JP2012120536A5 - - Google Patents
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- JP2012120536A5 JP2012120536A5 JP2012027445A JP2012027445A JP2012120536A5 JP 2012120536 A5 JP2012120536 A5 JP 2012120536A5 JP 2012027445 A JP2012027445 A JP 2012027445A JP 2012027445 A JP2012027445 A JP 2012027445A JP 2012120536 A5 JP2012120536 A5 JP 2012120536A5
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- Prior art keywords
- seq
- nucleic acid
- amino acid
- molecule encoding
- acid sequence
- Prior art date
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- 238000000034 method Methods 0.000 claims 39
- 102000039446 nucleic acids Human genes 0.000 claims 29
- 108020004707 nucleic acids Proteins 0.000 claims 29
- 150000007523 nucleic acids Chemical class 0.000 claims 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims 23
- 230000000694 effects Effects 0.000 claims 21
- 102000040430 polynucleotide Human genes 0.000 claims 15
- 108091033319 polynucleotide Proteins 0.000 claims 15
- 239000002157 polynucleotide Substances 0.000 claims 15
- 229920001184 polypeptide Polymers 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 13
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 12
- 239000004472 Lysine Substances 0.000 claims 12
- 101150033534 lysA gene Proteins 0.000 claims 8
- 241000186216 Corynebacterium Species 0.000 claims 7
- 101100465553 Dictyostelium discoideum psmB6 gene Proteins 0.000 claims 7
- 101100169519 Pyrococcus abyssi (strain GE5 / Orsay) dapAL gene Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 101150011371 dapA gene Proteins 0.000 claims 7
- 101150073654 dapB gene Proteins 0.000 claims 7
- 230000037361 pathway Effects 0.000 claims 7
- 101710159752 Poly(3-hydroxyalkanoate) polymerase subunit PhaE Proteins 0.000 claims 6
- 101710130262 Probable Vpr-like protein Proteins 0.000 claims 6
- 241000186226 Corynebacterium glutamicum Species 0.000 claims 5
- 108030003594 Diaminopimelate decarboxylases Proteins 0.000 claims 5
- 241000319304 [Brevibacterium] flavum Species 0.000 claims 4
- 108091000044 4-hydroxy-tetrahydrodipicolinate synthase Proteins 0.000 claims 3
- 108020004652 Aspartate-Semialdehyde Dehydrogenase Proteins 0.000 claims 3
- 108010014468 Dihydrodipicolinate Reductase Proteins 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 2
- 108010056578 diaminopimelate dehydrogenase Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 210000000349 chromosome Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000003362 replicative effect Effects 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17370799P | 1999-12-30 | 1999-12-30 | |
| US60/173,707 | 1999-12-30 | ||
| US18413000P | 2000-02-22 | 2000-02-22 | |
| US60/184,130 | 2000-02-22 | ||
| US09/722,441 | 2000-11-28 | ||
| US09/722,441 US6927046B1 (en) | 1999-12-30 | 2000-11-28 | Increased lysine production by gene amplification using coryneform bacteria |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011001545A Division JP5091330B2 (ja) | 1999-12-30 | 2011-01-06 | 遺伝子増幅によるリジン産生の増加 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012120536A JP2012120536A (ja) | 2012-06-28 |
| JP2012120536A5 true JP2012120536A5 (https=) | 2012-10-18 |
| JP5486029B2 JP5486029B2 (ja) | 2014-05-07 |
Family
ID=27390312
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001550382A Expired - Lifetime JP4963152B2 (ja) | 1999-12-30 | 2000-12-29 | 遺伝子増幅によるリジン産生の増加 |
| JP2011001545A Expired - Lifetime JP5091330B2 (ja) | 1999-12-30 | 2011-01-06 | 遺伝子増幅によるリジン産生の増加 |
| JP2012027445A Expired - Lifetime JP5486029B2 (ja) | 1999-12-30 | 2012-02-10 | 遺伝子増幅によるリジン産生の増加 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001550382A Expired - Lifetime JP4963152B2 (ja) | 1999-12-30 | 2000-12-29 | 遺伝子増幅によるリジン産生の増加 |
