JP2013507603A5 - - Google Patents
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- JP2013507603A5 JP2013507603A5 JP2012532458A JP2012532458A JP2013507603A5 JP 2013507603 A5 JP2013507603 A5 JP 2013507603A5 JP 2012532458 A JP2012532458 A JP 2012532458A JP 2012532458 A JP2012532458 A JP 2012532458A JP 2013507603 A5 JP2013507603 A5 JP 2013507603A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant
- peptide
- sample
- fraction
- signature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 6
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 4
- 238000011002 quantification Methods 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000008186 active pharmaceutical agent Substances 0.000 claims 2
- 238000001261 affinity purification Methods 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 230000029087 digestion Effects 0.000 claims 2
- 229940088679 drug related substance Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 239000011347 resin Substances 0.000 claims 2
- 229920005989 resin Polymers 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 241000282414 Homo sapiens Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 238000011088 calibration curve Methods 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012512 characterization method Methods 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 239000013583 drug formulation Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200901112 | 2009-10-09 | ||
| DKPA200901112 | 2009-10-09 | ||
| US25623209P | 2009-10-29 | 2009-10-29 | |
| US61/256,232 | 2009-10-29 | ||
| PCT/DK2010/050258 WO2011042027A2 (en) | 2009-10-09 | 2010-10-07 | Multiplex quantitation of individual recombinant proteins in a mixture by signature peptides and mass spectrometry |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013507603A JP2013507603A (ja) | 2013-03-04 |
| JP2013507603A5 true JP2013507603A5 (enExample) | 2013-11-21 |
Family
ID=42166454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532458A Pending JP2013507603A (ja) | 2009-10-09 | 2010-10-07 | 署名ペプチドおよび質量分析による混合物中の個々の組換えタンパク質の多重定量化 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20120264155A1 (enExample) |
| EP (1) | EP2486411A2 (enExample) |
| JP (1) | JP2013507603A (enExample) |
| KR (1) | KR20120100982A (enExample) |
| CN (1) | CN102687020A (enExample) |
| AU (1) | AU2010305150A1 (enExample) |
| BR (1) | BR112012007815A2 (enExample) |
| CA (1) | CA2776508A1 (enExample) |
| IL (1) | IL218821A0 (enExample) |
| IN (1) | IN2012DN03911A (enExample) |
| MX (1) | MX2012003538A (enExample) |
| RU (1) | RU2012118620A (enExample) |
| WO (1) | WO2011042027A2 (enExample) |
| ZA (1) | ZA201202431B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2241875A1 (en) * | 2009-04-14 | 2010-10-20 | Koninklijke Philips Electronics N.V. | Up-concentration of organic microobjects for microscopic imaging. |
| CA2833212C (en) | 2011-05-12 | 2020-06-09 | Genentech, Inc. | Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature peptides |
