MX2013007527A - Anticuerpo monoclonal que reconoce la proteina l2 de virus de papiloma humano y metodo para medir el titulo del anticuerpo neutralizante de vph utilizando el mismo. - Google Patents
Anticuerpo monoclonal que reconoce la proteina l2 de virus de papiloma humano y metodo para medir el titulo del anticuerpo neutralizante de vph utilizando el mismo.Info
- Publication number
- MX2013007527A MX2013007527A MX2013007527A MX2013007527A MX2013007527A MX 2013007527 A MX2013007527 A MX 2013007527A MX 2013007527 A MX2013007527 A MX 2013007527A MX 2013007527 A MX2013007527 A MX 2013007527A MX 2013007527 A MX2013007527 A MX 2013007527A
- Authority
- MX
- Mexico
- Prior art keywords
- hpv
- monoclonal antibody
- neutralizing antibody
- measuring
- protein
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57411—Specifically defined cancers of cervix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/26—Infectious diseases, e.g. generalised sepsis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Abstract
La presente invención se refiere al desarrollo de un anticuerpo monoclonal que tiene actividad de unión a muchos tipos de alto riesgo de VPH, etc. La presente invención también proporciona un método simple y de alto rendimiento para la medición de los títulos de anticuerpos neutralizantes cruzados, que se utilizan para ensayo de anticuerpos neutralizantes cruzados contra el VPH en muestras de suero de individuos, etc. El método de la presente invención para medir los títulos de anticuerpos neutralizantes cruzados comprende las etapas de: preparar un anticuerpo monoclonal en contra de un péptido que tiene una secuencia de aminoácidos específica común a tipos de alto riesgo de VPH; y ensayo de anticuerpos neutralizantes cruzados usando este anticuerpo monoclonal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010291067 | 2010-12-27 | ||
PCT/JP2011/079994 WO2012090895A1 (ja) | 2010-12-27 | 2011-12-26 | ヒトパピローマウィルス(hpv)l2蛋白質を認識するモノクローナル抗体とそれを使用したhpv中和抗体価測定法 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013007527A true MX2013007527A (es) | 2014-02-27 |
Family
ID=46382999
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013007527A MX2013007527A (es) | 2010-12-27 | 2011-12-26 | Anticuerpo monoclonal que reconoce la proteina l2 de virus de papiloma humano y metodo para medir el titulo del anticuerpo neutralizante de vph utilizando el mismo. |
Country Status (14)
Country | Link |
---|---|
US (2) | US9279161B2 (es) |
EP (1) | EP2641914B1 (es) |
JP (1) | JP6106837B2 (es) |
KR (1) | KR101889119B1 (es) |
CN (1) | CN103582651A (es) |
AU (1) | AU2011350832A1 (es) |
BR (1) | BR112013016495A2 (es) |
CA (1) | CA2819947C (es) |
MX (1) | MX2013007527A (es) |
NZ (1) | NZ611168A (es) |
RU (1) | RU2013129203A (es) |
SG (1) | SG191125A1 (es) |
TW (1) | TW201233686A (es) |
WO (1) | WO2012090895A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9862760B2 (en) | 2015-09-16 | 2018-01-09 | Novartis Ag | Polyomavirus neutralizing antibodies |
EP3359190A4 (en) * | 2015-10-05 | 2020-05-06 | Circle33 LLC | ANTIBODIES WITH IMPROVED STABILITY ABOUT DIGESTION |
CN111417651B (zh) * | 2017-12-01 | 2023-09-29 | 诺华股份有限公司 | 多瘤病毒中和抗体 |
CN110196332A (zh) * | 2019-05-22 | 2019-09-03 | 艾托金生物医药(苏州)有限公司 | 一种检测多亚型hpv e7蛋白的方法及其应用 |