| JP2011001545A Expired - Lifetime JP5091330B2 (ja) | 1999-12-30 | 2011-01-06 | 遺伝子増幅によるリジン産生の増加 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US6927046B1 (https=) |
| EP (1) | EP1246921B1 (https=) |
| JP (3) | JP4963152B2 (https=) |
| KR (1) | KR100760222B1 (https=) |
| CN (1) | CN1415014A (https=) |
| AT (1) | ATE437230T1 (https=) |
| AU (1) | AU783684B2 (https=) |
| BR (1) | BR0016833A (https=) |
| CA (2) | CA2396052C (https=) |
| DE (1) | DE60042612D1 (https=) |
| MX (1) | MXPA02006524A (https=) |
| NZ (1) | NZ520390A (https=) |
| WO (1) | WO2001049854A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6927046B1 (en) * | 1999-12-30 | 2005-08-09 | Archer-Daniels-Midland Company | Increased lysine production by gene amplification using coryneform bacteria |
| JP4207426B2 (ja) * | 2000-01-21 | 2009-01-14 | 味の素株式会社 | Ｌ−リジンの製造法 |
| EP1368367B1 (en) * | 2001-02-08 | 2017-05-03 | Archer-Daniels-Midland Company | Polynucleotide constructs for increased lysine production |
| BR0304860A (pt) * | 2002-11-11 | 2004-08-31 | Ajinomoto Kk | Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia |
| US7723097B2 (en) * | 2005-03-11 | 2010-05-25 | Archer-Daniels-Midland Company | Escherichia coli strains that over-produce L-threonine and processes for their production |
| US20070244719A1 (en) * | 2006-04-13 | 2007-10-18 | David Peter R | Compositions and methods for producing fermentation products and residuals |
| US20070243235A1 (en) * | 2006-04-13 | 2007-10-18 | David Peter R | Compositions and methods for producing fermentation products and residuals |
| US7309602B2 (en) * | 2006-04-13 | 2007-12-18 | Ambrozea, Inc. | Compositions and methods for producing fermentation products and residuals |
| DE102006032634A1 (de) | 2006-07-13 | 2008-01-17 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren |
| BRPI0716980A2 (pt) * | 2006-09-15 | 2013-10-22 | Cj Cheiljedang Corp | Corynebacteria com produtividade de l-lisina aumentada e método de produção da l-lisina usando a mesma |
| KR100830826B1 (ko) * | 2007-01-24 | 2008-05-19 | 씨제이제일제당 (주) | 코리네박테리아를 이용하여 글리세롤을 포함한탄소원으로부터 발효산물을 생산하는 방법 |
| KR100987281B1 (ko) * | 2008-01-31 | 2010-10-12 | 씨제이제일제당 (주) | 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법 |
| ES2510865T3 (es) | 2008-03-03 | 2014-10-21 | Global Bio-Chem Technology Group Company Limited | Microorganismo recombinante y procedimiento para producir L-lisina |
| KR101126041B1 (ko) * | 2008-04-10 | 2012-03-19 | 씨제이제일제당 (주) | 트랜스포존을 이용한 형질전환용 벡터, 상기 벡터로형질전환된 미생물 및 이를 이용한 ｌ-라이신 생산방법 |
| US8932861B2 (en) | 2008-04-10 | 2015-01-13 | Cj Cheiljedang Corporation | Transformation vector comprising transposon, microorganisms transformed with the vector, and method for producing L-lysine using the microorganism |
| DE102008001874A1 (de) | 2008-05-20 | 2009-11-26 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren |
| CN102089437B (zh) | 2008-07-09 | 2014-11-05 | 味之素株式会社 | 生产氨基羟基苯甲酸盐类化合物的方法 |
| KR20110035805A (ko) * | 2009-09-30 | 2011-04-06 | 씨제이제일제당 (주) | 사이코스-에피머화 효소의 고정화 및 이를 이용한 사이코스의 제조방법 |
| US8839078B2 (en) * | 2010-03-05 | 2014-09-16 | Samsung Electronics Co., Ltd. | Application layer FEC framework for WiGig |
| JP6183358B2 (ja) | 2012-05-29 | 2017-08-23 | 味の素株式会社 | ３−アセチルアミノ−４−ヒドロキシ安息香酸の製造方法 |
| DE102012016716A1 (de) | 2012-08-22 | 2014-02-27 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung von Vektoren enthaltend ein für in seiner feedback-Inhibierung gemindertes oder ausgeschaltetes Enzym kodierendes Gen und deren Verwendung für die Herstellung von Aminosäuren und Nukleotiden |
| KR101594156B1 (ko) | 2013-06-25 | 2016-02-15 | 씨제이제일제당 주식회사 | Ｌ-라이신 생산능이 향상된 미생물 및 그를 이용하여 ｌ-라이신을 생산하는 방법 |
| EP2940144A1 (de) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Verfahren zur Produktion von L-Lysin unter Verwendung eines alkaliphilen Bakteriums |
