JP2015514739A5 - - Google Patents

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Publication number
JP2015514739A5
JP2015514739A5 JP2015506258A JP2015506258A JP2015514739A5 JP 2015514739 A5 JP2015514739 A5 JP 2015514739A5 JP 2015506258 A JP2015506258 A JP 2015506258A JP 2015506258 A JP2015506258 A JP 2015506258A JP 2015514739 A5 JP2015514739 A5 JP 2015514739A5
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JP
Japan
Prior art keywords
agent
composition
radiprodil
antagonist
pharmaceutical
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JP2015506258A
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English (en)
Japanese (ja)
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JP2015514739A (ja
JP6042968B2 (ja
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Priority claimed from PCT/EP2013/058212 external-priority patent/WO2013156614A1/en
Publication of JP2015514739A publication Critical patent/JP2015514739A/ja
Publication of JP2015514739A5 publication Critical patent/JP2015514739A5/ja
Application granted granted Critical
Publication of JP6042968B2 publication Critical patent/JP6042968B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2015506258A 2012-04-20 2013-04-19 パーキンソン病の処置方法 Expired - Fee Related JP6042968B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261636054P 2012-04-20 2012-04-20
US61/636,054 2012-04-20
PCT/EP2013/058212 WO2013156614A1 (en) 2012-04-20 2013-04-19 Methods for treating parkinson's disease

Publications (3)

Publication Number Publication Date
JP2015514739A JP2015514739A (ja) 2015-05-21
JP2015514739A5 true JP2015514739A5 (https=) 2016-03-24
JP6042968B2 JP6042968B2 (ja) 2016-12-14

Family

ID=48182898

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015506258A Expired - Fee Related JP6042968B2 (ja) 2012-04-20 2013-04-19 パーキンソン病の処置方法

Country Status (9)

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US (2) US9387212B2 (https=)
EP (1) EP2838530B1 (https=)
JP (1) JP6042968B2 (https=)
KR (1) KR20140146217A (https=)
CN (1) CN104321057B (https=)
AU (1) AU2013251079B2 (https=)
CA (1) CA2869216A1 (https=)
ES (1) ES2627541T3 (https=)
WO (1) WO2013156614A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017107558A (ru) 2014-09-15 2018-10-18 Руджен Холдингс (Кайман) Лимитед Производные пирролопиримидина в качестве антагонистов nmda-рецептора nr2b
US10202363B2 (en) * 2014-12-23 2019-02-12 Cerecor, Inc. Compounds, compositions and methods
KR102613179B1 (ko) * 2015-06-01 2023-12-14 뤼겐 홀딩스 (케이맨) 리미티드 Nr2b nmda 수용체 길항제로서의 3,3-디플루오로피페리딘 카바메이트 헤테로사이클릭 화합물
WO2017136375A1 (en) * 2016-02-05 2017-08-10 Concert Pharmaceuticals, Inc. Deuterated tozadenant
CN106214652A (zh) * 2016-08-31 2016-12-14 安徽省润生医药股份有限公司 一种含有伊曲茶碱的药物组合物
US11000526B2 (en) 2016-11-22 2021-05-11 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
CN108864114B (zh) * 2018-06-04 2020-11-06 应世生物科技(南京)有限公司 选择性a2a受体拮抗剂
MX2021008094A (es) 2019-01-11 2021-09-21 Omeros Corp Metodos y composiciones para el tratamiento del cancer.
WO2025137652A2 (en) 2023-12-20 2025-06-26 Grin Therapeutics, Inc. Methods of using radiprodil in the treatment of disorders

