JP2013503643A5 - - Google Patents

Download PDF

Info

Publication number
JP2013503643A5
JP2013503643A5 JP2012528063A JP2012528063A JP2013503643A5 JP 2013503643 A5 JP2013503643 A5 JP 2013503643A5 JP 2012528063 A JP2012528063 A JP 2012528063A JP 2012528063 A JP2012528063 A JP 2012528063A JP 2013503643 A5 JP2013503643 A5 JP 2013503643A5
Authority
JP
Japan
Prior art keywords
subtype
genes
certain embodiments
protein
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012528063A
Other languages
English (en)
Japanese (ja)
Other versions
JP5996429B2 (ja
JP2013503643A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/047734 external-priority patent/WO2011028945A1/en
Publication of JP2013503643A publication Critical patent/JP2013503643A/ja
Publication of JP2013503643A5 publication Critical patent/JP2013503643A5/ja
Priority to JP2016124696A priority Critical patent/JP6895718B2/ja
Application granted granted Critical
Publication of JP5996429B2 publication Critical patent/JP5996429B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012528063A 2009-09-03 2010-09-02 関節リウマチの治療、診断及びモニターするための方法 Active JP5996429B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2016124696A JP6895718B2 (ja) 2009-09-03 2016-06-23 関節リウマチの治療、診断及びモニターするための方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27594809P 2009-09-03 2009-09-03
US61/275,948 2009-09-03
US25242409P 2009-10-16 2009-10-16
US61/252,424 2009-10-16
PCT/US2010/047734 WO2011028945A1 (en) 2009-09-03 2010-09-02 Methods for treating, diagnosing, and monitoring rheumatoid arthritis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016124696A Division JP6895718B2 (ja) 2009-09-03 2016-06-23 関節リウマチの治療、診断及びモニターするための方法

Publications (3)

Publication Number Publication Date
JP2013503643A JP2013503643A (ja) 2013-02-04
JP2013503643A5 true JP2013503643A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2014-05-22
JP5996429B2 JP5996429B2 (ja) 2016-09-21

Family

ID=43625246

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2012528063A Active JP5996429B2 (ja) 2009-09-03 2010-09-02 関節リウマチの治療、診断及びモニターするための方法
JP2016124696A Active JP6895718B2 (ja) 2009-09-03 2016-06-23 関節リウマチの治療、診断及びモニターするための方法
JP2020158134A Pending JP2021019594A (ja) 2009-09-03 2020-09-23 関節リウマチの治療、診断及びモニターするための方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2016124696A Active JP6895718B2 (ja) 2009-09-03 2016-06-23 関節リウマチの治療、診断及びモニターするための方法
JP2020158134A Pending JP2021019594A (ja) 2009-09-03 2020-09-23 関節リウマチの治療、診断及びモニターするための方法

Country Status (11)

Country Link
US (2) US8728730B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (2) EP2473637B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (3) JP5996429B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR20120104517A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (2) CN102597268B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR112012004777A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2772929A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN2012DN02485A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (2) MX2012002766A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (2) RU2539112C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO2011028945A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004026470D1 (de) 2003-11-05 2010-05-20 Roche Glycart Ag Fc-rezeptor und effektorfunktion
