JP2012507986A - キメラdnaポリメラーゼ - Google Patents

キメラdnaポリメラーゼ Download PDF

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Publication number
JP2012507986A
JP2012507986A JP2011534889A JP2011534889A JP2012507986A JP 2012507986 A JP2012507986 A JP 2012507986A JP 2011534889 A JP2011534889 A JP 2011534889A JP 2011534889 A JP2011534889 A JP 2011534889A JP 2012507986 A JP2012507986 A JP 2012507986A
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Prior art keywords
polymerase
amino acid
chimeric
dna
domain
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English (en)
Japanese (ja)
Inventor
ビャーネ ファウロルム,
ポール マッケワン,
ウィリアム ボーン,
ギャビン ラッシュ,
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カパバイオシステムズ
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • C12N9/1252DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/34Polynucleotides, e.g. nucleic acids, oligoribonucleotides

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2011534889A 2008-11-03 2009-11-03 キメラdnaポリメラーゼ Withdrawn JP2012507986A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11086208P 2008-11-03 2008-11-03
US61/110,862 2008-11-03
PCT/US2009/063166 WO2010062776A2 (en) 2008-11-03 2009-11-03 Chimeric dna polymerases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015111259A Division JP6150847B2 (ja) 2008-11-03 2015-06-01 キメラdnaポリメラーゼ

Publications (1)

Publication Number Publication Date
JP2012507986A true JP2012507986A (ja) 2012-04-05

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ID=42226349

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2011534889A Withdrawn JP2012507986A (ja) 2008-11-03 2009-11-03 キメラdnaポリメラーゼ
JP2015111259A Active JP6150847B2 (ja) 2008-11-03 2015-06-01 キメラdnaポリメラーゼ
JP2016219403A Pending JP2017029172A (ja) 2008-11-03 2016-11-10 キメラdnaポリメラーゼ

Family Applications After (2)

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JP2015111259A Active JP6150847B2 (ja) 2008-11-03 2015-06-01 キメラdnaポリメラーゼ
JP2016219403A Pending JP2017029172A (ja) 2008-11-03 2016-11-10 キメラdnaポリメラーゼ

Country Status (7)

Country Link
US (2) US9023633B2 (OSRAM)
EP (2) EP2352818B1 (OSRAM)
JP (3) JP2012507986A (OSRAM)
CN (1) CN102257136A (OSRAM)
CA (1) CA2742593C (OSRAM)
ES (2) ES2571446T3 (OSRAM)
WO (1) WO2010062776A2 (OSRAM)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016208917A (ja) * 2015-05-08 2016-12-15 国立研究開発法人産業技術総合研究所 フラビンアデニンジヌクレオチド依存型グルコース脱水素酵素活性を有するキメラタンパク質
JP2017108736A (ja) * 2015-12-11 2017-06-22 東洋紡株式会社 核酸増幅用組成物及び核酸増幅法
JP2017108735A (ja) * 2015-12-11 2017-06-22 東洋紡株式会社 核酸増幅用試薬及び核酸増幅法
JP2018042567A (ja) * 2013-08-06 2018-03-22 東洋紡株式会社 核酸増幅法
JP2019509717A (ja) * 2016-01-19 2019-04-11 ボード オブ リージェンツ ザ ユニヴァーシティ オブ テキサス システム 熱安定逆転写酵素
JP2020501573A (ja) * 2016-12-19 2020-01-23 クアンタム−エスアイ インコーポレイテッドQuantum−Si Incorporated シークエンシング反応用の重合酵素
CN113755465A (zh) * 2021-09-23 2021-12-07 武汉爱博泰克生物科技有限公司 嵌合体dna聚合酶及其制备方法
US11959105B2 (en) 2019-06-28 2024-04-16 Quantum-Si Incorporated Polymerizing enzymes for sequencing reactions

