ES2419059T3 - Evaluación del efecto de un agente en un estado biológico humano usando paneles de expresión génica de roedores - Google Patents

Evaluación del efecto de un agente en un estado biológico humano usando paneles de expresión génica de roedores Download PDF

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Publication number
ES2419059T3
ES2419059T3 ES07795008T ES07795008T ES2419059T3 ES 2419059 T3 ES2419059 T3 ES 2419059T3 ES 07795008 T ES07795008 T ES 07795008T ES 07795008 T ES07795008 T ES 07795008T ES 2419059 T3 ES2419059 T3 ES 2419059T3
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ES
Spain
Prior art keywords
gene expression
biological state
evaluation
agent
panel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07795008T
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English (en)
Inventor
Michael Bevilacqua
Victor Tryon
John Cheronis
Danute Bankaitis-Davis
Kathleen Storm
Karl Wassman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SOURCE MDX
DxTerity Diagnostics Inc
Original Assignee
SOURCE MDX
DxTerity Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by SOURCE MDX, DxTerity Diagnostics Inc filed Critical SOURCE MDX
Application granted granted Critical
Publication of ES2419059T3 publication Critical patent/ES2419059T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

Un procedimiento para identificar un panel de expresión génica distintivo de roedor para usar en la evaluación deun agente en un estado biológico humano de interés, comprendiendo el método: identificar un panel de expresión génica para seres humanos con respecto al cual los niveles de expresión de losconstituyentes son indicativos del estado biológico de interés; evaluar en una población de roedores los genes constituyentes del panel de expresión génica identificado paradeterminar que constituyentes presentan características análogas a las expresiones génicas en seres humanoscuando se miden en condiciones que son sustancialmente repetibles, y por lo tanto son indicativos del estadobiológico de interés tanto en seres humanos como en roedores, en el que un conjunto de constituyentes que se hadeterminado que es indicativo constituye el panel distintivo y en el que el panel distintivo consiste en una pluralidadde constituyentes de cualquiera de las tablas 3-9.
ES07795008T 2006-05-16 2007-05-16 Evaluación del efecto de un agente en un estado biológico humano usando paneles de expresión génica de roedores Active ES2419059T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80080206P 2006-05-16 2006-05-16
US800802P 2006-05-16
PCT/US2007/011873 WO2007136728A2 (en) 2006-05-16 2007-05-16 Assessment of effect of an agent on a human biological condition using rodent gene expression panels

Publications (1)

Publication Number Publication Date
ES2419059T3 true ES2419059T3 (es) 2013-08-19

Family

ID=38603395

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07795008T Active ES2419059T3 (es) 2006-05-16 2007-05-16 Evaluación del efecto de un agente en un estado biológico humano usando paneles de expresión génica de roedores

Country Status (6)

Country Link
US (2) US20080227655A1 (es)
EP (1) EP2024514B1 (es)
AU (1) AU2007254206A1 (es)
CA (1) CA2652239A1 (es)
ES (1) ES2419059T3 (es)
WO (1) WO2007136728A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5996429B2 (ja) * 2009-09-03 2016-09-21 ジェネンテック， インコーポレイテッド 関節リウマチの治療、診断及びモニターするための方法
EP2542696B1 (en) 2010-03-01 2016-09-28 Caris Life Sciences Switzerland Holdings GmbH Biomarkers for theranostics
AU2011237669B2 (en) 2010-04-06 2016-09-08 Caris Life Sciences Switzerland Holdings Gmbh Circulating biomarkers for disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6960439B2 (en) * 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
AU784233B2 (en) * 1999-06-28 2006-02-23 Life Technologies Corporation Systems and methods for characterizing a biological condition or agent using calibrated gene expression profiles
WO2003072827A1 (en) * 2001-10-31 2003-09-04 Children's Hospital Medical Center Method for diagnosis and treatment of rheumatoid arthritis
KR20040064275A (ko) * 2001-11-09 2004-07-16 소스 프리시전 메디슨, 인코포레이티드 유전자 발현 프로파일을 이용한 질병의 동정, 모니터링,치료 및 생물학적 상태의 확인
BR0317612A (pt) * 2002-12-19 2005-12-06 Source Precision Medicine Inc Identificação, monitoração e tratamento de doença infecciosa e caracterização de condições inflamatórias relacionadas com doença infecciosa empregando perfis de expressão de gene
WO2004110244A2 (en) * 2003-05-08 2004-12-23 Vanderbilt University A gene equation to diagnose rheumatoid arthritis
US7588892B2 (en) * 2004-07-19 2009-09-15 Entelos, Inc. Reagent sets and gene signatures for renal tubule injury
US20070059685A1 (en) * 2005-06-03 2007-03-15 Kohne David E Method for producing improved results for applications which directly or indirectly utilize gene expression assay results

Also Published As

Publication number Publication date
EP2024514B1 (en) 2013-02-27
EP2024514A2 (en) 2009-02-18
US20110092390A1 (en) 2011-04-21
WO2007136728A3 (en) 2008-01-24
AU2007254206A1 (en) 2007-11-29
CA2652239A1 (en) 2007-11-29
US20080227655A1 (en) 2008-09-18
WO2007136728A2 (en) 2007-11-29

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