JP2012025737A5 - - Google Patents

Download PDF

Info

Publication number
JP2012025737A5
JP2012025737A5 JP2011133929A JP2011133929A JP2012025737A5 JP 2012025737 A5 JP2012025737 A5 JP 2012025737A5 JP 2011133929 A JP2011133929 A JP 2011133929A JP 2011133929 A JP2011133929 A JP 2011133929A JP 2012025737 A5 JP2012025737 A5 JP 2012025737A5
Authority
JP
Japan
Prior art keywords
seq
polypeptide
extracellular domain
extracellular
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011133929A
Other languages
English (en)
Other versions
JP2012025737A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2012025737A publication Critical patent/JP2012025737A/ja
Publication of JP2012025737A5 publication Critical patent/JP2012025737A5/ja
Pending legal-status Critical Current

Links

Description

IL-20RB(SEQ ID NO:13-14、ならびに変異体SEQ ID NO:18および19)の細胞外ドメインは、SEQ ID NO:15、59、61、67、68、および69からなる群より選択されるポリペプチドからなる。好ましくは、IL-20RAポリペプチドの細胞外ドメインおよびIL-20RBポリペプチドの細胞外ドメインは一緒に共有結合している。好ましい態様では、これらの2つの細胞外サブユニットポリペプチドが一緒になって可溶性受容体を形成し、Igの重鎖と軽鎖との間でジスルフィド結合が形成されるように、一方の細胞外サブユニットポリペプチドは、そのカルボキシ末端と免疫グロブリンの重鎖定常領域が融合しており、他方の細胞外サブユニットは、そのカルボキシ末端と免疫グロブリン(Ig)の軽鎖定常領域が融合している。別の方法では、ペプチドリンカーがポリペプチドの2つのカルボキシ末端に融合して、共有結合した可溶性受容体を形成してもよい。
オリゴヌクレオチドSEQ ID NO:28およびSEQ ID NO:35を用いて、4つのタンパク質コードドメインをオーバーラップPCRによって連結した。IL-20RAとCH1タンパク質ドメインの間に(Gly4Ser) 3ペプチドリンカーを挿入した。(Gly4Ser) 3ペプチドリンカーは、PCRプライマーSEQ ID NO:32およびSEQ ID NO:31の上にコードされた。IL-20RA細胞外ドメイン/ドメインヒト免疫グロブリンγ1重鎖定常領域融合タンパク質およびDNA配列を、SEQ ID NO:22および23に示した。シグナル配列の無い予測成熟ポリペプチドはSEQ ID NO:62である。実際に使用したIL-20RA細胞外ドメインの部分は、SEQ ID NO:63からなった。
JP2011133929A 1999-12-23 2011-06-16 炎症を治療するための方法 Pending JP2012025737A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47089899A 1999-12-23 1999-12-23
US09/470,898 1999-12-23
US21334100P 2000-06-22 2000-06-22
US60/213,341 2000-06-22

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2001547170A Division JP2003535037A (ja) 1999-12-23 2000-12-22 炎症を治療する方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011210306A Division JP2012025766A (ja) 1999-12-23 2011-09-27 炎症を治療するための方法

Publications (2)

Publication Number Publication Date
JP2012025737A JP2012025737A (ja) 2012-02-09
JP2012025737A5 true JP2012025737A5 (ja) 2014-04-10

Family

ID=26907985

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2001547170A Withdrawn JP2003535037A (ja) 1999-12-23 2000-12-22 炎症を治療する方法
JP2011133929A Pending JP2012025737A (ja) 1999-12-23 2011-06-16 炎症を治療するための方法
JP2011210306A Pending JP2012025766A (ja) 1999-12-23 2011-09-27 炎症を治療するための方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2001547170A Withdrawn JP2003535037A (ja) 1999-12-23 2000-12-22 炎症を治療する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011210306A Pending JP2012025766A (ja) 1999-12-23 2011-09-27 炎症を治療するための方法

