Biaryl-verbindungen mit antiinfektiver wirkung |
| US7777051B2 (en) | 2003-05-13 | 2010-08-17 | Icagen, Inc. | Asymmetric benzimidazoles and related compounds as potassium channel modulators |
| EP2298770A1 (en) | 2005-11-03 | 2011-03-23 | ChemBridge Corporation | Heterocyclic compounds as TrkA modulators |
| ES2833035T3 (es) | 2009-07-31 | 2021-06-14 | Ascendis Pharma As | Hidrogeles biodegradables insolubles en agua a base de polietilenglicol |
| JP5744886B2 (ja) * | 2009-10-19 | 2015-07-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | シクロペンタンカルボキサミド誘導体、このような化合物を含む薬物及びそれらの使用 |
| JP2013538798A (ja) * | 2010-08-03 | 2013-10-17 | グラフィニティ ファーマシューティカルズ ゲーエムベーハー | アフィニティクロマトグラフィーによる抗体およびＦｃ融合タンパク質精製のためのリガンド |
| WO2012020080A2 (en) | 2010-08-12 | 2012-02-16 | Graffinity Pharmaceuticals Gmbh | LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY II |
| EP2696897A2 (en) | 2011-04-11 | 2014-02-19 | Yeda Research and Development Co. Ltd. | Albumin binding probes and drug conjugates thereof |
| UA115576C2 (uk) | 2012-12-06 | 2017-11-27 | Байєр Фарма Акцієнгезелльшафт | Похідні бензимідазолу як антагоністи ер4 |
| EP2752426A1 (en) | 2013-01-03 | 2014-07-09 | Covagen AG | Human serum albumin binding compounds and fusion proteins thereof |
-
2014
- 2014-10-01 EP EP14786355.9A patent/EP3052483B1/en active Active
- 2014-10-01 RU RU2016117052A patent/RU2016117052A/ru not_active Application Discontinuation
- 2014-10-01 US US15/026,725 patent/US9809558B2/en not_active Expired - Fee Related
- 2014-10-01 CN CN201480054551.4A patent/CN105593222B/zh not_active Expired - Fee Related
- 2014-10-01 AU AU2014330781A patent/AU2014330781B2/en not_active Ceased
- 2014-10-01 ES ES14786355T patent/ES2721098T3/es active Active
- 2014-10-01 KR KR1020167008267A patent/KR20160060660A/ko not_active Withdrawn
- 2014-10-01 JP JP2016519325A patent/JP2016534984A/ja active Pending
- 2014-10-01 BR BR112016007371A patent/BR112016007371A2/pt not_active Application Discontinuation
- 2014-10-01 WO PCT/IB2014/064998 patent/WO2015049651A1/en not_active Ceased
- 2014-10-01 SG SG11201601870VA patent/SG11201601870VA/en unknown
- 2014-10-01 CA CA2925862A patent/CA2925862A1/en not_active Abandoned
-
2017
- 2017-09-07 US US15/698,020 patent/US9938243B2/en active Active