JP2012526843A5 - - Google Patents
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- JP2012526843A5 JP2012526843A5 JP2012511011A JP2012511011A JP2012526843A5 JP 2012526843 A5 JP2012526843 A5 JP 2012526843A5 JP 2012511011 A JP2012511011 A JP 2012511011A JP 2012511011 A JP2012511011 A JP 2012511011A JP 2012526843 A5 JP2012526843 A5 JP 2012526843A5
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- 239000002245 particle Substances 0.000 claims 18
- 239000003814 drug Substances 0.000 claims 10
- 239000013543 active substance Substances 0.000 claims 7
- 239000011248 coating agent Substances 0.000 claims 5
- 238000000576 coating method Methods 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 4
- -1 Allosteric inhibitor Substances 0.000 claims 3
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 230000001430 anti-depressive effect Effects 0.000 claims 2
- 239000000935 antidepressant agent Substances 0.000 claims 2
- 229940005513 antidepressants Drugs 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
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- 229940125723 sedative agent Drugs 0.000 claims 2
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- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000000230 African Trypanosomiasis Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
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- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010008631 Cholera Diseases 0.000 claims 1
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- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
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- 206010014909 Enterovirus infection Diseases 0.000 claims 1
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- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
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- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
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- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
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- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 229940122313 Nucleoside reverse transcriptase inhibitor Drugs 0.000 claims 1
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- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
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- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
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- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 239000000150 Sympathomimetic Substances 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 241000223105 Trypanosoma brucei Species 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 210000000683 abdominal cavity Anatomy 0.000 claims 1
- 230000001800 adrenalinergic effect Effects 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 239000000674 adrenergic antagonist Substances 0.000 claims 1
- 229930013930 alkaloid Natural products 0.000 claims 1
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- 229940100198 alkylating agent Drugs 0.000 claims 1
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- 239000003146 anticoagulant agent Substances 0.000 claims 1
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- 229940127074 antifolate Drugs 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 229940030225 antihemorrhagics Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000003926 antimycobacterial agent Substances 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 239000003908 antipruritic agent Substances 0.000 claims 1
- 239000002221 antipyretic Substances 0.000 claims 1
- 239000003435 antirheumatic agent Substances 0.000 claims 1
- 239000003434 antitussive agent Substances 0.000 claims 1
- 229940124584 antitussives Drugs 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 239000002249 anxiolytic agent Substances 0.000 claims 1
- 239000002830 appetite depressant Substances 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
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- 230000004700 cellular uptake Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
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- 239000003246 corticosteroid Substances 0.000 claims 1
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- 239000002874 hemostatic agent Substances 0.000 claims 1
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- 208000002672 hepatitis B Diseases 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
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- 208000029080 human African trypanosomiasis Diseases 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 239000003326 hypnotic agent Substances 0.000 claims 1
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- 208000027866 inflammatory disease Diseases 0.000 claims 1
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- 238000001361 intraarterial administration Methods 0.000 claims 1
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- 238000007913 intrathecal administration Methods 0.000 claims 1
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- 201000010982 kidney cancer Diseases 0.000 claims 1
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- 230000003278 mimic effect Effects 0.000 claims 1
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- 206010028417 myasthenia gravis Diseases 0.000 claims 1
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- 239000003176 neuroleptic agent Substances 0.000 claims 1
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- 229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 claims 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 239000000734 parasympathomimetic agent Substances 0.000 claims 1
- 230000001499 parasympathomimetic effect Effects 0.000 claims 1
