ATE527345T1 - Chimäres fusionsprotein mit überlegenen chaperon- und faltungsaktivitäten - Google Patents
Chimäres fusionsprotein mit überlegenen chaperon- und faltungsaktivitätenInfo
- Publication number
- ATE527345T1 ATE527345T1 AT06829900T AT06829900T ATE527345T1 AT E527345 T1 ATE527345 T1 AT E527345T1 AT 06829900 T AT06829900 T AT 06829900T AT 06829900 T AT06829900 T AT 06829900T AT E527345 T1 ATE527345 T1 AT E527345T1
- Authority
- AT
- Austria
- Prior art keywords
- chimeric fusion
- fusion protein
- nucleotide sequences
- protein
- sequences coding
- Prior art date
Links
- 108010006519 Molecular Chaperones Proteins 0.000 title abstract 5
- 108020001507 fusion proteins Proteins 0.000 title abstract 5
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 4
- 102000037865 fusion proteins Human genes 0.000 abstract 4
- 102000005431 Molecular Chaperones Human genes 0.000 abstract 3
- 102000018679 Tacrolimus Binding Proteins Human genes 0.000 abstract 3
- 108010027179 Tacrolimus Binding Proteins Proteins 0.000 abstract 3
- 102000053602 DNA Human genes 0.000 abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102100038804 FK506-binding protein-like Human genes 0.000 abstract 1
- 101710169854 FK506-binding protein-like Proteins 0.000 abstract 1
- 102000004195 Isomerases Human genes 0.000 abstract 1
- 108090000769 Isomerases Proteins 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06000056 | 2006-01-03 | ||
| EP06009106 | 2006-05-03 | ||
| PCT/EP2006/012599 WO2007077008A1 (en) | 2006-01-03 | 2006-12-29 | Chimaeric fusion protein with superior chaperone and folding activities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE527345T1 true ATE527345T1 (de) | 2011-10-15 |
Family
ID=37908055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06829900T ATE527345T1 (de) | 2006-01-03 | 2006-12-29 | Chimäres fusionsprotein mit überlegenen chaperon- und faltungsaktivitäten |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7947494B2 (de) |
| EP (1) | EP1971684B1 (de) |
| JP (1) | JP4871960B2 (de) |
| CN (1) | CN101351550B (de) |
| AT (1) | ATE527345T1 (de) |
| CA (1) | CA2636075C (de) |
| ES (1) | ES2375863T3 (de) |
| WO (1) | WO2007077008A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2127678A1 (de) | 2008-05-26 | 2009-12-02 | Roche Diagnostics GmbH | SlpA als Werkzeug für recombinante Protein-und Enzym-technologie |
| AR086250A1 (es) | 2011-05-05 | 2013-11-27 | Hoffmann La Roche | Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo |
| EP2706115A1 (de) | 2012-09-06 | 2014-03-12 | Roche Diagnostics GmbH | Chaperon-Chaperon-Fusionspolypeptide zur Reduzierung der Störungen und Stabilisierung von Immunoassays |
| CA2884429A1 (en) * | 2012-11-08 | 2014-05-15 | Birgit Bossenmaier | Anti-her3/her4 antigen binding proteins binding to the beta-hairpin of her3 and the beta-hairpin of her4 |
| EP2917243B1 (de) * | 2012-11-08 | 2018-03-14 | F.Hoffmann-La Roche Ag | Die beta-haarnadel von her3 bindende her3-antikörper |
| WO2014071978A1 (en) | 2012-11-08 | 2014-05-15 | Roche Diagnostics Gmbh | Nucleic acids encoding chimeric polypeptides for library screening |
| WO2015044083A1 (en) * | 2013-09-27 | 2015-04-02 | F. Hoffmann-La Roche Ag | Thermus thermophilus slyd fkbp domain specific antibodies |
| US10316322B2 (en) | 2014-07-02 | 2019-06-11 | Sutro Biopharma, Inc. | High growth capacity auxotrophic Escherichia coli and methods of use |
| WO2016112295A1 (en) | 2015-01-09 | 2016-07-14 | Warp Drive Bio, Inc. | Compounds that participate in cooperative binding and uses thereof |
| JPWO2016129637A1 (ja) * | 2015-02-13 | 2017-11-24 | 積水化学工業株式会社 | 核酸、融合タンパク質、組換え細胞、並びに、イソプレン又は環式テルペンの生産方法 |