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2742800T3 (es) 2008-11-03 2020-02-17 Kapa Biosystems Inc ADN polimerasas de tipo A modificadas
CN102257136A (zh) 2008-11-03 2011-11-23 卡帕生物系统 嵌合dna聚合酶
US9315787B2 (en) 2011-01-14 2016-04-19 Kapa Biosystems, Inc. Modified DNA polymerases for improved amplification
CN102392000A (zh) * 2011-11-07 2012-03-28 李志茹 一种耐高温Pyrolobus聚合酶及其高效表达质粒和应用
US9309501B2 (en) 2012-12-24 2016-04-12 Industrial Technology Research Institute Isolated DNA polymerases, kits and applications thereof
CN104250641B (zh) * 2013-06-28 2017-09-01 北京福安华生物科技有限公司 一种高保真dna聚合酶及其制备和应用
EP3161154B1 (en) * 2014-06-27 2020-04-15 Illumina, Inc. Modified polymerases for improved incorporation of nucleotide analogues
US9963687B2 (en) 2014-08-27 2018-05-08 New England Biolabs, Inc. Fusion polymerase and method for using the same
JP6594955B2 (ja) * 2014-08-27 2019-10-23 ニユー・イングランド・バイオレイブス・インコーポレイテツド シントン形成
CN108064278B (zh) * 2014-11-14 2022-02-08 亿明达股份有限公司 聚合酶
CN106867978A (zh) * 2015-12-10 2017-06-20 江苏众红生物工程创药研究院有限公司 一种重组高保真dna聚合酶及其编码基因和表达方法
LT3402880T (lt) 2016-01-15 2024-03-12 Thermo Fisher Scientific Baltics Uab Termofiliniai dnr polimerazės mutantai
EP3458597B1 (en) 2016-05-18 2022-09-07 Roche Diagnostics GmbH Quantitative real time pcr amplification using an electrowetting-based device
FR3052462A1 (fr) * 2016-06-14 2017-12-15 Dna Script Variants d'une adn polymerase de la famille polx
CN106011100A (zh) * 2016-08-08 2016-10-12 吴江近岸蛋白质科技有限公司 一种Pfu DNA聚合酶及其制备方法
CN106754816B (zh) * 2017-02-24 2020-10-27 依科赛生物科技(太仓)有限公司 一种高保真快速扩增融合酶及其制备方法
US11618891B2 (en) 2017-06-26 2023-04-04 Thermo Fisher Scientific Baltics Uab Thermophilic DNA polymerase mutants
AU2018292104B2 (en) 2017-06-30 2025-03-27 Codexis, Inc. T7 RNA polymerase variants
JP7588391B2 (ja) 2017-06-30 2024-11-22 コデクシス, インコーポレイテッド T7 rnaポリメラーゼバリアント
EP4530346A3 (en) * 2017-07-12 2025-06-11 Genecast Co., Ltd. Dna polymerase with increased gene mutation specificity and pcr buffer composition for increasing activity thereof
WO2019084538A1 (en) 2017-10-27 2019-05-02 Board Of Regents, The University Of Texas System TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF
WO2019143622A1 (en) 2018-01-19 2019-07-25 Bio-Rad Laboratories, Inc. Mutant dna polymerases
EP3862427A4 (en) * 2018-09-03 2022-04-27 BGI Shenzhen RECOMBINANT KOD POLYMERASE
KR20210084349A (ko) * 2018-10-31 2021-07-07 일루미나, 인코포레이티드 중합효소, 조성물, 및 사용 방법
SG11202012559SA (en) 2018-12-05 2021-01-28 Illumina Inc Polymerases, compositions, and methods of use
CN109628424B (zh) * 2018-12-31 2022-04-26 苏州近岸蛋白质科技股份有限公司 一种新型嵌合dna聚合酶及其制备方法
US20220090194A1 (en) * 2019-01-09 2022-03-24 3Cr Bioscience Ltd. Method for detecting a nucleic acid sequence
GB2587177A (en) * 2019-01-09 2021-03-24 3Cr Bioscience Ltd Polymerase
CN114829593B (zh) * 2019-12-23 2023-11-14 深圳华大生命科学研究院 嵌合dna聚合酶及其应用
EP4103747A4 (en) * 2020-02-15 2024-03-13 Agency for Science, Technology and Research A method to amplify a nucleic acid
CN113604450B (zh) * 2021-08-18 2023-08-18 华南理工大学 一种kod dna聚合酶突变体及其制备方法与应用
EP4435098A4 (en) * 2021-11-15 2025-10-01 Bgi Shenzhen CHIMERIC DNA POLYMERASE AND ITS USE
CN119736271A (zh) * 2024-12-27 2025-04-01 安序源生物科技(深圳)有限公司 一种phi29 DNA聚合酶突变体及其用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05328969A (ja) * 1991-12-18 1993-12-14 New England Biolabs Inc Pyrococcus種から得られる精製耐熱性DNAポリメラーゼ
JPH07298879A (ja) * 1994-05-09 1995-11-14 Toyobo Co Ltd 超好熱始原菌由来のdnaポリメラーゼ遺伝子およびその用途
WO2001061015A2 (en) * 2000-02-17 2001-08-23 Qiagen Gmbh Thermostable chimeric nucleic acid polymerases and uses thereof
JP2002506637A (ja) * 1998-03-13 2002-03-05 ロシュ ダイアグノスティックス ゲーエムベーハー ポリメラーゼキメラ
JP2004502443A (ja) * 2000-07-12 2004-01-29 インヴィトロジェン コーポレーション 高忠実度ポリメラーゼおよびその使用方法
JP2006513726A (ja) * 2002-12-20 2006-04-27 ストラタジーン カリフォルニア Dnaポリメラーゼブレンドおよびその使用

