|
JP5207590B2
(ja)
|
2002-12-26 |
2013-06-12 |
マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド |
増強された生物学的能力を有するインターフェロン−βのポリマー結合体
|
|
GB0316294D0
(en)
|
2003-07-11 |
2003-08-13 |
Polytherics Ltd |
Conjugated biological molecules and their preparation
|
|
US7046714B2
(en)
*
|
2003-09-10 |
2006-05-16 |
Intel Corporation |
Method and apparatus for Raman ring resonator based laser/wavelength converter
|
|
JP4942643B2
(ja)
*
|
2004-03-02 |
2012-05-30 |
シアトル ジェネティックス， インコーポレイテッド |
部分的に付加された抗体およびそれらの結合体化方法
|
|
KR20080068004A
(ko)
*
|
2005-08-15 |
2008-07-22 |
아라나 테라퓨틱스 리미티드 |
뉴 월드 영장류 구조형성영역을 가진 조작 항체
|
|
US7846439B2
(en)
*
|
2006-02-01 |
2010-12-07 |
Cephalon Australia Pty Ltd |
Domain antibody construct
|
|
US20080139790A1
(en)
*
|
2006-12-08 |
2008-06-12 |
Jennings Philip A |
Chimeric antibodies
|
|
US8575397B2
(en)
|
2007-02-14 |
2013-11-05 |
Biocompatibles Uk Limited |
Derivatisation of biological molecules
|
|
GB0708376D0
(en)
|
2007-05-01 |
2007-06-06 |
Alligator Bioscience Ab |
Novel polypeptides and uses thereof
|
|
US8658148B2
(en)
|
2007-06-22 |
2014-02-25 |
Genzyme Corporation |
Chemically modified dendrimers
|
|
TWI360535B
(en)
*
|
2007-08-30 |
2012-03-21 |
Univ Nat Sun Yat Sen |
Sulfur-containing compound, method of preparation
|
|
CN101820920B
(zh)
*
|
2007-10-09 |
2014-08-06 |
宝力泰锐克斯有限公司 |
新的缀合蛋白质和肽
|
|
DK2280734T3
(da)
*
|
2008-04-24 |
2014-05-26 |
Cantab Biopharmaceuticals Patents Ltd |
Faktor-ix-konjugater med forlængede halveringstider
|
|
AU2009270405B2
(en)
|
2008-06-30 |
2014-06-05 |
Esbatech, An Alcon Biomedical Research Unit Llc |
Functionalized polypeptides
|
|
EP2769711A1
(en)
|
2008-07-10 |
2014-08-27 |
ESBATech, an Alcon Biomedical Research Unit LLC |
Methods and Compositions for Enhanced Delivery of Macromolecules
|
|
AU2009275358C1
(en)
*
|
2008-07-21 |
2015-09-24 |
Polytherics Limited |
Novel reagents and method for conjugating biological molecules
|
|
GB0817978D0
(en)
*
|
2008-10-01 |
2008-11-05 |
Imp Innovations Ltd |
Peptides
|
|
CN102272151B
(zh)
*
|
2008-11-04 |
2014-08-20 |
詹森药业有限公司 |
Crhr2肽激动剂及其用途
|
|
EP2403538B1
(en)
|
2009-03-04 |
2017-10-04 |
Polytherics Limited |
Conjugated proteins and peptides
|
|
GB0922354D0
(en)
|
2009-12-21 |
2010-02-03 |
Polytherics Ltd |
Novel polymer conjugates
|
|
GB0912485D0
(en)
|
2009-07-17 |
2009-08-26 |
Polytherics Ltd |
Improved conjugation method
|
|
WO2011005540A1
(en)
|
2009-06-22 |
2011-01-13 |
Burnham Institute For Medical Research |
Methods and compositions using peptides and proteins with c-terminal elements
|
|
GB0916578D0
(en)
|
2009-09-22 |
2009-10-28 |
Malmsten Nils M |
Polypeptides and uses thereof
|
|
GB0916576D0
(en)
|
