JP2012528599A5 - - Google Patents
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- JP2012528599A5 JP2012528599A5 JP2012514169A JP2012514169A JP2012528599A5 JP 2012528599 A5 JP2012528599 A5 JP 2012528599A5 JP 2012514169 A JP2012514169 A JP 2012514169A JP 2012514169 A JP2012514169 A JP 2012514169A JP 2012528599 A5 JP2012528599 A5 JP 2012528599A5
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- JP
- Japan
- Prior art keywords
- cells
- cell
- cell population
- item
- reprogramming
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 98
- 210000004027 cell Anatomy 0.000 claims description 72
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 50
- 108090000623 proteins and genes Proteins 0.000 claims description 30
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 26
- 230000008672 reprogramming Effects 0.000 claims description 25
- 102000004169 proteins and genes Human genes 0.000 claims description 24
- 238000013518 transcription Methods 0.000 claims description 16
- 230000035897 transcription Effects 0.000 claims description 16
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 15
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 14
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 14
- 239000013598 vector Substances 0.000 claims description 8
- 108090000695 Cytokines Proteins 0.000 claims description 7
- 102000004127 Cytokines Human genes 0.000 claims description 7
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 7
- 210000004369 blood Anatomy 0.000 claims description 6
- 239000008280 blood Substances 0.000 claims description 6
- 238000000338 in vitro Methods 0.000 claims description 5
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims description 4
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims description 4
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims description 4
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims description 4
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims description 4
- 241000700605 Viruses Species 0.000 claims description 4
- 101150111214 lin-28 gene Proteins 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000003550 marker Substances 0.000 claims description 3
- 101100239628 Danio rerio myca gene Proteins 0.000 claims description 2
- 101150099612 Esrrb gene Proteins 0.000 claims description 2
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims description 2
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims description 2
- 101100220044 Homo sapiens CD34 gene Proteins 0.000 claims description 2
- 108010002350 Interleukin-2 Proteins 0.000 claims description 2
- 108010002386 Interleukin-3 Proteins 0.000 claims description 2
- 101710177504 Kit ligand Proteins 0.000 claims description 2
- 101100510267 Mus musculus Klf4 gene Proteins 0.000 claims description 2
- 101150012532 NANOG gene Proteins 0.000 claims description 2
- 108091005804 Peptidases Proteins 0.000 claims description 2
- 239000004365 Protease Substances 0.000 claims description 2
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 2
- 108700042075 T-Cell Receptor Genes Proteins 0.000 claims description 2
- 239000012503 blood component Substances 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 210000004413 cardiac myocyte Anatomy 0.000 claims description 2
- 238000003776 cleavage reaction Methods 0.000 claims description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 2
- 230000001605 fetal effect Effects 0.000 claims description 2
- 210000002950 fibroblast Anatomy 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 210000001165 lymph node Anatomy 0.000 claims description 2
- 210000003071 memory t lymphocyte Anatomy 0.000 claims description 2
- 210000000581 natural killer T-cell Anatomy 0.000 claims description 2
- 210000002569 neuron Anatomy 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 210000003289 regulatory T cell Anatomy 0.000 claims description 2
- 230000001177 retroviral effect Effects 0.000 claims description 2
- 230000007017 scission Effects 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 230000026683 transduction Effects 0.000 claims description 2
- 238000010361 transduction Methods 0.000 claims description 2
- 210000003954 umbilical cord Anatomy 0.000 claims description 2
- 239000013603 viral vector Substances 0.000 claims description 2
- 230000003612 virological effect Effects 0.000 claims description 2