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5079352A (en) 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5066584A (en) 1988-09-23 1991-11-19 Cetus Corporation Methods for generating single stranded dna by the polymerase chain reaction
US5075216A (en) 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
US5091310A (en) 1988-09-23 1992-02-25 Cetus Corporation Structure-independent dna amplification by the polymerase chain reaction
US5023171A (en) 1989-08-10 1991-06-11 Mayo Foundation For Medical Education And Research Method for gene splicing by overlap extension using the polymerase chain reaction
US5104792A (en) 1989-12-21 1992-04-14 The United States Of America As Represented By The Department Of Health And Human Services Method for amplifying unknown nucleic acid sequences
US5545552A (en) 1990-12-03 1996-08-13 Stratagene Purified thermostable pyrococcus furiosus DNA polymerase I
US5948663A (en) 1990-12-03 1999-09-07 Stratagene Purified thermostable pyrococcus furiosus DNA polymerase I
US5866395A (en) 1990-12-03 1999-02-02 Stratagene Purified thermostable pyrococcus furiosus DNA polymerase I
US5556772A (en) 1993-12-08 1996-09-17 Stratagene Polymerase compositions and uses thereof
US6033859A (en) * 1996-05-24 2000-03-07 Toyo Boseki Kabushiki Kaisha Thermostable DNA polymerase from a hyperthermophilic archaeon strain KOD1
EP1013759B1 (en) * 1997-01-31 2007-01-24 Japan Science and Technology Agency Method and apparatus for predicting protein function site, method for improving protein function, and function-improved protein
PT1112077E (pt) 1998-08-18 2011-03-16 Dermtech Int Método para detecção de factores biológicos na epiderme
GB9921318D0 (en) * 1999-09-09 1999-11-10 Kristensen Tom Chimeric molecules
JP4949585B2 (ja) 1999-10-29 2012-06-13 アジレント・テクノロジーズ・インク Dnaポリメラーゼを使用した組成物および方法
US20050123940A1 (en) * 1999-10-29 2005-06-09 Stratagene California Compositions and methods for synthesizing cDNA
EP1154017B1 (en) 2000-05-11 2010-01-20 Toyo Boseki Kabushiki Kaisha Modified thermostable dna polymerase from pyrococcus kodakarensis
US6627424B1 (en) 2000-05-26 2003-09-30 Mj Bioworks, Inc. Nucleic acid modifying enzymes
GB2382321A (en) 2001-11-21 2003-05-28 Doyen Medipharm Ltd Process and apparatus for cutting sheets
US7704712B2 (en) 2003-03-25 2010-04-27 Stratagene California DNA polymerase fusions and uses thereof
US20040244310A1 (en) 2003-03-28 2004-12-09 Blumberg Marvin R. Data center
WO2005113760A2 (en) 2004-05-20 2005-12-01 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Thermostable y-family polymerases and chimeras
JP4990886B2 (ja) 2005-05-10 2012-08-01 ソレックサ リミテッド 改良ポリメラーゼ
US20070190538A1 (en) 2005-07-29 2007-08-16 Applera Corporation Chimeric polymerases
CA2633524A1 (en) 2005-12-22 2007-07-05 Pacific Biosciences Of California, Inc. Polymerases for nucleotide analogue incorporation
JP2007298879A (ja) 2006-05-02 2007-11-15 C & C:Kk ストロボ装置
US8962293B2 (en) 2006-10-18 2015-02-24 Roche Molecular Systems, Inc. DNA polymerases and related methods
AU2007309504B2 (en) 2006-10-23 2012-09-13 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
CN102257136A (zh) 2008-11-03 2011-11-23 卡帕生物系统 嵌合dna聚合酶
WO2010062779A2 (en) 2008-11-03 2010-06-03 Kapabiosystems Modified dna polymerases
JP5328696B2 (ja) 2010-03-01 2013-10-30 淀川ヒューテック株式会社 複層ベルト

