JP2004500072A5 - - Google Patents
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- JP2004500072A5 JP2004500072A5 JP2001550382A JP2001550382A JP2004500072A5 JP 2004500072 A5 JP2004500072 A5 JP 2004500072A5 JP 2001550382 A JP2001550382 A JP 2001550382A JP 2001550382 A JP2001550382 A JP 2001550382A JP 2004500072 A5 JP2004500072 A5 JP 2004500072A5
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- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- molecule encoding
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000039446 nucleic acids Human genes 0.000 description 58
- 108020004707 nucleic acids Proteins 0.000 description 58
- 150000007523 nucleic acids Chemical class 0.000 description 58
- 102000040430 polynucleotide Human genes 0.000 description 47
- 108091033319 polynucleotide Proteins 0.000 description 47
- 239000002157 polynucleotide Substances 0.000 description 47
- 125000003275 alpha amino acid group Chemical group 0.000 description 40
- 238000000034 method Methods 0.000 description 34
- 210000004027 cell Anatomy 0.000 description 22
- 230000000694 effects Effects 0.000 description 22
- 229920001184 polypeptide Polymers 0.000 description 22
- 108090000765 processed proteins & peptides Proteins 0.000 description 22
- 102000004196 processed proteins & peptides Human genes 0.000 description 22
- 101100465553 Dictyostelium discoideum psmB6 gene Proteins 0.000 description 12
- 101100169519 Pyrococcus abyssi (strain GE5 / Orsay) dapAL gene Proteins 0.000 description 12
- 101150011371 dapA gene Proteins 0.000 description 12
- 101150073654 dapB gene Proteins 0.000 description 12
- 101150033534 lysA gene Proteins 0.000 description 12
- 241000186216 Corynebacterium Species 0.000 description 11
- 101710159752 Poly(3-hydroxyalkanoate) polymerase subunit PhaE Proteins 0.000 description 11
- 101710130262 Probable Vpr-like protein Proteins 0.000 description 11
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 8
- 239000004472 Lysine Substances 0.000 description 8
- 230000037361 pathway Effects 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 241000186226 Corynebacterium glutamicum Species 0.000 description 5
- 108030003594 Diaminopimelate decarboxylases Proteins 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 230000001131 transforming effect Effects 0.000 description 4
- 108091000044 4-hydroxy-tetrahydrodipicolinate synthase Proteins 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 3
- 108010014468 Dihydrodipicolinate Reductase Proteins 0.000 description 3
- 241000319304 [Brevibacterium] flavum Species 0.000 description 3
- 108010056578 diaminopimelate dehydrogenase Proteins 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- 108020004652 Aspartate-Semialdehyde Dehydrogenase Proteins 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 241000186146 Brevibacterium Species 0.000 description 1
- 241000186249 Corynebacterium sp. Species 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 241000620209 Escherichia coli DH5[alpha] Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17370799P | 1999-12-30 | 1999-12-30 | |
| US60/173,707 | 1999-12-30 | ||
| US18413000P | 2000-02-22 | 2000-02-22 | |
| US60/184,130 | 2000-02-22 | ||
| US09/722,441 US6927046B1 (en) | 1999-12-30 | 2000-11-28 | Increased lysine production by gene amplification using coryneform bacteria |
| US09/722,441 | 2000-11-28 | ||
| PCT/US2000/035617 WO2001049854A2 (en) | 1999-12-30 | 2000-12-29 | Increased lysine production by gene amplification using coryneform bacteria |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011001545A Division JP5091330B2 (ja) | 1999-12-30 | 2011-01-06 | 遺伝子増幅によるリジン産生の増加 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004500072A JP2004500072A (ja) | 2004-01-08 |