2009-09-22 |
2009-10-28 |
Malmsten Nils M |
Polypeptides and uses thereof
|
|
FI124016B
(fi)
*
|
2009-10-26 |
2014-01-31 |
Vapo Oy |
Menetelmä biomassakuivattimessa käytetyn kuivatusilman lämmittämiseksi välipiirinesteen avulla sekä vesi-glykoliseoksen tai sitä vastaavan jäätymättömän välipiirinesteen käyttö biomassakuivattimessa käytetyn kuivatusilman lämmittämiseksi
|
|
US20110105397A1
(en)
*
|
2009-11-04 |
2011-05-05 |
Gengo Peter J |
Method for treating heart failure with stresscopin-like peptides
|
|
GB201007356D0
(en)
|
2010-04-30 |
2010-06-16 |
Leverton Licence Holdings Ltd |
Conjugated factor VIIa
|
|
GB201007357D0
(en)
|
2010-04-30 |
2010-06-16 |
Leverton Licence Holdings Ltd |
Conjugated factor VIII
|
|
WO2012118778A1
(en)
|
2011-02-28 |
2012-09-07 |
Sanford-Burnham Medical Research Institute |
Truncated car peptides and methods and compositions using truncated car peptides
|
|
GB2490655A
(en)
|
2011-04-28 |
2012-11-14 |
Univ Aston |
Modulators of tissue transglutaminase
|
|
AU2012262488A1
(en)
|
2011-05-31 |
2014-01-16 |
Airware, Inc. |
Re-calibration of AB NDIR gas sensors
|
|
US10179801B2
(en)
|
2011-08-26 |
2019-01-15 |
Sanford-Burnham Medical Research Institute |
Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
|
|
MY190257A
(en)
|
2012-04-16 |
2022-04-11 |
Cantab Biopharmaceuticals Patents Ltd |
Optimised subcutaneous therapeutic agents
|
|
WO2013177481A1
(en)
|
2012-05-25 |
2013-11-28 |
Immunogen, Inc. |
Benzodiazepines and conjugates thereof
|
|
GB201210770D0
(en)
|
2012-06-18 |
2012-08-01 |
Polytherics Ltd |
Novel conjugation reagents
|
|
US9650331B2
(en)
|
2012-06-18 |
2017-05-16 |
Polytherics Limited |
Conjugation reagents
|
|
EP2861261A2
(en)
*
|
2012-06-19 |
2015-04-22 |
Polytherics Limited |
Process for preparation of antibody conjugates and antibody conjugates
|
|
NO2789793T3
(https=)
|
2012-10-24 |
2018-01-27 |
|
|
|
US20150290342A1
(en)
|
2012-10-24 |
2015-10-15 |
Polytherics Limited |
Drug-protein conjugates
|
|
ES2732574T3
(es)
*
|
2012-11-30 |
2019-11-25 |
Novartis Ag |
Métodos para preparar conjugados a partir de proteínas que contienen disulfuro
|
|
WO2014093379A1
(en)
|
2012-12-10 |
2014-06-19 |
Mersana Therapeutics, Inc. |
Auristatin compounds and conjugates thereof
|
|
CA2892863C
(en)
|
2012-12-10 |
2022-03-15 |
Mersana Therapeutics, Inc. |
Polymeric scaffold based on phf for targeted drug delivery
|
|
WO2014093640A1
(en)
|
2012-12-12 |
2014-06-19 |
Mersana Therapeutics,Inc. |
Hydroxy-polmer-drug-protein conjugates
|
|
JP6847388B2
(ja)
|
2013-03-15 |
2021-03-31 |
レゲネロン ファーマシューティカルス，インコーポレーテッド |
生物活性分子、そのコンジュゲート、及び治療用途
|
|
GB201308738D0
(en)
*
|
2013-05-15 |
2013-06-26 |