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05328969A (ja) * 1991-12-18 1993-12-14 New England Biolabs Inc Pyrococcus種から得られる精製耐熱性DNAポリメラーゼ
JPH07298879A (ja) * 1994-05-09 1995-11-14 Toyobo Co Ltd 超好熱始原菌由来のdnaポリメラーゼ遺伝子およびその用途
JP2002506637A (ja) * 1998-03-13 2002-03-05 ロシュ ダイアグノスティックス ゲーエムベーハー ポリメラーゼキメラ
WO2001061015A2 (en) * 2000-02-17 2001-08-23 Qiagen Gmbh Thermostable chimeric nucleic acid polymerases and uses thereof
JP2004502443A (ja) * 2000-07-12 2004-01-29 インヴィトロジェン コーポレーション 高忠実度ポリメラーゼおよびその使用方法
JP2006513726A (ja) * 2002-12-20 2006-04-27 ストラタジーン カリフォルニア Dnaポリメラーゼブレンドおよびその使用

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018042567A (ja) * 2013-08-06 2018-03-22 東洋紡株式会社 核酸増幅法
JP2016208917A (ja) * 2015-05-08 2016-12-15 国立研究開発法人産業技術総合研究所 フラビンアデニンジヌクレオチド依存型グルコース脱水素酵素活性を有するキメラタンパク質
JP2021141898A (ja) * 2015-12-11 2021-09-24 東洋紡株式会社 核酸増幅用試薬及び核酸増幅法
JP2017108735A (ja) * 2015-12-11 2017-06-22 東洋紡株式会社 核酸増幅用試薬及び核酸増幅法
JP2017108736A (ja) * 2015-12-11 2017-06-22 東洋紡株式会社 核酸増幅用組成物及び核酸増幅法
JP7160142B2 (ja) 2015-12-11 2022-10-25 東洋紡株式会社 核酸増幅用試薬及び核酸増幅法
JP2019509717A (ja) * 2016-01-19 2019-04-11 ボード オブ リージェンツ ザ ユニヴァーシティ オブ テキサス システム 熱安定逆転写酵素
JP2021192618A (ja) * 2016-01-19 2021-12-23 ボード オブ リージェンツ ザ ユニヴァーシティ オブ テキサス システム 熱安定逆転写酵素
JP7256849B2 (ja) 2016-01-19 2023-04-12 ボード オブ リージェンツ ザ ユニヴァーシティ オブ テキサス システム 熱安定逆転写酵素
US11912991B2 (en) 2016-01-19 2024-02-27 Board Of Regents, The University Of Texas System Thermostable reverse transcriptase
JP2020501573A (ja) * 2016-12-19 2020-01-23 クアンタム−エスアイ インコーポレイテッドQuantum−Si Incorporated シークエンシング反応用の重合酵素
US11312944B2 (en) 2016-12-19 2022-04-26 Quantum-Si Incorporated Polymerizing enzymes for sequencing reactions
JP2023026651A (ja) * 2016-12-19 2023-02-24 クアンタム-エスアイ インコーポレイテッド シークエンシング反応用の重合酵素
US11959105B2 (en) 2019-06-28 2024-04-16 Quantum-Si Incorporated Polymerizing enzymes for sequencing reactions
CN113755465A (zh) * 2021-09-23 2021-12-07 武汉爱博泰克生物科技有限公司 嵌合体dna聚合酶及其制备方法

Also Published As

Publication number Publication date
JP2015154787A (ja) 2015-08-27
JP2017029172A (ja) 2017-02-09
CA2742593C (en) 2020-05-05
EP2927317B1 (en) 2018-12-19
EP2352818A4 (en) 2011-10-12
HK1216032A1 (en) 2016-10-07
WO2010062776A2 (en) 2010-06-03
US9023633B2 (en) 2015-05-05
ES2716402T3 (es) 2019-06-12
EP2352818B1 (en) 2016-02-10
JP6150847B2 (ja) 2017-06-21
EP2927317A1 (en) 2015-10-07
US20140363848A1 (en) 2014-12-11
CN102257136A (zh) 2011-11-23
US20120115188A1 (en) 2012-05-10
US9388396B2 (en) 2016-07-12
ES2571446T3 (es) 2016-05-25
EP2352818A2 (en) 2011-08-10
WO2010062776A3 (en) 2010-08-19
CA2742593A1 (en) 2010-06-03

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