|
BE791025A
(fr)
|
1971-11-19 |
1973-05-07 |
Allen & Hanburys Ltd |
Composes heterocycliques
|
|
US5217999A
(en)
|
1987-12-24 |
1993-06-08 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Styryl compounds which inhibit EGF receptor protein tyrosine kinase
|
|
ATE114661T1
(de)
|
1990-04-02 |
1994-12-15 |
Pfizer |
Benzylphosphonsäure-tyrosinkinaseinhibitoren.
|
|
US5302606A
(en)
|
1990-04-16 |
1994-04-12 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase
|
|
US6645969B1
(en)
|
1991-05-10 |
2003-11-11 |
Aventis Pharmaceuticals Inc. |
Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
|
|
JPH06503095A
(ja)
|
1991-05-29 |
1994-04-07 |
ファイザー・インコーポレーテッド |
三環式ポリヒドロキシ系のチロシンキナーゼ阻害薬
|
|
JP2914407B2
(ja)
|
1991-09-11 |
1999-06-28 |
富士電機株式会社 |
自動販売機
|
|
JP3240201B2
(ja)
*
|
1992-04-28 |
2001-12-17 |
広栄化学工業株式会社 |
クロロピラジン類の製造法
|
|
MX9304801A
(es)
|
1992-08-06 |
1997-06-28 |
Warner Lambert Co |
2-toindoles (selenoidoles) disulfuros (seleniduros) relacinados, los cuales inhiben a las proteinas tirosina cinasas y los cuales tienen propiedades anti-tumorales.
|
|
GB9226855D0
(en)
|
1992-12-23 |
1993-02-17 |
Erba Carlo Spa |
Vinylene-azaindole derivatives and process for their preparation
|
|
US20030108545A1
(en)
|
1994-02-10 |
2003-06-12 |
Patricia Rockwell |
Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist
|
|
GB9624482D0
(en)
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
|
CH690773A5
(de)
|
1996-02-01 |
2001-01-15 |
Novartis Ag |
Pyrrolo(2,3-d)pyrimide und ihre Verwendung.
|
|
US6514971B1
(en)
|
1996-03-15 |
2003-02-04 |
Zeneca Limited |
Cinnoline derivatives and use as medicine
|
|
US6232299B1
(en)
|
1996-05-01 |
2001-05-15 |
Eli Lilly And Company |
Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
|
|
GB9707800D0
(en)
|
1996-05-06 |
1997-06-04 |
Zeneca Ltd |
Chemical compounds
|
|
ZA200007412B
(en)
|
1998-05-15 |
2002-03-12 |
Imclone Systems Inc |
Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases.
|
|
US6713474B2
(en)
|
1998-09-18 |
2004-03-30 |
Abbott Gmbh & Co. Kg |
Pyrrolopyrimidines as therapeutic agents
|
|
WO2000035455A1
(en)
|
1998-12-15 |
2000-06-22 |
Telik, Inc. |
Heteroaryl-aryl ureas as igf-1 receptor antagonists
|
|
KR20020000223A
(ko)
|
1999-05-14 |
2002-01-05 |
존 비. 랜디스 |
표피성장인자 수용체 길항제를 사용한 인간 난치성 종양의치료 방법
|
|
US6982265B1
(en)
|
1999-05-21 |
2006-01-03 |
Bristol Myers Squibb Company |
Pyrrolotriazine inhibitors of kinases
|
|
CZ2002474A3
(cs)
|
1999-08-12 |
2003-02-12 |
American Cyanamid Company |
Prostředek pro léčení nebo inhibici polypů tlustého střeva a kolorektální rakoviny obsahující NSAID a inhibitor EGFR kinasy
|
|
GB9919558D0
(en)
|
1999-08-18 |
1999-10-20 |
Hoechst Schering Agrevo Gmbh |
Fungicidal compounds
|
|
US7087613B2
(en)
|
1999-11-11 |
2006-08-08 |
Osi Pharmaceuticals, Inc. |
Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
|
|
WO2001072751A1
(en)
|
2000-03-29 |
2001-10-04 |
Knoll Gesellschaft Mit Beschraenkter Haftung |
Pyrrolopyrimidines as tyrosine kinase inhibitors
|
|
GB0008368D0
(en)
|
2000-04-06 |
2000-05-24 |
Astrazeneca Ab |
Combination product
|
|
GB0017635D0
(en)
|
2000-07-18 |
2000-09-06 |
Pharmacia & Upjohn Spa |
Antitumor combined therapy
|
|
WO2002045653A2
(en)
|
2000-12-08 |
2002-06-13 |
Uab Research Foundation |
Combination radiation therapy and chemotherapy in conjuction with administration of growth factor receptor antibody
|
|
RU2292904C2
(ru)
|
2001-01-09 |
2007-02-10 |
Мерк Патент Гмбх |
Комбинированная терапия, использующая ингибиторы рецептора тирозинкиназы и ингибиторы ангиогенезиса
|
|
WO2002060492A1
(en)
|
2001-01-30 |
2002-08-08 |
Cytopia Pty Ltd |
Methods of inhibiting kinases
|
|
MXPA03008560A
(es)
|
2001-03-22 |
2004-06-30 |
Abbot Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos.