Polytherics Ltd |
Novel polymer conjugates
|
|
BR112016004023A2
(pt)
|
2013-08-26 |
2022-11-16 |
Regeneron Pharma |
Composição, métodos para preparar uma composição e para tratar uma doença, e, composto
|
|
JP6282745B2
(ja)
|
2013-09-12 |
2018-02-21 |
ハロザイム インコーポレイテッド |
修飾抗上皮成長因子受容体抗体およびその使用法
|
|
BR112015032713B1
(pt)
|
2013-09-17 |
2023-03-21 |
Obi Pharma, Inc |
Composto, composição farmacêutica, uso de uma quantidade terapeuticamente efetiva da composição farmacêutica, e uso do composto
|
|
KR102087850B1
(ko)
|
2013-10-11 |
2020-03-12 |
메르사나 테라퓨틱스, 인코포레이티드 |
단백질-고분자-약물 접합체
|
|
ES2754397T3
(es)
|
2013-10-11 |
2020-04-17 |
Asana Biosciences Llc |
Conjugados de proteína-polímero-fármaco
|
|
EA201691075A1
(ru)
|
2013-11-26 |
2016-09-30 |
Новартис Аг |
Способы оксимной конъюгации с кетон-модифицированными полипептидами
|
|
GB201403875D0
(en)
|
2014-03-05 |
2014-04-16 |
Cantargia Ab |
Novel antibodies and uses thereof
|
|
ES2792598T3
(es)
|
2014-05-23 |
2020-11-11 |
Novartis Ag |
Métodos para preparar conjugados a partir de proteínas que contienen disulfuro
|
|
US9951141B2
(en)
|
2014-06-02 |
2018-04-24 |
Regeneron Pharmaceuticals, Inc. |
Antibody-drug conjugates, their preparation and their therapeutic use
|
|
GB201413913D0
(en)
|
2014-08-06 |
2014-09-17 |
Cantargia Ab |
Novel antibodies and uses thereof
|
|
EP3218009B1
(en)
|
2014-10-14 |
2021-04-07 |
Polytherics Limited |
Process for the conjugation of a peptide or protein with a reagent comprising a leaving group including a portion of peg
|
|
AU2016214317B2
(en)
*
|
2015-02-05 |
2022-01-13 |
Ablynx N.V. |
Nanobody dimers linked via C-terminally engineered cysteins
|
|
BR112017020149A8
(pt)
|
2015-03-27 |
2023-05-02 |
Regeneron Pharma |
Derivados de maitansinoide, conjugados dos mesmos e métodos de uso
|
|
US10098960B2
(en)
|
2015-04-03 |
2018-10-16 |
Ucl Business Plc |
Polymer conjugate
|
|
US10509035B2
(en)
|
2015-08-07 |
2019-12-17 |
Gamamabs Pharma Sa |
Antibodies, antibody drug conjugates and methods of use
|
|
US10935544B2
(en)
|
2015-09-04 |
2021-03-02 |
Obi Pharma, Inc. |
Glycan arrays and method of use
|
|
EP3402825A1
(en)
|
2016-01-12 |
2018-11-21 |
Crescendo Biologics Limited |
Molecules that bind prostate specific membrane antigen (psma)
|
|
GB201601136D0
(en)
|
2016-01-21 |
2016-03-09 |
Mörgelin Matthias And Abdillahi Suado M |
Novel polypeptides and medical uses thereof
|
|
BR112018014759B1
(pt)
|
2016-01-25 |
2024-02-27 |
Regeneron Pharmaceuticals, Inc |
Compostos derivados de maitasinoide e seus conjugados, composição compreendendo os mesmos, seus métodos de fabricação e uso
|
|
WO2017161206A1
(en)
|
2016-03-16 |
2017-09-21 |
Halozyme, Inc. |
Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use
|
|
US10980894B2
(en)
|
2016-03-29 |
2021-04-20 |
Obi Pharma, Inc. |
Antibodies, pharmaceutical compositions and methods
|
|
BR112018070097A2
(pt)
|
2016-03-29 |
2019-02-12 |
Obi Pharma, Inc. |
anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos
|
|
CN109152845B
(zh)
|
2016-04-14 |
2022-07-12 |
宝力泰锐克斯有限公司 |
含有在环内包含至少两个(-ch2-ch2-o-)单元的接头的缀合物和缀合试剂
|
|
KR20230110820A
(ko)
|
2016-04-22 |
2023-07-25 |
오비아이 파머 인코퍼레이티드 |
글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에의한 암 면역요법
|
|
GB201608936D0
(en)
|
2016-05-20 |
2016-07-06 |
Polytherics Ltd |
Novel conjugates and novel conjugating reagents
|
|
EP3464379B1
(en)
|
2016-06-06 |
2023-09-27 |
Abzena (UK) Limited |
Antibodies, uses thereof and conjugates thereof
|
|
CN110072545A
(zh)
|
2016-07-27 |
2019-07-30 |
台湾浩鼎生技股份有限公司 |
免疫原性/治疗性聚糖组合物及其用途
|
|
US11643456B2
(en)
|
2016-07-29 |
2023-05-09 |
Obi Pharma, Inc. |
Human antibodies, pharmaceutical compositions and methods
|
|
GB201614162D0
(en)
|
2016-08-18 |
2016-10-05 |
Polytherics Ltd |
Antibodies, uses thereof and conjugates thereof
|
|
GB201615725D0
(en)
|
2016-09-15 |
2016-11-02 |
Polytherics Ltd |
Novel cytotoxic agents and conjugates thereof
|
|
TWI822055B
(zh)
|
2016-11-21 |
2023-11-11 |
台灣浩鼎生技股份有限公司 |
共軛生物分子、醫藥組成物及方法
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
AU2018290330A1
(en)
|
2017-06-22 |
2020-01-02 |
Mersana Therapeutics, Inc. |
Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
|
|
GB201711068D0
(en)
|
2017-07-10 |
2017-08-23 |
Crescendo Biologics Ltd |
Therapeutic molecules binding PSMA
|
|
TW202504930A
(zh)
|
2018-06-27 |
2025-02-01 |
台灣浩鼎生技股份有限公司 |
用於糖蛋白工程的糖苷合成酶變體及其使用方法
|
|
GB201814281D0
(en)
|
2018-09-03 |
2018-10-17 |
Femtogenix Ltd |
Cytotoxic agents
|
|
GB201901197D0
(en)
|
2019-01-29 |
2019-03-20 |
Femtogenix Ltd |
G-A Crosslinking cytotoxic agents
|
|
GB201909298D0
(en)
|
2019-06-28 |
2019-08-14 |
Colzyx Ab |
Novel compositions and uses thereof
|
|
GB2597532A
(en)
|
2020-07-28 |
2022-02-02 |
Femtogenix Ltd |
Cytotoxic compounds
|
|
GB202016456D0
(en)
|
2020-10-16 |
2020-12-02 |
Colzyx Ab |
Novel bioactive peptide combinations and uses thereof
|
|
CA3261603A1
(en)
|
2022-07-15 |
2024-01-18 |
Pheon Therapeutics Ltd |
ANTIBODY-DRUG CONJUGATES
|
|
CN115304524A
(zh)
*
|
2022-07-21 |
2022-11-08 |
湖南大学 |
一种β-酰基烯丙基甲基砜类化合物及其高效合成方法
|
|
WO2024067841A1
(zh)
|
2022-09-30 |
2024-04-04 |
上海迪诺医药科技有限公司 |
苯并氮杂卓衍生物、含其的偶联物及其应用
|
|
AU2023393382A1
(en)
|
2022-12-14 |
2025-06-19 |
Pheon Therapeutics Ltd |
Cytotoxic compounds
|
|
WO2025149667A1
(en)
|
2024-01-12 |
2025-07-17 |
Pheon Therapeutics Ltd |
Antibody drug conjugates and uses thereof
|