JP2013510561A5 - - Google Patents
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- JP2013510561A5 JP2013510561A5 JP2012538147A JP2012538147A JP2013510561A5 JP 2013510561 A5 JP2013510561 A5 JP 2013510561A5 JP 2012538147 A JP2012538147 A JP 2012538147A JP 2012538147 A JP2012538147 A JP 2012538147A JP 2013510561 A5 JP2013510561 A5 JP 2013510561A5
- Authority
- JP
- Japan
- Prior art keywords
- antisense oligonucleotide
- oligonucleotide molecule
- exon
- nucleotides
- molecule according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102220479948 Alkaline phosphatase, germ cell type_H45A_mutation Human genes 0.000 claims 22
- 108091034117 Oligonucleotide Proteins 0.000 claims 19
- 239000000074 antisense oligonucleotide Substances 0.000 claims 18
- 238000012230 antisense oligonucleotides Methods 0.000 claims 18
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 201000006938 muscular dystrophy Diseases 0.000 claims 3
- 108010069091 Dystrophin Proteins 0.000 claims 2
- 125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 1
- 102000001039 Dystrophin Human genes 0.000 claims 1
- 102100034343 Integrase Human genes 0.000 claims 1
- 101710203526 Integrase Proteins 0.000 claims 1
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 238000000137 annealing Methods 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 230000004700 cellular uptake Effects 0.000 claims 1
- BOKOVLFWCAFYHP-UHFFFAOYSA-N dihydroxy-methoxy-sulfanylidene-$l^{5}-phosphane Chemical compound COP(O)(O)=S BOKOVLFWCAFYHP-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- YACKEPLHDIMKIO-UHFFFAOYSA-L methylphosphonate(2-) Chemical compound CP([O-])([O-])=O YACKEPLHDIMKIO-UHFFFAOYSA-L 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2009905549A AU2009905549A0 (en) | 2009-11-12 | Antisense Molecules and Methods for Treating Pathologies | |
| AU2009905549 | 2009-11-12 | ||
| PCT/AU2010/001520 WO2011057350A1 (en) | 2009-11-12 | 2010-11-12 | Antisense molecules and methods for treating pathologies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016127827A Division JP6294393B2 (ja) | 2009-11-12 | 2016-06-28 | 病状を治療するためのアンチセンス分子及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013510561A JP2013510561A (ja) | 2013-03-28 |
| JP2013510561A5 true JP2013510561A5 (cg-RX-API-DMAC7.html) | 2014-01-09 |
| JP5963678B2 JP5963678B2 (ja) | 2016-08-03 |
Family
ID=43991096
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012538147A Active JP5963678B2 (ja) | 2009-11-12 | 2010-11-12 | 病状を治療するためのアンチセンス分子及び方法 |
| JP2016127827A Active JP6294393B2 (ja) | 2009-11-12 | 2016-06-28 | 病状を治療するためのアンチセンス分子及び方法 |
| JP2018001970A Active JP6525449B2 (ja) | 2009-11-12 | 2018-01-10 | 病状を治療するためのアンチセンス分子及び方法 |
| JP2019077083A Active JP6936830B2 (ja) | 2009-11-12 | 2019-04-15 | 病状を治療するためのアンチセンス分子及び方法 |
| JP2021139342A Withdrawn JP2022001053A (ja) | 2009-11-12 | 2021-08-27 | 病状を治療するためのアンチセンス分子及び方法 |
| JP2024007295A Pending JP2024029262A (ja) | 2009-11-12 | 2024-01-22 | 病状を治療するためのアンチセンス分子及び方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016127827A Active JP6294393B2 (ja) | 2009-11-12 | 2016-06-28 | 病状を治療するためのアンチセンス分子及び方法 |
| JP2018001970A Active JP6525449B2 (ja) | 2009-11-12 | 2018-01-10 | 病状を治療するためのアンチセンス分子及び方法 |
| JP2019077083A Active JP6936830B2 (ja) | 2009-11-12 | 2019-04-15 | 病状を治療するためのアンチセンス分子及び方法 |
| JP2021139342A Withdrawn JP2022001053A (ja) | 2009-11-12 | 2021-08-27 | 病状を治療するためのアンチセンス分子及び方法 |
| JP2024007295A Pending JP2024029262A (ja) | 2009-11-12 | 2024-01-22 | 病状を治療するためのアンチセンス分子及び方法 |
Country Status (23)
Families Citing this family (104)
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2020
- 2020-08-13 US US16/993,116 patent/US11447776B2/en active Active
- 2020-08-26 IL IL276947A patent/IL276947A/en unknown
- 2020-10-29 AU AU2020260498A patent/AU2020260498A1/en not_active Abandoned
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2021
- 2021-08-27 JP JP2021139342A patent/JP2022001053A/ja not_active Withdrawn
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2022
- 2022-08-04 US US17/817,588 patent/US20230063394A1/en active Pending
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2023
- 2023-05-17 AU AU2023203103A patent/AU2023203103A1/en not_active Abandoned
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2024
- 2024-01-22 JP JP2024007295A patent/JP2024029262A/ja active Pending