- 229940005542 parasympathomimetics Drugs 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 201000002628 peritoneum cancer Diseases 0.000 claims 1
- 210000001539 phagocyte Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
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- 238000002360 preparation method Methods 0.000 claims 1
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- 150000003180 prostaglandins Chemical class 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 229940121896 radiopharmaceutical Drugs 0.000 claims 1
- 239000012217 radiopharmaceutical Substances 0.000 claims 1
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- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 1
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- 239000000021 stimulant Substances 0.000 claims 1
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- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 206010043778 thyroiditis Diseases 0.000 claims 1
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- 210000004881 tumor cell Anatomy 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/467,230 | 2009-05-15 | ||
| US12/467,230 US10952965B2 (en) | 2009-05-15 | 2009-05-15 | Compositions and methods for drug delivery |
| PCT/US2010/034711 WO2010132664A1 (en) | 2009-05-15 | 2010-05-13 | Compositions and methods for drug delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526843A JP2012526843A (ja) | 2012-11-01 |
| JP2012526843A5 true JP2012526843A5 (https=) | 2013-05-30 |
| JP5668055B2 JP5668055B2 (ja) | 2015-02-12 |
Family
ID=42611234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511011A Active JP5668055B2 (ja) | 2009-05-15 | 2010-05-13 | 薬物送達のための組成物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10952965B2 (https=) |
| EP (1) | EP2429493B1 (https=) |
| JP (1) | JP5668055B2 (https=) |
| KR (1) | KR101722794B1 (https=) |
| CN (1) | CN102458369B (https=) |
| AU (1) | AU2010249008B2 (https=) |
| BR (1) | BRPI1010903A2 (https=) |
| CA (1) | CA2761801C (https=) |
| ES (1) | ES2509919T3 (https=) |
| IL (1) | IL216374A (https=) |
| MX (1) | MX2011012196A (https=) |
| SG (1) | SG176055A1 (https=) |
| WO (1) | WO2010132664A1 (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101660059B1 (ko) | 2008-08-22 | 2016-09-26 | 박스알타 인코퍼레이티드 | 중합체 벤질 카르보네이트-유도체 |
| US8480803B2 (en) | 2009-10-30 | 2013-07-09 | Corning Incorporated | Method of making an article of semiconducting material |
| EP2538929A4 (en) | 2010-02-25 | 2014-07-09 | Univ Johns Hopkins | DELAYED RELEASE OF THERAPIES IN A PART OF THE EYE |
| WO2011131943A2 (en) * | 2010-04-20 | 2011-10-27 | Cipla Limited | Pharmaceutical compositions |
| US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| WO2012109363A2 (en) | 2011-02-08 | 2012-08-16 | The Johns Hopkins University | Mucus penetrating gene carriers |
| CA2863632C (en) | 2012-01-19 | 2017-07-11 | The Johns Hopkins University | Nanoparticle formulations with enhanced mucosal penetration |
| JP6138904B2 (ja) | 2012-03-16 | 2017-05-31 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート |
| US8962577B2 (en) | 2012-03-16 | 2015-02-24 | The Johns Hopkins University | Controlled release formulations for the delivery of HIF-1 inhibitors |
| AU2013256064B2 (en) | 2012-05-03 | 2018-01-04 | Alcon Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
| US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| KR102310775B1 (ko) | 2012-05-03 | 2021-10-07 | 칼라 파마슈티컬스, 인크. | 개선된 점막 수송을 나타내는 제약 나노입자 |
| US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| AU2013256008B2 (en) | 2012-05-04 | 2016-02-25 | The Johns Hopkins University | Lipid-based drug carriers for rapid penetration through mucus linings |
| WO2014124006A1 (en) | 2013-02-05 | 2014-08-14 | The Johns Hopkins University | Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof |
| JP6669499B2 (ja) | 2013-02-15 | 2020-03-18 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物 |
| JP2016510000A (ja) | 2013-02-20 | 2016-04-04 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物およびその使用 |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
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| CN104225609B (zh) * | 2014-09-20 | 2018-05-18 | 中国药科大学 | 一种炎症靶向的中性粒细胞递药系统及其应用 |
| CN107635545A (zh) | 2015-01-27 | 2018-01-26 | 约翰霍普金斯大学 | 用于增强粘膜表面处活性剂的输送的低渗水凝胶制剂 |
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| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
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| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| WO2017218630A2 (en) * | 2016-06-15 | 2017-12-21 | Autotelic Llc | Phospholipid-coated therapeutic agent nanoparticles and related methods |
| RU2018145364A (ru) | 2016-06-27 | 2020-07-28 | Ачиллион Фармасьютикалс, Инк. | Хиназолиновые и индольные соединения для лечения медицинских нарушений |
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| KR20190051010A (ko) | 2016-09-08 | 2019-05-14 | 칼라 파마슈티컬스, 인크. | 치료 화합물의 결정형 및 그의 용도 |
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| EP3866773B1 (en) | 2018-10-16 | 2024-08-28 | Georgia State University Research Foundation, Inc. | Carbon monoxide prodrugs for the treatment of medical disorders |
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| CN120172958A (zh) | 2019-04-12 | 2025-06-20 | C4医药公司 | Ikaros和aiolos的三环降解物 |
| WO2021168320A1 (en) | 2020-02-20 | 2021-08-26 | Achillion Pharmaceuticals, Inc. | Heteroaryl compounds for treatment of complement factor d mediated disorders |
| AU2021231898A1 (en) | 2020-03-05 | 2022-10-27 | C4 Therapeutics, Inc. | Compounds for targeted degradation of BRD9 |
| ES3048084T3 (en) | 2020-05-19 | 2025-12-09 | Pharmacosmos Holding As | Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders |
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