|
|
EP1381598A4
(en)
|
2001-03-28 |
2008-03-19 |
Bristol Myers Squibb Co |
NEW INHIBITORS OF TYROSINE KINASE
|
|
BR0209147A
(pt)
|
2001-05-08 |
2004-06-08 |
Merck Patent Gmbh |
Terapia combinada que usa anticorpos anti-egfr e agentes anti-hormonais
|
|
AR035885A1
(es)
|
2001-05-14 |
2004-07-21 |
Novartis Ag |
Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
|
|
SE0102168D0
(sv)
|
2001-06-19 |
2001-06-19 |
Karolinska Innovations Ab |
New use and new compounds
|
|
AU2002315389A1
(en)
|
2001-06-21 |
2003-01-08 |
Ariad Pharmaceuticals, Inc. |
Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
|
|
US6939874B2
(en)
|
2001-08-22 |
2005-09-06 |
Amgen Inc. |
Substituted pyrimidinyl derivatives and methods of use
|
|
US7115617B2
(en)
|
2001-08-22 |
2006-10-03 |
Amgen Inc. |
Amino-substituted pyrimidinyl derivatives and methods of use
|
|
GB0122560D0
(en)
|
2001-09-19 |
2001-11-07 |
Aventis Pharma Ltd |
Chemical compounds
|
|
WO2003024967A2
(en)
|
2001-09-19 |
2003-03-27 |
Aventis Pharma S.A. |
Indolizines as kinase protein inhibitors
|
|
SE0104140D0
(sv)
|
2001-12-07 |
2001-12-07 |
Astrazeneca Ab |
Novel Compounds
|
|
AU2002359697A1
(en)
|
2001-12-20 |
2003-07-09 |
Tularik Inc. |
Identification of an amplified gene and target for drug intervention
|
|
US20050215564A1
(en)
|
2002-02-14 |
2005-09-29 |
Stiles Charles D |
Methods and compositions for treating hyperproliferative conditions
|
|
US20030199525A1
(en)
|
2002-03-21 |
2003-10-23 |
Hirst Gavin C. |
Kinase inhibitors
|
|
WO2003088971A1
(en)
|
2002-04-16 |
2003-10-30 |
Astrazeneca Ab |
Combination therapy for the treatment of cancer
|
|
DE10230604A1
(de)
|
2002-07-08 |
2004-01-29 |
Bayer Ag |
Heterocyclisch substituierte Imidazotriazine
|
|
DE10230605A1
(de)
|
2002-07-08 |
2004-01-29 |
Bayer Ag |
Substituierte Imidazotriazine
|
|
BR0313396A
(pt)
|
2002-08-12 |
2005-06-28 |
Sugen Inc |
3-pirrolil-piridopirazóis e 3-pirrolil-indazóis, como inibidores de quinase
|
|
TW200501960A
(en)
|
2002-10-02 |
2005-01-16 |
Bristol Myers Squibb Co |
Synergistic kits and compositions for treating cancer
|
|
US20040209930A1
(en)
|
2002-10-02 |
2004-10-21 |
Carboni Joan M. |
Synergistic methods and compositions for treating cancer
|
|
EP1422220A1
(en)
|
2002-11-20 |
2004-05-26 |
Bayer CropScience SA |
Process for the preparation of 2-aminomethylpyridine derivative
|
|
DE10254853A1
(de)
|
2002-11-25 |
2004-06-03 |
Basf Ag |
Verbessertes Verfahren zur Herstellung von Cyclopentenonen
|
|
UA80171C2
(en)
|
2002-12-19 |
2007-08-27 |
Pfizer Prod Inc |
Pyrrolopyrimidine derivatives
|
|
US7186832B2
(en)
|
2003-02-20 |
2007-03-06 |
Sugen Inc. |
Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
|
|
US7157460B2
(en)
|
2003-02-20 |
2007-01-02 |
Sugen Inc. |
Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
|
|
AU2004220327B2
(en)
|
2003-03-12 |
2010-06-24 |
Pfizer Products Inc. |
Pyridyloxymethyl and benzisoxazole azabicyclic derivatives
|
|
US20050043233A1
(en)
|
2003-04-29 |
2005-02-24 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
|
|
KR100872204B1
(ko)
|
2003-10-15 |
2008-12-09 |
오에스아이 파마슈티컬스, 인코포레이티드 |
이미다조피라진 티로신 키나제 억제제
|
|
TW200526684A
(en)
|
2003-11-21 |
2005-08-16 |
Schering Corp |
Anti-IGFR1 antibody therapeutic combinations
|
|
EP1694686A1
(en)
|
2003-12-19 |
2006-08-30 |
Takeda San Diego, Inc. |
Kinase inhibitors
|
|
DE602005014964D1
(de)
|
2004-04-02 |
2009-07-30 |
Osi Pharm Inc |
Mit einem 6,6-bicyclischen ring substituierte heterobicyclische proteinkinaseinhibitoren
|
|
AU2005243535A1
(en)
*
|
