JP2012526820A5 - - Google Patents

Download PDF

Info

Publication number
JP2012526820A5
JP2012526820A5 JP2012510917A JP2012510917A JP2012526820A5 JP 2012526820 A5 JP2012526820 A5 JP 2012526820A5 JP 2012510917 A JP2012510917 A JP 2012510917A JP 2012510917 A JP2012510917 A JP 2012510917A JP 2012526820 A5 JP2012526820 A5 JP 2012526820A5
Authority
JP
Japan
Prior art keywords
alkyl
group
hydrogen
aryl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012510917A
Other languages
English (en)
Japanese (ja)
Other versions
JP5918124B2 (ja
JP2012526820A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/034319 external-priority patent/WO2010132404A1/en
Publication of JP2012526820A publication Critical patent/JP2012526820A/ja
Publication of JP2012526820A5 publication Critical patent/JP2012526820A5/ja
Application granted granted Critical
Publication of JP5918124B2 publication Critical patent/JP5918124B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012510917A 2009-05-12 2010-05-11 ハロアルキルヘテロアリールベンズアミド化合物 Active JP5918124B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17762609P 2009-05-12 2009-05-12
US61/177,626 2009-05-12
PCT/US2010/034319 WO2010132404A1 (en) 2009-05-12 2010-05-11 Haloalkyl heteroaryl benzamide compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015134747A Division JP6193922B2 (ja) 2009-05-12 2015-07-03 ハロアルキルヘテロアリールベンズアミド化合物

Publications (3)

Publication Number Publication Date
JP2012526820A JP2012526820A (ja) 2012-11-01
JP2012526820A5 true JP2012526820A5 (https=) 2013-06-27
JP5918124B2 JP5918124B2 (ja) 2016-05-18

Family

ID=43069021

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012510917A Active JP5918124B2 (ja) 2009-05-12 2010-05-11 ハロアルキルヘテロアリールベンズアミド化合物
JP2015134747A Expired - Fee Related JP6193922B2 (ja) 2009-05-12 2015-07-03 ハロアルキルヘテロアリールベンズアミド化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015134747A Expired - Fee Related JP6193922B2 (ja) 2009-05-12 2015-07-03 ハロアルキルヘテロアリールベンズアミド化合物

Country Status (24)