Country Status (10)

Country Link
EP (6) EP1743648B1 (ja)
JP (3) JP2003535037A (ja)
AT (2) ATE339450T1 (ja)
AU (1) AU2458001A (ja)
CA (1) CA2395406C (ja)
DE (2) DE60043957D1 (ja)
DK (1) DK1616575T3 (ja)
ES (1) ES2387394T3 (ja)
PT (1) PT1616575E (ja)
WO (1) WO2001046261A1 (ja)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1618969A (zh) * 1997-11-26 2005-05-25 津莫吉尼蒂克斯公司 哺乳动物细胞因子样多肽－10
US7189400B2 (en) 1998-03-17 2007-03-13 Genetics Institute, Llc Methods of treatment with antagonists of MU-1
US6057128A (en) 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
US7198789B2 (en) 1998-03-17 2007-04-03 Genetics Institute, Llc Methods and compositions for modulating interleukin-21 receptor activity
US6610286B2 (en) 1999-12-23 2003-08-26 Zymogenetics, Inc. Method for treating inflammation using soluble receptors to interleukin-20
US7122632B2 (en) 1999-12-23 2006-10-17 Zymogenetics, Inc. Soluble Interleukin-20 receptor
DE60045139D1 (de) 1999-12-23 2010-12-02 Zymogenetics Inc Löslicher Interleukin-20-Rezeptor
EP1743648B1 (en) * 1999-12-23 2010-03-03 ZymoGenetics, Inc. Method for treating inflammation
US20030023033A1 (en) * 2001-07-26 2003-01-30 Laure Dumoutier Novel class II cytokine receptors and uses thereof
CA2418950A1 (en) 2000-08-08 2002-02-14 Zymogenetics, Inc. Soluble zcytor 11 cytokine receptors
US7855269B2 (en) 2000-09-15 2010-12-21 Zymogenetics, Inc. Method for treating inflammation
US20050272120A1 (en) 2001-06-20 2005-12-08 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
CA2451239A1 (en) * 2001-06-20 2003-01-03 Genentech, Inc. Antibodies against tumor-associated antigenic taget (tat) polypeptides
CA2460916A1 (en) * 2001-10-04 2003-04-10 Laura Carter Methods and compositions for modulating interleukin-21 receptor activity
WO2003051384A1 (en) 2001-12-17 2003-06-26 Zymogenetics, Inc. Method for treating cervical cancer
AU2003235948A1 (en) * 2002-04-25 2003-11-10 Chugai Seiyaku Kabushiki Kaisha Remedy for lung cancer
US20060134756A1 (en) * 2003-03-24 2006-06-22 Wenfeng Xu Anti-IL-20 antibodies and binding partners and methods of using in inflammation
WO2005014028A1 (en) * 2003-08-08 2005-02-17 Novo Nordisk A/S Interleukin-20 for treating and diagnosing conditions associated with neovascularisation
NZ583292A (en) 2003-11-06 2012-03-30 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
EP1697418A2 (en) * 2003-11-21 2006-09-06 ZymoGenetics, Inc. Anti-il-20 receptor antibodies and binding partners and methods of using in inflammation
CN102973947A (zh) 2004-06-01 2013-03-20 健泰科生物技术公司 抗体-药物偶联物和方法
BRPI0516284A (pt) 2004-09-23 2008-09-02 Genentech Inc anticorpo construìdo com cisteìna, método de selecionar anticorpos, compostos conjugados de droga-anticorpo, composição farmacêutica, método para matar ou inibir a proliferação de células de tumor, métodos de inibir a proliferação celular e o crescimento de células de tumor, artigo manufaturado e método para produzir um composto
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
US7537761B2 (en) 2004-10-22 2009-05-26 Zymogenetics, Inc. Anti-IL-22RA antibodies and binding partners and methods of using in inflammation
RU2011101969A (ru) * 2008-06-30 2012-08-10 Ново Нордиск А/С (DK) Антитела к человеческому интерлейкину-20
CN102281898B (zh) * 2008-10-07 2015-06-03 成功大学 Il-20拮抗剂在治疗类风湿性关节炎和骨质疏松症中的应用
US8454956B2 (en) 2009-08-31 2013-06-04 National Cheng Kung University Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies
EP2475391B1 (en) 2009-09-09 2018-09-12 Centrose, LLC Extracellular targeted drug conjugates
CN102939303A (zh) 2009-12-22 2013-02-20 诺瓦提斯公司 四价cd47-抗体恒定区融合蛋白用于治疗
EA024730B1 (ru) 2010-04-15 2016-10-31 Медимьюн Лимитед Пирролбензодиазепиновые соединения, их конъюгаты, фармацевтические композиции, содержащие указанные конъюгаты, и применение указанных конъюгатов
KR101839163B1 (ko) 2010-06-08 2018-03-15 제넨테크, 인크. 시스테인 조작된 항체 및 접합체
EP2640727B1 (en) 2010-11-17 2015-05-13 Genentech, Inc. Alaninyl maytansinol antibody conjugates
ES2567276T3 (es) 2011-05-12 2016-04-21 Genentech, Inc. Método de LC-MS/MS de monitoreo de múltiples reacciones para detectar anticuerpos terapéuticos en muestras de animales usando péptidos de cambio de marco
BR112013031762A2 (pt) 2011-06-16 2016-09-13 Novartis Ag proteínas solúveis para utilização como terapêuticos
US9006400B2 (en) 2011-09-26 2015-04-14 Novartis Ag Fibroblast growth factor-21-Fc fusion proteins
UY34347A (es) 2011-09-26 2013-04-30 Novartis Ag Proteínas de función dual para tratar trastornos metabólicos
PT2750713E (pt) 2011-10-14 2016-01-20 Genentech Inc Pirrolobenzodiazepinas e conjugados das mesmas
WO2013117751A2 (en) 2012-02-10 2013-08-15 Novo Nordisk A/S Methods related to treatment of inflammatory diseases and disorders
WO2013130093A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
WO2013164440A1 (en) 2012-05-03 2013-11-07 Novo Nordisk A/S Methods related to treatment of inflammatory diseases and disorders
WO2014015133A1 (en) * 2012-07-19 2014-01-23 National Cheng Kung University Treatment of osteoarthritis using il-20 antagonists
US8852588B2 (en) 2012-08-07 2014-10-07 National Cheng Kung University Treating allergic airway disorders using anti-IL-20 receptor antibodies