TW201438738A (zh) 2008-09-16 2014-10-16 Genentech Inc 治療進展型多發性硬化症之方法
US8728730B2 (en) 2009-09-03 2014-05-20 Genentech, Inc. Methods for treating, diagnosing, and monitoring rheumatoid arthritis
JP5947727B2 (ja) 2010-01-20 2016-07-06 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 抗ilt5抗体およびilt5結合抗体断片による免疫調節
JP2013517330A (ja) 2010-01-20 2013-05-16 トーラックス インコーポレイテッド 抗ilt5抗体およびilt5結合抗体断片
US9795674B2 (en) 2010-02-26 2017-10-24 Novo Nordisk A/S Stable antibody containing compositions
US9290573B2 (en) 2010-05-06 2016-03-22 Novartis Ag Therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies
EP3345926B1 (en) 2010-05-06 2023-04-05 Novartis AG Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (lrp6) antibodies
WO2011147921A1 (en) 2010-05-28 2011-12-01 Novo Nordisk A/S Stable multi-dose compositions comprising an antibody and a preservative
PT3461847T (pt) 2010-12-06 2020-12-24 Seagen Inc Anticorpos humanizados para liv-1 e uso dos mesmos para tratar cancro
JP5885926B2 (ja) * 2011-01-28 2016-03-16 シスメックス株式会社 関節リウマチの存在の評価方法およびその方法に用いられるバイオマーカーセット
JP6271254B2 (ja) * 2011-02-28 2018-01-31 ジェネンテック, インコーポレイテッド B細胞アンタゴニストに対する生物学的マーカー及び応答を予測するための方法
WO2012167186A1 (en) * 2011-06-02 2012-12-06 Health Datastream Inc. System and method for scoring illness complexity to predict healthcare cost
JP2015502741A (ja) 2011-11-04 2015-01-29 ノバルティス アーゲー 低比重リポタンパク質関連タンパク質6(lrp6)−半減期延長構築物
CA2864133A1 (en) 2012-02-10 2013-08-15 Novo Nordisk A/S Methods related to treatment of inflammatory diseases and disorders
WO2013135789A1 (en) * 2012-03-15 2013-09-19 Universiteit Hasselt Means and methods for the determination of the joint destruction progression rate in rheumatoid arthritis patients
WO2013164440A1 (en) 2012-05-03 2013-11-07 Novo Nordisk A/S Methods related to treatment of inflammatory diseases and disorders
WO2014028374A1 (en) * 2012-08-17 2014-02-20 Eli Lilly And Company Biomarkers predictive of rheumatoid arthritis or systemic lupus erythematosus response to anti-baff antibody therapy
WO2014118550A1 (en) * 2013-01-31 2014-08-07 The University Of Birmingham Biomarkers of autoimmune and/or chronic diseases associated with joint inflammation
EP2813850A1 (en) * 2013-06-10 2014-12-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting rheumatoid arthritis treatment response
EP3012634B1 (en) * 2013-06-21 2019-01-02 Catholic University Industry-Academic Cooperation Foundation Biomarker for rheumatoid arthritis diagnosis or activity evaluation
AR096687A1 (es) 2013-06-24 2016-01-27 Genentech Inc Anticuerpos anti-fcrh5
CN103399147B (zh) * 2013-08-07 2015-06-17 苏州大学 多聚半乳糖醛酸的新应用
