KR100760222B1 - 유전자 증폭에 의해 증가된 리신 생산 - Google Patents

유전자 증폭에 의해 증가된 리신 생산 Download PDF

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KR100760222B1
KR100760222B1 KR1020027008533A KR20027008533A KR100760222B1 KR 100760222 B1 KR100760222 B1 KR 100760222B1 KR 1020027008533 A KR1020027008533 A KR 1020027008533A KR 20027008533 A KR20027008533 A KR 20027008533A KR 100760222 B1 KR100760222 B1 KR 100760222B1
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ala
amino acid
nucleic acid
val
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KR20020089320A (ko
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폴 디 한크
링 유 리델리아
피 존 라야파티
홀리 제이 왈쉬
코레이 엠 크라프톤
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아처 다니엘 미드랜드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/345—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Brevibacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020027008533A 1999-12-30 2000-12-29 유전자 증폭에 의해 증가된 리신 생산 Expired - Lifetime KR100760222B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US17370799P 1999-12-30 1999-12-30
US60/173,707 1999-12-30
US18413000P 2000-02-22 2000-02-22
US60/184,130 2000-02-22
US09/722,441 2000-11-28
US09/722,441 US6927046B1 (en) 1999-12-30 2000-11-28 Increased lysine production by gene amplification using coryneform bacteria

Publications (2)

Publication Number Publication Date
KR20020089320A KR20020089320A (ko) 2002-11-29
KR100760222B1 true KR100760222B1 (ko) 2007-10-04

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KR1020027008533A Expired - Lifetime KR100760222B1 (ko) 1999-12-30 2000-12-29 유전자 증폭에 의해 증가된 리신 생산

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Country Link
US (5) US6927046B1 (https=)
EP (1) EP1246921B1 (https=)
JP (3) JP4963152B2 (https=)
KR (1) KR100760222B1 (https=)
CN (1) CN1415014A (https=)
AT (1) ATE437230T1 (https=)
AU (1) AU783684B2 (https=)
BR (1) BR0016833A (https=)
CA (2) CA2396052C (https=)
DE (1) DE60042612D1 (https=)
MX (1) MXPA02006524A (https=)
NZ (1) NZ520390A (https=)
WO (1) WO2001049854A2 (https=)

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US6927046B1 (en) * 1999-12-30 2005-08-09 Archer-Daniels-Midland Company Increased lysine production by gene amplification using coryneform bacteria
JP4207426B2 (ja) * 2000-01-21 2009-01-14 味の素株式会社 Ｌ−リジンの製造法
EP1368367B1 (en) * 2001-02-08 2017-05-03 Archer-Daniels-Midland Company Polynucleotide constructs for increased lysine production
BR0304860A (pt) * 2002-11-11 2004-08-31 Ajinomoto Kk Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia
US7723097B2 (en) * 2005-03-11 2010-05-25 Archer-Daniels-Midland Company Escherichia coli strains that over-produce L-threonine and processes for their production
US20070244719A1 (en) * 2006-04-13 2007-10-18 David Peter R Compositions and methods for producing fermentation products and residuals
US20070243235A1 (en) * 2006-04-13 2007-10-18 David Peter R Compositions and methods for producing fermentation products and residuals
US7309602B2 (en) * 2006-04-13 2007-12-18 Ambrozea, Inc. Compositions and methods for producing fermentation products and residuals
DE102006032634A1 (de) 2006-07-13 2008-01-17 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren
BRPI0716980A2 (pt) * 2006-09-15 2013-10-22 Cj Cheiljedang Corp Corynebacteria com produtividade de l-lisina aumentada e método de produção da l-lisina usando a mesma
KR100830826B1 (ko) * 2007-01-24 2008-05-19 씨제이제일제당 (주) 코리네박테리아를 이용하여 글리세롤을 포함한탄소원으로부터 발효산물을 생산하는 방법
KR100987281B1 (ko) * 2008-01-31 2010-10-12 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법
ES2510865T3 (es) 2008-03-03 2014-10-21 Global Bio-Chem Technology Group Company Limited Microorganismo recombinante y procedimiento para producir L-lisina
KR101126041B1 (ko) * 2008-04-10 2012-03-19 씨제이제일제당 (주) 트랜스포존을 이용한 형질전환용 벡터, 상기 벡터로형질전환된 미생물 및 이를 이용한 ｌ-라이신 생산방법
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KR101594156B1 (ko) 2013-06-25 2016-02-15 씨제이제일제당 주식회사 Ｌ-라이신 생산능이 향상된 미생물 및 그를 이용하여 ｌ-라이신을 생산하는 방법
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KR20200026874A (ko) * 2017-06-06 2020-03-11 지머젠 인코포레이티드 대장균 개량을 위한 htp 게놈 공학 플랫폼
CN107916246A (zh) * 2017-11-17 2018-04-17 江南大学 遗传改造谷氨酸棒杆菌中dhdpr提高赖氨酸产量的方法
WO2019118548A1 (en) * 2017-12-15 2019-06-20 Archer Daniels Midland Company Engineered strains of corynebacteria
US20240254526A1 (en) * 2018-09-07 2024-08-01 Archer Daniels Midland Company Engineered strains of corynebacteria
KR102126951B1 (ko) * 2019-09-26 2020-06-26 씨제이제일제당 주식회사 디하이드로디피콜린산 리덕타제 변이형 폴리펩티드 및 이를 이용한 l-쓰레오닌 생산방법
CN110951662B (zh) * 2019-12-26 2024-03-12 新疆梅花氨基酸有限责任公司 一种高产赖氨酸的棒状细菌及其构建方法与应用
CN111411092B (zh) * 2020-03-08 2022-07-05 安徽丰原发酵技术工程研究有限公司 高产l-赖氨酸的谷氨酸棒状杆菌及其应用
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JP7743531B2 (ja) * 2021-03-09 2025-09-24 デサン・コーポレイション Ｌ－リジン生産能が向上したコリネバクテリウム・グルタミカム変異株およびこれを用いたｌ－リジンの生産方法
KR102668767B1 (ko) * 2021-04-30 2024-05-24 씨제이제일제당 주식회사 L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법
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US8067210B2 (en) 2011-11-29
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