| WO2013019714A1 (en) | 2011-07-29 | 2013-02-07 | The Trustees Of Columbia University In The City Of New York | Mems affinity sensor for continuous monitoring of analytes |
| WO2016022696A1 (en) * | 2014-08-05 | 2016-02-11 | The Trustees Of Columbia University In The City Of New York | Method of isolating aptamers for minimal residual disease detection |
| EP3268746B1 (en) | 2015-03-12 | 2024-07-17 | Mars, Incorporated | Ultra high resolution mass spectrometry and methods of using the same |
| WO2016179397A1 (en) * | 2015-05-06 | 2016-11-10 | Momenta Pharmaceuticals, Inc. | Methods of glycoprotein analysis |
| CN105242050A (zh) * | 2015-09-16 | 2016-01-13 | 同济大学 | 一种不同生理或病理条件下整体蛋白质的定量分析方法 |
| CN105218671A (zh) * | 2015-09-29 | 2016-01-06 | 李艳华 | 一种传染病病原体全人源化抗体的制备方法 |
| GB201603291D0 (en) | 2016-02-25 | 2016-04-13 | Binding Site Group The Ltd | Antibodies |
| EP3433621A1 (en) * | 2016-03-25 | 2019-01-30 | H. Hoffnabb-La Roche Ag | Multiplexed total antibody and antibody-conjugated drug quantification assay |
| WO2017205741A1 (en) | 2016-05-27 | 2017-11-30 | Genentech, Inc. | Bioanalytical method for the characterization of site-specific antibody-drug conjugates |
| CN107525934A (zh) * | 2016-06-21 | 2017-12-29 | 张效龙 | 一种测定血液中抗体氨基酸序列的方法 |
| US20210333288A1 (en) * | 2016-08-17 | 2021-10-28 | Momenta Pharmaceuticals, Inc. | Glycan oxonium ion profiling of glycosylated proteins |
| CN108072728A (zh) * | 2016-11-16 | 2018-05-25 | 中国科学院大连化学物理研究所 | 一种基于数据依赖性质谱扫描模式的谱图库建立方法及其应用 |
| CN108956789A (zh) * | 2017-05-17 | 2018-12-07 | 中国科学院大连化学物理研究所 | 一种血清中免疫球蛋白g糖肽的绝对定量分析方法 |
| EA202090399A1 (ru) * | 2017-08-01 | 2020-05-20 | Эмджен Инк. | Системы и способы для подготовки в режиме реального времени образца полипептида для анализа с помощью масс-спектрометрии |
| US10615016B2 (en) * | 2017-09-07 | 2020-04-07 | Thermo Fisher Scientific (Bremen) Gmbh | Determining isotope ratios using mass spectrometry |
| CN108226516B (zh) * | 2017-11-30 | 2020-05-19 | 中国农业科学院北京畜牧兽医研究所 | 一种相对定量分析肉鸡脂肪酸去饱和酶fads1的方法 |
| CN108169397B (zh) * | 2017-11-30 | 2019-11-15 | 中国农业科学院北京畜牧兽医研究所 | 一种相对定量分析肉鸡谷胱甘肽s转移酶gsta2的方法 |
| CN109900815B (zh) * | 2017-12-08 | 2021-06-29 | 中国科学院大连化学物理研究所 | 血清中IgG糖肽的绝对定量分析 |
| JP7301054B2 (ja) * | 2018-01-31 | 2023-06-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 治療用モノクローナル抗体に対する酸性翻訳後修飾としてのグルクロニル化 |
| JP7205077B2 (ja) * | 2018-05-10 | 2023-01-17 | 株式会社島津製作所 | 分析方法、処理装置、分析装置およびプログラム |
| CN110824096B (zh) * | 2018-08-13 | 2022-11-29 | 齐鲁制药有限公司 | 一种蛋白错配二硫键的分析方法 |
| CN110007019A (zh) * | 2019-03-29 | 2019-07-12 | 绿城农科检测技术有限公司 | 一种同时定量检测母乳中三种抗体含量的方法 |
| GB201910697D0 (en) * | 2019-07-26 | 2019-09-11 | Binding Site Group Ltd | Lonisation control |
| JP7778705B2 (ja) | 2020-02-21 | 2025-12-02 | ジェンマブ ビー．ブイ． | 糖蛋白質の定量のための方法 |
| CN111551739A (zh) * | 2020-04-27 | 2020-08-18 | 杭州璞湃科技有限公司 | 一种免疫球蛋白a和免疫球蛋白a1的检测方法及其试剂盒 |
| US20230228763A1 (en) * | 2020-06-18 | 2023-07-20 | Northwestern University | Process for direct readout of immunoglobulins |
| JP7478040B2 (ja) * | 2020-06-25 | 2024-05-02 | シスメックス株式会社 | Ａβペプチドの測定方法及びその方法に用いられる試薬組成物 |
| CN111766323B (zh) * | 2020-07-10 | 2022-06-14 | 中国检验检疫科学研究院 | 一种用于检测骆驼奶中掺入牛奶的特征肽组合及方法 |