KR101628035B1 (ko) * 2013-09-13 2016-06-09 인제대학교 산학협력단 Vsig4를 이용한 난소암 치료제 스크리닝 방법
CN103513040B (zh) * 2013-10-16 2015-03-11 常晓天 蛋白cd38在制备类风湿性关节炎诊断标记物中的应用
EP2863231A1 (en) * 2013-10-17 2015-04-22 Institut D'Investigaciones Biomédiques August Pi i Sunyer Diagnostic method for detecting a GABA(A) related autoimmune disease and related subject-matter
ES2824108T3 (es) 2014-03-12 2021-05-11 Icahn School Med Mount Sinai Método para identificar receptores de aloinjertos de riñón en riesgo de lesión crónica
RU2554755C1 (ru) * 2014-05-26 2015-06-27 Федеральное бюджетное учреждение науки "Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии им. Пастера" (ФБУН НИИ эпидемиологии и микробиологии имени Пастера) Способ диагностики ревматоидного артрита
AU2015279542B2 (en) 2014-06-26 2021-07-29 Icahn School Of Medicine At Mount Sinai Method for diagnosing subclinical and clinical acute rejection by analysis of predictive gene sets
KR20160048442A (ko) * 2014-10-24 2016-05-04 가톨릭대학교 산학협력단 류마티스 관절염 관련 바이오마커
CA2971315C (en) * 2015-01-29 2023-02-14 Ares Trading S.A. Immunoassays for high positively charged proteins
CN105988009B (zh) * 2015-02-28 2018-03-13 复旦大学附属华山医院 Netrin‑4在制备检测胃癌及预后标志物的制剂中的用途
US20180120329A1 (en) * 2015-03-25 2018-05-03 La Jolla Institute For Allergy And Immunology Cxcl13 as an indicator of germinal activity and immune response
JP6663000B2 (ja) * 2015-05-12 2020-03-11 ザ ジェネラル ホスピタル コーポレーション ドゥーイング ビジネス アズ マサチューセッツ ジェネラル ホスピタル 関節リウマチの診断のための自己抗原
EP3310814B1 (en) 2015-06-16 2023-08-02 F. Hoffmann-La Roche AG Humanized and affinity matured antibodies to fcrh5 and methods of use
CN105200159B (zh) * 2015-11-06 2018-06-15 北京致成生物医学科技有限公司 骨性关节炎诊疗试剂及其应用
GB201521357D0 (en) * 2015-12-03 2016-01-20 Univ Liverpool Methods for predicting response to anti-TNF therapy
MA45324A (fr) 2016-03-15 2019-01-23 Seattle Genetics Inc Polythérapie utilisant un adc-liv1 et un agent chimiothérapeutique
WO2017181038A1 (en) * 2016-04-15 2017-10-19 Rowan University Serum biomarkers for predicting and evaluating response to tnf inhibitor therapy in rheumatoid arthritis patients
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
EP3463441B1 (en) 2016-06-07 2023-10-25 The General Hospital Corporation Identification of a t cell epitope of prevotella copri that induces t cell responses in patients with rheumatoid arthritis
RU2622597C1 (ru) * 2016-07-05 2017-06-16 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО КубГМУ Минздрава России) Способ прогнозирования суставного болевого синдрома у пациентов с признаками дисплазии соединительной ткани
GB201616557D0 (en) * 2016-09-29 2016-11-16 Secretary Of State For Health The Assay for distinguishing between sepsis and systemic inflammatory response syndrome
CN106526196B (zh) * 2016-10-08 2018-08-10 北京大学人民医院 Sr-a作为类风湿关节炎诊断标志物及干预靶点的应用
EP3835311B1 (en) * 2016-11-09 2024-08-28 ICM Co., Ltd. Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient
TWI791471B (zh) 2016-11-15 2023-02-11 美商建南德克公司 用於用抗cd20/抗cd3雙特異性抗體進行治療之給藥
KR102588627B1 (ko) 2017-03-08 2023-10-16 김성진 Mast4 유전자를 이용한 세포외 기질 생산용 조성물 및 그 제조방법
WO2018164507A2 (ko) * 2017-03-08 2018-09-13 주식회사 길로 Mast4 유전자를 이용한 세포외 기질 생산용 조성물 및 그 제조방법
WO2019041024A1 (en) * 2017-08-29 2019-03-07 Gary Levy FGL2 ANTIBODIES AND BINDING FRAGMENTS THEREOF AND USES THEREOF
CN114023403A (zh) * 2017-11-13 2022-02-08 多发性骨髓瘤研究基金会公司 综合、分子、组学、免疫疗法、代谢、表观遗传学和临床数据库
EP4502182A3 (en) * 2018-01-24 2025-07-09 Genentech, Inc. Diagnostic and therapeutic methods for the treatment of rheumatoid arthritis (ra)
CN108359726B (zh) * 2018-02-28 2020-09-04 固安博健生物技术有限公司 Coro2b作为分子诊治标志物的用途
WO2019178546A1 (en) 2018-03-16 2019-09-19 Scipher Medicine Corporation Methods and systems for predicting response to anti-tnf therapies
JP7464279B2 (ja) 2018-04-16 2024-04-09 アイカーン スクール オブ メディスン アット マウント シナイ レシピエント血液における移植前トランスクリプトームシグネチャーを使用した急性拒絶反応および腎臓同種異系移植喪失の予測のための方法およびキット
US20190336585A1 (en) * 2018-05-03 2019-11-07 John Lawrence Mee Method for sustainable human cognitive enhancement
US20190359985A1 (en) * 2018-05-22 2019-11-28 John Lawrence Mee Adjustable method for sustainable human cognitive enhancement
CN109142729B (zh) * 2018-06-14 2021-04-23 郑州大学第一附属医院 一种肺癌标志物抗-hmgb3自身抗体及其应用
EP3790662A1 (en) * 2018-06-21 2021-03-17 Astraveus Microfluidic device and method for processing particles
US20190390193A1 (en) * 2018-06-23 2019-12-26 John Lawrence Mee Reversible method for sustainable human cognitive enhancement
US10723191B1 (en) 2018-07-01 2020-07-28 Softwheel Ltd. In-wheel three-arm suspension for vehicles
CN110917351A (zh) * 2018-09-20 2020-03-27 华中科技大学同济医学院附属同济医院 Mbd2抑制剂在预防和治疗纤维化疾病中的用途
WO2020082090A1 (en) * 2018-10-19 2020-04-23 The Regents Of The University Of Michigan Method for monitoring autoimmune disease
CN109207584A (zh) * 2018-11-01 2019-01-15 固安博健生物技术有限公司 Marco作为早期诊断骨关节炎的分子标志物的应用
EP3921335A4 (en) * 2019-02-08 2023-02-08 The Regents Of The University Of California COMPOSITIONS AND METHODS INVOLVING LAYILINE
PE20220425A1 (es) 2019-04-29 2022-03-29 Solent Therapeutics Llc Derivado de 1,1-dioxido de 3-amino-4h-benzo[e][1,2,4]tiadiazina como inhibidores de mrgx2
KR20220017892A (ko) 2019-05-08 2022-02-14 얀센 바이오테크 인코포레이티드 T세포 매개 면역의 조절을 위한 물질 및 방법
KR20220044720A (ko) 2019-06-27 2022-04-11 사이퍼 메디슨 코퍼레이션 환자를 계층화하기 위한 분류기의 개발
CN110456074B (zh) * 2019-08-27 2022-06-03 广东菲鹏生物有限公司 瓜氨酸肽及其应用、类风湿关节炎的检测试剂与试剂盒
CN110408590B (zh) * 2019-09-06 2022-10-25 遵义医学院附属医院 一种诱导人间充质干细胞向成骨细胞分化的方法与应用
GB201914079D0 (en) * 2019-09-30 2019-11-13 Univ London Queen Mary Method of predicting requirement for biologic therapy
KR102596937B1 (ko) * 2019-11-07 2023-11-03 가톨릭대학교 산학협력단 류마티스 관절염의 판누스 진단용 바이오마커 및 이의 이용
CN111091909B (zh) * 2019-11-26 2022-05-31 中国信息通信研究院 一种医学影像识别方法和装置
CN113122628B (zh) * 2019-12-30 2023-08-11 广州医科大学附属第三医院(广州重症孕产妇救治中心、广州柔济医院) Clec5a基因作为标志物在子宫内膜癌中诊断及治疗的应用
IL294337A (en) * 2020-01-10 2022-08-01 Somalogic Operating Co Inc Methods of determining impaired glucose tolerance