| JP6967002B2 (ja) * | 2015-12-15 | 2021-11-17 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | トランスグルタミナーゼ認識部位を有するｆｋｂｐドメイン |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| WO2017215619A1 (zh) * | 2016-06-15 | 2017-12-21 | 中国科学院上海生命科学研究院 | 在细胞内产生点突变的融合蛋白、其制备及用途 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| WO2018161038A1 (en) * | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Il12 compositions and methods for immunotherapy |
| US20210285955A1 (en) * | 2017-04-05 | 2021-09-16 | Revolution Medicines, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| US20210210159A1 (en) * | 2018-05-31 | 2021-07-08 | Trustees Of Dartmouth College | Computational protein design using tertiary or quaternary structural motifs |
| CA3137018A1 (en) * | 2019-04-16 | 2020-10-22 | University Of Washington | Amantadine binding protein |
| EP4519285A1 (de) * | 2022-05-03 | 2025-03-12 | F. Hoffmann-La Roche AG | Hiv gp41 varianten für immundiagnostische tests |
| WO2025098623A1 (en) | 2023-11-09 | 2025-05-15 | Roche Diagnostics Gmbh | Transglutaminase substrates for labeling |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997010253A1 (en) | 1995-09-15 | 1997-03-20 | Merck & Co., Inc. | A high throughput assay using fusion proteins |
| US5989868A (en) | 1997-09-12 | 1999-11-23 | The Board Of Regents Of The University Of Oklahoma | Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli |
| US7094884B2 (en) * | 2001-06-22 | 2006-08-22 | Roche Diagnostics Corporation | Soluble complexes of amylod β peptide and peptidyl prolyl isomerase chaperone and methods of making and using them |
| US6962982B2 (en) * | 2001-06-22 | 2005-11-08 | Roche Diagnostics Corporation | Soluble complexes of target proteins and peptidyl prolyl isomerase chaperones and methods of making and using them |
| KR100702373B1 (ko) | 2001-06-22 | 2007-04-02 | 에프. 호프만-라 로슈 아게 | 레트로바이러스 표면 당단백질을 함유하는 가용성 복합체 |
| US7094757B2 (en) * | 2001-06-22 | 2006-08-22 | Roche Diagnostics Corporation | Complexes comprising a prion protein and a peptidyl prolyl isomerase chaperone, and method for producing and using them |
| DE60331311D1 (de) | 2002-06-25 | 2010-04-01 | Sekisui Chemical Co Ltd | Expressionsvektor, wirt, fusionsprotein, verfahren zur herstellung von fusionsprotein und verfahren zur herstellung von protein |
| CA2522221A1 (en) * | 2003-04-18 | 2004-10-28 | Sekisui Chemical Co., Ltd. | Immunogen, composition for immunological use, and method of producing a ntibody using the same |
| US7604935B2 (en) * | 2005-10-26 | 2009-10-20 | Roche Diagnostics Operations, Inc. | Soluble rubella E1 envelope protein variants |
-
2006
- 2006-12-29 JP JP2008548951A patent/JP4871960B2/ja active Active
- 2006-12-29 ES ES06829900T patent/ES2375863T3/es active Active
- 2006-12-29 CA CA2636075A patent/CA2636075C/en not_active Expired - Fee Related
- 2006-12-29 EP EP06829900A patent/EP1971684B1/de active Active
- 2006-12-29 AT AT06829900T patent/ATE527345T1/de active
- 2006-12-29 WO PCT/EP2006/012599 patent/WO2007077008A1/en not_active Ceased
- 2006-12-29 CN CN2006800501808A patent/CN101351550B/zh active Active
-
2008
- 2008-07-02 US US12/166,574 patent/US7947494B2/en active Active
-
2011
- 2011-04-11 US US13/083,903 patent/US8247206B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1971684A1 (de) | 2008-09-24 |
| ES2375863T3 (es) | 2012-03-07 |
| EP1971684B1 (de) | 2011-10-05 |
| CN101351550A (zh) | 2009-01-21 |
| WO2007077008A1 (en) | 2007-07-12 |
| CN101351550B (zh) | 2012-10-10 |
| HK1128727A1 (en) | 2009-11-06 |
| US8247206B2 (en) | 2012-08-21 |
| US7947494B2 (en) | 2011-05-24 |
| US20110189754A1 (en) | 2011-08-04 |
| JP2009521938A (ja) | 2009-06-11 |
| CA2636075C (en) | 2011-11-08 |
| JP4871960B2 (ja) | 2012-02-08 |
| US20090042251A1 (en) | 2009-02-12 |
| CA2636075A1 (en) | 2007-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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