ATE437230T1 - Erhöhte produktion von lysin durch gen- amplifizierung unter verwendung von coryneformen bakterien - Google Patents

Erhöhte produktion von lysin durch gen- amplifizierung unter verwendung von coryneformen bakterien

Info

Publication number
ATE437230T1
ATE437230T1 AT00989600T AT00989600T ATE437230T1 AT E437230 T1 ATE437230 T1 AT E437230T1 AT 00989600 T AT00989600 T AT 00989600T AT 00989600 T AT00989600 T AT 00989600T AT E437230 T1 ATE437230 T1 AT E437230T1
Authority
AT
Austria
Prior art keywords
lysine
dapb
asd
ask
production
Prior art date
Application number
AT00989600T
Other languages
German (de)
English (en)
Inventor
Paul Hanke
Elia Lhing-Yew Li-D
P John Rayapati
Holly J Walsh
Original Assignee
Archer Daniels Midland Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Archer Daniels Midland Co filed Critical Archer Daniels Midland Co
Application granted granted Critical
Publication of ATE437230T1 publication Critical patent/ATE437230T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/345—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Brevibacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT00989600T 1999-12-30 2000-12-29 Erhöhte produktion von lysin durch gen- amplifizierung unter verwendung von coryneformen bakterien ATE437230T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17370799P 1999-12-30 1999-12-30
US18413000P 2000-02-22 2000-02-22
US09/722,441 US6927046B1 (en) 1999-12-30 2000-11-28 Increased lysine production by gene amplification using coryneform bacteria
PCT/US2000/035617 WO2001049854A2 (en) 1999-12-30 2000-12-29 Increased lysine production by gene amplification using coryneform bacteria

Publications (1)

Publication Number Publication Date
ATE437230T1 true ATE437230T1 (de) 2009-08-15

Family

ID=27390312

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00989600T ATE437230T1 (de) 1999-12-30 2000-12-29 Erhöhte produktion von lysin durch gen- amplifizierung unter verwendung von coryneformen bakterien

Country Status (13)

Country Link
US (5) US6927046B1 (https=)
EP (1) EP1246921B1 (https=)
JP (3) JP4963152B2 (https=)
KR (1) KR100760222B1 (https=)
CN (1) CN1415014A (https=)
AT (1) ATE437230T1 (https=)
AU (1) AU783684B2 (https=)
BR (1) BR0016833A (https=)
CA (2) CA2396052C (https=)
DE (1) DE60042612D1 (https=)
MX (1) MXPA02006524A (https=)
NZ (1) NZ520390A (https=)
WO (1) WO2001049854A2 (https=)

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JP4207426B2 (ja) * 2000-01-21 2009-01-14 味の素株式会社 Ｌ−リジンの製造法
EP1368367B1 (en) * 2001-02-08 2017-05-03 Archer-Daniels-Midland Company Polynucleotide constructs for increased lysine production
BR0304860A (pt) * 2002-11-11 2004-08-31 Ajinomoto Kk Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia
US7723097B2 (en) * 2005-03-11 2010-05-25 Archer-Daniels-Midland Company Escherichia coli strains that over-produce L-threonine and processes for their production
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US20240254526A1 (en) * 2018-09-07 2024-08-01 Archer Daniels Midland Company Engineered strains of corynebacteria
KR102126951B1 (ko) * 2019-09-26 2020-06-26 씨제이제일제당 주식회사 디하이드로디피콜린산 리덕타제 변이형 폴리펩티드 및 이를 이용한 l-쓰레오닌 생산방법
CN110951662B (zh) * 2019-12-26 2024-03-12 新疆梅花氨基酸有限责任公司 一种高产赖氨酸的棒状细菌及其构建方法与应用
CN111411092B (zh) * 2020-03-08 2022-07-05 安徽丰原发酵技术工程研究有限公司 高产l-赖氨酸的谷氨酸棒状杆菌及其应用
EP4306644A4 (en) * 2021-03-09 2025-04-16 CJ Cheiljedang Corporation CORYNEBACTERIUM GLUTAMICUM VARIANT WITH IMPROVED L-LYSINE PRODUCTION CAPACITY AND METHOD FOR PRODUCING L-LYSINE USING SAME
JP7743531B2 (ja) * 2021-03-09 2025-09-24 デサン・コーポレイション Ｌ－リジン生産能が向上したコリネバクテリウム・グルタミカム変異株およびこれを用いたｌ－リジンの生産方法
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US8067210B2 (en) 2011-11-29
US20110045549A1 (en) 2011-02-24
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