US8603470B1 (en) 2012-08-07 2013-12-10 National Cheng Kung University Use of IL-20 antagonists for treating liver diseases
MX364329B (es) 2012-10-12 2019-04-23 Medimmune Ltd Conjugados del anticuerpo pirrolobenzodiazepina.
US10736903B2 (en) 2012-10-12 2020-08-11 Medimmune Limited Pyrrolobenzodiazepine-anti-PSMA antibody conjugates
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
JP5993093B2 (ja) 2012-10-12 2016-09-14 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピン類およびその複合体
SI2906296T1 (en) 2012-10-12 2018-06-29 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
MX364326B (es) 2012-10-12 2019-04-23 Medimmune Ltd Conjugados del anticuerpo pirrolobenzodiazepina - anti-psma.
PT2906251T (pt) 2012-10-12 2017-12-04 Medimmune Ltd Conjugados de pirrolobenzodiazepina-anticorpo anti-cd22
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
EA031585B1 (ru) 2012-12-21 2019-01-31 Медимьюн Лимитед Пирролобензодиазепины и их конъюгаты
NZ712035A (en) 2013-03-13 2019-06-28 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CA2904044C (en) 2013-03-13 2020-03-31 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
SG11201507214SA (en) 2013-03-13 2015-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
KR20160042080A (ko) 2013-08-12 2016-04-18 제넨테크, 인크. 1-(클로로메틸)-2,3-디히드로-1H-벤조[e]인돌 이량체 항체-약물 접합체 화합물, 및 사용 및 치료 방법
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
US9956299B2 (en) 2013-10-11 2018-05-01 Medimmune Limited Pyrrolobenzodiazepine—antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
PE20161394A1 (es) 2013-12-16 2017-01-06 Genentech Inc Compuestos peptidomimeticos y sus conjugados de anticuerpo-farmaco
EP3082874A2 (en) 2013-12-16 2016-10-26 Genentech, Inc. Peptidomimetic compounds and antibody-drug conjugates thereof
WO2015095212A1 (en) 2013-12-16 2015-06-25 Genentech, Inc. 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
EP3610924B1 (en) 2014-06-06 2021-11-03 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
WO2016037644A1 (en) 2014-09-10 2016-03-17 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
EP3191134B1 (en) 2014-09-12 2019-11-20 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CN107108724A (zh) 2014-09-12 2017-08-29 豪夫迈·罗氏有限公司 半胱氨酸改造抗体和缀合物
US20160074527A1 (en) 2014-09-17 2016-03-17 Genentech, Inc. Pyrrolobenzodiazepines and antibody disulfide conjugates thereof
EA035766B1 (ru) 2014-11-21 2020-08-07 Бристол-Майерс Сквибб Компани Антитело к cd73 и его применения
SI3221346T1 (sl) 2014-11-21 2020-11-30 Bristol-Myers Squibb Company Protitelesa vsebujoča modificirana težko konstantna območja
CA2968447A1 (en) 2014-11-25 2016-06-02 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates and their use to treat neoplasms
WO2016090050A1 (en) 2014-12-03 2016-06-09 Genentech, Inc. Quaternary amine compounds and antibody-drug conjugates thereof
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
US10690674B2 (en) 2015-06-03 2020-06-23 Bristol-Myers Squibb Company Anti-GITR antibodies for cancer diagnostics
MA43345A (fr) 2015-10-02 2018-08-08 Hoffmann La Roche Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
MA43354A (fr) 2015-10-16 2018-08-22 Genentech Inc Conjugués médicamenteux à pont disulfure encombré
MA45326A (fr) 2015-10-20 2018-08-29 Genentech Inc Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
US11213586B2 (en) 2015-11-19 2022-01-04 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR)
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
JP6943872B2 (ja) 2016-03-25 2021-10-06 ジェネンテック， インコーポレイテッド 多重全抗体及び抗体複合体化薬物定量化アッセイ
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CN109152843A (zh) 2016-05-20 2019-01-04 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
WO2017205741A1 (en) 2016-05-27 2017-11-30 Genentech, Inc. Bioanalytical method for the characterization of site-specific antibody-drug conjugates
EP3464280B1 (en) 2016-06-06 2021-10-06 F. Hoffmann-La Roche AG Silvestrol antibody-drug conjugates and methods of use
WO2018031662A1 (en) 2016-08-11 2018-02-15 Genentech, Inc. Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
EP3522933B1 (en) 2016-10-05 2021-12-15 F. Hoffmann-La Roche AG Methods for preparing antibody drug conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
DK3544636T3 (da) 2017-02-08 2021-05-10 Adc Therapeutics Sa Pyrrolobenzodiazepin-antistof-konjugater
RS63502B1 (sr) 2017-04-18 2022-09-30 Medimmune Ltd Konjugati pirolobenzodiazepina
CA3057748A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
EP3625260A1 (en) 2017-05-16 2020-03-25 Bristol-Myers Squibb Company Treatment of cancer with anti-gitr agonist antibodies
UA127900C2 (uk) 2017-06-14 2024-02-07 Ейдісі Терапьютікс Са Схема дозування для введення adc до cd19
WO2019034764A1 (en) 2017-08-18 2019-02-21 Medimmune Limited CONJUGATES OF PYRROLOBENZODIAZEPINE
US10301319B2 (en) 2017-09-20 2019-05-28 Ph Pharma Co., Ltd. Thailanstatin analogs
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
JP2022505450A (ja) 2018-10-24 2022-01-14 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト コンジュゲート化された化学的分解誘導物質および使用方法
CN113227119A (zh) 2018-12-10 2021-08-06 基因泰克公司 用于与含Fc的蛋白质进行位点特异性缀合的光交联肽
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
TW202130364A (zh) * 2019-10-28 2021-08-16 永福生物科技股份有限公司 以介白素２４或介白素２０拮抗劑治療組織纖維化和／或損傷和／或器官衰竭