Country Link
US (4) US8846727B2 (https=)
EP (2) EP2429986B1 (https=)
JP (2) JP5918124B2 (https=)
KR (1) KR101760956B1 (https=)
CN (2) CN102803203B (https=)
AP (1) AP3074A (https=)
AU (2) AU2010247816B2 (https=)
BR (1) BRPI1010547A2 (https=)
CA (2) CA2761876C (https=)
CL (1) CL2011002830A1 (https=)
CO (1) CO6460766A2 (https=)
CR (1) CR20110607A (https=)
DO (1) DOP2011000353A (https=)
EA (1) EA021587B1 (https=)
EC (1) ECSP11011511A (https=)
HK (1) HK1223819A1 (https=)
HN (1) HN2011003002A (https=)
IL (2) IL216331B (https=)
MX (1) MX337460B (https=)
NI (1) NI201100199A (https=)
NZ (1) NZ596538A (https=)
PE (1) PE20121118A1 (https=)
SG (2) SG176045A1 (https=)
WO (1) WO2010132404A1 (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2839425B2 (ja) 1993-04-14 1998-12-16 新日本製鐵株式会社 ドッグボーン型粗形鋼片の製造方法
PE20121118A1 (es) 2009-05-12 2012-09-05 Romark Lab Lc Compuestos de haloalquil heteroaril benzamida
AP2012006064A0 (en) * 2009-06-26 2012-02-29 Romark Lab Lc Compounds and methods for treating influenza.
WO2012126932A1 (de) 2011-03-22 2012-09-27 Bayer Cropscience Ag N-(1,3,4-oxadiazol-2-yl)arylcarbonsäureamide und ihre verwendung als herbizide
CN103717581B (zh) * 2011-08-03 2016-04-06 拜耳知识产权有限责任公司 N-(四唑-5-基)芳基甲酰胺和n-(三唑-5-基)芳基甲酰胺及其作为除草剂的用途
US9056867B2 (en) 2011-09-16 2015-06-16 Novartis Ag N-substituted heterocyclyl carboxamides
US9758494B2 (en) 2012-12-06 2017-09-12 Bayer Cropscience Ag N-(oxazol-2-yl)-aryl-carboxylic acid amides and use thereof as herbicides
CN105209031A (zh) 2012-12-27 2015-12-30 德雷克塞尔大学 针对hbv感染的新型抗病毒剂
JP6371077B2 (ja) * 2014-02-25 2018-08-08 国立大学法人佐賀大学 ジフルオロメチル基含有化合物及びその用途
WO2015170218A1 (en) 2014-05-07 2015-11-12 Pfizer Inc. Tropomyosin-related kinase inhibitors
CN107105660A (zh) 2014-11-11 2017-08-29 罗马克实验室有限公司 使用替唑尼特、其类似物或盐的前药的治疗组合物和治疗方法
CN107001352B (zh) * 2014-12-01 2021-06-04 先正达参股股份有限公司 具有含硫取代基的杀有害生物活性酰胺杂环衍生物
JP6904970B2 (ja) 2016-03-07 2021-07-21 エナンタ ファーマシューティカルズ インコーポレイテッド Ｂ型肝炎抗ウイルス剤
CN108289961A (zh) 2016-03-31 2018-07-17 罗马克实验室有限公司 用于治疗病毒性感染的噻唑化物化合物
EA202191466A1 (ru) 2016-04-11 2021-12-31 Женфит Способы лечения холестатических и фибротических заболеваний
BR112019012822A2 (pt) 2016-12-22 2019-11-26 Bayer Ag 1,2,4-tiadiazolilpirrolonas e 1,2,4-tiadiazolil-hidantoínas e sais das mesmas e uso das mesmas como herbicidas
US11173149B2 (en) 2017-04-18 2021-11-16 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase A3
US10952978B2 (en) 2017-08-28 2021-03-23 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
TW202028190A (zh) 2018-10-22 2020-08-01 美商艾森伯利生物科學公司 用於治療hbv之5員雜芳甲醯胺化合物
US11198693B2 (en) 2018-11-21 2021-12-14 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
HUE066072T2 (hu) * 2019-07-19 2024-07-28 Abivax Aril-N-aril-származékok RNS vírus fertõzés kezelésére
WO2021016543A1 (en) * 2019-07-25 2021-01-28 Romark Laboratories L.C. Antiviral combinations of thiazolide compounds
KR102782229B1 (ko) * 2019-10-02 2025-03-20 (주)카이노스메드 N-(1h-이미다졸-2-일)벤즈아미드 화합물 및 활성 성분으로 이를 포함하는 약학 조성물
CN111187215B (zh) * 2020-01-21 2023-02-24 西北农林科技大学 含氟吡唑酰胺类衍生物、制备方法及其应用
WO2021147273A1 (zh) * 2020-01-21 2021-07-29 中国人民解放军军事科学院军事医学研究院 硝唑尼特及其活性形式替唑尼特在治疗SARS-CoV-2感染中的应用
WO2021180251A1 (zh) * 2020-03-09 2021-09-16 北京强新生物科技有限公司 治疗冠状病毒感染的联用药物及治疗方法
CN113398125B (zh) 2020-03-16 2024-05-03 绍兴君科臻元医药科技有限公司 替唑尼特药物组合物及其医药用途
WO2021188414A1 (en) 2020-03-16 2021-09-23 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
EP4182304A1 (en) 2020-07-20 2023-05-24 Romark Laboratories, L.C. Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine
MX2023002208A (es) 2020-08-24 2023-05-17 Romark Laboratories Lc Uso de tiazolidas contra los coronavirus.
ES2999626T3 (en) * 2020-10-09 2025-02-26 Bristol Myers Squibb Co Aminoimidazole fpr2 agonists
WO2022109148A1 (en) * 2020-11-18 2022-05-27 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Small molecule inhibitors of sars-cov-2 infections
WO2022130406A1 (en) * 2020-12-15 2022-06-23 Cipla Limited Inhalation composition of nitazoxanide or its derivatives for use in coronavirus disease
US12146029B1 (en) 2021-02-08 2024-11-19 Futurefuel Chemical Company Polymers enhanced with hydrated sodium sulfoisophthalic acid salts
CN116003323B (zh) * 2023-02-14 2023-12-08 西北农林科技大学 含氟吡唑苯乙酰胺类衍生物及其应用