CN112114126B (zh) * 2020-08-13 2023-03-24 川北医学院 一种系统性红斑狼疮的诊断标志物及其应用
EP4217508A1 (en) * 2020-09-22 2023-08-02 The Secretary Of State For Defence Apparatus, kits and methods for predicting the development of sepsis
CA3199767A1 (en) 2020-10-28 2022-05-05 Janssen Biotech, Inc. Compositions and methods for modulating delta gamma chain mediated immunity
US12351643B2 (en) 2020-11-04 2025-07-08 Genentech, Inc. Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies
CN112646887B (zh) * 2020-12-23 2023-02-28 广州医科大学附属第五医院 Znf239作为肝癌诊治的靶标
CN112946269B (zh) * 2020-12-29 2022-12-27 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) Abca1与cd68作为预后标记物在制备肝癌预后预测试剂盒中的应用
CN113186281B (zh) * 2021-04-02 2023-02-28 广州医科大学附属第五医院 作为肝细胞癌标志物的inava
CN113512582A (zh) * 2021-04-15 2021-10-19 上海鸿准生物医药科技有限公司 Slc22a18在过敏变态反应性疾病与炎症性疾病中的应用
CN113307835B (zh) * 2021-04-21 2022-12-13 南通大学 一种siRNA及其在制备慢性疼痛治疗药物中的应用
CN117321078A (zh) 2021-04-30 2023-12-29 豪夫迈·罗氏有限公司 针对用抗cd20/抗cd3双特异性抗体和抗cd79b抗体药物缀合物进行组合治疗的给药
WO2022241235A1 (en) 2021-05-14 2022-11-17 Genentech, Inc. Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin
WO2022264134A1 (en) * 2021-06-13 2022-12-22 Technion Research & Development Foundation Limited Method for determining suitability to anti-tnf alpha therapy
EP4479973A1 (en) * 2022-02-16 2024-12-25 Ampel Biosolutions, LLC Unsupervised machine learning methods
CN114994327B (zh) * 2022-04-12 2025-04-15 浙江大学医学院附属第二医院 一种生物标志物gsdme的应用
EP4619005A2 (en) * 2022-11-18 2025-09-24 The United States Government As Represented By The Department Of Veterans Affairs Methods for treating rheumatoid arthritis using a syndecan-1 inhibitor or a syntenin-1 inhibitor
CN116144761A (zh) * 2023-02-24 2023-05-23 山西医科大学 一种类风湿性关节炎诊断分类器的构建方法及其应用
CN116064784A (zh) * 2023-03-23 2023-05-05 上海市光华中西医结合医院 Fgf10在制备检测类风湿性关节炎试剂盒中的应用
JP2024179174A (ja) * 2023-06-14 2024-12-26 シスメックス株式会社 膜性腎症患者に対する化学療法の奏効性に関する情報を取得する方法、膜性腎症患者に対する化学療法の奏効性の判定を補助する方法及び試薬キット
CN117567626B (zh) * 2024-01-15 2024-04-26 北京大学人民医院 一种抗瓜氨酸化清道夫受体a多肽抗体及其在制备诊断类风湿关节炎的产品中的应用
CN119424633B (zh) * 2024-11-07 2025-07-25 浙江赛尔共银生物科技有限公司 一种包含间充质干细胞治疗退行性关节炎的组合物及其制备方法

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434227A (en) 1982-02-08 1984-02-28 Abbott Laboratories Immunoassay for class specific immunoglobulin antibodies
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
CA1261257A (en) 1984-09-19 1989-09-26 Helgi Valdimarsson Prognostic value of rheumatoid factor isotypes and their association with disease activity
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
DK0463151T3 (da) 1990-01-12 1996-07-01 Cell Genesys Inc Frembringelse af xenogene antistoffer
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US6407213B1 (en) 1991-06-14 2002-06-18 Genentech, Inc. Method for making humanized antibodies
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5484892A (en) 1993-05-21 1996-01-16 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells
US5595721A (en) 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