| JP2004500072A5 true JP2004500072A5 (https=) | 2008-02-14 |
| JP4963152B2 JP4963152B2 (ja) | 2012-06-27 |
Family
ID=27390312
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001550382A Expired - Lifetime JP4963152B2 (ja) | 1999-12-30 | 2000-12-29 | 遺伝子増幅によるリジン産生の増加 |
| JP2011001545A Expired - Lifetime JP5091330B2 (ja) | 1999-12-30 | 2011-01-06 | 遺伝子増幅によるリジン産生の増加 |
| JP2012027445A Expired - Lifetime JP5486029B2 (ja) | 1999-12-30 | 2012-02-10 | 遺伝子増幅によるリジン産生の増加 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011001545A Expired - Lifetime JP5091330B2 (ja) | 1999-12-30 | 2011-01-06 | 遺伝子増幅によるリジン産生の増加 |
| JP2012027445A Expired - Lifetime JP5486029B2 (ja) | 1999-12-30 | 2012-02-10 | 遺伝子増幅によるリジン産生の増加 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US6927046B1 (https=) |
| EP (1) | EP1246921B1 (https=) |
| JP (3) | JP4963152B2 (https=) |
| KR (1) | KR100760222B1 (https=) |
| CN (1) | CN1415014A (https=) |
| AT (1) | ATE437230T1 (https=) |
| AU (1) | AU783684B2 (https=) |
| BR (1) | BR0016833A (https=) |
| CA (2) | CA2396052C (https=) |
| DE (1) | DE60042612D1 (https=) |
| MX (1) | MXPA02006524A (https=) |
| NZ (1) | NZ520390A (https=) |
| WO (1) | WO2001049854A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6927046B1 (en) | 1999-12-30 | 2005-08-09 | Archer-Daniels-Midland Company | Increased lysine production by gene amplification using coryneform bacteria |
| ES2313878T3 (es) * | 2000-01-21 | 2009-03-16 | Ajinomoto Co., Inc. | Procedimiento para la produccion de l-lisina. |
| AR032570A1 (es) * | 2001-02-08 | 2003-11-12 | Archer Daniels Midland Co | Construcciones de polinucleotidicas para aumentar la produccion de lisina |
| BR0304860A (pt) * | 2002-11-11 | 2004-08-31 | Ajinomoto Kk | Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia |
| US7723097B2 (en) * | 2005-03-11 | 2010-05-25 | Archer-Daniels-Midland Company | Escherichia coli strains that over-produce L-threonine and processes for their production |
| US20070244719A1 (en) * | 2006-04-13 | 2007-10-18 | David Peter R | Compositions and methods for producing fermentation products and residuals |
| US20070243235A1 (en) * | 2006-04-13 | 2007-10-18 | David Peter R | Compositions and methods for producing fermentation products and residuals |
| US7309602B2 (en) * | 2006-04-13 | 2007-12-18 | Ambrozea, Inc. | Compositions and methods for producing fermentation products and residuals |
| DE102006032634A1 (de) | 2006-07-13 | 2008-01-17 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren |
| WO2008033001A1 (en) * | 2006-09-15 | 2008-03-20 | Cj Cheiljedang Corporation | A corynebacteria having enhanced l-lysine productivity and a method of producing l-lysine using the same |
| KR100830826B1 (ko) * | 2007-01-24 | 2008-05-19 | 씨제이제일제당 (주) | 코리네박테리아를 이용하여 글리세롤을 포함한탄소원으로부터 발효산물을 생산하는 방법 |
| KR100987281B1 (ko) * | 2008-01-31 | 2010-10-12 | 씨제이제일제당 (주) | 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법 |
| KR101368922B1 (ko) | 2008-03-03 | 2014-02-27 | 글로벌 바이오-켐 테크놀로지 그룹 컴퍼니 리미티드 | 재조합 미생물 및 ｌ－리신을 생산하는 방법 |
| US8932861B2 (en) | 2008-04-10 | 2015-01-13 | Cj Cheiljedang Corporation | Transformation vector comprising transposon, microorganisms transformed with the vector, and method for producing L-lysine using the microorganism |
| KR101126041B1 (ko) * | 2008-04-10 | 2012-03-19 | 씨제이제일제당 (주) | 트랜스포존을 이용한 형질전환용 벡터, 상기 벡터로형질전환된 미생물 및 이를 이용한 ｌ-라이신 생산방법 |
| DE102008001874A1 (de) | 2008-05-20 | 2009-11-26 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren |
| JP5445453B2 (ja) | 2008-07-09 | 2014-03-19 | 味の素株式会社 | アミノヒドロキシ安息香酸類の製造方法 |
| KR20110035805A (ko) | 2009-09-30 | 2011-04-06 | 씨제이제일제당 (주) | 사이코스-에피머화 효소의 고정화 및 이를 이용한 사이코스의 제조방법 |