- -1 Nanog Proteins 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 101150101299 gene 4 gene Proteins 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 210000002510 keratinocyte Anatomy 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 2
- 108010071942 Colony-Stimulating Factors Proteins 0.000 description 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18454609P | 2009-06-05 | 2009-06-05 | |
| US61/184,546 | 2009-06-05 | ||
| US24011609P | 2009-09-04 | 2009-09-04 | |
| US61/240,116 | 2009-09-04 | ||
| PCT/US2010/037376 WO2010141801A2 (en) | 2009-06-05 | 2010-06-04 | Reprogramming t cells and hematophietic cells |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014171199A Division JP2014217393A (ja) | 2009-06-05 | 2014-08-26 | リプログラミングｔ細胞および造血細胞 |
| JP2017052542A Division JP2017104140A (ja) | 2009-06-05 | 2017-03-17 | リプログラミングｔ細胞および造血細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012528599A JP2012528599A (ja) | 2012-11-15 |
| JP2012528599A5 true JP2012528599A5 (https=) | 2013-02-14 |
Family
ID=42357428
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514169A Pending JP2012528599A (ja) | 2009-06-05 | 2010-06-04 | リプログラミングｔ細胞および造血細胞 |
| JP2014171199A Pending JP2014217393A (ja) | 2009-06-05 | 2014-08-26 | リプログラミングｔ細胞および造血細胞 |
| JP2017052542A Pending JP2017104140A (ja) | 2009-06-05 | 2017-03-17 | リプログラミングｔ細胞および造血細胞 |
| JP2017229990A Pending JP2018029622A (ja) | 2009-06-05 | 2017-11-30 | リプログラミングｔ細胞および造血細胞 |
| JP2018138432A Pending JP2018198604A (ja) | 2009-06-05 | 2018-07-24 | リプログラミングｔ細胞および造血細胞 |
| JP2018138431A Active JP6865199B2 (ja) | 2009-06-05 | 2018-07-24 | リプログラミングｔ細胞および造血細胞 |
| JP2019172230A Pending JP2020022462A (ja) | 2009-06-05 | 2019-09-20 | リプログラミングｔ細胞および造血細胞 |
| JP2020070196A Pending JP2020124197A (ja) | 2009-06-05 | 2020-04-09 | リプログラミングｔ細胞および造血細胞 |
| JP2020160507A Pending JP2021000131A (ja) | 2009-06-05 | 2020-09-25 | リプログラミングｔ細胞および造血細胞 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014171199A Pending JP2014217393A (ja) | 2009-06-05 | 2014-08-26 | リプログラミングｔ細胞および造血細胞 |
| JP2017052542A Pending JP2017104140A (ja) | 2009-06-05 | 2017-03-17 | リプログラミングｔ細胞および造血細胞 |
| JP2017229990A Pending JP2018029622A (ja) | 2009-06-05 | 2017-11-30 | リプログラミングｔ細胞および造血細胞 |
| JP2018138432A Pending JP2018198604A (ja) | 2009-06-05 | 2018-07-24 | リプログラミングｔ細胞および造血細胞 |
| JP2018138431A Active JP6865199B2 (ja) | 2009-06-05 | 2018-07-24 | リプログラミングｔ細胞および造血細胞 |
| JP2019172230A Pending JP2020022462A (ja) | 2009-06-05 | 2019-09-20 | リプログラミングｔ細胞および造血細胞 |
| JP2020070196A Pending JP2020124197A (ja) | 2009-06-05 | 2020-04-09 | リプログラミングｔ細胞および造血細胞 |
| JP2020160507A Pending JP2021000131A (ja) | 2009-06-05 | 2020-09-25 | リプログラミングｔ細胞および造血細胞 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8741648B2 (https=) |
| EP (3) | EP2548950B1 (https=) |
| JP (9) | JP2012528599A (https=) |
| KR (3) | KR101811235B1 (https=) |
| CN (3) | CN103087991B (https=) |
| AU (1) | AU2010254811B2 (https=) |
| CA (2) | CA2764373C (https=) |
| DK (3) | DK2548950T3 (https=) |
| IL (2) | IL216707B (https=) |
| WO (1) | WO2010141801A2 (https=) |
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| US9206394B2 (en) | 2010-02-03 | 2015-12-08 | The University Of Tokyo | Method for reconstructing immune function using pluripotent stem cells |
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| WO2011159684A2 (en) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
| CA2806858C (en) * | 2010-08-04 | 2021-06-15 | Cellular Dynamics International, Inc. | Reprogramming immortalized b cells |
| CA2826386C (en) | 2011-02-08 | 2020-04-28 | FUJIFILM Cellular Dynamics, Inc. | Hematopoietic precursor cell production by programming |
| CA2875858C (en) | 2011-06-21 | 2022-05-03 | Georgia Tech Research Corporation | Adhesive signature-based methods for the isolation of stem cells and cells derived therefrom |
| WO2013070468A1 (en) * | 2011-11-08 | 2013-05-16 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
| US10428309B2 (en) | 2011-12-01 | 2019-10-01 | New York Stem Cell Foundation, Inc. | Systems and methods for producing stem cells and differentiated cells |
| ES2773863T3 (es) * | 2011-12-01 | 2020-07-15 | New York Stem Cell Found Inc | Sistema automatizado para la producción de células madre pluripotentes inducidas o células diferenciadas |
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| WO2014165707A2 (en) | 2013-04-03 | 2014-10-09 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted t-cells derived from pluripotent stem cells |
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