2004-05-13 |
2005-11-24 |
Boehringer Ingelheim International Gmbh |
Novel substituted thiophenecarboxamides, their production and their use as medicaments
|
|
CN1968706A
(zh)
|
2004-06-03 |
2007-05-23 |
霍夫曼-拉罗奇有限公司 |
用顺铂和egfr-抑制剂治疗
|
|
WO2006004703A2
(en)
|
2004-06-29 |
2006-01-12 |
Amgen Inc. |
PYRROLO[2,3-d]PYRIMIDINES THAT MODULATE ACK1 AND LCK ACTIVITY
|
|
TW200613306A
(en)
|
2004-07-20 |
2006-05-01 |
Osi Pharm Inc |
Imidazotriazines as protein kinase inhibitors
|
|
US7674907B2
(en)
|
2004-07-23 |
2010-03-09 |
Amgen Inc. |
Furanopyridine derivatives and methods of use
|
|
WO2006033001A1
(en)
|
2004-09-23 |
2006-03-30 |
Pfizer Products Inc. |
Quinoline compounds
|
|
US20070149567A1
(en)
|
2004-09-23 |
2007-06-28 |
Pfizer Inc |
Quinoline compounds
|
|
DE202005016343U1
(de)
|
2005-10-19 |
2007-02-22 |
Weidmüller Interface GmbH & Co. KG |
Elektrische Steckverbindung mit Schnellentriegelung
|
|
PT2385053E
(pt)
|
2005-11-17 |
2013-12-17 |
Osi Pharm Inc |
Intermediários para a preparação de compostos bicíclicos condensados como inibidores mtor
|
|
AR057960A1
(es)
|
2005-12-02 |
2007-12-26 |
Osi Pharm Inc |
Inhibidores de proteina quinasa biciclicos
|
|
CA2633252A1
(en)
*
|
2005-12-14 |
2007-06-21 |
Bristol-Myers Squibb Company |
Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
|
|
WO2007075554A2
(en)
|
2005-12-19 |
2007-07-05 |
Osi Pharmaceuticals, Inc. |
Combination of igfr inhibitor and anti-cancer agent
|
|
US8575164B2
(en)
|
2005-12-19 |
2013-11-05 |
OSI Pharmaceuticals, LLC |
Combination cancer therapy
|
|
TW201307354A
(zh)
*
|
2005-12-29 |
2013-02-16 |
Abbott Lab |
蛋白質激酶抑制劑
|
|
US7659274B2
(en)
|
2006-01-25 |
2010-02-09 |
Osi Pharmaceuticals, Inc. |
Unsaturated mTOR inhibitors
|
|
WO2007106503A2
(en)
|
2006-03-13 |
2007-09-20 |
Osi Pharmaceuticals, Inc. |
Combined treatment with an egfr kinase inhibitor and an agent that sensitizes tumor cells to the effects of egfr kinase inhibitors
|
|
BRPI0712531A2
(pt)
|
2006-05-31 |
2012-12-25 |
Galapagos Nv |
composto de triazolopirazina éteis para o tratamento de doenÇas degenarativas e inflamatàrias
|
|
EP2526934B1
(en)
|
2006-09-22 |
2015-12-09 |
Pharmacyclics LLC |
Inhibitors of bruton's tyrosine kinase
|
|
JP2008105970A
(ja)
*
|
2006-10-24 |
2008-05-08 |
Ohara Yakuhin Kogyo Kk |
ジヒドロキノリン誘導体の製造方法及びその中間体
|
|
TW200900070A
(en)
|
2007-02-27 |
2009-01-01 |
Osi Pharm Inc |
Combination cancer therapy
|
|
US20090263397A1
(en)
|
2007-07-06 |
2009-10-22 |
Buck Elizabeth A |
Combination anti-cancer therapy
|
|
JP2010532756A
(ja)
|
2007-07-06 |
2010-10-14 |
オーエスアイ・ファーマスーティカルズ・インコーポレーテッド |
mTORC1及びmTORC2の両方の阻害剤を含む組み合わせ抗癌療法
|
|
AU2008307634A1
(en)
|
2007-10-03 |
2009-04-09 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
|
JP2011510018A
(ja)
|
2008-01-18 |
2011-03-31 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
癌治療のためのイミダゾピラジノール誘導体
|
|
EP2283020B8
(en)
|
2008-05-19 |
2012-12-12 |
OSI Pharmaceuticals, LLC |
Substituted imidazopyr-and imidazotri-azines
|
|
AU2010236825A1
(en)
|
2009-04-16 |
2011-09-15 |
Merck Sharp & Dohme Corp. |
Compositions and methods for treating cancer
|
|
JP2012526138A
(ja)
|
2009-05-07 |
2012-10-25 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
副腎皮質癌を治療するためのosi−906の使用
|
|
WO2011112666A1
(en)
|
2010-03-09 |
2011-09-15 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
WO2011163430A1
(en)
|
2010-06-23 |
2011-12-29 |
OSI Pharmaceuticals, LLC |
Polymorphs of osi-906
|
|
WO2012129145A1
(en)
|
2011-03-18 |
2012-09-27 |
OSI Pharmaceuticals, LLC |
Nscle combination therapy
|