| US8839078B2 (en) * | 2010-03-05 | 2014-09-16 | Samsung Electronics Co., Ltd. | Application layer FEC framework for WiGig |
| WO2013179711A1 (ja) | 2012-05-29 | 2013-12-05 | 味の素株式会社 | ３－アセチルアミノ－４－ヒドロキシ安息香酸の製造方法 |
| DE102012016716A1 (de) | 2012-08-22 | 2014-02-27 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung von Vektoren enthaltend ein für in seiner feedback-Inhibierung gemindertes oder ausgeschaltetes Enzym kodierendes Gen und deren Verwendung für die Herstellung von Aminosäuren und Nukleotiden |
| KR101594156B1 (ko) * | 2013-06-25 | 2016-02-15 | 씨제이제일제당 주식회사 | Ｌ-라이신 생산능이 향상된 미생물 및 그를 이용하여 ｌ-라이신을 생산하는 방법 |
| EP2940144A1 (de) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Verfahren zur Produktion von L-Lysin unter Verwendung eines alkaliphilen Bakteriums |
| WO2018226880A1 (en) * | 2017-06-06 | 2018-12-13 | Zymergen Inc. | A htp genomic engineering platform for improving escherichia coli |
| CN107916246A (zh) * | 2017-11-17 | 2018-04-17 | 江南大学 | 遗传改造谷氨酸棒杆菌中dhdpr提高赖氨酸产量的方法 |
| WO2019118548A1 (en) * | 2017-12-15 | 2019-06-20 | Archer Daniels Midland Company | Engineered strains of corynebacteria |
| JP2022500024A (ja) * | 2018-09-07 | 2022-01-04 | アーチャー−ダニエルズ−ミッドランド カンパニー | エンジニアリングされたコリネバクテリア（Ｃｏｒｙｎｅｂａｃｔｅｒｉａ）株 |
| KR102126951B1 (ko) * | 2019-09-26 | 2020-06-26 | 씨제이제일제당 주식회사 | 디하이드로디피콜린산 리덕타제 변이형 폴리펩티드 및 이를 이용한 l-쓰레오닌 생산방법 |
| CN110951662B (zh) * | 2019-12-26 | 2024-03-12 | 新疆梅花氨基酸有限责任公司 | 一种高产赖氨酸的棒状细菌及其构建方法与应用 |
| CN111411092B (zh) * | 2020-03-08 | 2022-07-05 | 安徽丰原发酵技术工程研究有限公司 | 高产l-赖氨酸的谷氨酸棒状杆菌及其应用 |
| BR112023018219A2 (pt) * | 2021-03-09 | 2023-11-28 | Daesang Corp | Variante de corynebacterium glutamicum que tem capacidade de produção de l-lisina aprimorada e método para produzir l-lisina com o uso da mesma |
| US20240175064A1 (en) * | 2021-03-09 | 2024-05-30 | Daesang Corporation | Mutant of corynebacterium glutamicum with enhanced l-lysine productivity and method for preparing l-lysine using the same |
| KR102668767B1 (ko) * | 2021-04-30 | 2024-05-24 | 씨제이제일제당 주식회사 | L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법 |
| EP4525843A1 (en) | 2022-05-18 | 2025-03-26 | Evonik Operations GmbH | Biotechnological production of monomers of bisucaberins, desferrioxamines and analogs thereof |
| EP4525842A1 (en) | 2022-05-18 | 2025-03-26 | Evonik Operations GmbH | Biotechnological production of bisucaberins, desferrioxamines and analogs thereof |
| EP4526436A1 (en) | 2022-05-18 | 2025-03-26 | Evonik Operations GmbH | Biotechnological production of desferrioxamines and analogs thereof |
| CN116042416B (zh) * | 2023-01-09 | 2024-09-27 | 天津科技大学 | 高产ε-聚赖氨酸的多基因过表达链霉菌工程菌株及方法与应用 |
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-
2000
- 2000-11-28 US US09/722,441 patent/US6927046B1/en not_active Expired - Lifetime
- 2000-12-29 CA CA002396052A patent/CA2396052C/en not_active Expired - Fee Related
- 2000-12-29 CA CA2654770A patent/CA2654770C/en not_active Expired - Fee Related
- 2000-12-29 DE DE60042612T patent/DE60042612D1/de not_active Expired - Lifetime
- 2000-12-29 WO PCT/US2000/035617 patent/WO2001049854A2/en not_active Ceased
- 2000-12-29 MX MXPA02006524A patent/MXPA02006524A/es active IP Right Grant
- 2000-12-29 JP JP2001550382A patent/JP4963152B2/ja not_active Expired - Lifetime
- 2000-12-29 KR KR1020027008533A patent/KR100760222B1/ko not_active Expired - Lifetime
- 2000-12-29 CN CN00817929A patent/CN1415014A/zh active Pending
- 2000-12-29 BR BR0016833-5A patent/BR0016833A/pt not_active Application Discontinuation
- 2000-12-29 AT AT00989600T patent/ATE437230T1/de not_active IP Right Cessation
- 2000-12-29 AU AU26088/01A patent/AU783684B2/en not_active Ceased
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