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567584A (en) 1988-01-22 1996-10-22 Zymogenetics, Inc. Methods of using biologically active dimerized polypeptide fusions to detect PDGF
CA2241174C (en) 1996-01-11 2006-09-12 Immunex Corporation Expression augmenting sequence elements (ease) for eukaryotic expression systems
US5945511A (en) 1997-02-20 1999-08-31 Zymogenetics, Inc. Class II cytokine receptor
US6486301B1 (en) * 1997-07-16 2002-11-26 Human Genome Sciences, Inc. Interleukin-20
JP2001510035A (ja) * 1997-07-16 2001-07-31 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド インターロイキン−２０
CN1618969A (zh) 1997-11-26 2005-05-25 津莫吉尼蒂克斯公司 哺乳动物细胞因子样多肽－10
WO1999046379A2 (en) 1998-03-09 1999-09-16 Schering Corporation Human receptor proteins; related reagents and methods
WO1999062934A1 (en) * 1998-06-05 1999-12-09 Human Genome Sciences, Inc. Interferon receptor hkaef92
EP1141008A1 (en) * 1998-12-31 2001-10-10 Millennium Pharmaceuticals, Inc. Class ii cytokine receptor-like proteins and nucleic acids encoding them
DE60045139D1 (de) * 1999-12-23 2010-12-02 Zymogenetics Inc Löslicher Interleukin-20-Rezeptor
EP1743648B1 (en) * 1999-12-23 2010-03-03 ZymoGenetics, Inc. Method for treating inflammation