EP0811059A4 (en) 1995-02-08 1998-04-01 Human Genome Sciences Inc BETA-11 HUMAN CHEMOKINE AND ALPHA-1 HUMAN CHEMOKINE
US6139832A (en) 1995-02-08 2000-10-31 Human Genome Sciences, Inc. Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides
ATE390933T1 (de) 1995-04-27 2008-04-15 Amgen Fremont Inc Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
AU723891B2 (en) 1995-06-05 2000-09-07 Human Genome Sciences, Inc. Human chemokine beta-11 and human chemokine alpha-1
US6254868B1 (en) 1996-03-20 2001-07-03 Immunomedics, Inc. Glycosylated humanized B-cell specific antibodies
DE69635088T3 (de) 1996-10-25 2012-01-26 Human Genome Sciences, Inc. NEUTROKIN alpha
KR100643058B1 (ko) 1996-12-03 2006-11-13 아브게닉스, 인크. 복수의 Vн 및 Vк 영역을 함유하는 인간 면역글로불린 유전자좌를 갖는 트랜스제닉 포유동물 및 이로부터 생성된 항체
WO1998027114A2 (en) 1996-12-17 1998-06-25 Schering Corporation Mammalian cell surface antigens; related reagents
US6183744B1 (en) 1997-03-24 2001-02-06 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
CA2232743A1 (en) 1997-04-02 1998-10-02 Smithkline Beecham Corporation A tnf homologue, tl5
IL134480A0 (en) 1997-09-12 2001-04-30 Apotech Sa Kay - an immune system protein and dna sequences encoding the same
WO1999021577A1 (fr) * 1997-10-29 1999-05-06 Otsuka Pharmaceutical Co., Ltd. Compositions inhibant la proliferation des muscles lisses, procede de diagnostic de l'arteriosclerose et trousses correspondantes
US6110695A (en) 1997-12-02 2000-08-29 The Regents Of The University Of California Modulating the interaction of the chemokine, B Lymphocyte Hemoattractant, and its Receptor, BLR1
AU2093499A (en) 1997-12-30 1999-07-19 Chiron Corporation Members of tnf and tnfr families
ES2292236T3 (es) 1998-04-02 2008-03-01 Genentech, Inc. Variantes de anticuerpos y sus fragmentos.
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
ES2338661T3 (es) 1999-01-07 2010-05-11 Zymogenetics, Inc. Usos terapeuticos de receptores solubles br43x2.
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
HUP0104865A3 (en) 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
EP2289551A1 (en) 1999-06-09 2011-03-02 Immunomedics, Inc. Immunotherapy of autoimmune disorders using antibodies which target B-cells
BR0013391A (pt) 1999-08-17 2002-07-09 Biogen Inc Uso do receptor baff (bcma) como um agente imunoregulador
DE10041402A1 (de) 2000-08-23 2002-03-14 Morphochem Ag Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
JP2003508448A (ja) * 1999-09-01 2003-03-04 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 自己免疫疾患を処置するための方法および組成物
US7105149B1 (en) 1999-11-29 2006-09-12 The Trustees Of Columbia University In The City Of New York Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/myeloma
CA2408617A1 (en) 2000-05-12 2001-11-22 Amgen Inc. Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci
MXPA02012434A (es) 2000-06-16 2004-09-06 Cambridge Antibody Tech Anticuerpos que se unen inmunoespecificamente a estimulador de linfocitos ii.
