JP2013512962A5 - - Google Patents
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- Publication number
- JP2013512962A5 JP2013512962A5 JP2012543213A JP2012543213A JP2013512962A5 JP 2013512962 A5 JP2013512962 A5 JP 2013512962A5 JP 2012543213 A JP2012543213 A JP 2012543213A JP 2012543213 A JP2012543213 A JP 2012543213A JP 2013512962 A5 JP2013512962 A5 JP 2013512962A5
- Authority
- JP
- Japan
- Prior art keywords
- sulfonamide
- alkyl
- aryl
- benzene
- methanesulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26740109P | 2009-12-07 | 2009-12-07 | |
| US61/267,401 | 2009-12-07 | ||
| US29122409P | 2009-12-30 | 2009-12-30 | |
| US61/291,224 | 2009-12-30 | ||
| PCT/US2010/059335 WO2011071951A2 (en) | 2009-12-07 | 2010-12-07 | N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015203216A Division JP2016094394A (ja) | 2009-12-07 | 2015-10-14 | N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512962A JP2013512962A (ja) | 2013-04-18 |
| JP2013512962A5 true JP2013512962A5 (cg-RX-API-DMAC10.html) | 2014-01-23 |
| JP5826762B2 JP5826762B2 (ja) | 2015-12-02 |
Family
ID=43877339
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543213A Expired - Fee Related JP5826762B2 (ja) | 2009-12-07 | 2010-12-07 | N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体 |
| JP2015203216A Pending JP2016094394A (ja) | 2009-12-07 | 2015-10-14 | N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015203216A Pending JP2016094394A (ja) | 2009-12-07 | 2015-10-14 | N−アシルオキシスルホンアミドおよびn−ヒドロキシ−n−アシルスルホンアミド誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20110144067A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2509941B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5826762B2 (cg-RX-API-DMAC10.html) |
| CN (2) | CN102753520B (cg-RX-API-DMAC10.html) |
| AU (2) | AU2010328234B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2782110A1 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2719101T3 (cg-RX-API-DMAC10.html) |
| IN (1) | IN2012DN05025A (cg-RX-API-DMAC10.html) |
| MX (1) | MX2012006349A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2011071951A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2699567C (en) | 2007-09-26 | 2018-01-09 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
| WO2011063339A1 (en) * | 2009-11-23 | 2011-05-26 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl donors for the treatment of pulmonary hypertension |
| AU2010328230B2 (en) | 2009-12-07 | 2016-06-02 | Cardioxyl Pharmaceuticals, Inc. | Bis-acylated hydroxylamine derivatives |
| HK1200168A1 (en) | 2011-10-17 | 2015-07-31 | The Johns Hopkins University | Meldrum 's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors |
| JP6306602B2 (ja) | 2012-11-01 | 2018-04-04 | ザ ジョンズ ホプキンス ユニバーシティ | 分子内環化−脱離による制御されたhno放出 |
| SMT201900575T1 (it) | 2013-01-18 | 2019-11-13 | Cardioxyl Pharmaceuticals Inc | Donatori di nitrossile con indice terapeutico migliorato |
| ES2734060T3 (es) | 2014-01-17 | 2019-12-04 | Cardioxyl Pharmaceuticals Inc | Donadores de nitroxilo de N-hidroximetanosulfonamida |
| EP3148972B1 (en) | 2014-05-27 | 2019-08-21 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| EP3148983A1 (en) | 2014-05-27 | 2017-04-05 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives as nitroxyl donors |
| HK1254957A1 (zh) * | 2015-06-26 | 2019-08-02 | 约翰斯霍普金斯大学 | 作为有效的hno供体的具有碳基离去基团的n-取代的异羟肟酸及其用途 |
| CN108349911B (zh) * | 2015-09-07 | 2022-05-13 | 浙江华海药业股份有限公司 | 可释放一氧化氮的前药分子 |
| WO2017070081A1 (en) | 2015-10-19 | 2017-04-27 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| WO2017070084A1 (en) * | 2015-10-19 | 2017-04-27 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as nitroxyl donors |
| WO2018022899A1 (en) | 2016-07-28 | 2018-02-01 | The Johns Hopkins University | O-substituted hydroxamic acids |
| SG10202107533RA (en) | 2017-01-03 | 2021-08-30 | Cardioxyl Pharmaceuticals Inc | Method of administering nitroxyl donating compounds |