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE258067T1 (de) * 1995-05-26 2004-02-15 Pfizer Kombinationspräparat zur behandlung der parkinsonschen krankheit, das selektive nmda- antagonisten enthält
DE69834500T2 (de) * 1997-09-05 2007-05-03 Kyowa Hakko Kogyo Co., Ltd. Xanthinderivative zur behandlung von hirnischämie
WO2000067803A1 (en) 1999-05-10 2000-11-16 Princeton University Compositions and methods for improving learning and memory
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
AU1153601A (en) 1999-10-29 2001-05-08 Merck Sharp & Dohme Limited Method to treat pain utilizing benzimidazole NMDA NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
GB0015488D0 (en) 2000-06-23 2000-08-16 Merck Sharp & Dohme Therapeutic agents
EP1296958A4 (en) 2000-06-26 2004-01-28 Merck & Co Inc ANTIAGONISTS OF NMDA NR2B RECEPTORS OF IMINOPYRIMIDINE
WO2002009736A1 (en) 2000-07-27 2002-02-07 Washington University Methods and agents for treating persistent pain
AU2001280996A1 (en) 2000-08-04 2002-02-18 Cis Biotech, Inc. Rapid multiple panel of biomarkers in laboratory blood tests for tia/stroke
HU227197B1 (en) 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
PL364625A1 (en) 2001-02-23 2004-12-13 Merck & Co, Inc. N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
CA2443108A1 (en) 2001-04-03 2002-10-17 Merck & Co. Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
JP2004537526A (ja) 2001-06-12 2004-12-16 メルク エンド カムパニー インコーポレーテッド 片頭痛の治療又は予防用nr2b受容体拮抗薬
CA2453383C (en) 2001-07-24 2010-04-06 Richter Gedeon Vegyeszeti Gyar Rt Piperidine derivatives as nmda receptor antagonists
AU2003230758A1 (en) 2002-04-02 2003-10-20 Merck And Co., Inc. 5h-benzo(4,5)cyclohepta(1,2-b)pyridine nmda/nr2b antagonists
US6713490B2 (en) 2002-04-26 2004-03-30 Pfizer, Inc. 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
JP2006509763A (ja) 2002-11-22 2006-03-23 メルク エンド カムパニー インコーポレーテッド Nr2b受容体アンタゴニストとしての2−[(4−ベンジル)−1−ピペリジニル)メチル]ベンゾイミダゾール−5−オール誘導体
AU2003303042A1 (en) 2002-12-17 2004-07-09 Pfizer Inc. 2-pyridyl and 2-pyrimidyl cycloalkylene amide compounds as nr2b receptor antagonists
US20060106040A1 (en) 2002-12-19 2006-05-18 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
US20060128694A1 (en) 2002-12-19 2006-06-15 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
BRPI0409241A (pt) 2003-04-10 2006-03-28 Pfizer compostos bicìclicos como antagonistas do receptor de nr2b, composições farmacêuticas compreendendo os mesmos e seu uso
SI1648882T1 (sl) 2003-06-04 2009-02-28 Merck & Co Inc 3-fluoro-piperidini kot nmda/nr2b antagonisti
DE602004004278T2 (de) 2003-08-15 2007-10-31 Merck & Co, Inc. 4-cycloalkylaminopyrazolopyrimidin als nmda/nr2b-antagonisten
WO2005019222A1 (en) 2003-08-15 2005-03-03 Merck & Co., Inc. 4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists
JP4737418B2 (ja) 2003-09-25 2011-08-03 塩野義製薬株式会社 Nmda受容体拮抗作用を有するピペリジン誘導体
WO2005035522A1 (en) 2003-10-08 2005-04-21 Pfizer Japan, Inc. 1-‘2-(4-hydroxyphenyl)-2-hydroxyethyl!-piperidin-4-ol compounds as nmda receptor antagonists
WO2005035523A1 (en) 2003-10-08 2005-04-21 Pfizer Japan Inc. Fused lactam compounds
WO2005080317A2 (en) 2004-02-11 2005-09-01 Pfizer Japan, Inc. Therapeutic amide derivatives
WO2005102390A2 (en) 2004-04-22 2005-11-03 Pfizer Japan, Inc. Combinations comprising alpha-2-delta ligands and nmda receptor antagonists
RS50574B (sr) * 2004-05-24 2010-05-07 F. Hoffmann-La Roche Ag. (4-metoksi-7-morfolin-4-il-benzotiazol-2-il)-amid 4-hidroksi-4-metil-piperidin-1-karboksilne kiseline
HU226977B1 (en) 2004-07-29 2010-04-28 Richter Gedeon Nyrt Kynurenic acid amide derivatives, pharmaceutical compositions containing them and process for producing them
HUP0401522A2 (en) 2004-07-29 2006-04-28 Richter Gedeon Vegyeszet New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
CN1993363A (zh) 2004-08-03 2007-07-04 默克公司 1,3-二取代的杂芳基nmda/nr2b拮抗剂