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1177206A (en) 1967-11-28 1970-01-07 Pfizer & Co C Lung Antiviral Factor
GB1437800A (en) * 1973-08-08 1976-06-03 Phavic Sprl Derivatives of 2-benzamido-5-nitro-thiazoles
US4337081A (en) * 1979-01-23 1982-06-29 Olin Corporation 5-Amido-3-trihalomethyl-1,2,4-thiadiazoles and their use as herbicides
US4343945A (en) * 1979-01-23 1982-08-10 Olin Corporation 5-Benzamido-3-trichloromethyl-1,2,4-thiadiazoles and their use as herbicides, fungicides and insecticides
SU910628A1 (ru) 1980-04-22 1982-03-07 Гродненский государственный медицинский институт Способ получени 2-ациламинотиазолов
JPS56158703A (en) * 1980-05-10 1981-12-07 Sankyo Co Ltd Fungicide
US4416683A (en) * 1980-09-16 1983-11-22 Eli Lilly And Company Benzamides, compositions and agricultural method
MA19269A1 (fr) * 1980-09-16 1982-04-01 Lilly Co Eli Perfectionnement relatif a des derives de n-arylbenzamides .
JPS649978A (en) 1987-07-02 1989-01-13 Shionogi & Co Perfluoroalkylisoxazole derivative
US4874864A (en) 1988-05-24 1989-10-17 Pfizer Inc. Benzamide protease inhibitors
US5169846A (en) 1989-10-12 1992-12-08 Crooks Michael J Non-aqueous micellar solutions of anthelmintic benzimidazoles, closantel, or phenothiazine, and insect growth regulators
PT740650E (pt) 1994-01-28 2004-10-29 Univ Kentucky Res Found Co-farmacos como um metodo de administracao controlada de farmacos
US5578621A (en) * 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives
PT755386E (pt) 1994-04-13 2002-11-29 Romark Lab Lc Derivado de benzamida composicoes contendo o referido derivado e sua utilizacao
MX9604483A (es) * 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US5968961A (en) 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
ES2232687T3 (es) * 1997-05-07 2005-06-01 Romark Laboratories, L.C. Composiciones farmaceuticas de tizoxanida y/o nitazoxanida.
GB9725298D0 (en) * 1997-11-28 1998-01-28 Zeneca Ltd Insecticidal thiazole derivatives
CN1332943C (zh) 1998-07-08 2007-08-22 萨诺费－阿文蒂斯德国有限公司 硫取代的磺酰基氨基羧酸n－芳基酰胺,其制备方法、用途以及含有该化合物的药物制剂
GB9823871D0 (en) 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
US6849254B1 (en) * 1999-04-19 2005-02-01 Schering Corporation HCV combination therapy
US6136835A (en) * 1999-05-17 2000-10-24 The Procter & Gamble Company Methods of treatment for viral infections
CA2433018A1 (en) * 2000-12-21 2002-06-27 Joel C. Barrish Thiazolyl inhibitors of tec family tyrosine kinases
EP1256578B1 (en) * 2001-05-11 2006-01-11 Pfizer Products Inc. Thiazole derivatives and their use as cdk inhibitors
WO2002092584A1 (en) * 2001-05-14 2002-11-21 Nihon Nohyaku Co., Ltd. Thiadiazole derivatives, pesticides for agricultural and horticultural use and usage thereof
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
JP2003335680A (ja) 2002-05-21 2003-11-25 Otsuka Pharmaceut Factory Inc Ａｃａｔ−１阻害剤
WO2003103648A1 (ja) * 2002-06-05 2003-12-18 株式会社医薬分子設計研究所 糖尿病治療薬
MXPA05003287A (es) 2002-09-28 2005-07-05 Massachusetts Inst Technology Influenza terapeutica.
US20040242518A1 (en) * 2002-09-28 2004-12-02 Massachusetts Institute Of Technology Influenza therapeutic
US6737382B1 (en) * 2002-10-23 2004-05-18 Nippon Soda Co. Ltd. Insecticidal aminothiazole derivatives
US7807174B2 (en) * 2002-11-22 2010-10-05 Nexbio, Inc. Class of therapeutic protein based molecules
NZ541824A (en) * 2003-02-26 2010-04-30 Banyu Pharma Co Ltd Heteroarylcarbamoylbenzene derivatives as glucokinase activators
US7285576B2 (en) 2003-03-12 2007-10-23 3M Innovative Properties Co. Absorbent polymer compositions, medical articles, and methods
WO2004085433A2 (en) * 2003-03-28 2004-10-07 Pharmacia & Upjohn Company Llc Positive allosteric modulators of the nicotinic acetylcholine receptor