| CN108318615A (zh) * | 2018-03-16 | 2018-07-24 | 湖北亿诺瑞生物制药有限公司 | 顶空气相色谱法检测肝素钠中残留溶剂的方法 |
| CN113621098B (zh) * | 2020-05-09 | 2022-11-04 | 中国石油天然气股份有限公司 | 丙烯聚合催化剂、丙烯聚合催化剂体系及其制备与应用 |
| CN114195731A (zh) * | 2021-11-24 | 2022-03-18 | 海南大学 | 一种氢化亚硝酰供体化合物及其制备方法 |
| WO2025043108A1 (en) | 2023-08-23 | 2025-02-27 | Bristol -Myers S Quibb Company | Co-crystals of nitroxyl donating compounds |
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| FR1283890A (fr) * | 1959-12-28 | 1962-02-09 | Ajinomoto Kk | Procédé de préparation d'inosinate de sodium |
| US3219428A (en) * | 1961-04-17 | 1965-11-23 | Hooker Chemical Corp | O,n-diacylated-3,4-dihalophenylhydroxylamines as herbicides |
| US3382243A (en) * | 1965-05-17 | 1968-05-07 | American Home Prod | Acetamides and their preparation |
| US3458570A (en) * | 1966-07-28 | 1969-07-29 | Stauffer Chemical Co | N-substituted phenylsulfonyl-hydroxylamines |
| US3948967A (en) * | 1968-01-03 | 1976-04-06 | Velsicol Chemical Corporation | Aryl urea carbonates |
| US3661944A (en) * | 1970-07-01 | 1972-05-09 | Smith Kline French Lab | 4-(n-lower alkanoyl)hydroxylamino-4'-aminodiphenylsulfone compounds |
| US3746727A (en) * | 1971-06-07 | 1973-07-17 | Shell Oil Co | Benzenesulfhydroxamic acids and their derivatives |
| GB1570362A (en) * | 1976-03-09 | 1980-07-02 | Agfa Gevaert Ag | Method of introducing photographic additives into silver salt emulsions |
| JPS567710A (en) * | 1979-06-28 | 1981-01-27 | Sansho Seiyaku Kk | Whitening cosmetic |
| US4405357A (en) * | 1980-06-02 | 1983-09-20 | Fmc Corporation | Herbicidal 3-isoxazolidinones and hydroxamic acids |
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| DE3583799D1 (de) | 1985-01-11 | 1991-09-19 | Abbott Lab Ltd | Feste zubereitung mit langsamer freisetzung. |
| US4663351A (en) | 1985-08-23 | 1987-05-05 | Berlex Laboratories, Inc. | Dobutamine tri-isobutyric acid ester and the use thereof as a cardiotonic agent |
| US4798824A (en) * | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US4954526A (en) * | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
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| JP2773959B2 (ja) | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| US5418212A (en) * | 1990-11-30 | 1995-05-23 | Kumiai Chemical Industry Co., Ltd. | Alkanoic acid amide derivative or its salt, and herbicidal composition |
| JPH05341461A (ja) * | 1992-06-05 | 1993-12-24 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| US5278192A (en) * | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
| PT726768E (pt) * | 1993-11-02 | 2000-11-30 | Us Health | Utilizacao de compostos libertadores de acido nitrico para o fabrico de um medicamento para proteccao na lesao por isquemia-reperfusao |
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| DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
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| US5674894A (en) * | 1995-05-15 | 1997-10-07 | G.D. Searle & Co. | Amidine derivatives useful as platelet aggregation inhibitors and vasodilators |
| US5714511A (en) * | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
| DE19545878A1 (de) * | 1995-12-08 | 1997-06-12 | Basf Ag | Pyridylcarbamate, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung |
| US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| JP4278008B2 (ja) * | 1996-08-23 | 2009-06-10 | 興和株式会社 | ジアミド化合物及びこれを含有する医薬 |
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| TW453999B (en) * | 1997-06-27 | 2001-09-11 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| GB9726989D0 (en) * | 1997-12-22 | 1998-02-18 | Ciba Geigy Ag | Organic compounds |
| UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| CN1163223C (zh) * | 1998-07-28 | 2004-08-25 | 田边制药株式会社 | 肠内目标部位释放型制剂 |
| JP2002528495A (ja) * | 1998-10-30 | 2002-09-03 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化された非ステロイド抗炎症性化合物、組成物および使用方法 |