US20090041751A1 (en) 2005-02-01 2009-02-12 University Of Medicine And Dentistry Of New Jersey Sepsis Prevention Through Adenosine Receptor Modulation
EP1874318A2 (en) 2005-04-19 2008-01-09 Merck & Co., Inc. N-alkyl-azacycloalkyl nmda/nr2b antagonists
US9107917B2 (en) 2005-05-13 2015-08-18 The Feinstein Institute For Medical Research Treatment of sepsis and inflammation with alpha2A adrenergic antagonists
WO2006129626A1 (ja) 2005-05-30 2006-12-07 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]トリアゾロ[1,5-c]ピリミジン誘導体の製造法
EP1894930A4 (en) 2005-06-23 2010-06-23 Kyowa Hakko Kirin Co Ltd THIAZOLE DERIVATIVE
JPWO2006137465A1 (ja) 2005-06-24 2009-01-22 塩野義製薬株式会社 含窒素複素環誘導体
US20100048653A1 (en) 2005-07-14 2010-02-25 The University Of British Columbia Neuroprotective modulation of nmda receptor subtype activities
US7799947B2 (en) 2005-11-29 2010-09-21 Hammersmith Imanet Limited In vivo imaging compounds
WO2007063839A1 (ja) 2005-11-30 2007-06-07 Shionogi & Co., Ltd. シクロヘキサン誘導体
EP2520567A3 (en) 2006-02-23 2012-12-12 Shionogi & Co., Ltd. Nitrogen-containing heterocycle derivatives substituted with cyclic group
ATE457988T1 (de) * 2006-06-26 2010-03-15 Schering Corp A2a-adenosin-rezeptor-antagonisten
RU2009121815A (ru) 2006-11-09 2010-12-20 Сантр Де Решерш Пюблик Де Ля Сантэ (Lu) Применение антагониста аденозина
WO2008155778A2 (en) 2007-06-19 2008-12-24 Rajiv Gandhi Centre For Biotechnology Assay for detection of transient intracellular ca2+
WO2009025265A1 (ja) 2007-08-21 2009-02-26 Shionogi & Co., Ltd. ピペラジン誘導体
US20090181934A1 (en) 2007-10-17 2009-07-16 Novartis Ag Organic Compounds
AU2008317034A1 (en) 2007-10-24 2009-04-30 Janssen Pharmaceutica, N.V. Arylindenopyrimidines and their use as Adenosine A2a receptor antagonists
WO2009054544A1 (en) * 2007-10-26 2009-04-30 Eisai R & D Management Co., Ltd. Ampa receptor antagonists for parkinson's disease and movement disorders
EP2215073A4 (en) 2007-10-31 2011-04-06 Merck Sharp & Dohme SLEEP MODULATION WITH NR2B RECEPTOR ANTAGONISTS
MX2010009649A (es) 2008-03-27 2010-12-17 Evotecv Neurosciences Gmbh Metodos para tratar trastornos utilizando un antagonista selectivo del subtipo nr2b de nmda.
US8684624B2 (en) 2008-07-01 2014-04-01 Saint-Gobain Performance Plastics Rencol Limited Tolerance ring
WO2010003712A1 (de) 2008-07-09 2010-01-14 Siemens Aktiengesellschaft Verfahren, kommunikationsverbund und software zum auffinden von gesuchten objekten
EP2144462A1 (en) 2008-07-09 2010-01-13 Nokia Siemens Networks OY Reduced resource allocation parameter signalling
AU2009282822A1 (en) * 2008-08-21 2010-02-25 Richter Gedeon Nyrt. Methods for treating CNS disorders
AU2009296235A1 (en) 2008-09-29 2010-04-01 Gilead Sciences, Inc. Combinations of a rate control agent and an A-2-alpha receptor antagonist for use in multidetector computed tomography methods
US8536306B2 (en) 2008-10-01 2013-09-17 The Scripps Research Institute Human A2A adenosine receptor crystals and uses thereof
US8282042B2 (en) 2009-06-22 2012-10-09 The Boeing Company Skin panel joint for improved airflow
US8301311B2 (en) 2009-07-06 2012-10-30 Siemens Aktiengesellschaft Frequency-responsive wind turbine output control
US20110007639A1 (en) 2009-07-10 2011-01-13 Qualcomm Incorporated Methods and apparatus for detecting identifiers
US20110105540A1 (en) 2009-10-29 2011-05-05 Jackson Paul F 2-AMINO-9-[4-(4-METHOXY-PHENOXY)-PIPERIDIN-1-YL]-4-PHENYL-INDENO[1,2-D]PYRIMIDIN-5-ONE AND ITS USE AS A HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONIST
DE102010026274A1 (de) 2010-07-06 2012-01-12 Voith Patent Gmbh Bremsanlage und Verfahren zum Einstellen eines Bremsmomentes einer solchen
AU2011306358B2 (en) * 2010-09-24 2014-08-14 Impetis Biosciences Ltd. Fused tricyclic compounds as adenosine receptor antagonist

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