RU2006104697A (ru) * 2003-07-16 2006-06-27 Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. (Jp) Лекарственное средство для лечения пигментации кожи
US20050090506A1 (en) * 2003-10-24 2005-04-28 Nippon Soda Co., Ltd. Insecticidal perfluoroalkylthiazole derivatives
US7683097B2 (en) * 2004-05-27 2010-03-23 Propharmacon Inc. Topoisomerase inhibitors
UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
US8357664B2 (en) * 2004-10-26 2013-01-22 Avi Biopharma, Inc. Antisense antiviral compound and method for treating influenza viral infection
CA2604640A1 (en) 2005-04-12 2006-10-19 Romark Laboratories L.C. Methods for treating diseases through interruption of protein maturation, compounds that inhibit the function of molecular chaperones such as protein disulfide isomerases or interfere with glycosylation, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents
NZ563866A (en) 2005-05-09 2011-03-31 Achillion Pharmaceuticals Inc Thiazole compounds and methods of use
AU2006343359A1 (en) * 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
TW200711649A (en) * 2005-06-17 2007-04-01 Combinatorx Inc Combination therapy for the treatment of immunoinflammatory disorders
US8703805B2 (en) 2005-06-27 2014-04-22 Exelixis Patent Company Llc Modulators of LXR
WO2007008541A2 (en) 2005-07-08 2007-01-18 Kalypsys, Inc. Cellular cholesterol absorption modifiers
JP2009503073A (ja) 2005-08-02 2009-01-29 アイアールエム・リミテッド・ライアビリティ・カンパニー タンパク質キナーゼ阻害剤としての５−置換チアゾール−２−イルアミノ化合物および組成物
EP1979348B1 (en) * 2005-12-21 2012-01-18 Abbott Laboratories Anti-viral compounds
AP2907A (en) * 2006-01-09 2014-05-31 Romark Lab Lc Viral hepatitis treatment
CA2649577A1 (en) 2006-04-28 2007-11-08 Transtech Pharma, Inc. Benzamide glucokinase activators
CN101454302A (zh) * 2006-05-31 2009-06-10 艾博特公司 用作大麻素受体配位体的噻唑化合物及其用途
PE20080401A1 (es) * 2006-07-07 2008-06-23 Boehringer Ingelheim Int DERIVADOS DE HETEROARIL-FENIL SUSTITUIDOS COMO INHIBIDORES DE B-Raf-QUINASAS
US20080161324A1 (en) 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US8044075B2 (en) * 2006-12-05 2011-10-25 Glaxosmithkline IL-8 receptor antagonists
WO2009001214A2 (en) * 2007-06-28 2008-12-31 Pfizer Products Inc. Thieno[2,3-d]pyrimidin-4(3h)-one, isoxazolo[5,4-d]pyrimidin-4(5h)-one and isothiazolo[5,4-d]pyrimidin-4(5h)-one derivatives as calcium receptor antagonists
EP2178852B9 (en) * 2007-08-03 2016-06-22 Romark Laboratories, L.C. Alkylsulfonyl-substituted thiazolide compounds
WO2009065096A1 (en) * 2007-11-16 2009-05-22 University Of Medicine And Dentistry Of New Jersey Mechanism-based small-molecule parasite inhibitors
US20100009970A1 (en) * 2008-03-19 2010-01-14 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
US20100081713A1 (en) * 2008-03-19 2010-04-01 CombinatoRx, (Singapore) Pte. Ltd. Compositions and methods for treating viral infections
EP2297097A2 (en) * 2008-06-11 2011-03-23 Irm Llc Compounds and compositions useful for the treatment of malaria
TW201014860A (en) * 2008-09-08 2010-04-16 Boehringer Ingelheim Int New chemical compounds
UY32138A (es) * 2008-09-25 2010-04-30 Boehringer Ingelheim Int Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables
AU2009316790A1 (en) * 2008-11-19 2010-05-27 Schering Corporation Inhibitors of diacylglycerol acyltransferase
WO2010107736A2 (en) 2009-03-20 2010-09-23 University Of Virginia Patent Foundation Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials
PE20121118A1 (es) 2009-05-12 2012-09-05 Romark Lab Lc Compuestos de haloalquil heteroaril benzamida
AP2012006064A0 (en) 2009-06-26 2012-02-29 Romark Lab Lc Compounds and methods for treating influenza.