| RU2276997C2 (ru) * | 1999-08-30 | 2006-05-27 | Санофи-Авентис Дойчланд Гмбх | Применение ингибиторов ренин-ангиотензиновой системы для профилактики сердечно-сосудистых явлений |
| DE10127922A1 (de) * | 2000-06-08 | 2001-12-13 | Jomaa Pharmaka Gmbh | Verwendung von phosphororganischen Hydroxamsäurederivaten zur Herstellung von Arzneimitteln für die therapeutische und prophylaktische Behandlung von Infektionen |
| WO2001097797A1 (en) * | 2000-06-20 | 2001-12-27 | Bond Richard A | Paradoxical pharmacology |
| JP2004501143A (ja) * | 2000-06-22 | 2004-01-15 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化タキサン、組成物および使用方法 |
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| US20030068386A1 (en) | 2001-09-05 | 2003-04-10 | Stoyanovsky Detcho A. | Method of treating cancerous disease |
| US20040038947A1 (en) * | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
| US20040077691A1 (en) * | 2002-06-21 | 2004-04-22 | Medinox, Inc. | Hydroxamate derivatives of non-steroidal anti-inflammatory drugs |
| US6936639B2 (en) * | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
| US20090281067A1 (en) * | 2004-01-30 | 2009-11-12 | The John Hopkins University | Nitroxyl progenitor compounds and methods of use |
| JP2008543947A (ja) | 2005-06-23 | 2008-12-04 | ジョンズ ホプキンス ユニバーシティ | チオール感受性の正の変力物質 |
| TWI282084B (en) | 2005-07-08 | 2007-06-01 | Jeng-Tzung Chen | Guitar |
| US20070088043A1 (en) * | 2005-10-18 | 2007-04-19 | Orchid Research Laboratories Limited. | Novel HDAC inhibitors |
| JP2009518397A (ja) * | 2005-12-08 | 2009-05-07 | ジョンズ ホプキンズ ユニヴァーシティー | 高い抗癌活性及び持続性抗マラリア活性を有するトリオキサンダイマー |
| SI2586434T1 (sl) * | 2006-03-17 | 2016-09-30 | The Johns Hopkins University | Derivati n-hidroksilsulfonamida kot novi fiziološko uporabni donorji nitroksila |
| JP4783657B2 (ja) * | 2006-03-27 | 2011-09-28 | 富士フイルム株式会社 | ポジ型レジスト組成物及び該組成物を用いたパターン形成方法 |
| CA2648384A1 (en) | 2006-04-13 | 2007-10-25 | Wake Forest University Health Sciences | C-nitroso-derived nitroxyl donors |
| CA2699567C (en) * | 2007-09-26 | 2018-01-09 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
| PT2278975T (pt) | 2008-05-07 | 2016-11-08 | Cardioxyl Pharmaceuticals Inc | Novos compostos de nitroso como dadores de nitroxilo e métodos de utilização dos mesmos |
| WO2011063339A1 (en) * | 2009-11-23 | 2011-05-26 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl donors for the treatment of pulmonary hypertension |
| AU2010328230B2 (en) * | 2009-12-07 | 2016-06-02 | Cardioxyl Pharmaceuticals, Inc. | Bis-acylated hydroxylamine derivatives |
-
2010
- 2010-12-07 US US12/962,572 patent/US20110144067A1/en not_active Abandoned
- 2010-12-07 IN IN5025DEN2012 patent/IN2012DN05025A/en unknown
- 2010-12-07 CN CN201080063223.2A patent/CN102753520B/zh not_active Expired - Fee Related
- 2010-12-07 ES ES10793381T patent/ES2719101T3/es active Active
- 2010-12-07 MX MX2012006349A patent/MX2012006349A/es not_active Application Discontinuation
- 2010-12-07 JP JP2012543213A patent/JP5826762B2/ja not_active Expired - Fee Related
- 2010-12-07 CA CA2782110A patent/CA2782110A1/en not_active Abandoned
- 2010-12-07 CN CN201610319052.4A patent/CN105919987B/zh not_active Expired - Fee Related
- 2010-12-07 AU AU2010328234A patent/AU2010328234B2/en not_active Ceased
- 2010-12-07 EP EP10793381.4A patent/EP2509941B1/en not_active Not-in-force
- 2010-12-07 WO PCT/US2010/059335 patent/WO2011071951A2/en not_active Ceased
-
2014
- 2014-04-25 US US14/262,223 patent/US20140235636A1/en not_active Abandoned
-
2015
- 2015-10-14 JP JP2015203216A patent/JP2016094394A/ja active Pending
- 2015-10-30 US US14/927,658 patent/US20160046570A1/en not_active Abandoned
-
2016
- 2016-07-22 AU AU2016206369A patent/AU2016206369B2/en not_active Ceased
-
2017
- 2017-10-24 US US15/792,352 patent/US20180050985A1/en not_active Abandoned
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