JP2013508296A5 - - Google Patents
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- Publication number
- JP2013508296A5 JP2013508296A5 JP2012534391A JP2012534391A JP2013508296A5 JP 2013508296 A5 JP2013508296 A5 JP 2013508296A5 JP 2012534391 A JP2012534391 A JP 2012534391A JP 2012534391 A JP2012534391 A JP 2012534391A JP 2013508296 A5 JP2013508296 A5 JP 2013508296A5
- Authority
- JP
- Japan
- Prior art keywords
- fatty acid
- emulsion
- omega
- composition
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 74
- 239000000839 emulsion Substances 0.000 claims 51
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 41
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 39
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 35
- 239000003921 oil Substances 0.000 claims 34
- 239000012141 concentrate Substances 0.000 claims 21
- 239000004094 surface-active agent Substances 0.000 claims 15
- 238000009472 formulation Methods 0.000 claims 8
- 235000021588 free fatty acids Nutrition 0.000 claims 8
- 239000006184 cosolvent Substances 0.000 claims 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 150000002148 esters Chemical class 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 6
- -1 polyoxyethylene Polymers 0.000 claims 6
- 239000000047 product Substances 0.000 claims 6
- 239000004359 castor oil Substances 0.000 claims 4
- 235000019438 castor oil Nutrition 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 4
- 239000006014 omega-3 oil Substances 0.000 claims 4
- 239000008346 aqueous phase Substances 0.000 claims 3
- 235000015872 dietary supplement Nutrition 0.000 claims 3
- 235000016709 nutrition Nutrition 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 229940127557 pharmaceutical product Drugs 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 230000035622 drinking Effects 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 150000003138 primary alcohols Chemical class 0.000 claims 2
- 150000003333 secondary alcohols Chemical class 0.000 claims 2
- 150000003509 tertiary alcohols Chemical class 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 235000009421 Myristica fragrans Nutrition 0.000 claims 1
- 230000003143 atherosclerotic effect Effects 0.000 claims 1
- 230000007211 cardiovascular event Effects 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 239000007902 hard capsule Substances 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 239000001115 mace Substances 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
- 238000004094 preconcentration Methods 0.000 claims 1
- 239000007901 soft capsule Substances 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 230000006441 vascular event Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25231009P | 2009-10-16 | 2009-10-16 | |
| US61/252,310 | 2009-10-16 | ||
| US26769709P | 2009-12-08 | 2009-12-08 | |
| US61/267,697 | 2009-12-08 | ||
| PCT/US2010/052840 WO2011047259A1 (en) | 2009-10-16 | 2010-10-15 | Compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016113002A Division JP2016222672A (ja) | 2009-10-16 | 2016-06-06 | 組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013508296A JP2013508296A (ja) | 2013-03-07 |
| JP2013508296A5 true JP2013508296A5 (enExample) | 2013-12-05 |
| JP5951489B2 JP5951489B2 (ja) | 2016-07-13 |
Family
ID=43876577
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534391A Active JP5951489B2 (ja) | 2009-10-16 | 2010-10-15 | 組成物 |
| JP2016113002A Pending JP2016222672A (ja) | 2009-10-16 | 2016-06-06 | 組成物 |
| JP2017201136A Active JP6430608B2 (ja) | 2009-10-16 | 2017-10-17 | 組成物 |
| JP2018204583A Active JP6728303B2 (ja) | 2009-10-16 | 2018-10-31 | 組成物 |
| JP2020112593A Active JP7055840B2 (ja) | 2009-10-16 | 2020-06-30 | 組成物 |
| JP2022063232A Pending JP2022095815A (ja) | 2009-10-16 | 2022-04-06 | 組成物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016113002A Pending JP2016222672A (ja) | 2009-10-16 | 2016-06-06 | 組成物 |
| JP2017201136A Active JP6430608B2 (ja) | 2009-10-16 | 2017-10-17 | 組成物 |
| JP2018204583A Active JP6728303B2 (ja) | 2009-10-16 | 2018-10-31 | 組成物 |
| JP2020112593A Active JP7055840B2 (ja) | 2009-10-16 | 2020-06-30 | 組成物 |
| JP2022063232A Pending JP2022095815A (ja) | 2009-10-16 | 2022-04-06 | 組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9717703B2 (enExample) |
| EP (1) | EP2488022B1 (enExample) |
| JP (6) | JP5951489B2 (enExample) |
| ES (1) | ES2661812T3 (enExample) |
| WO (1) | WO2011047259A1 (enExample) |
Families Citing this family (51)
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| EP3187182B1 (en) | 2008-09-02 | 2021-03-03 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same |
| CN102421422A (zh) | 2009-03-09 | 2012-04-18 | 普罗诺瓦生物医药挪威公司 | 含有脂肪酸油混合物和表面活性剂的组合物及其方法和用途 |
| CN107233337A (zh) | 2009-04-29 | 2017-10-10 | 阿马里纳药物爱尔兰有限公司 | 含有epa和心血管剂的药物组合物以及使用其的方法 |
| MX377553B (es) | 2009-04-29 | 2025-03-10 | Amarin Pharma Inc | Composicion farmaceutica estable y metodos de uso de la misma. |
| BRPI1011883A2 (pt) | 2009-06-15 | 2016-09-13 | Amarin Pharma Inc | uso de composições para redução de triglicerídeos sem elevar os níveis de o ldl-c em um paciente sob o tratamento concomitante com estatina |
| NZ599061A (en) | 2009-09-23 | 2014-05-30 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
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2010
- 2010-10-15 ES ES10824162.1T patent/ES2661812T3/es active Active
- 2010-10-15 US US13/502,214 patent/US9717703B2/en active Active
- 2010-10-15 WO PCT/US2010/052840 patent/WO2011047259A1/en not_active Ceased
- 2010-10-15 EP EP10824162.1A patent/EP2488022B1/en active Active
- 2010-10-15 JP JP2012534391A patent/JP5951489B2/ja active Active
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2016
- 2016-06-06 JP JP2016113002A patent/JP2016222672A/ja active Pending
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2017
- 2017-06-23 US US15/631,104 patent/US10668038B2/en active Active
- 2017-10-17 JP JP2017201136A patent/JP6430608B2/ja active Active
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2018
- 2018-10-31 JP JP2018204583A patent/JP6728303B2/ja active Active
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2020
- 2020-04-20 US US16/852,603 patent/US20200246299A1/en not_active Abandoned
- 2020-06-30 JP JP2020112593A patent/JP7055840B2/ja active Active
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2022
- 2022-04-06 JP JP2022063232A patent/JP2022095815A/ja active Pending
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