EP2267015A3 (en) 2000-08-18 2011-04-20 Human Genome Sciences, Inc. Binding polypeptides for B lymphocyte stimulator protein (BLyS)
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
DE60138927D1 (de) 2000-11-07 2009-07-16 Zymogenetics Inc Menschlicher rezeptor für tumor necrosis factor
WO2002066516A2 (en) 2001-02-20 2002-08-29 Zymogenetics, Inc. Antibodies that bind both bcma and taci
US6818406B2 (en) 2001-03-23 2004-11-16 Mayo Foundation For Medical Education And Research Rheumatoid arthritis markers
PL393317A1 (pl) 2001-05-11 2011-05-23 Amgen Inc. Peptydy oraz pokrewne cząsteczki wiążące TALL-1
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7321026B2 (en) 2001-06-27 2008-01-22 Skytech Technology Limited Framework-patched immunoglobulins
WO2003014294A2 (en) 2001-08-03 2003-02-20 Genentech, Inc. Tacis and br3 polypeptides and uses thereof
US7256015B2 (en) 2001-09-21 2007-08-14 Amgen Inc. TALL-1 receptor molecules and uses thereof
US7825089B2 (en) 2001-10-24 2010-11-02 National Jewish Health Three-dimensional structures of TALL-1 and its cognate receptors and modified proteins and methods related thereto
AU2002367732A1 (en) 2001-10-31 2003-09-09 Children's Hospital Medical Center Method for diagnosis and treatment of rheumatoid arthritis
US20030224386A1 (en) * 2001-12-19 2003-12-04 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of rheumatoid arthritis
RU2004127458A (ru) 2002-02-14 2005-10-27 Иммуномедикс, Инк. (Us) Анти-cd20 антитела, их гибридные белки и способы их использования
WO2003072736A2 (en) 2002-02-21 2003-09-04 Duke University Reagents and treatment methods for autoimmune diseases
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
CA2492232A1 (en) 2002-07-18 2004-01-29 Fabio Perini S.P.A. Storage unit for elongated products
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
KR20110140142A (ko) 2002-10-17 2011-12-30 젠맵 에이/에스 Cd20에 대한 인간 모노클로날 항체
EP2301966A1 (en) 2002-12-16 2011-03-30 Genentech, Inc. Immunoglobulin variants and uses thereof
SE0300959D0 (sv) * 2002-12-19 2003-04-02 Pharmacia Ab Methods for predicting therapeutic response to agents acting on the growth hormone receptor
US6962006B2 (en) 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US20050163775A1 (en) 2003-06-05 2005-07-28 Genentech, Inc. Combination therapy for B cell disorders
CA2526402A1 (en) 2003-06-05 2005-01-20 Genentech, Inc. Blys antagonists and uses thereof
IL156495A0 (en) 2003-06-17 2004-01-04 Prochon Biotech Ltd Use of fgfr3 antagonists for treating t cell mediated diseases
US20060094056A1 (en) 2003-09-15 2006-05-04 Oklahoma Medical Research Foundation Method of using cytokine assays to diagnose treat, and evaluate inflammatory and autoimmune diseases
DE102004016437A1 (de) * 2004-04-04 2005-10-20 Oligene Gmbh Verfahren zur Erkennung von Signaturen in komplexen Genexpressionsprofilen
CA2501422C (en) 2004-04-29 2014-08-12 University Of Rochester Lymphoid chemokines in the diagnosis, monitoring and treatment of autoimmune disease
CA2568336A1 (en) 2004-06-04 2005-12-22 Genentech, Inc. Method for treating lupus
WO2006039238A2 (en) 2004-09-30 2006-04-13 The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Irta2 antibodies and methods of use
KR20070100228A (ko) 2004-10-05 2007-10-10 제넨테크, 인크. 혈관염의 치료 방법
WO2006138275A2 (en) 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
EP1919505A2 (en) * 2005-07-25 2008-05-14 Trubion Pharmaceuticals, Inc. Single dose use of cd20-specific binding molecules
CN101262876A (zh) 2005-08-09 2008-09-10 酶遗传学股份有限公司 用taci-ig融合分子治疗b细胞恶性肿瘤的方法
WO2007038501A2 (en) 2005-09-27 2007-04-05 The Feinstein Institute For Medical Research Rheumatoid arthritis markers
WO2007038754A2 (en) * 2005-09-27 2007-04-05 Source Mdx Gene expression profiling for identification monitoring and treatment of rheumatoid arthritis