| KR20200026874A (ko) * | 2017-06-06 | 2020-03-11 | 지머젠 인코포레이티드 | 대장균 개량을 위한 htp 게놈 공학 플랫폼 |
| CN107916246A (zh) * | 2017-11-17 | 2018-04-17 | 江南大学 | 遗传改造谷氨酸棒杆菌中dhdpr提高赖氨酸产量的方法 |
| WO2019118548A1 (en) * | 2017-12-15 | 2019-06-20 | Archer Daniels Midland Company | Engineered strains of corynebacteria |
| US20240254526A1 (en) * | 2018-09-07 | 2024-08-01 | Archer Daniels Midland Company | Engineered strains of corynebacteria |
| KR102126951B1 (ko) * | 2019-09-26 | 2020-06-26 | 씨제이제일제당 주식회사 | 디하이드로디피콜린산 리덕타제 변이형 폴리펩티드 및 이를 이용한 l-쓰레오닌 생산방법 |
| CN110951662B (zh) * | 2019-12-26 | 2024-03-12 | 新疆梅花氨基酸有限责任公司 | 一种高产赖氨酸的棒状细菌及其构建方法与应用 |
| CN111411092B (zh) * | 2020-03-08 | 2022-07-05 | 安徽丰原发酵技术工程研究有限公司 | 高产l-赖氨酸的谷氨酸棒状杆菌及其应用 |
| EP4306644A4 (en) * | 2021-03-09 | 2025-04-16 | CJ Cheiljedang Corporation | CORYNEBACTERIUM GLUTAMICUM VARIANT WITH IMPROVED L-LYSINE PRODUCTION CAPACITY AND METHOD FOR PRODUCING L-LYSINE USING SAME |
| JP7743531B2 (ja) * | 2021-03-09 | 2025-09-24 | デサン・コーポレイション | Ｌ－リジン生産能が向上したコリネバクテリウム・グルタミカム変異株およびこれを用いたｌ－リジンの生産方法 |
| KR102668767B1 (ko) * | 2021-04-30 | 2024-05-24 | 씨제이제일제당 주식회사 | L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법 |
| US20250313872A1 (en) | 2022-05-18 | 2025-10-09 | Evonik Operations Gmbh | Biotechnological production of bisucaberins, desferrioxamines and analogs thereof |
| WO2023222505A1 (en) | 2022-05-18 | 2023-11-23 | Evonik Operations Gmbh | Biotechnological production of monomers of bisucaberins, desferrioxamines and analogs thereof |
| EP4526436A1 (en) | 2022-05-18 | 2025-03-26 | Evonik Operations GmbH | Biotechnological production of desferrioxamines and analogs thereof |
| CN116042416B (zh) * | 2023-01-09 | 2024-09-27 | 天津科技大学 | 高产ε-聚赖氨酸的多基因过表达链霉菌工程菌株及方法与应用 |
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-
2000
- 2000-11-28 US US09/722,441 patent/US6927046B1/en not_active Expired - Lifetime
- 2000-12-29 WO PCT/US2000/035617 patent/WO2001049854A2/en not_active Ceased
- 2000-12-29 CA CA002396052A patent/CA2396052C/en not_active Expired - Fee Related
- 2000-12-29 JP JP2001550382A patent/JP4963152B2/ja not_active Expired - Lifetime
- 2000-12-29 CA CA2654770A patent/CA2654770C/en not_active Expired - Fee Related
- 2000-12-29 AT AT00989600T patent/ATE437230T1/de not_active IP Right Cessation
- 2000-12-29 NZ NZ520390A patent/NZ520390A/en not_active IP Right Cessation
- 2000-12-29 MX MXPA02006524A patent/MXPA02006524A/es active IP Right Grant
- 2000-12-29 CN CN00817929A patent/CN1415014A/zh active Pending
- 2000-12-29 BR BR0016833-5A patent/BR0016833A/pt not_active Application Discontinuation
- 2000-12-29 AU AU26088/01A patent/AU783684B2/en not_active Ceased
- 2000-12-29 EP EP00989600A patent/EP1246921B1/en not_active Expired - Lifetime
- 2000-12-29 KR KR1020027008533A patent/KR100760222B1/ko not_active Expired - Lifetime
- 2000-12-29 DE DE60042612T patent/DE60042612D1/de not_active Expired - Lifetime
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2002
- 2002-02-08 US US10/067,974 patent/US7368276B2/en not_active Expired - Lifetime
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2004
- 2004-02-04 US US10/771,695 patent/US7741460B2/en not_active Expired - Fee Related
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2006
- 2006-08-25 US US11/510,084 patent/US8685719B2/en not_active Expired - Fee Related
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2010
- 2010-05-03 US US12/772,538 patent/US8067210B2/en not_active Expired - Fee Related
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2011
- 2011-01-06 JP JP2011001545A patent/JP5091330B2/ja not_active Expired - Lifetime
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2012
- 2012-02-10 JP JP2012027445A patent/JP5486029B2/ja not_active Expired - Lifetime
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