CN112125972B (zh) * | 2019-06-25 | 2022-07-29 | 神州细胞工程有限公司 | 抗hpv16 l1蛋白单克隆抗体及应用该抗体的检测方法 |
CN113125756B (zh) * | 2020-07-15 | 2022-10-25 | 南京岚煜生物科技有限公司 | 抗体标准品赋值和抗原中和当量确定的方法 |
KR20220155712A (ko) | 2021-05-17 | 2022-11-24 | (주)베데스다 | 인유두종 바이러스 및 자궁경부암 감지용 다클론성 항체 및 이의 제조방법 |
CN113444168B (zh) * | 2021-06-23 | 2023-07-14 | 上海博唯生物科技有限公司 | 一种抗hpv35抗体及其制备方法和用途 |
CN115112885B (zh) * | 2022-06-18 | 2023-07-28 | 杭州爱光健康科技有限公司 | 一种hpv检测试剂盒及其制备方法和应用 |
CN117143226B (zh) * | 2023-09-12 | 2024-04-05 | 怡道生物科技(苏州)有限公司 | 与hpv33型衣壳蛋白l1特异性结合的抗体或其抗原结合片段及其应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2007358A (en) * | 1931-11-27 | 1935-07-09 | Edward W Anger | Drainage valve |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
JPH05227970A (ja) | 1992-02-19 | 1993-09-07 | Chugai Pharmaceut Co Ltd | ヒトインターロイキン−6受容体に対する再構成ヒト抗体 |
JP4825958B2 (ja) * | 2005-08-10 | 2011-11-30 | 財団法人ヒューマンサイエンス振興財団 | 高リスク群ヒトパピローマウイルスの中和抗体を誘導する抗原 |
AU2008268014B2 (en) | 2007-06-26 | 2013-10-31 | Japan As Represented By The Director-General Of National Institute Of Infectious Diseases | Vaccine antigen capable of inducing cross-reacting and neutralizing antibody against high-risk-type human papillomavirus |
EP2199301A1 (en) | 2008-12-19 | 2010-06-23 | DKFZ Deutsches Krebsforschungszentrum | Immunogenic polypeptides comprising a scaffold polypeptide and a L2 polypeptide or fragment thereof |
-
2011
- 2011-12-26 KR KR1020137016754A patent/KR101889119B1/ko active IP Right Grant
- 2011-12-26 WO PCT/JP2011/079994 patent/WO2012090895A1/ja active Application Filing
- 2011-12-26 EP EP11853408.0A patent/EP2641914B1/en active Active
- 2011-12-26 TW TW100148559A patent/TW201233686A/zh unknown
- 2011-12-26 MX MX2013007527A patent/MX2013007527A/es not_active Application Discontinuation
- 2011-12-26 BR BR112013016495-6A patent/BR112013016495A2/pt not_active IP Right Cessation
- 2011-12-26 RU RU2013129203/10A patent/RU2013129203A/ru not_active Application Discontinuation
- 2011-12-26 JP JP2012550917A patent/JP6106837B2/ja active Active
- 2011-12-26 AU AU2011350832A patent/AU2011350832A1/en not_active Abandoned
- 2011-12-26 NZ NZ61116811A patent/NZ611168A/en not_active IP Right Cessation
- 2011-12-26 US US13/997,902 patent/US9279161B2/en active Active
- 2011-12-26 CN CN201180063220.3A patent/CN103582651A/zh active Pending
- 2011-12-26 CA CA2819947A patent/CA2819947C/en active Active
- 2011-12-26 SG SG2013045273A patent/SG191125A1/en unknown
-
2015
- 2015-12-17 US US14/973,240 patent/US9683997B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
TW201233686A (en) | 2012-08-16 |
US20130337438A1 (en) | 2013-12-19 |
WO2012090895A1 (ja) | 2012-07-05 |
US9683997B2 (en) | 2017-06-20 |
BR112013016495A2 (pt) | 2018-05-22 |
EP2641914B1 (en) | 2018-11-14 |
CA2819947C (en) | 2020-03-24 |
US20160154007A1 (en) | 2016-06-02 |
KR20140016875A (ko) | 2014-02-10 |
EP2641914A9 (en) | 2014-12-03 |
NZ611168A (en) | 2015-03-27 |
JPWO2012090895A1 (ja) | 2014-06-05 |
KR101889119B1 (ko) | 2018-08-16 |
EP2641914A1 (en) | 2013-09-25 |
US9279161B2 (en) | 2016-03-08 |
JP6106837B2 (ja) | 2017-04-05 |
SG191125A1 (en) | 2013-07-31 |
CN103582651A (zh) | 2014-02-12 |
AU2011350832A1 (en) | 2013-06-20 |
EP2641914A4 (en) | 2014-04-23 |
CA2819947A1 (en) | 2012-07-05 |
RU2013129203A (ru) | 2015-02-10 |
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