CN101405685A (zh) 2006-03-15 2009-04-08 皇家飞利浦电子股份有限公司 具有滚动检测的遥控指向技术
GB0607774D0 (en) 2006-04-20 2006-05-31 Renovo Group Plc Medicaments
KR101484025B1 (ko) 2006-04-21 2015-01-19 얀센 바이오테크 인코포레이티드 염증성 질환의 치료를 위한 cxcl13 길항제 및 이의 용도
ES2419059T3 (es) * 2006-05-16 2013-08-19 Dxterity Diagnostics Inc. Evaluación del efecto de un agente en un estado biológico humano usando paneles de expresión génica de roedores
EP1857559A1 (en) 2006-05-16 2007-11-21 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for predicting responsiveness to TNF alpha blocking agents
US20070269827A1 (en) * 2006-05-18 2007-11-22 Oklahoma Medical Research Foundation Predicting and Diagnosing Patients With Autoimmune Disease
WO2008156494A1 (en) * 2006-11-03 2008-12-24 The Johns Hopkins University Use of high-dose oxazaphosphorine drugs in combination with monoclonal antibodies for treating immune disorders
EP2084298A1 (en) 2006-11-09 2009-08-05 Institut National De La Sante Et De La Recherche Medicale Method for predicting therapeutic responsiveness to tnf-alpha blocking agents
US20080227704A1 (en) 2006-12-21 2008-09-18 Kamens Joanne S CXCL13 binding proteins
US20080199481A1 (en) 2007-02-21 2008-08-21 Astrazeneca Ab Compounds
WO2008104608A1 (en) 2007-03-01 2008-09-04 Universite Catholique De Louvain Method for the determination and the classification of rheumatic conditions
CA2682666A1 (en) 2007-03-30 2008-10-09 Centocor Ortho Biotech Inc. Cxcl13 antagonists and their use for the treatment of inflammatory diseases
MX2009010620A (es) * 2007-04-02 2009-11-25 Genentech Inc Marcadores biologicos predictivos de respuesta de artritis reumatoide a antagonistas de celula-b.
WO2008132176A2 (en) 2007-04-27 2008-11-06 Universite Catholique De Louvain Method for evaluating the response of an individual to tnf blocking therapy
EP2617837A3 (en) 2007-06-08 2013-10-23 Biogen Idec MA Inc. Biomarkers for predicting anti-TNF responsiveness or non-responsiveness
US20100261881A1 (en) 2007-09-03 2010-10-14 Protagen Ag Marker sequences for rheumatoid arthritis and use thereof
WO2009102366A2 (en) 2007-11-19 2009-08-20 Wyeth Expression of orphan gpr64 in inflammatory diseases
US8121883B2 (en) * 2008-02-07 2012-02-21 International Business Machines Corporation Method and system for automatically prioritizing opportunity based customer requirements
JP6132548B2 (ja) 2009-04-01 2017-05-24 ジェネンテック, インコーポレイテッド 抗FcRH5抗体および免疫接合体および使用方法
US8728730B2 (en) 2009-09-03 2014-05-20 Genentech, Inc. Methods for treating, diagnosing, and monitoring rheumatoid arthritis

Similar Documents

Publication Publication Date Title
JP5996429B2 (ja) 関節リウマチの治療、診断及びモニターするための方法
JP6271254B2 (ja) B細胞アンタゴニストに対する生物学的マーカー及び応答を予測するための方法
JP2013503643A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP5730576B2 (ja) 抗cd40抗体による治療に対するb細胞リンパ腫の応答性を評価するための方法及び組成物
WO2012061620A1 (en) Methods for treating, diagnosing, and monitoring rheumatoid arthritis
JP2010527325A (ja) B細胞アンタゴニストに応答する関節リウマチを予測するバイオマーカー
WO2008157282A1 (en) Biological markers predictive of rheumatoid arthritis response to b-cell antagonists
MX2011003352A (es) Marcadores biologicos predictivos de la respuesta de la artritis reumatoide a antagonistas de linfotoxina.
HK1245341B (zh) 用於治疗、诊断和监控类风湿性关节炎的方法
EP2297347B1 (en) Methods and kits for monitoring the effects of immunomodulators on adaptive immunity
HK1172061A (en) Methods for treating, diagnosing, and monitoring rheumatoid arthritis
HK1172061B (en) Methods for treating, diagnosing, and monitoring rheumatoid arthritis
HK1193437A (en) Biological markers and methods for predicting response to b-cell antagonists
HK1193437B (en) Biological markers and methods for predicting response to b-cell antagonists