JP2012513409A - 抗ウイルス化合物 - Google Patents
抗ウイルス化合物 Download PDFInfo
- Publication number
- JP2012513409A JP2012513409A JP2011542569A JP2011542569A JP2012513409A JP 2012513409 A JP2012513409 A JP 2012513409A JP 2011542569 A JP2011542569 A JP 2011542569A JP 2011542569 A JP2011542569 A JP 2011542569A JP 2012513409 A JP2012513409 A JP 2012513409A
- Authority
- JP
- Japan
- Prior art keywords
- optionally
- independently
- substituted
- compound
- carbocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*1CC(*)*CC1 Chemical compound C*1CC(*)*CC1 0.000 description 20
- HIULMGYXMIXYRK-UHFFFAOYSA-N CC(C)(C)OC(Nc(cc1)ccc1Sc(ccc(C(OC)=O)c1)c1N)=O Chemical compound CC(C)(C)OC(Nc(cc1)ccc1Sc(ccc(C(OC)=O)c1)c1N)=O HIULMGYXMIXYRK-UHFFFAOYSA-N 0.000 description 1
- QBAVTNSMVBYKEB-UHFFFAOYSA-N CC(C)C(C1)NC(C2)C2[S]1(=O)#[O] Chemical compound CC(C)C(C1)NC(C2)C2[S]1(=O)#[O] QBAVTNSMVBYKEB-UHFFFAOYSA-N 0.000 description 1
- OUIJIAOVRCTYBT-VAASOWBASA-N CC(C)c1nc2ncnc(Nc(cc(cc3)C(Nc(cc4)ccc4-c4c[nH]c([C@H](CCC5)N5C([C@@H](c5ccccc5)N(C)C)=O)n4)=O)c3Sc(cc3)ccc3N)c2cc1 Chemical compound CC(C)c1nc2ncnc(Nc(cc(cc3)C(Nc(cc4)ccc4-c4c[nH]c([C@H](CCC5)N5C([C@@H](c5ccccc5)N(C)C)=O)n4)=O)c3Sc(cc3)ccc3N)c2cc1 OUIJIAOVRCTYBT-VAASOWBASA-N 0.000 description 1
- IKRZXBMAUFQQTP-KDXMTYKHSA-N CC(C)c1nc2ncnc(Nc(cc(cc3)C(Nc(cc4)ccc4NC([C@H](CCC4)N4C(OCc4ccccc4)=O)=O)=O)c3Sc(cc3)ccc3NC(OC(C)(C)C)=O)c2cc1 Chemical compound CC(C)c1nc2ncnc(Nc(cc(cc3)C(Nc(cc4)ccc4NC([C@H](CCC4)N4C(OCc4ccccc4)=O)=O)=O)c3Sc(cc3)ccc3NC(OC(C)(C)C)=O)c2cc1 IKRZXBMAUFQQTP-KDXMTYKHSA-N 0.000 description 1
- PPYXGJROOZEQCM-UHFFFAOYSA-N CC(C)c1nc2ncnc(Nc3cc(C(OC)=O)ccc3Sc(cc3)ccc3NC(OC(C)(C)C)=O)c2cc1 Chemical compound CC(C)c1nc2ncnc(Nc3cc(C(OC)=O)ccc3Sc(cc3)ccc3NC(OC(C)(C)C)=O)c2cc1 PPYXGJROOZEQCM-UHFFFAOYSA-N 0.000 description 1
- VZHQSAPDOFCTKH-UHFFFAOYSA-N CC(C1)N(C)CS1(=O)=O Chemical compound CC(C1)N(C)CS1(=O)=O VZHQSAPDOFCTKH-UHFFFAOYSA-N 0.000 description 1
- UZSNYCMHANJBLO-UHFFFAOYSA-N CC(N(C)CC1)S1(=O)=O Chemical compound CC(N(C)CC1)S1(=O)=O UZSNYCMHANJBLO-UHFFFAOYSA-N 0.000 description 1
- GCAXQJJBQBHDJW-UHFFFAOYSA-N CC(N(C)CC1)S1=O Chemical compound CC(N(C)CC1)S1=O GCAXQJJBQBHDJW-UHFFFAOYSA-N 0.000 description 1
- SNBKIYGGKKMWGW-UHFFFAOYSA-N CC1N(C)CSC1 Chemical compound CC1N(C)CSC1 SNBKIYGGKKMWGW-UHFFFAOYSA-N 0.000 description 1
- SUGYCWJDMKSOPH-UHFFFAOYSA-N CC1NCSC1 Chemical compound CC1NCSC1 SUGYCWJDMKSOPH-UHFFFAOYSA-N 0.000 description 1
- HMRGPRJMXCAEFX-UHFFFAOYSA-N CC1SCCN1C Chemical compound CC1SCCN1C HMRGPRJMXCAEFX-UHFFFAOYSA-N 0.000 description 1
- BPUJVGZCYPCDPU-UHFFFAOYSA-N CCN1C(C)OCC1 Chemical compound CCN1C(C)OCC1 BPUJVGZCYPCDPU-UHFFFAOYSA-N 0.000 description 1
- NLOPKMYDLBWGOM-LEWJYISDSA-N CN(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2[N+]([O-])=O)c[nH]1)=O)c1ccccc1 Chemical compound CN(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2[N+]([O-])=O)c[nH]1)=O)c1ccccc1 NLOPKMYDLBWGOM-LEWJYISDSA-N 0.000 description 1
- VTUMEDQCLWAWRJ-IBGZPJMESA-N Nc(cc1)ccc1-c1c[nH]c([C@H](CCC2)N2C(Cc2ccccc2)=O)n1 Chemical compound Nc(cc1)ccc1-c1c[nH]c([C@H](CCC2)N2C(Cc2ccccc2)=O)n1 VTUMEDQCLWAWRJ-IBGZPJMESA-N 0.000 description 1
