BRPI1016245A2 - Preparação de c-pirazina-metilaminas. - Google Patents

Preparação de c-pirazina-metilaminas.

Info

Publication number
BRPI1016245A2
BRPI1016245A2 BRPI1016245-3A BRPI1016245A BRPI1016245A2 BR PI1016245 A2 BRPI1016245 A2 BR PI1016245A2 BR PI1016245 A BRPI1016245 A BR PI1016245A BR PI1016245 A2 BRPI1016245 A2 BR PI1016245A2
Authority
BR
Brazil
Prior art keywords
methylamines
pyrazine
preparation
pyrazine methylamines
Prior art date
Application number
BRPI1016245-3A
Other languages
English (en)
Portuguese (pt)
Inventor
Yunyu Mao
Kristen Michelle Mulvihill
Josef A Rechka
Paula A Tavares-Greco
Original Assignee
Osi Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharmaceuticals Llc filed Critical Osi Pharmaceuticals Llc
Publication of BRPI1016245A2 publication Critical patent/BRPI1016245A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/16—Halogen atoms; Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI1016245-3A 2009-04-20 2010-04-19 Preparação de c-pirazina-metilaminas. BRPI1016245A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17091109P 2009-04-20 2009-04-20
PCT/US2010/031547 WO2010123792A1 (en) 2009-04-20 2010-04-19 Preparation of c-pyrazine-methylamines

Publications (1)

Publication Number Publication Date
BRPI1016245A2 true BRPI1016245A2 (pt) 2015-09-01

Family

ID=42269933

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1016245-3A BRPI1016245A2 (pt) 2009-04-20 2010-04-19 Preparação de c-pirazina-metilaminas.

Country Status (9)

Country Link
US (2) US8513415B2 (enExample)
EP (1) EP2421837A1 (enExample)
JP (1) JP2012524119A (enExample)
KR (1) KR20120020099A (enExample)
CN (1) CN102405214A (enExample)
BR (1) BRPI1016245A2 (enExample)
CA (1) CA2752826A1 (enExample)
MX (1) MX2011011025A (enExample)
WO (1) WO2010123792A1 (enExample)

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CN103214424B (zh) * 2013-04-25 2015-05-13 兰州康寓信生物科技有限公司 吡嗪甲胺衍生物的合成方法
UY35693A (es) 2013-08-08 2015-02-27 Bayer Pharma AG Pirazolo[1,5-a]piridin-3-carboxamidas sustituidas y su uso
JP2017537922A (ja) 2014-12-02 2017-12-21 バイエル・ファルマ・アクティエンゲゼルシャフト 置換ピラゾロ［１，５−ａ］ピリジンおよびイミダゾ［１，２−ａ］ピラジンならびにそれらの使用
WO2016124565A1 (de) 2015-02-05 2016-08-11 Bayer Pharma Aktiengesellschaft Substituierte pyrazolo[1,5-a]pyridin-3-carboxamide und ihre verwendung
CN109553570A (zh) * 2017-09-27 2019-04-02 胜兴化工(上海)有限公司 3-氯-5-三氟甲基-2-吡啶甲胺盐的制备方法
CN109182286B (zh) * 2018-09-21 2021-07-30 泰州学院 一种改进的氰基还原酶及其在合成3-氯吡嗪-2甲胺中的应用

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Also Published As

Publication number Publication date
CN102405214A (zh) 2012-04-04
MX2011011025A (es) 2011-11-02
US8513415B2 (en) 2013-08-20
WO2010123792A1 (en) 2010-10-28
JP2012524119A (ja) 2012-10-11
US20130261306A1 (en) 2013-10-03
EP2421837A1 (en) 2012-02-29
US20120041202A1 (en) 2012-02-16
KR20120020099A (ko) 2012-03-07
CA2752826A1 (en) 2010-10-28

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Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.