| CN113933409B (zh) * | 2021-09-14 | 2023-11-14 | 上海中科新生命生物科技有限公司 | 基于液相色谱-质谱检测血清中特瑞普利单抗的方法 |
| DE102022115561B4 (de) * | 2022-06-22 | 2024-06-13 | Bruker Daltonics GmbH & Co. KG | Massenspektrometrische Bestimmung der Zelltoxizität |
| CN118221778A (zh) * | 2024-04-25 | 2024-06-21 | 烟台大学 | 拟穴青蟹Scyreprocin蛋白的特征肽段及其在雌雄鉴别方面的应用 |
| CN120399082B (zh) * | 2025-07-04 | 2025-08-26 | 北京溯本源和生物科技有限公司 | 一种用于检测猫Cys-C蛋白的单克隆抗体组合及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040033530A1 (en) * | 2002-04-08 | 2004-02-19 | Awrey Donald E. | High throughput purification, characterization and identification of recombinant proteins |
| CA2501000C (en) | 2002-10-03 | 2015-05-26 | Norman Leigh Anderson | High sensitivity quantitation of peptides by mass spectrometry |
| WO2005124341A2 (en) * | 2004-06-09 | 2005-12-29 | Anderson Forschung Group Llc | Stable isotope labeled polypeptide standards for protein quantitation |
| RU2426795C2 (ru) * | 2004-07-20 | 2011-08-20 | Симфоген А/С | Способ структурной характеристики рекомбинантного поликлонального белка или поликлональной клеточной линии |
| BRPI0513706A (pt) | 2004-07-20 | 2008-05-13 | Symphogen As | anticorpo policlonal recombinante anti-rhesus d e métodos de produção |
| WO2006080396A1 (ja) * | 2005-01-28 | 2006-08-03 | Shionogi & Co., Ltd. | 組換え蛋白質の定量法 |
| JP2006300758A (ja) * | 2005-04-21 | 2006-11-02 | Apro Life Science Institute Inc | 内部標準ペプチドを用いて生体由来試料に含まれる標的タンパク質を定量する方法 |
| JP2009518320A (ja) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
| KR20080113223A (ko) | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
| PL2132229T3 (pl) | 2007-03-01 | 2016-12-30 | Kompozycje rekombinowanych przeciwciał anty-receptor czynnika wzrostu naskórka | |
| CN101679513A (zh) | 2007-03-06 | 2010-03-24 | 西福根有限公司 | 用于治疗呼吸道合胞病毒感染的重组抗体 |
| US20090000419A1 (en) * | 2007-06-29 | 2009-01-01 | Harley-Davidson Motor Company Group, Inc. | Handlebar assembly with axial locking feature |
-
2010
- 2010-10-07 JP JP2012532458A patent/JP2013507603A/ja active Pending
- 2010-10-07 RU RU2012118620/15A patent/RU2012118620A/ru unknown
- 2010-10-07 CN CN2010800562278A patent/CN102687020A/zh active Pending
- 2010-10-07 US US13/501,051 patent/US20120264155A1/en not_active Abandoned
- 2010-10-07 AU AU2010305150A patent/AU2010305150A1/en not_active Abandoned
- 2010-10-07 IN IN3911DEN2012 patent/IN2012DN03911A/en unknown
- 2010-10-07 WO PCT/DK2010/050258 patent/WO2011042027A2/en not_active Ceased
- 2010-10-07 EP EP10774121A patent/EP2486411A2/en not_active Withdrawn
- 2010-10-07 BR BR112012007815A patent/BR112012007815A2/pt not_active IP Right Cessation
- 2010-10-07 MX MX2012003538A patent/MX2012003538A/es not_active Application Discontinuation
- 2010-10-07 CA CA2776508A patent/CA2776508A1/en not_active Abandoned
- 2010-10-07 KR KR1020127011934A patent/KR20120100982A/ko not_active Withdrawn
-
2012
- 2012-03-25 IL IL218821A patent/IL218821A0/en unknown
- 2012-04-03 ZA ZA2012/02431A patent/ZA201202431B/en unknown
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