Similar Documents

Publication Publication Date Title
JP2012025766A5 (ja)
JP2012025737A5 (ja)
JP2015530983A5 (ja)
JP2018033454A5 (ja)
WO2008114149A3 (en) Respiratory syncytial virus (rsv) chimeric polypeptide comprising the g protein central region domain located in between the f2 and f1 fusion protein domains
RU2021134101A (ru) Модифицированная j-цепь
RU2015129640A (ru) Связанные дисульфидом мультивалентные многофункциональные белки, содержащие молекулы гкгс класса 1
JP2019500862A5 (ja)
JP7138046B2 (ja) 二特異性抗体基幹
JP2016533174A5 (ja)
HRP20161656T4 (hr) Sredstva za vezanje na cd33
JP2016511277A5 (ja)
JP2016185981A5 (ja)
CN112839955A (zh) 经工程改造双特异性蛋白
JP2017527272A5 (ja)
NZ618129A (en) Compositions of humanized notch fusion proteins and methods of treatment
EA201400568A1 (ru) Альбуминсвязывающие антитела и их связывающие фрагменты
HRP20130877T1 (hr) Antitijela koja neutraliziraju humani citomegalovirus i njihova primjena
EA200870555A1 (ru) Слитые белки, их применение и способы их получения
NZ602905A (en) Fgf-r4 receptor-specific antagonists
NZ592151A (en) Anti-igf antibodies
RU2013140472A (ru) Слитый белок антиангиогенного индуцирующего фактора и его применение
JP2014503198A5 (ja)
ATE527345T1 (de) Chimäres fusionsprotein mit überlegenen chaperon- und faltungsaktivitäten
JP2017509323A5 (ja)