Similar Documents

Publication Publication Date Title
JP2012526820A5 (https=)
JP2009535307A5 (https=)
JP2004527515A5 (https=)
RU2006112593A (ru) Производные 2, 4-ди(гетеро)ариламинопиримидина в качестве ингибиторов zap-70 и/или syk
JP2010526145A5 (https=)
JP2013516395A5 (https=)
JP2008509166A5 (https=)
RU2007137987A (ru) Цис-2, 4, 5-триарилимидазолины и их применение в качестве противораковых лекарственных средств
JP2006501181A5 (https=)
RU2502730C2 (ru) Сульфонамидные соединения и их применение
CA2683059A1 (en) Atropisomer of pyrrole derivative
RU2002123350A (ru) Дипептиднитрильные ингибиторы катепсина К
JP2004523582A5 (https=)
RU2006137706A (ru) 9-замещенное производное 8-оксоаденина
RU2001122164A (ru) Кристаллическая кальциевая соль бис[(е)-7-[4-(4-фторфенил)-6-изопропил-2-[метил(метилсульфонил)амино]- пиримидин-5-ил]-(3r,5s)-3,5-дигидроксигепт-6-еновой кислоты]
RU2394028C2 (ru) Производные бензилтриазолона в качестве ненуклеозидных ингибиторов обратной транскриптазы
RU2001111023A (ru) Новые производные n-(иминометил)аминов, их получение, их использование в качестве лекарственных средств и содержащие их фармацевтические композиции
RU2007101236A (ru) Новые гидантоиновые производные для лечения обструктивных заболеваний дыхательных путей
RU95117068A (ru) Антигипертриглицеридемическая композиция, способ ее получения, способ лечения или профилактики гипертриглицеридемии, применение соединений
WO2011089529A4 (en) Salicylate fatty acid derivatives
JP2015519322A5 (https=)
RU2007101237A (ru) Гетороциклические конденсированные соединения, полезные в качестве антидиуретических агентов
RU2008151755A (ru) Ингибитор hsp90
RU2007147344A (ru) Новые производные 2-азетидинона для лечения гиперлипидемических заболеваний
HRP20100433T1 (hr) Diazaindol-dikarbonil-piperazinil antivirotici