- HFAWHKZTEXPOBH-KRWDZBQOSA-N Nc(cc1)ccc1NC([C@H](CCC1)N1C(OCc1ccccc1)=O)=O Chemical compound Nc(cc1)ccc1NC([C@H](CCC1)N1C(OCc1ccccc1)=O)=O HFAWHKZTEXPOBH-KRWDZBQOSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14026208P | 2008-12-23 | 2008-12-23 | |
| US61/140,262 | 2008-12-23 | ||
| PCT/US2009/069177 WO2010075376A2 (en) | 2008-12-23 | 2009-12-22 | Anti-viral compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012513409A true JP2012513409A (ja) | 2012-06-14 |
| JP2012513409A5 JP2012513409A5 (enExample) | 2013-02-14 |
Family
ID=42169497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011542569A Pending JP2012513409A (ja) | 2008-12-23 | 2009-12-22 | 抗ウイルス化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8541424B2 (enExample) |
| EP (1) | EP2367824B1 (enExample) |
| JP (1) | JP2012513409A (enExample) |
| CN (1) | CN102264737A (enExample) |
| CA (1) | CA2740193A1 (enExample) |
| ES (1) | ES2567047T3 (enExample) |
| MX (1) | MX2011006332A (enExample) |
| RU (1) | RU2505540C2 (enExample) |
| SG (1) | SG172352A1 (enExample) |
| WO (1) | WO2010075376A2 (enExample) |
| ZA (1) | ZA201105355B (enExample) |
Families Citing this family (204)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2370424A1 (en) | 2008-11-10 | 2011-10-05 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2376485B1 (en) | 2008-12-19 | 2017-12-06 | Vertex Pharmaceuticals Incorporated | Pyrazine derivatives useful as inhibitors of atr kinase |
| US8541424B2 (en) | 2008-12-23 | 2013-09-24 | Abbott Laboratories | Anti-viral compounds |
| RU2505539C2 (ru) | 2008-12-23 | 2014-01-27 | Эбботт Лэборетриз | Антивирусные соединения |
| US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
| US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JP5734956B2 (ja) * | 2009-04-15 | 2015-06-17 | アッヴィ・インコーポレイテッド | 抗ウィルス化合物 |
| US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| PL2368890T3 (pl) * | 2009-06-11 | 2013-10-31 | Abbvie Bahamas Ltd | Inhibitory wirusa zapalenia wątroby C |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN102791687B (zh) * | 2009-12-18 | 2015-02-11 | 北京凯因科技股份有限公司 | C型肝炎病毒复制的新型抑制剂 |
| US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2569286B1 (en) | 2010-05-12 | 2014-08-20 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| KR20130066633A (ko) | 2010-05-12 | 2013-06-20 | 버텍스 파마슈티칼스 인코포레이티드 | Atr 키나제의 억제제로서 유용한 화합물 |
| WO2011143399A1 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| JP2013526540A (ja) | 2010-05-12 | 2013-06-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
| US8962631B2 (en) | 2010-05-12 | 2015-02-24 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2569284B1 (en) | 2010-05-12 | 2015-07-08 | Vertex Pharmaceuticals Incorporated | 2-aminopyridine derivatives useful as inhibitors of atr kinase |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| WO2011163527A1 (en) | 2010-06-23 | 2011-12-29 | Vertex Pharmaceuticals Incorporated | Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase |
| JP5878171B2 (ja) | 2010-06-24 | 2016-03-08 | ギリアード サイエンシーズ, インコーポレイテッド | 抗ウイルス剤としてのピラゾロ[1,5−a]ピリミジン |
| MX355782B (es) | 2010-11-03 | 2018-04-30 | Dow Agrosciences Llc | Composiciones pesticidas y procesos relacionados a las mismas. |
| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2012138938A1 (en) | 2011-04-05 | 2012-10-11 | Vertex Pharmaceuticals Incorporated | Aminopyrazine compounds useful as inhibitors of tra kinase |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| HRP20161786T1 (hr) | 2011-05-13 | 2017-03-10 | Array Biopharma, Inc. | Pirolidinil urea, pirolidinil tiourea i pirolidinil gvanidin spojevi kao inhibitori trka kinaze |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| US8822469B2 (en) | 2011-06-22 | 2014-09-02 | Vertex Pharmaceuticals Incorporated | Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| US9096602B2 (en) | 2011-06-22 | 2015-08-04 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-B]pyrazines as ATR kinase inhibitors |
| BR112014007690B1 (pt) | 2011-09-30 | 2022-10-04 | Vertex Pharmaceuticals Incorporated | Usos de inibidores de atr no tratamento de câncer pancreático e câncer de pulmão de células não pequenas |
| US8853217B2 (en) | 2011-09-30 | 2014-10-07 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2751088B1 (en) | 2011-09-30 | 2016-04-13 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| CN103987709B (zh) | 2011-09-30 | 2016-09-28 | 沃泰克斯药物股份有限公司 | 用于制备可用作atr激酶抑制剂的化合物的方法 |
| IN2014KN00943A (enExample) | 2011-09-30 | 2015-08-21 | Vertex Pharma | |
| EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
| PT2763984T (pt) | 2011-10-03 | 2016-07-25 | Respivert Ltd | 1-pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il) ureias como inibidores da map cinase p38 |
| JP6117191B2 (ja) | 2011-10-07 | 2017-04-19 | 武田薬品工業株式会社 | 神経変性疾患の治療に有用な1−アリールカルボニル−4−オキシ−ピペリジン化合物 |
| CN104010505B (zh) | 2011-10-26 | 2017-03-15 | 陶氏益农公司 | 杀虫组合物和与其相关的方法 |
| US8841449B2 (en) | 2011-11-09 | 2014-09-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2013071090A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013071093A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
| WO2013071094A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US8846917B2 (en) | 2011-11-09 | 2014-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2794611B1 (en) | 2011-12-22 | 2017-10-11 | Gilead Sciences, Inc. | Pyrazolo[1,5-a]pyrimidines as antiviral agents |
| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP3311816A1 (en) | 2012-04-05 | 2018-04-25 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase for the treatment of cancer |
| HRP20191754T1 (hr) | 2012-04-17 | 2020-01-24 | Gilead Sciences, Inc. | Spojevi i postupci za antivirusno liječenje |
| EP2855489B1 (en) | 2012-04-26 | 2017-01-04 | Bristol-Myers Squibb Company | Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| EP2847200B1 (en) | 2012-04-26 | 2017-03-29 | Bristol-Myers Squibb Company | Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| JP6073464B2 (ja) | 2012-04-26 | 2017-02-01 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 血小板凝集を治療するためのプロテアーゼ活性化受容体4(par4)阻害剤としてのイミダゾチアジアゾールおよびイミダゾピラジン誘導体 |
| BR122014028247A2 (pt) | 2012-04-27 | 2019-05-07 | Dow Agrosciences Llc | composições pesticidas, processo para controlar praga, uso de uma molécula, processo para aumentar a saúde, rendimento, vigor, qualidade ou tolerância de uma planta e processos para produção de compostos |
| US9708288B2 (en) | 2012-04-27 | 2017-07-18 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| US9282739B2 (en) | 2012-04-27 | 2016-03-15 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| KR101742954B1 (ko) | 2012-05-31 | 2017-06-02 | 페넥스 파마슈티컬스 아게 | 고아 핵 수용체 ror[감마]의 조절제로서의 카복사미드 또는 설폰아미드가 치환된 티아졸 및 관련된 유도체 |
| JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
| GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| GB201215357D0 (en) | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
| US8999632B2 (en) | 2012-10-04 | 2015-04-07 | Vertex Pharmaceuticals Incorporated | Method for measuring ATR inhibition mediated increases in DNA damage |
| EP2909202A1 (en) | 2012-10-16 | 2015-08-26 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US9809578B2 (en) | 2012-11-13 | 2017-11-07 | Array Biopharma Inc. | Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors |
| WO2014078328A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | N-bicyclic aryl,n'-pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| WO2014078372A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| WO2014078331A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | N-(arylalkyl)-n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| UA117573C2 (uk) | 2012-11-13 | 2018-08-27 | Ерей Біофарма Інк. | Біциклічні сполуки сечовини, тіосечовини, гуанідину й ціаногуанідину, придатні для лікування болю |
| US9981959B2 (en) | 2012-11-13 | 2018-05-29 | Array Biopharma Inc. | Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors |
| US9822118B2 (en) | 2012-11-13 | 2017-11-21 | Array Biopharma Inc. | Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors |
| US9828360B2 (en) | 2012-11-13 | 2017-11-28 | Array Biopharma Inc. | Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors |
| WO2014078325A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | N-(monocyclic aryl),n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
| UA116455C2 (uk) | 2012-11-13 | 2018-03-26 | Еррей Біофарма Інк. | Сполуки n-піролідинілсечовини, n'-піразолілсечовини, тіосечовини, гуанідину та ціаногуанідину як інгібітори кінази trka |
| PL3808749T3 (pl) | 2012-12-07 | 2023-07-10 | Vertex Pharmaceuticals Incorporated | Pirazolo[1,5-a]pirymidyny użyteczne jako inhibitory kinazy atr do leczenia chorób nowotworowych |
| MA38287B1 (fr) | 2013-01-23 | 2018-08-31 | Astrazeneca Ab | Nouveaux dérivés aminopyrazine pour le traitement ou la prévention du cancer |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| US20160016934A1 (en) | 2013-03-14 | 2016-01-21 | Respivert Limited | Kinase inhibitors |
| JP2016512815A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体 |
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| JP2009521460A (ja) * | 2005-12-21 | 2009-06-04 | アボット・ラボラトリーズ | 抗ウイルス化合物 |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN102264737A (zh) | 2011-11-30 |
| CA2740193A1 (en) | 2010-07-01 |
| US8541424B2 (en) | 2013-09-24 |
| US20100168138A1 (en) | 2010-07-01 |
| RU2505540C2 (ru) | 2014-01-27 |
| ES2567047T3 (es) | 2016-04-19 |
| US20140213601A1 (en) | 2014-07-31 |
| WO2010075376A2 (en) | 2010-07-01 |
| HK1159619A1 (zh) | 2012-08-03 |
| MX2011006332A (es) | 2011-06-27 |
| WO2010075376A3 (en) | 2010-09-30 |
| ZA201105355B (en) | 2012-03-28 |
| US9163017B2 (en) | 2015-10-20 |
| EP2367824B1 (en) | 2016-03-23 |
| SG172352A1 (en) | 2011-07-28 |
| EP2367824A2 (en) | 2011-09-28 |
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