MX2011006332A - Compuestos antivirales. - Google Patents
Compuestos antivirales.Info
- Publication number
- MX2011006332A MX2011006332A MX2011006332A MX2011006332A MX2011006332A MX 2011006332 A MX2011006332 A MX 2011006332A MX 2011006332 A MX2011006332 A MX 2011006332A MX 2011006332 A MX2011006332 A MX 2011006332A MX 2011006332 A MX2011006332 A MX 2011006332A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- independently
- salt
- optionally substituted
- occurrence
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 167
- 230000000840 anti-viral effect Effects 0.000 title description 2
- 238000000034 method Methods 0.000 claims abstract description 37
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- 230000002401 inhibitory effect Effects 0.000 claims abstract description 8
- 230000008569 process Effects 0.000 claims abstract description 7
- -1 hydroxy, mercapto, amino, carboxy Chemical group 0.000 claims description 156
- 125000000623 heterocyclic group Chemical group 0.000 claims description 153
- 229910052739 hydrogen Inorganic materials 0.000 claims description 85
- 239000001257 hydrogen Substances 0.000 claims description 85
- 150000003839 salts Chemical class 0.000 claims description 80
- 229910052736 halogen Inorganic materials 0.000 claims description 76
- 150000002367 halogens Chemical class 0.000 claims description 72
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 72
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 70
- 229910019142 PO4 Inorganic materials 0.000 claims description 69
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 69
- 239000010452 phosphate Substances 0.000 claims description 69
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 68
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 68
- 125000004043 oxo group Chemical group O=* 0.000 claims description 68
- 125000000464 thioxo group Chemical group S=* 0.000 claims description 68
- 125000001424 substituent group Chemical group 0.000 claims description 67
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- 125000004429 atom Chemical group 0.000 claims description 30
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
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- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims description 4
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- 125000001544 thienyl group Chemical group 0.000 description 10
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- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 8
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 8
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- 241000700605 Viruses Species 0.000 description 7
- 125000003118 aryl group Chemical group 0.000 description 7
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- 239000003054 catalyst Substances 0.000 description 7
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 description 7
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 description 7
- 125000002971 oxazolyl group Chemical group 0.000 description 7
- 125000003373 pyrazinyl group Chemical group 0.000 description 7
- 125000003226 pyrazolyl group Chemical group 0.000 description 7
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- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 7
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- 125000001425 triazolyl group Chemical group 0.000 description 7
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- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
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- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 6
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14026208P | 2008-12-23 | 2008-12-23 | |
| PCT/US2009/069177 WO2010075376A2 (en) | 2008-12-23 | 2009-12-22 | Anti-viral compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011006332A true MX2011006332A (es) | 2011-06-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011006332A MX2011006332A (es) | 2008-12-23 | 2009-12-22 | Compuestos antivirales. |
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| US (2) | US8541424B2 (enExample) |
| EP (1) | EP2367824B1 (enExample) |
| JP (1) | JP2012513409A (enExample) |
| CN (1) | CN102264737A (enExample) |
| CA (1) | CA2740193A1 (enExample) |
| ES (1) | ES2567047T3 (enExample) |
| MX (1) | MX2011006332A (enExample) |
| RU (1) | RU2505540C2 (enExample) |
| SG (1) | SG172352A1 (enExample) |
| WO (1) | WO2010075376A2 (enExample) |
| ZA (1) | ZA201105355B (enExample) |
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| JP5702293B2 (ja) | 2008-11-10 | 2015-04-15 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用な化合物 |
| BRPI0924084B1 (pt) | 2008-12-19 | 2021-12-21 | Vertex Pharmaceuticals Incorporated | Derivados de pirazina e composição farmacêutica que os compreende |
| WO2010075380A1 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
| WO2010075376A2 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
| US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
| US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2419404B1 (en) | 2009-04-15 | 2015-11-04 | AbbVie Inc. | Anti-viral compounds |
| US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| EA020031B1 (ru) * | 2009-06-11 | 2014-08-29 | Эббви Бахамаз Лтд. | Противовирусные соединения |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
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| WO2011075607A1 (en) * | 2009-12-18 | 2011-06-23 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
| US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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| CA2740193A1 (en) | 2010-07-01 |
| CN102264737A (zh) | 2011-11-30 |
| US20100168138A1 (en) | 2010-07-01 |
| EP2367824A2 (en) | 2011-09-28 |
| HK1159619A1 (zh) | 2012-08-03 |
| US9163017B2 (en) | 2015-10-20 |
| SG172352A1 (en) | 2011-07-28 |
| RU2505540C2 (ru) | 2014-01-27 |
| US8541424B2 (en) | 2013-09-24 |
| EP2367824B1 (en) | 2016-03-23 |
| WO2010075376A2 (en) | 2010-07-01 |
| WO2010075376A3 (en) | 2010-09-30 |
| US20140213601A1 (en) | 2014-07-31 |
| ES2567047T3 (es) | 2016-04-19 |
| JP2012513409A (ja) | 2012-06-14 |
| ZA201105355B (en) | 2012-03-28 |
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